Mycobacterium leprae-induced Insulin-like Growth Factor I attenuates antimicrobial mechanisms, promoting bacterial survival in macrophages
Autor(a) principal: | |
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Data de Publicação: | 2016 |
Outros Autores: | , , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
Texto Completo: | https://www.arca.fiocruz.br/handle/icict/14693 |
Resumo: | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Microbiologia Celular. Rio de Janeiro, RJ, Brasil. |
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Silva, L. R. BatistaRodrigues, Luciana SilvaVivarini, Aislan de CarvalhoCosta, Fabrício da Mota RamalhoMattos, Katherine Antunes deCosta, Maria Renata Sales NogueiraRosa, Patricia SammarcoPinto, T. G. ToledoDias, André AlvesMoura, Danielle FonsecaSarno, Euzenir NunesLopes, Ulisses GazosPessolani, Maria Cristina Vidal2016-07-03T00:00:26Z2016-07-07T12:20:07Z2016-07-03T00:00:26Z2016-07-07T12:20:07Z2016SILVA, L. R. Batista; et al. Mycobacterium leprae-induced Insulin-like Growth Factor I attenuates antimicrobial mechanisms, promoting bacterial survival in macrophages. Scientific Reports, v.6, 27632, 13p, June 2016.https://www.arca.fiocruz.br/handle/icict/1469310.1038/srep276322045-2322engNature Publishing GroupHanseníaseMycobacterium lepraeMacrófagosMycobacterium lepraeLeprosyMacrophagesMycobacterium leprae-induced Insulin-like Growth Factor I attenuates antimicrobial mechanisms, promoting bacterial survival in macrophagesinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Microbiologia Celular. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Microbiologia Celular. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Instituto Carlos Chagas Filho. Laboratório de Parasitologia Molecular. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Microbiologia Celular. Rio de Janeiro, RJ, BrasilFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Microbiologia Celular. Rio de Janeiro, RJ, BrasilInstituto Lauro de Souza Lima. Bauru, SP, Brasil.Instituto Lauro de Souza Lima. Bauru, SP, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hanseníase. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Microbiologia Celular. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hanseníase. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hanseníase. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Instituto Carlos Chagas Filho. Laboratório de Parasitologia Molecular. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Microbiologia Celular. Rio de Janeiro, RJ, Brasil.Mycobacterium leprae (ML), the etiologic agent of leprosy, can subvert macrophage antimicrobial activity by mechanisms that remain only partially understood. In the present study, the participation of hormone insulin-like growth factor I (IGF-I) in this phenomenum was investigated. Macrophages from the dermal lesions of the disseminated multibacillary lepromatous form (LL) of leprosy expressed higher levels of IGF-I than those from the self-limited paucibacillary tuberculoid form (BT). Higher levels of IGF-I secretion by ML-infected macrophages were confirmed in ex vivo and in vitro studies. Of note, the dampening of IGF-I signaling reverted the capacity of ML-infected human and murine macrophages to produce antimicrobial molecules and promoted bacterial killing. Moreover, IGF-I was shown to inhibit the JAK/STAT1-dependent signaling pathways triggered by both mycobacteria and IFN-γ most probably through its capacity to induce the suppressor of cytokine signaling-3 (SOCS3). Finally, these in vitro findings were corroborated by in vivo observations in which higher SOCS3 expression and lower phosphorylation of STAT1 levels were found in LL versus BT dermal lesions. Altogether, our data strongly suggest that IGF-I contributes to the maintenance of a functional program in infected macrophages that suits ML persistence in the host, reinforcing a key role for IGF-I in leprosy pathogenesis.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZTEXTkatherine_mattos_etal_IOC_2016.pdf.txtkatherine_mattos_etal_IOC_2016.pdf.txtExtracted texttext/plain65894https://www.arca.fiocruz.br/bitstream/icict/14693/4/katherine_mattos_etal_IOC_2016.pdf.txte5afd9deb877b4e5fae199967e48b1f7MD54ORIGINALkatherine_mattos_etal_IOC_2016.pdfapplication/pdf1295630https://www.arca.fiocruz.br/bitstream/icict/14693/2/katherine_mattos_etal_IOC_2016.pdff98c045639477298b4060493549ed5f8MD52LICENSElicense.txttext/plain2991https://www.arca.fiocruz.br/bitstream/icict/14693/3/license.txt5a560609d32a3863062d77ff32785d58MD53icict/146932022-06-24 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dc.title.pt_BR.fl_str_mv |
Mycobacterium leprae-induced Insulin-like Growth Factor I attenuates antimicrobial mechanisms, promoting bacterial survival in macrophages |
title |
Mycobacterium leprae-induced Insulin-like Growth Factor I attenuates antimicrobial mechanisms, promoting bacterial survival in macrophages |
spellingShingle |
Mycobacterium leprae-induced Insulin-like Growth Factor I attenuates antimicrobial mechanisms, promoting bacterial survival in macrophages Silva, L. R. Batista Hanseníase Mycobacterium leprae Macrófagos Mycobacterium leprae Leprosy Macrophages |
title_short |
Mycobacterium leprae-induced Insulin-like Growth Factor I attenuates antimicrobial mechanisms, promoting bacterial survival in macrophages |
title_full |
Mycobacterium leprae-induced Insulin-like Growth Factor I attenuates antimicrobial mechanisms, promoting bacterial survival in macrophages |
title_fullStr |
Mycobacterium leprae-induced Insulin-like Growth Factor I attenuates antimicrobial mechanisms, promoting bacterial survival in macrophages |
title_full_unstemmed |
Mycobacterium leprae-induced Insulin-like Growth Factor I attenuates antimicrobial mechanisms, promoting bacterial survival in macrophages |
title_sort |
Mycobacterium leprae-induced Insulin-like Growth Factor I attenuates antimicrobial mechanisms, promoting bacterial survival in macrophages |
author |
Silva, L. R. Batista |
author_facet |
Silva, L. R. Batista Rodrigues, Luciana Silva Vivarini, Aislan de Carvalho Costa, Fabrício da Mota Ramalho Mattos, Katherine Antunes de Costa, Maria Renata Sales Nogueira Rosa, Patricia Sammarco Pinto, T. G. Toledo Dias, André Alves Moura, Danielle Fonseca Sarno, Euzenir Nunes Lopes, Ulisses Gazos Pessolani, Maria Cristina Vidal |
author_role |
author |
author2 |
Rodrigues, Luciana Silva Vivarini, Aislan de Carvalho Costa, Fabrício da Mota Ramalho Mattos, Katherine Antunes de Costa, Maria Renata Sales Nogueira Rosa, Patricia Sammarco Pinto, T. G. Toledo Dias, André Alves Moura, Danielle Fonseca Sarno, Euzenir Nunes Lopes, Ulisses Gazos Pessolani, Maria Cristina Vidal |
author2_role |
author author author author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Silva, L. R. Batista Rodrigues, Luciana Silva Vivarini, Aislan de Carvalho Costa, Fabrício da Mota Ramalho Mattos, Katherine Antunes de Costa, Maria Renata Sales Nogueira Rosa, Patricia Sammarco Pinto, T. G. Toledo Dias, André Alves Moura, Danielle Fonseca Sarno, Euzenir Nunes Lopes, Ulisses Gazos Pessolani, Maria Cristina Vidal |
dc.subject.other.pt_BR.fl_str_mv |
Hanseníase Mycobacterium leprae Macrófagos |
topic |
Hanseníase Mycobacterium leprae Macrófagos Mycobacterium leprae Leprosy Macrophages |
dc.subject.en.pt_BR.fl_str_mv |
Mycobacterium leprae Leprosy Macrophages |
description |
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Microbiologia Celular. Rio de Janeiro, RJ, Brasil. |
publishDate |
2016 |
dc.date.accessioned.fl_str_mv |
2016-07-03T00:00:26Z 2016-07-07T12:20:07Z |
dc.date.available.fl_str_mv |
2016-07-03T00:00:26Z 2016-07-07T12:20:07Z |
dc.date.issued.fl_str_mv |
2016 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
SILVA, L. R. Batista; et al. Mycobacterium leprae-induced Insulin-like Growth Factor I attenuates antimicrobial mechanisms, promoting bacterial survival in macrophages. Scientific Reports, v.6, 27632, 13p, June 2016. |
dc.identifier.uri.fl_str_mv |
https://www.arca.fiocruz.br/handle/icict/14693 |
dc.identifier.doi.pt_BR.fl_str_mv |
10.1038/srep27632 |
dc.identifier.eissn.pt_BR.fl_str_mv |
2045-2322 |
identifier_str_mv |
SILVA, L. R. Batista; et al. Mycobacterium leprae-induced Insulin-like Growth Factor I attenuates antimicrobial mechanisms, promoting bacterial survival in macrophages. Scientific Reports, v.6, 27632, 13p, June 2016. 10.1038/srep27632 2045-2322 |
url |
https://www.arca.fiocruz.br/handle/icict/14693 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.publisher.none.fl_str_mv |
Nature Publishing Group |
publisher.none.fl_str_mv |
Nature Publishing Group |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da FIOCRUZ (ARCA) instname:Fundação Oswaldo Cruz (FIOCRUZ) instacron:FIOCRUZ |
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Repositório Institucional da FIOCRUZ (ARCA) |
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