Resolvin D1 drives establishment of Leishmania amazonensis infection
Autor(a) principal: | |
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Data de Publicação: | 2017 |
Outros Autores: | , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
Texto Completo: | https://www.arca.fiocruz.br/handle/icict/18964 |
Resumo: | Amparo à Pesquisa do Estado da Bahia-FAPESB (RED0018/2013 to V. M. B.) and from Conselho Nacional de Desenvolvimento Científico e Tecnológico-CNPq (478480/2013-0 to V. M. B.) |
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Santos, Hayna MaltaAndrade, Bruno de BezerrilZanette, Dalila LucíolaCosta, Jackson MauricíoBozza, Patrícia TorresMelo, Christianne BandeiraBarral, Aldina Maria PradoCosta, Jaqueline FrançaBorges, Valéria de Matos2017-05-18T13:47:17Z2017-05-18T13:47:17Z2017SANTOS, H. M. et al. Resolvin D1 drives establishment of Leishmania amazonensis infection. Scientific Reports, v. 7, p. 46363, 2017.2045-2322https://www.arca.fiocruz.br/handle/icict/1896410.1038/srep46363Amparo à Pesquisa do Estado da Bahia-FAPESB (RED0018/2013 to V. M. B.) and from Conselho Nacional de Desenvolvimento Científico e Tecnológico-CNPq (478480/2013-0 to V. M. B.)Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Salvador, BA, BrasilFundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Fundação José Silveira. Multinational Organization Network Sponsoring Translational and Epidemiological Research Initiative. Salvador, BA, BrazilFundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ, BrasilUniversidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Rio de Janeiro, RJ, BrasilFundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Salvador, BA, BrasilFundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Salvador, BA, BrasilFundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Salvador, BA, BrasilPrevious studies have indicated that the balance between different eicosanoids reflect the intensity of the inflammatory profile in patients with tegumentary leishmaniasis. More recently, pro-resolution lipid mediators have been shown to play critical roles in dampening pathological inflammatory processes to reestablish homeostasis in a diverse range of experimental settings. Among these lipid mediator, resolvins from D series have been described as potent anti-inflammatory and immunomodulatory mediators, and its activities include inhibition of leukocyte chemotaxis and blockage production of proinflammatory cytokines, while increasing the expression of regulatory mediators. Whether resolvins play significant roles in establishment and persistence of Leishmania infection is currently unknown. We addressed this question in the current study by assessing circulating levels of D-series resolvins in tegumentary leishmaniasis patients presenting with localized or diffuse disease. We found heightened expression of resolvin D1 in diffuse cutaneous leishmaniasis which was correlated with expression profile of biomarkers associated with disease pathogenesis. Additional in vitro experiments using primary human macrophages indicated that resolvin D1 may promote intracellular Leishmania amazonensis replication through a mechanism associated with induction of heme oxygenase-1. These results suggest that targeting resolvin D1 could serve as potential strategy for host directed therapy in diffuse cutaneous leishmaniasis.engNature Publishing GroupLeishmania amazonensisLeishmaniaInfecçãoEicosanóidesMediadores lipídicosLeishmania amazonensisLeishmaniaInfectionEicosanoidsLeishmania Mexicana AmazonensisLeishmaniose Tegumentar AmericanaInfecçãoEicosanóidesMediadores lipídicosResolvin D1 drives establishment of Leishmania amazonensis infectioninfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/18964/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALSantos HM Resolvin D1 drives....pdfSantos HM Resolvin D1 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dc.title.pt_BR.fl_str_mv |
Resolvin D1 drives establishment of Leishmania amazonensis infection |
title |
Resolvin D1 drives establishment of Leishmania amazonensis infection |
spellingShingle |
Resolvin D1 drives establishment of Leishmania amazonensis infection Santos, Hayna Malta Leishmania amazonensis Leishmania Infecção Eicosanóides Mediadores lipídicos Leishmania amazonensis Leishmania Infection Eicosanoids Leishmania Mexicana Amazonensis Leishmaniose Tegumentar Americana Infecção Eicosanóides Mediadores lipídicos |
title_short |
Resolvin D1 drives establishment of Leishmania amazonensis infection |
title_full |
Resolvin D1 drives establishment of Leishmania amazonensis infection |
title_fullStr |
Resolvin D1 drives establishment of Leishmania amazonensis infection |
title_full_unstemmed |
Resolvin D1 drives establishment of Leishmania amazonensis infection |
title_sort |
Resolvin D1 drives establishment of Leishmania amazonensis infection |
author |
Santos, Hayna Malta |
author_facet |
Santos, Hayna Malta Andrade, Bruno de Bezerril Zanette, Dalila Lucíola Costa, Jackson Mauricío Bozza, Patrícia Torres Melo, Christianne Bandeira Barral, Aldina Maria Prado Costa, Jaqueline França Borges, Valéria de Matos |
author_role |
author |
author2 |
Andrade, Bruno de Bezerril Zanette, Dalila Lucíola Costa, Jackson Mauricío Bozza, Patrícia Torres Melo, Christianne Bandeira Barral, Aldina Maria Prado Costa, Jaqueline França Borges, Valéria de Matos |
author2_role |
author author author author author author author author |
dc.contributor.author.fl_str_mv |
Santos, Hayna Malta Andrade, Bruno de Bezerril Zanette, Dalila Lucíola Costa, Jackson Mauricío Bozza, Patrícia Torres Melo, Christianne Bandeira Barral, Aldina Maria Prado Costa, Jaqueline França Borges, Valéria de Matos |
dc.subject.other.pt_BR.fl_str_mv |
Leishmania amazonensis Leishmania Infecção Eicosanóides Mediadores lipídicos |
topic |
Leishmania amazonensis Leishmania Infecção Eicosanóides Mediadores lipídicos Leishmania amazonensis Leishmania Infection Eicosanoids Leishmania Mexicana Amazonensis Leishmaniose Tegumentar Americana Infecção Eicosanóides Mediadores lipídicos |
dc.subject.en.pt_BR.fl_str_mv |
Leishmania amazonensis Leishmania Infection Eicosanoids |
dc.subject.decs.pt_BR.fl_str_mv |
Leishmania Mexicana Amazonensis Leishmaniose Tegumentar Americana Infecção Eicosanóides Mediadores lipídicos |
description |
Amparo à Pesquisa do Estado da Bahia-FAPESB (RED0018/2013 to V. M. B.) and from Conselho Nacional de Desenvolvimento Científico e Tecnológico-CNPq (478480/2013-0 to V. M. B.) |
publishDate |
2017 |
dc.date.accessioned.fl_str_mv |
2017-05-18T13:47:17Z |
dc.date.available.fl_str_mv |
2017-05-18T13:47:17Z |
dc.date.issued.fl_str_mv |
2017 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
SANTOS, H. M. et al. Resolvin D1 drives establishment of Leishmania amazonensis infection. Scientific Reports, v. 7, p. 46363, 2017. |
dc.identifier.uri.fl_str_mv |
https://www.arca.fiocruz.br/handle/icict/18964 |
dc.identifier.issn.pt_BR.fl_str_mv |
2045-2322 |
dc.identifier.doi.none.fl_str_mv |
10.1038/srep46363 |
identifier_str_mv |
SANTOS, H. M. et al. Resolvin D1 drives establishment of Leishmania amazonensis infection. Scientific Reports, v. 7, p. 46363, 2017. 2045-2322 10.1038/srep46363 |
url |
https://www.arca.fiocruz.br/handle/icict/18964 |
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eng |
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eng |
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info:eu-repo/semantics/openAccess |
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Nature Publishing Group |
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Nature Publishing Group |
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