Antiepileptic and neuroprotective effects of human umbilical cord blood mononuclear cells in a pilocarpine-induced epilepsy model
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2014 |
| Outros Autores: | , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/8952 |
Resumo: | Hospital São Rafael. Centro de Biotecnologia e Terapia Celular. Salvador, BA, Brasil. |
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Ferro, Zaquer Suzana Munhoz CostaCunha, Fernanda de BorbaSouza, Bruno Solano de FreitasLeal, Marcos Maurício TostaSilva, Adelson Alves daKühn, Telma Ingrid Borges de BellisForte, AndresaSekiya, Eliseo JojiSoares, Milena Botelho PereiraSantos, Ricardo Ribeiro dos2014-11-24T17:59:13Z2014-11-24T17:59:13Z2014FERRO, Zaquer Suzana Munhoz Costa et al. Antiepileptic and neuroprotective effects of human umbilical cord blood mononuclear cells in a pilocarpine-induced epilepsy model. Cytotechnology, v. 66, n. 2, p. 193-199, 2014.0920-906910.1007/s10616-013-9557-3https://www.arca.fiocruz.br/handle/icict/8952engSpringer VerlagAntiepileptic and neuroprotective effects of human umbilical cord blood mononuclear cells in a pilocarpine-induced epilepsy modelinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleHospital São Rafael. Centro de Biotecnologia e Terapia Celular. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil.Hospital São Rafael. Centro de Biotecnologia e Terapia Celular. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil.Hemocentro São Lucas. São Paulo, SP, Brasil.CordCell. Umbilical Cord Blood Stem Cell Center. São Paulo, SP, Brasil,CordCell. Umbilical Cord Blood Stem Cell Center. São Paulo, SP, Brasil.Hemocentro São Lucas. São Paulo, SP, Brasil.Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil.Hospital São Rafael. Centro de Biotecnologia e Terapia Celular. Salvador, BA, Brasil.Status epilepticus (SE) is a condition of persistent seizure that leads to brain damage and, frequently, to the establishment of chronic epilepsy. Cord blood is an important source of adult stem cells for the treatment of neurological disorders. The present study aimed to evaluate the effects of human umbilical cord blood mononuclear cells (HUCBC) transplanted into rats after induction of SE by the administration of lithium and pilocarpine chloride. Transplantation of HUCBC into epileptic rats protected against neuronal loss in the hippocampal subfields CA1, CA3 and in the hilus of the dentate gyrus, up to 300 days after SE induction. Moreover, transplanted rats had reduced frequency and duration of spontaneous recurrent seizures (SRS) 15, 120 and 300 days after the SE. Our study shows that HUCBC provide prominent antiepileptic and neuroprotective effects in the experimental model of epilepsy and reinforces that early interventions can protect the brain against the establishment of epilepsy.EpilepsyPilocarpineCord bloodCell therapyNeuroprotectionSeizure frequencyNeuronal lossinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-81914https://www.arca.fiocruz.br/bitstream/icict/8952/1/license.txt7d48279ffeed55da8dfe2f8e81f3b81fMD51ORIGINALCosta-Ferro ZSM Antiepileptic....pdfCosta-Ferro ZSM Antiepileptic....pdfapplication/pdf1919637https://www.arca.fiocruz.br/bitstream/icict/8952/2/Costa-Ferro%20ZSM%20Antiepileptic....pdf1a29ba60fca53e173b971686c08d992cMD52TEXTCosta-Ferro ZSM Antiepileptic....pdf.txtCosta-Ferro ZSM Antiepileptic....pdf.txtExtracted texttext/plain20060https://www.arca.fiocruz.br/bitstream/icict/8952/3/Costa-Ferro%20ZSM%20Antiepileptic....pdf.txt7f0c8f2808721885b91e3bee7074c74fMD53icict/89522023-03-15 14:33:01.529oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-03-15T17:33:01Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false |
| dc.title.pt_BR.fl_str_mv |
Antiepileptic and neuroprotective effects of human umbilical cord blood mononuclear cells in a pilocarpine-induced epilepsy model |
| title |
Antiepileptic and neuroprotective effects of human umbilical cord blood mononuclear cells in a pilocarpine-induced epilepsy model |
| spellingShingle |
Antiepileptic and neuroprotective effects of human umbilical cord blood mononuclear cells in a pilocarpine-induced epilepsy model Ferro, Zaquer Suzana Munhoz Costa Epilepsy Pilocarpine Cord blood Cell therapy Neuroprotection Seizure frequency Neuronal loss |
| title_short |
Antiepileptic and neuroprotective effects of human umbilical cord blood mononuclear cells in a pilocarpine-induced epilepsy model |
| title_full |
Antiepileptic and neuroprotective effects of human umbilical cord blood mononuclear cells in a pilocarpine-induced epilepsy model |
| title_fullStr |
Antiepileptic and neuroprotective effects of human umbilical cord blood mononuclear cells in a pilocarpine-induced epilepsy model |
| title_full_unstemmed |
Antiepileptic and neuroprotective effects of human umbilical cord blood mononuclear cells in a pilocarpine-induced epilepsy model |
| title_sort |
Antiepileptic and neuroprotective effects of human umbilical cord blood mononuclear cells in a pilocarpine-induced epilepsy model |
| author |
Ferro, Zaquer Suzana Munhoz Costa |
| author_facet |
Ferro, Zaquer Suzana Munhoz Costa Cunha, Fernanda de Borba Souza, Bruno Solano de Freitas Leal, Marcos Maurício Tosta Silva, Adelson Alves da Kühn, Telma Ingrid Borges de Bellis Forte, Andresa Sekiya, Eliseo Joji Soares, Milena Botelho Pereira Santos, Ricardo Ribeiro dos |
| author_role |
author |
| author2 |
Cunha, Fernanda de Borba Souza, Bruno Solano de Freitas Leal, Marcos Maurício Tosta Silva, Adelson Alves da Kühn, Telma Ingrid Borges de Bellis Forte, Andresa Sekiya, Eliseo Joji Soares, Milena Botelho Pereira Santos, Ricardo Ribeiro dos |
| author2_role |
author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Ferro, Zaquer Suzana Munhoz Costa Cunha, Fernanda de Borba Souza, Bruno Solano de Freitas Leal, Marcos Maurício Tosta Silva, Adelson Alves da Kühn, Telma Ingrid Borges de Bellis Forte, Andresa Sekiya, Eliseo Joji Soares, Milena Botelho Pereira Santos, Ricardo Ribeiro dos |
| dc.subject.en.pt_BR.fl_str_mv |
Epilepsy Pilocarpine Cord blood Cell therapy Neuroprotection Seizure frequency Neuronal loss |
| topic |
Epilepsy Pilocarpine Cord blood Cell therapy Neuroprotection Seizure frequency Neuronal loss |
| description |
Hospital São Rafael. Centro de Biotecnologia e Terapia Celular. Salvador, BA, Brasil. |
| publishDate |
2014 |
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2014-11-24T17:59:13Z |
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2014-11-24T17:59:13Z |
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2014 |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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FERRO, Zaquer Suzana Munhoz Costa et al. Antiepileptic and neuroprotective effects of human umbilical cord blood mononuclear cells in a pilocarpine-induced epilepsy model. Cytotechnology, v. 66, n. 2, p. 193-199, 2014. |
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https://www.arca.fiocruz.br/handle/icict/8952 |
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0920-9069 10.1007/s10616-013-9557-3 |
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FERRO, Zaquer Suzana Munhoz Costa et al. Antiepileptic and neuroprotective effects of human umbilical cord blood mononuclear cells in a pilocarpine-induced epilepsy model. Cytotechnology, v. 66, n. 2, p. 193-199, 2014. 0920-9069 10.1007/s10616-013-9557-3 |
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Springer Verlag |
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