Toxicity mechanisms of onion (Allium cepa) extracts and compounds in multidrug resistant erythroleukemic cell line

Detalhes bibliográficos
Autor(a) principal: Votto, Ana P. S.
Data de Publicação: 2010
Outros Autores: Domingues, Beatriz S., Souza, Michele M. de, Silva Júnior, Flavio M. R. da, Caldas, Sergiane S., Filgueira, Daza M. V. B., Clementin, Rosilene M., Primel, Ednei G., Vallochi, Adriana L., Furlong, Eliana B, Trindade, Gilma S.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/30436
Resumo: Universidade Federal do Rio Grande. Instituto de Ciências Biológicas. Rio Grande, RS, Brasil / Universidade Federal do Rio Grande. Programa de Pós-Graduação em Ciências Fisiológicas, Fisiologia Animal Comparada. Rio Grande, RS, Brasil.
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spelling Votto, Ana P. S.Domingues, Beatriz S.Souza, Michele M. deSilva Júnior, Flavio M. R. daCaldas, Sergiane S.Filgueira, Daza M. V. B.Clementin, Rosilene M.Primel, Ednei G.Vallochi, Adriana L.Furlong, Eliana B,Trindade, Gilma S.2018-12-08T13:24:08Z2018-12-08T13:24:08Z2010VOTTO, Ana P. S. et al. Toxicity mechanisms of onion (Allium cepa) extracts and compounds in multidrug resistant erythroleukemic cell line. Biol. Res., v.43, p.429-437, 2010.0716-9760https://www.arca.fiocruz.br/handle/icict/304360717-6287engBMCantioxidanteapoptose e / ou necroseDanos no DNAFenótipo MDRcélula tumoralcebola (Allium cepa)antioxidantapoptosis and/or necrosisDNA damageMDR phenotypeonion (Allium cepa)tumoral cellToxicity mechanisms of onion (Allium cepa) extracts and compounds in multidrug resistant erythroleukemic cell lineinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade Federal do Rio Grande. Instituto de Ciências Biológicas. Rio Grande, RS, Brasil / Universidade Federal do Rio Grande. Programa de Pós-Graduação em Ciências Fisiológicas, Fisiologia Animal Comparada. Rio Grande, RS, Brasil.Universidade Federal do Rio Grande. Instituto de Ciências Biológicas. Rio Grande, RS, Brasil / Universidade Federal do Rio Grande. Programa de Pós-Graduação em Ciências Fisiológicas, Fisiologia Animal Comparada. Rio Grande, RS, Brasil.Universidade Federal do Rio Grande. Escola de Química e Alimentos. Laboratório de Ciência de Alimentos. Rio Grande, RS, Brasil.Universidade Federal do Rio Grande. Programa de Pós-Graduação em Ciências Fisiológicas, Fisiologia Animal Comparada. Rio Grande, RS, Brasil.Universidade Federal do Rio Grande. Escola de Química e Alimentos. Laboratório de Análises de Compostos Orgânicos e Metais. Rio Grande, RS, Brasil.Universidade Federal do Rio Grande. Instituto de Ciências Biológicas. Rio Grande, RS, Brasil / Universidade Federal do Rio Grande. Programa de Pós-Graduação em Ciências Fisiológicas, Fisiologia Animal Comparada. Rio Grande, RS, Brasil.Universidade Federal do Rio Grande. Escola de Química e Alimentos. Laboratório de Análises de Compostos Orgânicos e Metais. Rio Grande, RS, Brasil.Universidade Federal do Rio Grande. Escola de Química e Alimentos. Laboratório de Análises de Compostos Orgânicos e Metais. Rio Grande, RS, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio Grande. Escola de Química e Alimentos. Laboratório de Ciência de Alimentos. Rio Grande, RS, Brasil.Universidade Federal do Rio Grande. Instituto de Ciências Biológicas. Rio Grande, RS, Brasil / Universidade Federal do Rio Grande. Programa de Pós-Graduação em Ciências Fisiológicas, Fisiologia Animal Comparada. Rio Grande, RS, Brasil.Onion (Allium cepa) is being studied as a potential anticancer agent, but little is known regarding its effect in multidrug resistance (MDR) cells. In this work, the cytotoxicity of crude onion extract (OE) and fractioned extract (aqueous, methanolic and ethyl acetate), as well as some onion compounds (quercetin and propyl disulfide) were evaluated in Lucena MDR human erythroleukemic and its K562 parental cell line. The capacity of OE to induce apoptosis and/or necrosis in these cells, the possible participation of oxidative stress and DNA damage were also assessed. Similar sensitivities were obtained for both tumoral cells, however only OE caused significant effects in the cells. In K562 cells, a significant increase of apoptosis was verified while the Lucena cells experienced a significant increase of necrosis. An antioxidant capacity was verified for OE discarding oxidative damage. However, OE provoked similar significant DNA damage in both cell lines. Thus, the OE capacity to overcome the MDR phenotype suggests anti-MDR action of OE.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/30436/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALadrianal_vallochi_etal_IOC_2010.pdfadrianal_vallochi_etal_IOC_2010.pdfapplication/pdf985063https://www.arca.fiocruz.br/bitstream/icict/30436/2/adrianal_vallochi_etal_IOC_2010.pdf36f93731c1a65ff17b7ae26b47f21deaMD52TEXTadrianal_vallochi_etal_IOC_2010.pdf.txtadrianal_vallochi_etal_IOC_2010.pdf.txtExtracted texttext/plain40397https://www.arca.fiocruz.br/bitstream/icict/30436/3/adrianal_vallochi_etal_IOC_2010.pdf.txt1aa8009aabbc5cd13264b134ee59e64dMD53icict/304362018-12-09 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dc.title.pt_BR.fl_str_mv Toxicity mechanisms of onion (Allium cepa) extracts and compounds in multidrug resistant erythroleukemic cell line
title Toxicity mechanisms of onion (Allium cepa) extracts and compounds in multidrug resistant erythroleukemic cell line
spellingShingle Toxicity mechanisms of onion (Allium cepa) extracts and compounds in multidrug resistant erythroleukemic cell line
Votto, Ana P. S.
antioxidante
apoptose e / ou necrose
Danos no DNA
Fenótipo MDR
célula tumoral
cebola (Allium cepa)
antioxidant
apoptosis and/or necrosis
DNA damage
MDR phenotype
onion (Allium cepa)
tumoral cell
title_short Toxicity mechanisms of onion (Allium cepa) extracts and compounds in multidrug resistant erythroleukemic cell line
title_full Toxicity mechanisms of onion (Allium cepa) extracts and compounds in multidrug resistant erythroleukemic cell line
title_fullStr Toxicity mechanisms of onion (Allium cepa) extracts and compounds in multidrug resistant erythroleukemic cell line
title_full_unstemmed Toxicity mechanisms of onion (Allium cepa) extracts and compounds in multidrug resistant erythroleukemic cell line
title_sort Toxicity mechanisms of onion (Allium cepa) extracts and compounds in multidrug resistant erythroleukemic cell line
author Votto, Ana P. S.
author_facet Votto, Ana P. S.
Domingues, Beatriz S.
Souza, Michele M. de
Silva Júnior, Flavio M. R. da
Caldas, Sergiane S.
Filgueira, Daza M. V. B.
Clementin, Rosilene M.
Primel, Ednei G.
Vallochi, Adriana L.
Furlong, Eliana B,
Trindade, Gilma S.
author_role author
author2 Domingues, Beatriz S.
Souza, Michele M. de
Silva Júnior, Flavio M. R. da
Caldas, Sergiane S.
Filgueira, Daza M. V. B.
Clementin, Rosilene M.
Primel, Ednei G.
Vallochi, Adriana L.
Furlong, Eliana B,
Trindade, Gilma S.
author2_role author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Votto, Ana P. S.
Domingues, Beatriz S.
Souza, Michele M. de
Silva Júnior, Flavio M. R. da
Caldas, Sergiane S.
Filgueira, Daza M. V. B.
Clementin, Rosilene M.
Primel, Ednei G.
Vallochi, Adriana L.
Furlong, Eliana B,
Trindade, Gilma S.
dc.subject.other.pt_BR.fl_str_mv antioxidante
apoptose e / ou necrose
Danos no DNA
Fenótipo MDR
célula tumoral
cebola (Allium cepa)
topic antioxidante
apoptose e / ou necrose
Danos no DNA
Fenótipo MDR
célula tumoral
cebola (Allium cepa)
antioxidant
apoptosis and/or necrosis
DNA damage
MDR phenotype
onion (Allium cepa)
tumoral cell
dc.subject.en.pt_BR.fl_str_mv antioxidant
apoptosis and/or necrosis
DNA damage
MDR phenotype
onion (Allium cepa)
tumoral cell
description Universidade Federal do Rio Grande. Instituto de Ciências Biológicas. Rio Grande, RS, Brasil / Universidade Federal do Rio Grande. Programa de Pós-Graduação em Ciências Fisiológicas, Fisiologia Animal Comparada. Rio Grande, RS, Brasil.
publishDate 2010
dc.date.issued.fl_str_mv 2010
dc.date.accessioned.fl_str_mv 2018-12-08T13:24:08Z
dc.date.available.fl_str_mv 2018-12-08T13:24:08Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv VOTTO, Ana P. S. et al. Toxicity mechanisms of onion (Allium cepa) extracts and compounds in multidrug resistant erythroleukemic cell line. Biol. Res., v.43, p.429-437, 2010.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/30436
dc.identifier.issn.pt_BR.fl_str_mv 0716-9760
dc.identifier.eissn.none.fl_str_mv 0717-6287
identifier_str_mv VOTTO, Ana P. S. et al. Toxicity mechanisms of onion (Allium cepa) extracts and compounds in multidrug resistant erythroleukemic cell line. Biol. Res., v.43, p.429-437, 2010.
0716-9760
0717-6287
url https://www.arca.fiocruz.br/handle/icict/30436
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv BMC
publisher.none.fl_str_mv BMC
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/30436/1/license.txt
https://www.arca.fiocruz.br/bitstream/icict/30436/2/adrianal_vallochi_etal_IOC_2010.pdf
https://www.arca.fiocruz.br/bitstream/icict/30436/3/adrianal_vallochi_etal_IOC_2010.pdf.txt
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