Antimicrobial Resistance among Leprosy Patients in Brazil: Real-World Data Based on the National Surveillance Plan

Detalhes bibliográficos
Autor(a) principal: Andrade, Elaine Silva Nascimento
Data de Publicação: 2022
Outros Autores: Brandão, Jurema Guerrieri, Silva, Juliana Souza da, Coriolano, Carmelita Ribeiro Filha, Rosa, Patricia Sammarco, Moraes, Milton Ozório, Ferreira, Cynthia de Oliveira, Gomes, Ciro Martins, Araújo, Wildo Navegantes de
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/55375
Resumo: Ministério da Saúde. Secretaria de Vigilância em Saúde. Departamento de Doenças de Condições Crônicas e Infecções Sexualmente Transmissíveis – DCCI. Coordenação Geral de Doenças em Eliminação – CGDE. Brasília, DF, Brasil / Universidade de Brasilia. Faculdade de Medicina. Programa de Pós-Graduação em Saúde Coletiva. Brasília, DF, Brasil.
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spelling Andrade, Elaine Silva NascimentoBrandão, Jurema GuerrieriSilva, Juliana Souza daCoriolano, Carmelita Ribeiro FilhaRosa, Patricia SammarcoMoraes, Milton OzórioFerreira, Cynthia de OliveiraGomes, Ciro MartinsAraújo, Wildo Navegantes de2022-10-26T19:07:29Z2022-10-26T19:07:29Z2022ANDRADE, Elaine Silva Nascimento et al. Antimicrobial Resistance among Leprosy Patients in Brazil: Real-World Data Based on the National Surveillance Plan. Antimicrobial Agents and Chemotherapy, v,. 66, n. 5, p. 1 - 9, April 2022.1098-6596https://www.arca.fiocruz.br/handle/icict/5537510.1128/aac.02170-21engAmerican Society for MicrobiologyBrasilM. lepraeResistência à medicamentosAnálise de sequênciaDNAVigilânciaHanseníaseBrazilDrug resistanceM. lepraeSequence analysisDNASurveillanceLeprosyAntimicrobial Resistance among Leprosy Patients in Brazil: Real-World Data Based on the National Surveillance Planinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleMinistério da Saúde. Secretaria de Vigilância em Saúde. Departamento de Doenças de Condições Crônicas e Infecções Sexualmente Transmissíveis – DCCI. Coordenação Geral de Doenças em Eliminação – CGDE. Brasília, DF, Brasil / Universidade de Brasilia. Faculdade de Medicina. Programa de Pós-Graduação em Saúde Coletiva. Brasília, DF, Brasil.Ministério da Saúde. Secretaria de Vigilância em Saúde. Departamento de Doenças de Condições Crônicas e Infecções Sexualmente Transmissíveis – DCCI. Coordenação Geral de Doenças em Eliminação – CGDE. Brasília, DF, Brasil / Universidade de Brasília. Faculdade de Medicina. Programa de Pós-Graduação em Ciências Médicas,. Brasilia, DF, Brasil.Ministério da Saúde. Secretaria de Vigilância em Saúde. Departamento de Doenças de Condições Crônicas e Infecções Sexualmente Transmissíveis – DCCI. Coordenação Geral de Doenças em Eliminação – CGDE. Brasília, DF, BrasilMinistério da Saúde. Secretaria de Vigilância em Saúde. Departamento de Doenças de Condições Crônicas e Infecções Sexualmente Transmissíveis – DCCI. Coordenação Geral de Doenças em Eliminação – CGDE. Brasília, DF, BrasilInstituto Lauro de Souza Lima, Laboratório de Biologia Molecular. Bauru, SP, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório Hanseníase,. Rio de Janeiro, RJ, Brasil.Fundação Alfredo da Matta. Laboratório de Biologia Molecular. Manaus, AM, Brasil / Laboratório de Biologia Molecular. Programa de Pós-Graduação em Medicina Tropical. Manaus, AM, Brasil.Universidade de Brasília. Faculdade de Medicina. Programa de Pós-Graduação em Ciências Médicas,. Brasilia, DF, Brasil / Universidade de Brasília. Programa de Pós-Graduação em Medicina Tropical, Núcleo de Medicina Tropical,. Brasília, DF, Brasil.Universidade de Brasilia. Faculdade de Medicina. Programa de Pós-Graduação em Saúde Coletiva. Brasília, DF, Brasil / Universidade de Brasília. Programa de Pós-Graduação em Medicina Tropical, Núcleo de Medicina Tropical,. Brasília, DF, Brasil / Universidade de Brasília. Faculdade UnB Ceilândia,. Brasília, DF, Brasil / Instituto Nacional de Ciência e Tecnologia para Avaliação de Tecnologia em Saúde. Porto Alegre, RS, Brasil.Brazil ranks second among countries for new cases and first for relapse cases of leprosy worldwide. The Mycobacterium leprae Resistance Surveillance Plan was established. We aimed to present the results of a 2-year follow-up of the National Surveillance Plan in Brazil. A cross-sectional study of leprosy cases was performed to investigate antimicrobial resistance (AMR) in Brazil from October 2018 to September 2020. Molecular screening targeting genes related to dapsone (folP1), rifampin (rpoB), and ofloxacin resistance (gyrA) was performed. During the referral period, 63,520 active leprosy patients were registered in Brazil, and 1,183 fulfilled the inclusion criteria for molecular AMR investigation. In total, only 16 (1.4%) patients had genetic polymorphisms associated with AMR. Of these, 8 (50%) had cases of leprosy relapse, 7 (43.8%) had cases of suspected therapeutic failure with standard treatment, and 1 (6.2%) was a case of new leprosy presentation. M. leprae strains with AMR-associated mutations were found for all three genes screened. Isolates from two patients showed simultaneous resistance to dapsone and rifampin, indicating multidrug resistance (MDR). No significant relationship between clinical variables and the presence of AMR was identified. Our study revealed a low frequency of AMR in Brazil. Isolates were resistant mainly to dapsone, and a very low number of isolates were resistant to rifampin, the main bactericidal agent for leprosy, or presented MDR, reinforcing the importance of the standard World Health Organization multidrug therapy. The greater frequency of AMR among relapsed patients supports the need to constantly monitor this group.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/55375/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALMiltonMoraes_JulianaSSilva_etal_IOC_2022.pdfMiltonMoraes_JulianaSSilva_etal_IOC_2022.pdfapplication/pdf773372https://www.arca.fiocruz.br/bitstream/icict/55375/2/MiltonMoraes_JulianaSSilva_etal_IOC_2022.pdfec11ee7e15a4a0238e4d2e80ce424323MD52icict/553752023-09-04 11:03:02.48oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-09-04T14:03:02Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.en_US.fl_str_mv Antimicrobial Resistance among Leprosy Patients in Brazil: Real-World Data Based on the National Surveillance Plan
title Antimicrobial Resistance among Leprosy Patients in Brazil: Real-World Data Based on the National Surveillance Plan
spellingShingle Antimicrobial Resistance among Leprosy Patients in Brazil: Real-World Data Based on the National Surveillance Plan
Andrade, Elaine Silva Nascimento
Brasil
M. leprae
Resistência à medicamentos
Análise de sequência
DNA
Vigilância
Hanseníase
Brazil
Drug resistance
M. leprae
Sequence analysis
DNA
Surveillance
Leprosy
title_short Antimicrobial Resistance among Leprosy Patients in Brazil: Real-World Data Based on the National Surveillance Plan
title_full Antimicrobial Resistance among Leprosy Patients in Brazil: Real-World Data Based on the National Surveillance Plan
title_fullStr Antimicrobial Resistance among Leprosy Patients in Brazil: Real-World Data Based on the National Surveillance Plan
title_full_unstemmed Antimicrobial Resistance among Leprosy Patients in Brazil: Real-World Data Based on the National Surveillance Plan
title_sort Antimicrobial Resistance among Leprosy Patients in Brazil: Real-World Data Based on the National Surveillance Plan
author Andrade, Elaine Silva Nascimento
author_facet Andrade, Elaine Silva Nascimento
Brandão, Jurema Guerrieri
Silva, Juliana Souza da
Coriolano, Carmelita Ribeiro Filha
Rosa, Patricia Sammarco
Moraes, Milton Ozório
Ferreira, Cynthia de Oliveira
Gomes, Ciro Martins
Araújo, Wildo Navegantes de
author_role author
author2 Brandão, Jurema Guerrieri
Silva, Juliana Souza da
Coriolano, Carmelita Ribeiro Filha
Rosa, Patricia Sammarco
Moraes, Milton Ozório
Ferreira, Cynthia de Oliveira
Gomes, Ciro Martins
Araújo, Wildo Navegantes de
author2_role author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Andrade, Elaine Silva Nascimento
Brandão, Jurema Guerrieri
Silva, Juliana Souza da
Coriolano, Carmelita Ribeiro Filha
Rosa, Patricia Sammarco
Moraes, Milton Ozório
Ferreira, Cynthia de Oliveira
Gomes, Ciro Martins
Araújo, Wildo Navegantes de
dc.subject.other.en_US.fl_str_mv Brasil
M. leprae
Resistência à medicamentos
Análise de sequência
DNA
Vigilância
Hanseníase
topic Brasil
M. leprae
Resistência à medicamentos
Análise de sequência
DNA
Vigilância
Hanseníase
Brazil
Drug resistance
M. leprae
Sequence analysis
DNA
Surveillance
Leprosy
dc.subject.en.en_US.fl_str_mv Brazil
Drug resistance
M. leprae
Sequence analysis
DNA
Surveillance
Leprosy
description Ministério da Saúde. Secretaria de Vigilância em Saúde. Departamento de Doenças de Condições Crônicas e Infecções Sexualmente Transmissíveis – DCCI. Coordenação Geral de Doenças em Eliminação – CGDE. Brasília, DF, Brasil / Universidade de Brasilia. Faculdade de Medicina. Programa de Pós-Graduação em Saúde Coletiva. Brasília, DF, Brasil.
publishDate 2022
dc.date.accessioned.fl_str_mv 2022-10-26T19:07:29Z
dc.date.available.fl_str_mv 2022-10-26T19:07:29Z
dc.date.issued.fl_str_mv 2022
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv ANDRADE, Elaine Silva Nascimento et al. Antimicrobial Resistance among Leprosy Patients in Brazil: Real-World Data Based on the National Surveillance Plan. Antimicrobial Agents and Chemotherapy, v,. 66, n. 5, p. 1 - 9, April 2022.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/55375
dc.identifier.issn.en_US.fl_str_mv 1098-6596
dc.identifier.doi.none.fl_str_mv 10.1128/aac.02170-21
identifier_str_mv ANDRADE, Elaine Silva Nascimento et al. Antimicrobial Resistance among Leprosy Patients in Brazil: Real-World Data Based on the National Surveillance Plan. Antimicrobial Agents and Chemotherapy, v,. 66, n. 5, p. 1 - 9, April 2022.
1098-6596
10.1128/aac.02170-21
url https://www.arca.fiocruz.br/handle/icict/55375
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv American Society for Microbiology
publisher.none.fl_str_mv American Society for Microbiology
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/55375/1/license.txt
https://www.arca.fiocruz.br/bitstream/icict/55375/2/MiltonMoraes_JulianaSSilva_etal_IOC_2022.pdf
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repository.name.fl_str_mv Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)
repository.mail.fl_str_mv repositorio.arca@fiocruz.br
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