Inheritance and heritability of deltamethrin resistance under laboratory conditions of Triatoma infestans from Bolivia

Detalhes bibliográficos
Autor(a) principal: Gomez, Marinely Blanca Bustamante
Data de Publicação: 2015
Outros Autores: Pessoa, Grasielle Caldas D Ávila, Rosa, Aline Cristine Luiz, Echeverria, Jorge Espinoza, Diotaiuti, Liléia Gonçalves
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/13548
Resumo: Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Laboratório de Referência em Triatomíneos e Epidemiologia da Doença de Chagas. Belo Horizonte, MG, Brasil
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spelling Gomez, Marinely Blanca BustamantePessoa, Grasielle Caldas D ÁvilaRosa, Aline Cristine LuizEcheverria, Jorge EspinozaDiotaiuti, Liléia Gonçalves2016-04-05T18:57:36Z2016-04-05T18:57:36Z2015GOMEZ, Marinely Bustamante Blanca et al. Inheritance and heritability of deltamethrin resistance under laboratory conditions of Triatoma infestans from Bolivia. Parasit Vectors, vol. 8, p. 595, 2015.1756-3305https://www.arca.fiocruz.br/handle/icict/1354810.1186/s13071-015-1211-9engBioMed CentralInheritance and heritability of deltamethrin resistance under laboratory conditions of Triatoma infestans from Boliviainfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Laboratório de Referência em Triatomíneos e Epidemiologia da Doença de Chagas. Belo Horizonte, MG, BrasilFundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Laboratório de Referência em Triatomíneos e Epidemiologia da Doença de Chagas. Belo Horizonte, MG, BrasilFundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Laboratório de Referência em Triatomíneos e Epidemiologia da Doença de Chagas. Belo Horizonte, MG, BrasilFundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Laboratório de Referência em Triatomíneos e Epidemiologia da Doença de Chagas. Belo Horizonte, MG, BrasilFundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Laboratório de Referência em Triatomíneos e Epidemiologia da Doença de Chagas. Belo Horizonte, MG, BrasilBackground: Over the last few decades, pyrethroid-resistant in Triatoma infestans populations have been reported, mainly on the border between Argentina and Bolivia. Understanding the genetic basis of inheritance mode and heritability of resistance to insecticides under laboratory conditions is crucial for vector management and monitoring of insecticide resistance. Currently, few studies have been performed to characterize the inheritance mode of resistance to pyrethroids in T. infestans; for this reason, the present study aims to characterize the inheritance and heritability of deltamethrin resistance in T. infestans populations from Bolivia with different toxicological profiles. Methods: Experimental crosses were performed between a susceptible (S) colony and resistant (R) and reduced susceptibility (RS) colonies in both directions (♀ x ♂ and ♂ x ♀), and inheritance mode was determined based on degree of dominance (DO) and effective dominance (DML). In addition, realized heritability (h2) was estimated based on a resistant colony, and select pressure was performed for two generations based on the diagnostic dose (10 ng. i. a. /nymph). The F1 progeny of the experimental crosses and the selection were tested by a standard insecticide resistance bioassay. Results: The result for DO and DML (< 1) indicates that resistance is an incompletely dominant character, and inheritance is autosomal, not sex-linked. The LD50 for F1 of ♀S x ♂R and ♂S x ♀R was 0.74 and 3.97, respectively, which is indicative of dilution effect. In the resistant colony, after selection pressure, the value of h2 was 0.37; thus, the LD50 value increased 2.25-fold (F2) and 26.83-fold (F3) compared with the parental colony. Conclusion: The inheritance mode of resistance of T. infestans to deltamethrin, is autosomal and an incompletely dominant character; this is a previously known process, confirmed in the present study on T. infestans populations from Bolivia. The lethal doses (LD50) increase from one generation to another rapidly after selection pressure with deltamethrin. This suggests that resistance is an additive and cumulative factor, mainly in highly structured populations with limited dispersal capacity, such as T. infestans. This phenomenon was demonstrated for the first time for T. infestans in the present study. These results are very important for vector control strategies in problematic areas where high resistance ratios of T. infestans have been reported.Triatoma infestansInheritanceHeritabilityInsecticide resistanceDeltamethrinControlinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/13548/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALInheritance and heritability of deltamethrin resistance under laboratory conditions of Triatoma infestans from Bolivia.pdfInheritance and heritability of deltamethrin resistance under laboratory conditions of Triatoma infestans from Bolivia.pdfapplication/pdf5217942https://www.arca.fiocruz.br/bitstream/icict/13548/2/Inheritance%20and%20heritability%20of%20deltamethrin%20resistance%20under%20laboratory%20conditions%20of%20Triatoma%20infestans%20from%20Bolivia.pdf285b1b55bc8ff585ef9878da7e69dd2bMD52TEXTInheritance and heritability of deltamethrin resistance under laboratory conditions of Triatoma infestans from Bolivia.pdf.txtInheritance and heritability of deltamethrin resistance under laboratory conditions of Triatoma infestans from Bolivia.pdf.txtExtracted texttext/plain89https://www.arca.fiocruz.br/bitstream/icict/13548/3/Inheritance%20and%20heritability%20of%20deltamethrin%20resistance%20under%20laboratory%20conditions%20of%20Triatoma%20infestans%20from%20Bolivia.pdf.txtd0d20f318cf098a92d2176cf5d335542MD53icict/135482022-01-26 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dc.title.pt_BR.fl_str_mv Inheritance and heritability of deltamethrin resistance under laboratory conditions of Triatoma infestans from Bolivia
title Inheritance and heritability of deltamethrin resistance under laboratory conditions of Triatoma infestans from Bolivia
spellingShingle Inheritance and heritability of deltamethrin resistance under laboratory conditions of Triatoma infestans from Bolivia
Gomez, Marinely Blanca Bustamante
Triatoma infestans
Inheritance
Heritability
Insecticide resistance
Deltamethrin
Control
title_short Inheritance and heritability of deltamethrin resistance under laboratory conditions of Triatoma infestans from Bolivia
title_full Inheritance and heritability of deltamethrin resistance under laboratory conditions of Triatoma infestans from Bolivia
title_fullStr Inheritance and heritability of deltamethrin resistance under laboratory conditions of Triatoma infestans from Bolivia
title_full_unstemmed Inheritance and heritability of deltamethrin resistance under laboratory conditions of Triatoma infestans from Bolivia
title_sort Inheritance and heritability of deltamethrin resistance under laboratory conditions of Triatoma infestans from Bolivia
author Gomez, Marinely Blanca Bustamante
author_facet Gomez, Marinely Blanca Bustamante
Pessoa, Grasielle Caldas D Ávila
Rosa, Aline Cristine Luiz
Echeverria, Jorge Espinoza
Diotaiuti, Liléia Gonçalves
author_role author
author2 Pessoa, Grasielle Caldas D Ávila
Rosa, Aline Cristine Luiz
Echeverria, Jorge Espinoza
Diotaiuti, Liléia Gonçalves
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Gomez, Marinely Blanca Bustamante
Pessoa, Grasielle Caldas D Ávila
Rosa, Aline Cristine Luiz
Echeverria, Jorge Espinoza
Diotaiuti, Liléia Gonçalves
dc.subject.en.pt_BR.fl_str_mv Triatoma infestans
Inheritance
Heritability
Insecticide resistance
Deltamethrin
Control
topic Triatoma infestans
Inheritance
Heritability
Insecticide resistance
Deltamethrin
Control
description Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Laboratório de Referência em Triatomíneos e Epidemiologia da Doença de Chagas. Belo Horizonte, MG, Brasil
publishDate 2015
dc.date.issued.fl_str_mv 2015
dc.date.accessioned.fl_str_mv 2016-04-05T18:57:36Z
dc.date.available.fl_str_mv 2016-04-05T18:57:36Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv GOMEZ, Marinely Bustamante Blanca et al. Inheritance and heritability of deltamethrin resistance under laboratory conditions of Triatoma infestans from Bolivia. Parasit Vectors, vol. 8, p. 595, 2015.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/13548
dc.identifier.issn.none.fl_str_mv 1756-3305
dc.identifier.doi.none.fl_str_mv 10.1186/s13071-015-1211-9
identifier_str_mv GOMEZ, Marinely Bustamante Blanca et al. Inheritance and heritability of deltamethrin resistance under laboratory conditions of Triatoma infestans from Bolivia. Parasit Vectors, vol. 8, p. 595, 2015.
1756-3305
10.1186/s13071-015-1211-9
url https://www.arca.fiocruz.br/handle/icict/13548
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv BioMed Central
publisher.none.fl_str_mv BioMed Central
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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