Effects of the ethanol extract of the inner bark of Syderoxylum obtusifolium in the cyclophosphamide-induced cystitis in rats
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2013 |
| Outros Autores: | , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/20777 |
Resumo: | Bezerra, Daniel Pereira “Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta à informação no documento”. |
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Pereira, Denyson SantanaMorais, Janaína PereiraSantana, Danielle GomesSantos, Cliomar AlvesThomazzi, Sara MariaSantos, Charles Estevam dosAntoniolli, Angelo RobertoBezerra, Daniel PereiraCamargo, Enilton Aparecido2017-08-28T13:47:44Z2017-08-28T13:47:44Z2013PEREIRA, D. S. et al. Effects of the ethanol extract of the inner bark of Syderoxylum obtusifolium in the cyclophosphamide-induced cystitis in rats. Journal of Medicinal Plants Research, v. 7, n. 20, p. 1411-1417, 2013.1996-0875https://www.arca.fiocruz.br/handle/icict/20777Bezerra, Daniel Pereira “Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta à informação no documento”.Fundação de Apoio a Pesquisa e Inovação Tecnológica (FAPITEC/SE; No 019.203.02344/2009-7) and Conselho Nacional de Pesquisa e Desenvolvimento Científico (CNPq; No 562478/2010-8)Federal University of Sergipe. Department of Physiology. São Cristóvão, SE, BrazilFederal University of Sergipe. Department of Physiology. São Cristóvão, SE, BrazilFederal University of Sergipe. Department of Physiology. São Cristóvão, SE, BrazilFederal University of Sergipe. Department of Physiology. São Cristóvão, SE, BrazilFederal University of Sergipe. Department of Physiology. São Cristóvão, SE, BrazilFederal University of Sergipe. Department of Physiology. São Cristóvão, SE, BrazilFederal University of Sergipe. Department of Physiology. São Cristóvão, SE, BrazilFederal University of Sergipe. Department of Physiology. São Cristóvão, SE, BrazilFederal University of Sergipe. Department of Physiology. São Cristóvão, SE, BrazilIn this study, the ethanol extract of the inner bark of the Syderoxylum obtusifolium (EESob) was tested in the model of cyclophosphamide-induced hemorrhagic cystitis. Male Wistar rats were submitted to the injection of cyclophosphamide, 1 h after the treatment with EESob (200 or 400 mg/kg) or vehicle. After 24 h, the urinary bladder was excised and the edema, myeloperoxidase activity and malondialdehyde formation were measured. Also, myeloperoxidase activity and malondialdehyde formation in lung, spleen and liver and leukocyte counts in the peripheral blood were evaluated. Injection of cyclophosphamide increased myeloperoxidase activity and edema. The former was inhibited by the EESob at 400 mg/kg, but the latter was not affected. Although cyclophosphamide did not alter the bladder malondialdehyde formation, pre-treatment with EESob at both doses markedly increased this parameter. Lung and liver parameters or leukocyte counts were not altered by EESob. The spleen myeloperoxidase activity and malondialdehyde formation were not affected by cyclophosphamide, but were increased by the treatment with EESob. These results suggests that EESob administration to rats decrease myeloperoxidase activity in bladder tissue, but is accompanied by lipoperoxidation in this tissue, as well as in spleen, which do not support the use of EESob to treat cystitis.engAcademic JournalsCiclofosfamidainflamaçãoPeroxidação de lipídeosCistiteSyderoxylum obtusifoliumCyclophosphamideInflammationLipid peroxidationHemorrhagic cystitisEffects of the ethanol extract of the inner bark of Syderoxylum obtusifolium in the cyclophosphamide-induced cystitis in ratsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/20777/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALPereira DS Effects of the ethanol extract of the inner....pdfPereira DS Effects of the 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| dc.title.pt_BR.fl_str_mv |
Effects of the ethanol extract of the inner bark of Syderoxylum obtusifolium in the cyclophosphamide-induced cystitis in rats |
| title |
Effects of the ethanol extract of the inner bark of Syderoxylum obtusifolium in the cyclophosphamide-induced cystitis in rats |
| spellingShingle |
Effects of the ethanol extract of the inner bark of Syderoxylum obtusifolium in the cyclophosphamide-induced cystitis in rats Pereira, Denyson Santana Ciclofosfamida inflamação Peroxidação de lipídeos Cistite Syderoxylum obtusifolium Cyclophosphamide Inflammation Lipid peroxidation Hemorrhagic cystitis |
| title_short |
Effects of the ethanol extract of the inner bark of Syderoxylum obtusifolium in the cyclophosphamide-induced cystitis in rats |
| title_full |
Effects of the ethanol extract of the inner bark of Syderoxylum obtusifolium in the cyclophosphamide-induced cystitis in rats |
| title_fullStr |
Effects of the ethanol extract of the inner bark of Syderoxylum obtusifolium in the cyclophosphamide-induced cystitis in rats |
| title_full_unstemmed |
Effects of the ethanol extract of the inner bark of Syderoxylum obtusifolium in the cyclophosphamide-induced cystitis in rats |
| title_sort |
Effects of the ethanol extract of the inner bark of Syderoxylum obtusifolium in the cyclophosphamide-induced cystitis in rats |
| author |
Pereira, Denyson Santana |
| author_facet |
Pereira, Denyson Santana Morais, Janaína Pereira Santana, Danielle Gomes Santos, Cliomar Alves Thomazzi, Sara Maria Santos, Charles Estevam dos Antoniolli, Angelo Roberto Bezerra, Daniel Pereira Camargo, Enilton Aparecido |
| author_role |
author |
| author2 |
Morais, Janaína Pereira Santana, Danielle Gomes Santos, Cliomar Alves Thomazzi, Sara Maria Santos, Charles Estevam dos Antoniolli, Angelo Roberto Bezerra, Daniel Pereira Camargo, Enilton Aparecido |
| author2_role |
author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Pereira, Denyson Santana Morais, Janaína Pereira Santana, Danielle Gomes Santos, Cliomar Alves Thomazzi, Sara Maria Santos, Charles Estevam dos Antoniolli, Angelo Roberto Bezerra, Daniel Pereira Camargo, Enilton Aparecido |
| dc.subject.other.pt_BR.fl_str_mv |
Ciclofosfamida inflamação Peroxidação de lipídeos Cistite |
| topic |
Ciclofosfamida inflamação Peroxidação de lipídeos Cistite Syderoxylum obtusifolium Cyclophosphamide Inflammation Lipid peroxidation Hemorrhagic cystitis |
| dc.subject.en.pt_BR.fl_str_mv |
Syderoxylum obtusifolium Cyclophosphamide Inflammation Lipid peroxidation Hemorrhagic cystitis |
| description |
Bezerra, Daniel Pereira “Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta à informação no documento”. |
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2013 |
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2013 |
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2017-08-28T13:47:44Z |
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2017-08-28T13:47:44Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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PEREIRA, D. S. et al. Effects of the ethanol extract of the inner bark of Syderoxylum obtusifolium in the cyclophosphamide-induced cystitis in rats. Journal of Medicinal Plants Research, v. 7, n. 20, p. 1411-1417, 2013. |
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https://www.arca.fiocruz.br/handle/icict/20777 |
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1996-0875 |
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PEREIRA, D. S. et al. Effects of the ethanol extract of the inner bark of Syderoxylum obtusifolium in the cyclophosphamide-induced cystitis in rats. Journal of Medicinal Plants Research, v. 7, n. 20, p. 1411-1417, 2013. 1996-0875 |
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