HLA class II alleles and chronic hepatitis C virus infection

Detalhes bibliográficos
Autor(a) principal: Cangussu, Luiz Otavio Freire
Data de Publicação: 2011
Outros Autores: Teixeira, Rosângela, Campos, Erika Fernandes, Rampim, G. F., Mingoti, Sueli Aparecida, Martins Filho, Olindo Assis, Lima, Maria Gerbase de
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/8130
Resumo: Instituto Alfa de Gastroenterologia. Divisão de Hepatite Viral. Belo Horizonte, MG, Brasil/Universidade Federal de Minas Gerais. Hospital das Clínicas. Belo Horizonte, MG, Brasil
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spelling Cangussu, Luiz Otavio FreireTeixeira, RosângelaCampos, Erika FernandesRampim, G. F.Mingoti, Sueli AparecidaMartins Filho, Olindo AssisLima, Maria Gerbase de2014-08-04T19:23:32Z2014-08-04T19:23:32Z2011CANGUSSU, Luiz Otavio Freire et al. HLA class II alleles and chronic hepatitis C virus infection. Scand J Immunol, 74(3): 282-287,20110300-9475https://www.arca.fiocruz.br/handle/icict/813010.1111/j.1365-3083.2011.02568.x.engBlackwell Scientific PublicationsLimaCD4-Positive T-LymphocytesHepatitis C, Chronic/geneticsHepatitis C, Chronic/pathologyHLA-DRB1*11 antigenHLA class II alleles and chronic hepatitis C virus infectioninfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleInstituto Alfa de Gastroenterologia. Divisão de Hepatite Viral. Belo Horizonte, MG, Brasil/Universidade Federal de Minas Gerais. Hospital das Clínicas. Belo Horizonte, MG, BrasilInstituto Alfa de Gastroenterologia. Divisão de Hepatite Viral. Belo Horizonte, MG, Brasil/Universidade Federal de Minas Gerais. Hospital das Clínicas. Belo Horizonte, MG, Brasil/Universidade Federal de Minas Gerais. Faculdade de Medicina. Departamento de Medicina Interna. Belo Horizonte, MG, BrasilUniversidade Federal de São Paulo. Escola Paulista de Medicina. Departamento de Pediatria. Divisão de Imunogenetica São Paulo, SP, BrazilUniversidade Federal de São Paulo. Escola Paulista de Medicina. Departamento de Pediatria. Divisão de Imunogenetica São Paulo, SP, BrazilUniversidade Federal de Minas Gerais. Instituto de Ciências Exatas. Belo Horizonte, MG, BrazilFundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Laboratório de Biomarcadores de Diagnóstico e Monitoração. Belo Horizonte, MG, BrasilUniversidade Federal de São Paulo. Escola Paulista de Medicina. Departamento de Pediatria. Divisão de Imunogenetica São Paulo, SP, BrazilThe aim of this study was to investigate association of human leucocyte antigens (HLA)-DRB1 and DQB1 polymorphisms with hepatitis C virus (HCV) infection and with the occurrence of severe liver fibrosis/cirrhosis in chronically infected patients. Ninety-nine white patients, from southeast Brazil, with confirmed HCV chronic infection were included in the study. Severe fibrosis/cirrhosis (METAVIR scores F3-F4) was present in 49 patients. HLA-DRB1 specificities and DRB1*11 and DQB1* alleles were determined by PCR-SSP, and their frequencies were compared between patients and a control group of 103 healthy white Brazilian individuals. The results confirmed previous reports of the association of DRB1*11 and DQB1*03 with protection from chronic HCV infection, but did not confirm their association with protection from severe fibrosis/cirrhosis. Furthermore, the results suggested that the polymorphic sites on HLA molecules responsible for protection from chronic HCV infection are encoded not only by the DRB1*1101 and DQB1*0301, as suggested in the literature, but also by other DRB1*11 and DQB1*03 alleles. Thus, we hypothesized that the common polymorphic residues shared by different DRB1*11 and/or DQB1*03 alleles might be responsible for selection of viral epitopes for presentation to CD4(+) T cells, leading to an efficient immune response against the virus.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINALHLA class II alleles and chronic hepatitis C virus infection.pdfHLA class II alleles and chronic hepatitis C virus infection.pdfapplication/pdf1047796https://www.arca.fiocruz.br/bitstream/icict/8130/1/HLA%20class%20II%20alleles%20and%20chronic%20hepatitis%20C%20virus%20infection.pdf552d342f541f8b8ef92b58ab890226e7MD51LICENSElicense.txtlicense.txttext/plain; charset=utf-81914https://www.arca.fiocruz.br/bitstream/icict/8130/2/license.txt7d48279ffeed55da8dfe2f8e81f3b81fMD52TEXTHLA class II alleles and chronic hepatitis C virus infection.pdf.txtHLA class II alleles and chronic hepatitis C virus infection.pdf.txtExtracted texttext/plain6https://www.arca.fiocruz.br/bitstream/icict/8130/3/HLA%20class%20II%20alleles%20and%20chronic%20hepatitis%20C%20virus%20infection.pdf.txt6d93d3216dc4a7f5df47d4876fbec4d3MD53icict/81302018-04-05 23:45:32.481oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352018-04-06T02:45:32Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv HLA class II alleles and chronic hepatitis C virus infection
title HLA class II alleles and chronic hepatitis C virus infection
spellingShingle HLA class II alleles and chronic hepatitis C virus infection
Cangussu, Luiz Otavio Freire
Lima
CD4-Positive T-Lymphocytes
Hepatitis C, Chronic/genetics
Hepatitis C, Chronic/pathology
HLA-DRB1*11 antigen
title_short HLA class II alleles and chronic hepatitis C virus infection
title_full HLA class II alleles and chronic hepatitis C virus infection
title_fullStr HLA class II alleles and chronic hepatitis C virus infection
title_full_unstemmed HLA class II alleles and chronic hepatitis C virus infection
title_sort HLA class II alleles and chronic hepatitis C virus infection
author Cangussu, Luiz Otavio Freire
author_facet Cangussu, Luiz Otavio Freire
Teixeira, Rosângela
Campos, Erika Fernandes
Rampim, G. F.
Mingoti, Sueli Aparecida
Martins Filho, Olindo Assis
Lima, Maria Gerbase de
author_role author
author2 Teixeira, Rosângela
Campos, Erika Fernandes
Rampim, G. F.
Mingoti, Sueli Aparecida
Martins Filho, Olindo Assis
Lima, Maria Gerbase de
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Cangussu, Luiz Otavio Freire
Teixeira, Rosângela
Campos, Erika Fernandes
Rampim, G. F.
Mingoti, Sueli Aparecida
Martins Filho, Olindo Assis
Lima, Maria Gerbase de
dc.subject.other.pt_BR.fl_str_mv Lima
topic Lima
CD4-Positive T-Lymphocytes
Hepatitis C, Chronic/genetics
Hepatitis C, Chronic/pathology
HLA-DRB1*11 antigen
dc.subject.en.pt_BR.fl_str_mv CD4-Positive T-Lymphocytes
Hepatitis C, Chronic/genetics
Hepatitis C, Chronic/pathology
HLA-DRB1*11 antigen
description Instituto Alfa de Gastroenterologia. Divisão de Hepatite Viral. Belo Horizonte, MG, Brasil/Universidade Federal de Minas Gerais. Hospital das Clínicas. Belo Horizonte, MG, Brasil
publishDate 2011
dc.date.issued.fl_str_mv 2011
dc.date.accessioned.fl_str_mv 2014-08-04T19:23:32Z
dc.date.available.fl_str_mv 2014-08-04T19:23:32Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv CANGUSSU, Luiz Otavio Freire et al. HLA class II alleles and chronic hepatitis C virus infection. Scand J Immunol, 74(3): 282-287,2011
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/8130
dc.identifier.issn.none.fl_str_mv 0300-9475
dc.identifier.doi.none.fl_str_mv 10.1111/j.1365-3083.2011.02568.x.
identifier_str_mv CANGUSSU, Luiz Otavio Freire et al. HLA class II alleles and chronic hepatitis C virus infection. Scand J Immunol, 74(3): 282-287,2011
0300-9475
10.1111/j.1365-3083.2011.02568.x.
url https://www.arca.fiocruz.br/handle/icict/8130
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Blackwell Scientific Publications
publisher.none.fl_str_mv Blackwell Scientific Publications
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
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