Simultaneous enterovirus EV-D68 and CVA6 infections causing acute respiratory distress syndrome and hand, foot and mouth disease

Detalhes bibliográficos
Autor(a) principal: Sousa Jr, Ivanildo Pedro de
Data de Publicação: 2021
Outros Autores: Giamberardino, Heloisa Ihle, Raboni, Sonia Mara, Debur, Maria Carmo, Oliveira, Maria de Lourdes Aguiar, Burlandy, Fernanda Marcicano, Silva, Edson Elias da
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/47539
Resumo: Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Enterovirus. Rio de Janeiro, RJ, Brasil.
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spelling Sousa Jr, Ivanildo Pedro deGiamberardino, Heloisa IhleRaboni, Sonia MaraDebur, Maria CarmoOliveira, Maria de Lourdes AguiarBurlandy, Fernanda MarcicanoSilva, Edson Elias da2021-06-05T18:34:48Z2021-06-05T18:34:48Z2021SOUSA JR., Ivanildo Pedro de et al. Simultaneous enterovirus EV-D68 and CVA6 infections causing acute respiratory distress syndrome and hand, foot and mouth disease. Virology Journal, v. 18, n. 88, 6 p, 2021.1743-422Xhttps://www.arca.fiocruz.br/handle/icict/4753910.1186/s12985-021-01560-wengBMCEV-D68EnterovírusDoença da febre aftosaSíndrome do desconforto respiratório agudoCVA6EnterovirusHand, foot and mouth diseaseAcute respiratory distress syndromeEV-D68CVA6Simultaneous enterovirus EV-D68 and CVA6 infections causing acute respiratory distress syndrome and hand, foot and mouth diseaseinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Enterovirus. Rio de Janeiro, RJ, Brasil.Hospital Pequeno Príncipe. Divisão de Epidemiologia. Curitiba, PR, Brasil.Universidade Federal Do Paraná. Laboratório de Virologia. Curitiba, PR, Brasil.Secretaria de Saúde do Estado do Paraná. Laboratório de Saúde Pública. Curitiba, PR, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Vírus Respiratórios e do Sarampo. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Enterovirus. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Enterovirus. Rio de Janeiro, RJ, Brasil.Background: Although most enterovirus (EV) infections can be asymptomatic, these viral agents can cause serious conditions associated with central nervous system, respiratory disease and uncommon manifestations of hand, foot and mouth disease (HFMD). EV-coinfections have been rarely reported with development of complications and severe clinical outcome. An atypical case of a child presenting HFMD and severe acute respiratory syndrome, coinfected with EV-D68 and CVA6, is reported herein. Case presentation: A 3-year-old boy was admitted in the emergency department unit showing fever, abdominal pain and tachycardia. Twenty-four hours after hospitalization the child developed severe clinical symptoms associated with HFMD and was discharged after recovery. Two days later, the child was readmitted with fever, cough and respiratory distress. RT-PCR and Sanger sequencing confrmed positivity for EV-D68 and CVA6 in oro and nasopharynges swabs and vesicles fuid, respectively. Phylogenetic analysis based on VP1 gene sequences suggested that CVA6 was closely related with HFMD viruses circulating in Turkey, while EV-D68 was genetically related to a Chinese strain. Conclusions: To the best of our knowledge, this case is the frst report of a double infection caused by CVA6 and EV-D68, which shed light on the pathogenesis of enterovirus infections. Further studies must be conducted to ascertain the role and clinical signifcance of EV co-infections, as well as a potential synergistic pathway between these viruses.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/47539/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALIvanildoSJunior_EdsonESilva_etal_IOC_2021.pdfIvanildoSJunior_EdsonESilva_etal_IOC_2021.pdfapplication/pdf891335https://www.arca.fiocruz.br/bitstream/icict/47539/2/IvanildoSJunior_EdsonESilva_etal_IOC_2021.pdffdc8e9ab90450f85ff390065fee57803MD52TEXTIvanildoSJunior_EdsonESilva_etal_IOC_2021.pdf.txtIvanildoSJunior_EdsonESilva_etal_IOC_2021.pdf.txtExtracted 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dc.title.pt_BR.fl_str_mv Simultaneous enterovirus EV-D68 and CVA6 infections causing acute respiratory distress syndrome and hand, foot and mouth disease
title Simultaneous enterovirus EV-D68 and CVA6 infections causing acute respiratory distress syndrome and hand, foot and mouth disease
spellingShingle Simultaneous enterovirus EV-D68 and CVA6 infections causing acute respiratory distress syndrome and hand, foot and mouth disease
Sousa Jr, Ivanildo Pedro de
EV-D68
Enterovírus
Doença da febre aftosa
Síndrome do desconforto respiratório agudo
CVA6
Enterovirus
Hand, foot and mouth disease
Acute respiratory distress syndrome
EV-D68
CVA6
title_short Simultaneous enterovirus EV-D68 and CVA6 infections causing acute respiratory distress syndrome and hand, foot and mouth disease
title_full Simultaneous enterovirus EV-D68 and CVA6 infections causing acute respiratory distress syndrome and hand, foot and mouth disease
title_fullStr Simultaneous enterovirus EV-D68 and CVA6 infections causing acute respiratory distress syndrome and hand, foot and mouth disease
title_full_unstemmed Simultaneous enterovirus EV-D68 and CVA6 infections causing acute respiratory distress syndrome and hand, foot and mouth disease
title_sort Simultaneous enterovirus EV-D68 and CVA6 infections causing acute respiratory distress syndrome and hand, foot and mouth disease
author Sousa Jr, Ivanildo Pedro de
author_facet Sousa Jr, Ivanildo Pedro de
Giamberardino, Heloisa Ihle
Raboni, Sonia Mara
Debur, Maria Carmo
Oliveira, Maria de Lourdes Aguiar
Burlandy, Fernanda Marcicano
Silva, Edson Elias da
author_role author
author2 Giamberardino, Heloisa Ihle
Raboni, Sonia Mara
Debur, Maria Carmo
Oliveira, Maria de Lourdes Aguiar
Burlandy, Fernanda Marcicano
Silva, Edson Elias da
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Sousa Jr, Ivanildo Pedro de
Giamberardino, Heloisa Ihle
Raboni, Sonia Mara
Debur, Maria Carmo
Oliveira, Maria de Lourdes Aguiar
Burlandy, Fernanda Marcicano
Silva, Edson Elias da
dc.subject.other.pt_BR.fl_str_mv EV-D68
Enterovírus
Doença da febre aftosa
Síndrome do desconforto respiratório agudo
CVA6
topic EV-D68
Enterovírus
Doença da febre aftosa
Síndrome do desconforto respiratório agudo
CVA6
Enterovirus
Hand, foot and mouth disease
Acute respiratory distress syndrome
EV-D68
CVA6
dc.subject.en.pt_BR.fl_str_mv Enterovirus
Hand, foot and mouth disease
Acute respiratory distress syndrome
EV-D68
CVA6
description Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Enterovirus. Rio de Janeiro, RJ, Brasil.
publishDate 2021
dc.date.accessioned.fl_str_mv 2021-06-05T18:34:48Z
dc.date.available.fl_str_mv 2021-06-05T18:34:48Z
dc.date.issued.fl_str_mv 2021
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv SOUSA JR., Ivanildo Pedro de et al. Simultaneous enterovirus EV-D68 and CVA6 infections causing acute respiratory distress syndrome and hand, foot and mouth disease. Virology Journal, v. 18, n. 88, 6 p, 2021.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/47539
dc.identifier.issn.pt_BR.fl_str_mv 1743-422X
dc.identifier.doi.none.fl_str_mv 10.1186/s12985-021-01560-w
identifier_str_mv SOUSA JR., Ivanildo Pedro de et al. Simultaneous enterovirus EV-D68 and CVA6 infections causing acute respiratory distress syndrome and hand, foot and mouth disease. Virology Journal, v. 18, n. 88, 6 p, 2021.
1743-422X
10.1186/s12985-021-01560-w
url https://www.arca.fiocruz.br/handle/icict/47539
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv BMC
publisher.none.fl_str_mv BMC
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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