Newborns with Zika virus-associated microcephaly exhibit marked systemic inflammatory imbalance

Detalhes bibliográficos
Autor(a) principal: Vinhaes, Caian L.
Data de Publicação: 2020
Outros Autores: Arriaga Gutiérrez, María Belen, Almeida, Breno L. de, Oliveira, João V., Santos, Cleiton S., Calcagno, Juan I., Carvalho, Tereza X., Giovanetti, Marta, Alcantara, Luiz Carlos Junior, Siqueira, Isadora Cristina de, Andrade, Bruno de Bezerril
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/41601
Resumo: Fundação Oswaldo Cruz, Conselho Nacional de Desenvolvimento Científico e Tecnológico ([CNPq] award numbers 443875/2018-9 and 425380/2016) and Fundação de Amparo à Pesquisa do Estado da Bahia ([FAPESB] award number PPSUS/BA-FAPESB003/2017/ SESAB/CNPq/MS 5125/2017). L. C. J. A., M. G., and B. L. d. A. were supported by CNPq/Ministério da Ciência, Tecnologia e Inovação (MCTI), Departamento de Ciência e Tecnologia (DECIT)/Secretaria de Ciência, Tecnologia e Insumos Estratégicos (SCTIE)/Ministério da Saúde (440685/2016–8), and Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) (88887.130716/2016-00). L. C. J. A. and I. C. d. S. were supported by the European Union’s Horizon 2020 Programme through ZIKAlliance (Grant No. PRES-005- FEX-17-4-2-33). The work from B. B. A. was supported by the National Institutes of Health (U01AI115940) and by CNPq (senior fellowship). M. B. A. received a fellowship from the FAPESB. C. L. V. is a scientific initiation fellow from CNPq.
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spelling Vinhaes, Caian L.Arriaga Gutiérrez, María BelenAlmeida, Breno L. deOliveira, João V.Santos, Cleiton S.Calcagno, Juan I.Carvalho, Tereza X.Giovanetti, MartaAlcantara, Luiz Carlos JuniorSiqueira, Isadora Cristina deAndrade, Bruno de Bezerril2020-06-10T13:39:46Z2020-06-10T13:39:46Z2020VINHAES, Caian L. et al. wNewborns with Zika virus-associated microcephaly exhibit marked systemic inflammatory imbalance. The Journal of Infectious Disease, p. 1-11, 2020.0022-1899https://www.arca.fiocruz.br/handle/icict/4160110.1093/infdis/jiaa197Fundação Oswaldo Cruz, Conselho Nacional de Desenvolvimento Científico e Tecnológico ([CNPq] award numbers 443875/2018-9 and 425380/2016) and Fundação de Amparo à Pesquisa do Estado da Bahia ([FAPESB] award number PPSUS/BA-FAPESB003/2017/ SESAB/CNPq/MS 5125/2017). L. C. J. A., M. G., and B. L. d. A. were supported by CNPq/Ministério da Ciência, Tecnologia e Inovação (MCTI), Departamento de Ciência e Tecnologia (DECIT)/Secretaria de Ciência, Tecnologia e Insumos Estratégicos (SCTIE)/Ministério da Saúde (440685/2016–8), and Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) (88887.130716/2016-00). L. C. J. A. and I. C. d. S. were supported by the European Union’s Horizon 2020 Programme through ZIKAlliance (Grant No. PRES-005- FEX-17-4-2-33). The work from B. B. A. was supported by the National Institutes of Health (U01AI115940) and by CNPq (senior fellowship). M. B. A. received a fellowship from the FAPESB. C. L. V. is a scientific initiation fellow from CNPq.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Multinational Organization Network Sponsoring Translational and Epidemiological Research Initiative. Salvador, BA, Brazil / Faculdade de Tecnologia e Ciências. Curso de Medicina. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Multinational Organization Network Sponsoring Translational and Epidemiological Research Initiative. Salvador, BA, Brazil / Universidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil.Secretaria de Saúde do Estado da Bahia. Maternidade de Referência Prof. José Maria de Magalhães Netto. Salvador, BA, Brasil.Secretaria de Saúde do Estado da Bahia. Maternidade de Referência Prof. José Maria de Magalhães Netto. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Flavivírus. Rio de Janeiro, RJ, Brasil / Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Laboratório de Genética Celular e Molecular. Belo Horizonte, MG, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Multinational Organization Network Sponsoring Translational and Epidemiological Research Initiative. Salvador, BA, Brazil / Faculdade de Tecnologia e Ciências. Curso de Medicina. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, Brasil / Universidade Salvador. Laureate Universities. Salvador, BA, Brasil / IUniversity of Cape Town. Institute of Infectious Disease and Molecular Medicine. Centre for Infectious Disease Research in Africa. Cape Town, South Africa / Escola Bahiana de Medicina e Saúde Pública, Salvador, BA, Brasil.Zika Virus (ZIKV) is an emergent flavivirus initially considered a benign and self-limited exanthematic illness. In 2015, a new epidemic emerged in northeastern of Brazil with increased incidence of a previously rare clinical outcome, microcephaly, in newborns from mothers who were infected during pregnancy. Little is known about the immunopathogenesis of ZIKV-associated microcephaly. Understanding the inflammatory profile and degree of inflammation of persons affected with such condition is an important step towards development of innovative therapeutic strategies.engOxford University PressInflamaçãoMicrocefaliaRecém-nascidosVírus zikaInflammationMicrocephalyNewbornsZika virusNewborns with Zika virus-associated microcephaly exhibit marked systemic inflammatory imbalanceinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/41601/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALVinhaes, L.C. Newborns....pdfVinhaes, L.C. 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dc.title.pt_BR.fl_str_mv Newborns with Zika virus-associated microcephaly exhibit marked systemic inflammatory imbalance
title Newborns with Zika virus-associated microcephaly exhibit marked systemic inflammatory imbalance
spellingShingle Newborns with Zika virus-associated microcephaly exhibit marked systemic inflammatory imbalance
Vinhaes, Caian L.
Inflamação
Microcefalia
Recém-nascidos
Vírus zika
Inflammation
Microcephaly
Newborns
Zika virus
title_short Newborns with Zika virus-associated microcephaly exhibit marked systemic inflammatory imbalance
title_full Newborns with Zika virus-associated microcephaly exhibit marked systemic inflammatory imbalance
title_fullStr Newborns with Zika virus-associated microcephaly exhibit marked systemic inflammatory imbalance
title_full_unstemmed Newborns with Zika virus-associated microcephaly exhibit marked systemic inflammatory imbalance
title_sort Newborns with Zika virus-associated microcephaly exhibit marked systemic inflammatory imbalance
author Vinhaes, Caian L.
author_facet Vinhaes, Caian L.
Arriaga Gutiérrez, María Belen
Almeida, Breno L. de
Oliveira, João V.
Santos, Cleiton S.
Calcagno, Juan I.
Carvalho, Tereza X.
Giovanetti, Marta
Alcantara, Luiz Carlos Junior
Siqueira, Isadora Cristina de
Andrade, Bruno de Bezerril
author_role author
author2 Arriaga Gutiérrez, María Belen
Almeida, Breno L. de
Oliveira, João V.
Santos, Cleiton S.
Calcagno, Juan I.
Carvalho, Tereza X.
Giovanetti, Marta
Alcantara, Luiz Carlos Junior
Siqueira, Isadora Cristina de
Andrade, Bruno de Bezerril
author2_role author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Vinhaes, Caian L.
Arriaga Gutiérrez, María Belen
Almeida, Breno L. de
Oliveira, João V.
Santos, Cleiton S.
Calcagno, Juan I.
Carvalho, Tereza X.
Giovanetti, Marta
Alcantara, Luiz Carlos Junior
Siqueira, Isadora Cristina de
Andrade, Bruno de Bezerril
dc.subject.other.pt_BR.fl_str_mv Inflamação
Microcefalia
Recém-nascidos
Vírus zika
topic Inflamação
Microcefalia
Recém-nascidos
Vírus zika
Inflammation
Microcephaly
Newborns
Zika virus
dc.subject.en.pt_BR.fl_str_mv Inflammation
Microcephaly
Newborns
Zika virus
description Fundação Oswaldo Cruz, Conselho Nacional de Desenvolvimento Científico e Tecnológico ([CNPq] award numbers 443875/2018-9 and 425380/2016) and Fundação de Amparo à Pesquisa do Estado da Bahia ([FAPESB] award number PPSUS/BA-FAPESB003/2017/ SESAB/CNPq/MS 5125/2017). L. C. J. A., M. G., and B. L. d. A. were supported by CNPq/Ministério da Ciência, Tecnologia e Inovação (MCTI), Departamento de Ciência e Tecnologia (DECIT)/Secretaria de Ciência, Tecnologia e Insumos Estratégicos (SCTIE)/Ministério da Saúde (440685/2016–8), and Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) (88887.130716/2016-00). L. C. J. A. and I. C. d. S. were supported by the European Union’s Horizon 2020 Programme through ZIKAlliance (Grant No. PRES-005- FEX-17-4-2-33). The work from B. B. A. was supported by the National Institutes of Health (U01AI115940) and by CNPq (senior fellowship). M. B. A. received a fellowship from the FAPESB. C. L. V. is a scientific initiation fellow from CNPq.
publishDate 2020
dc.date.accessioned.fl_str_mv 2020-06-10T13:39:46Z
dc.date.available.fl_str_mv 2020-06-10T13:39:46Z
dc.date.issued.fl_str_mv 2020
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv VINHAES, Caian L. et al. wNewborns with Zika virus-associated microcephaly exhibit marked systemic inflammatory imbalance. The Journal of Infectious Disease, p. 1-11, 2020.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/41601
dc.identifier.issn.pt_BR.fl_str_mv 0022-1899
dc.identifier.doi.none.fl_str_mv 10.1093/infdis/jiaa197
identifier_str_mv VINHAES, Caian L. et al. wNewborns with Zika virus-associated microcephaly exhibit marked systemic inflammatory imbalance. The Journal of Infectious Disease, p. 1-11, 2020.
0022-1899
10.1093/infdis/jiaa197
url https://www.arca.fiocruz.br/handle/icict/41601
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Oxford University Press
publisher.none.fl_str_mv Oxford University Press
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
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