Effects of umbelliferone in a murine model of allergic airway inflammation
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2009 |
| Outros Autores: | , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/1895 |
Resumo: | Centro de Pesquisas Gonçalo Moniz - FIOCRUZ, Bahia, Brasil |
| id |
CRUZ_1bc51d93cde75c074fb6d419babf449d |
|---|---|
| oai_identifier_str |
oai:www.arca.fiocruz.br:icict/1895 |
| network_acronym_str |
CRUZ |
| network_name_str |
Repositório Institucional da FIOCRUZ (ARCA) |
| repository_id_str |
2135 |
| spelling |
Vasconcelos, Juliana FragaTeixeira, Mauro MartinsBarbosa Filho, José MariaAgra, Maria de FátimaNunes, Xirley PereiraHarley, Ana Maria GiuliettiSantos, Ricardo Ribeiro dosSoares, Milena Botelho Pereira2011-04-13T01:11:58Z2011-04-13T01:11:58Z2009VASCONCELOS, J. F. et al. Effects of umbelliferone in a murine model of allergic airway inflammation. European Journal of Pharmacology, v. 609, n.1-3, p.126–131, 2009.1879-0712https://www.arca.fiocruz.br/handle/icict/189510.1016/j.ejphar.2009.03.027engEffects of umbelliferone in a murine model of allergic airway inflammationinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleCentro de Pesquisas Gonçalo Moniz - FIOCRUZ, Bahia, BrasilInstituto de Ciências Biomédicas, Universidade Federal de Minas Gerais, Belo Horizonte, MG, BrasilLaboratório de Tecnologia Farmacêutica, Universidade Federal da Paraíba, João Pessoa, PB, BrasilLaboratório de Tecnologia Farmacêutica, Universidade Federal da Paraíba, João Pessoa, PB, BrasilColegiado do Curso de Medicina, Universidade Federal do Vale do São Francisco, Petrolina, PE, BrasilDepartamento de Ciências Biológicas, Universidade Estadual de Feira de Santana, Feira de Santana, BA, BrasilCentro de Pesquisas Gonçalo Moniz - FIOCRUZ, Bahia, BrasilCentro de Pesquisas Gonçalo Moniz - FIOCRUZ, Bahia, BrasilThe therapeutic effects of umbelliferone (30, 60 and 90 mg/kg), a coumarin isolated from Typha domingensis (Typhaceae) were investigated in a mouse model of bronchial asthma. BALB/c mice were immunized and challenged by nasal administration of ovalbumin. Treatment with umbelliferone (60 and 90 mg/kg) caused a marked reduction of cellularity and eosinophil numbers in bronchoalveolar lavage fluids from asthmatic mice. In addition, a decrease in mucus production and lung inflammation were observed in mice treated with umbelliferone. A reduction of IL-4, IL-5, and IL-13, but not of IFN-gamma, was found in bronchoalveolar lavage fluids of mice treated with umbelliferone, similar to that observed with dexamethasone. The levels of ovalbumin-specific IgE were not significantly altered after treatment with umbelliferone. In conclusion, our results demonstrate that umbelliferone attenuates the alteration characteristics of allergic airway inflammation. The investigation of the mechanisms of action of this molecule may contribute for the development of new drugs for the treatment of asthma.UmbelliferoneCoumarinTypha domingensisBronquic asthmaMouseAsmaPneumoniaUmbeliferonasAntiasmáticosModelos Animais de DoençasCamundongos Endogâmicos BALB Cinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINALEffects of umbelliferone in a murine model.pdfEffects of umbelliferone in a murine model.pdfapplication/pdf508211https://www.arca.fiocruz.br/bitstream/icict/1895/1/Effects%20of%20umbelliferone%20in%20a%20murine%20model.pdf533dde1fe9c4888e829173bcbe9f6772MD51LICENSElicense.txtlicense.txttext/plain; charset=utf-81648https://www.arca.fiocruz.br/bitstream/icict/1895/2/license.txte095249ac7cacefbfe39684dfe45e706MD52TEXTEffects of umbelliferone in a murine model.pdf.txtEffects of umbelliferone in a murine model.pdf.txtExtracted texttext/plain36718https://www.arca.fiocruz.br/bitstream/icict/1895/5/Effects%20of%20umbelliferone%20in%20a%20murine%20model.pdf.txt169cfce9af0412e66409d21f46751656MD55THUMBNAILEffects of umbelliferone in a murine model.pdf.jpgEffects of umbelliferone in a murine model.pdf.jpgGenerated Thumbnailimage/jpeg2159https://www.arca.fiocruz.br/bitstream/icict/1895/4/Effects%20of%20umbelliferone%20in%20a%20murine%20model.pdf.jpg3624fa53b6ac8e589853ee6805713465MD54icict/18952023-03-15 14:33:14.116oai:www.arca.fiocruz.br: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Repositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-03-15T17:33:14Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false |
| dc.title.pt_BR.fl_str_mv |
Effects of umbelliferone in a murine model of allergic airway inflammation |
| title |
Effects of umbelliferone in a murine model of allergic airway inflammation |
| spellingShingle |
Effects of umbelliferone in a murine model of allergic airway inflammation Vasconcelos, Juliana Fraga Umbelliferone Coumarin Typha domingensis Bronquic asthma Mouse Asma Pneumonia Umbeliferonas Antiasmáticos Modelos Animais de Doenças Camundongos Endogâmicos BALB C |
| title_short |
Effects of umbelliferone in a murine model of allergic airway inflammation |
| title_full |
Effects of umbelliferone in a murine model of allergic airway inflammation |
| title_fullStr |
Effects of umbelliferone in a murine model of allergic airway inflammation |
| title_full_unstemmed |
Effects of umbelliferone in a murine model of allergic airway inflammation |
| title_sort |
Effects of umbelliferone in a murine model of allergic airway inflammation |
| author |
Vasconcelos, Juliana Fraga |
| author_facet |
Vasconcelos, Juliana Fraga Teixeira, Mauro Martins Barbosa Filho, José Maria Agra, Maria de Fátima Nunes, Xirley Pereira Harley, Ana Maria Giulietti Santos, Ricardo Ribeiro dos Soares, Milena Botelho Pereira |
| author_role |
author |
| author2 |
Teixeira, Mauro Martins Barbosa Filho, José Maria Agra, Maria de Fátima Nunes, Xirley Pereira Harley, Ana Maria Giulietti Santos, Ricardo Ribeiro dos Soares, Milena Botelho Pereira |
| author2_role |
author author author author author author author |
| dc.contributor.author.fl_str_mv |
Vasconcelos, Juliana Fraga Teixeira, Mauro Martins Barbosa Filho, José Maria Agra, Maria de Fátima Nunes, Xirley Pereira Harley, Ana Maria Giulietti Santos, Ricardo Ribeiro dos Soares, Milena Botelho Pereira |
| dc.subject.en.pt_BR.fl_str_mv |
Umbelliferone Coumarin Typha domingensis Bronquic asthma Mouse |
| topic |
Umbelliferone Coumarin Typha domingensis Bronquic asthma Mouse Asma Pneumonia Umbeliferonas Antiasmáticos Modelos Animais de Doenças Camundongos Endogâmicos BALB C |
| dc.subject.decs.pt_BR.fl_str_mv |
Asma Pneumonia Umbeliferonas Antiasmáticos Modelos Animais de Doenças Camundongos Endogâmicos BALB C |
| description |
Centro de Pesquisas Gonçalo Moniz - FIOCRUZ, Bahia, Brasil |
| publishDate |
2009 |
| dc.date.issued.fl_str_mv |
2009 |
| dc.date.accessioned.fl_str_mv |
2011-04-13T01:11:58Z |
| dc.date.available.fl_str_mv |
2011-04-13T01:11:58Z |
| dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
| dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.citation.fl_str_mv |
VASCONCELOS, J. F. et al. Effects of umbelliferone in a murine model of allergic airway inflammation. European Journal of Pharmacology, v. 609, n.1-3, p.126–131, 2009. |
| dc.identifier.uri.fl_str_mv |
https://www.arca.fiocruz.br/handle/icict/1895 |
| dc.identifier.issn.none.fl_str_mv |
1879-0712 |
| dc.identifier.doi.none.fl_str_mv |
10.1016/j.ejphar.2009.03.027 |
| identifier_str_mv |
VASCONCELOS, J. F. et al. Effects of umbelliferone in a murine model of allergic airway inflammation. European Journal of Pharmacology, v. 609, n.1-3, p.126–131, 2009. 1879-0712 10.1016/j.ejphar.2009.03.027 |
| url |
https://www.arca.fiocruz.br/handle/icict/1895 |
| dc.language.iso.fl_str_mv |
eng |
| language |
eng |
| dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
| eu_rights_str_mv |
openAccess |
| dc.source.none.fl_str_mv |
reponame:Repositório Institucional da FIOCRUZ (ARCA) instname:Fundação Oswaldo Cruz (FIOCRUZ) instacron:FIOCRUZ |
| instname_str |
Fundação Oswaldo Cruz (FIOCRUZ) |
| instacron_str |
FIOCRUZ |
| institution |
FIOCRUZ |
| reponame_str |
Repositório Institucional da FIOCRUZ (ARCA) |
| collection |
Repositório Institucional da FIOCRUZ (ARCA) |
| bitstream.url.fl_str_mv |
https://www.arca.fiocruz.br/bitstream/icict/1895/1/Effects%20of%20umbelliferone%20in%20a%20murine%20model.pdf https://www.arca.fiocruz.br/bitstream/icict/1895/2/license.txt https://www.arca.fiocruz.br/bitstream/icict/1895/5/Effects%20of%20umbelliferone%20in%20a%20murine%20model.pdf.txt https://www.arca.fiocruz.br/bitstream/icict/1895/4/Effects%20of%20umbelliferone%20in%20a%20murine%20model.pdf.jpg |
| bitstream.checksum.fl_str_mv |
533dde1fe9c4888e829173bcbe9f6772 e095249ac7cacefbfe39684dfe45e706 169cfce9af0412e66409d21f46751656 3624fa53b6ac8e589853ee6805713465 |
| bitstream.checksumAlgorithm.fl_str_mv |
MD5 MD5 MD5 MD5 |
| repository.name.fl_str_mv |
Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ) |
| repository.mail.fl_str_mv |
repositorio.arca@fiocruz.br |
| _version_ |
1794075653146935296 |