Chemical composition, larvicidal and cytotoxic activity of Annona salzmannii (Annonaceae) seed oil
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2021 |
| Outros Autores: | , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/49786 |
Resumo: | Brazilian agencies CAPES, CNPq, FINEP, FAPITEC/SE, FAPESB, Fundação Araucária for their financial support and fellowships. |
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Ribeiro, Jane Cristina LaraBruginski, EstevanZuccolotto, TatianaSantos, Alan Diego da ConceiçãoBomfim, Larissa MendesRocha, Suellen Laila AndradeBarison, AnderssonSassaki, GuilhermeCavalcanti, Sócrates Cabral de HolandaCosta, Emmanoel VilaçaSoares, Milena Botelho PereiraBezerra, Daniel PereiraCampos, Francinete Ramos2021-11-11T19:18:20Z2021-11-11T19:18:20Z2021RIBEIRO, Jane Cristina Lara et al. Chemical composition, larvicidal and cytotoxic activity of Annona salzmannii (Annonaceae) seed oil. Brazilian journal of pharmaceutical sciences, 2021.1984-8250https://www.arca.fiocruz.br/handle/icict/4978610.1590/s2175-97902020000418479Brazilian agencies CAPES, CNPq, FINEP, FAPITEC/SE, FAPESB, Fundação Araucária for their financial support and fellowships.Federal University of Paraná. Department of Pharmacy. Curitiba, PR, Brazil.Federal University of Paraná. Department of Pharmacy. Curitiba, PR, Brazil.Federal University of Paraná. Department of Pharmacy. Curitiba, PR, Brazil.Federal University of Paraná. Curitiba, PR, Brazil / Federal University of Amazonas. Department of Chemistry. Manaus, AM, Brazil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Bahia, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Bahia, Brasil.Federal University of Paraná. Curitiba, PR, Brazil.Federal University of Paraná. Curitiba, PR, Brazil.Federal University of Sergipe. Department of Pharmacy. Aracaju, SE, Brazil.Federal University of Amazonas. Department of Chemistry. Manaus, AM, Brazil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Bahia, Brasil.Fundação Oswaldo Cruz, Instituto de Gonçalo Moniz. Salvador, BA, Brasil.Federal University of Paraná. Department of Pharmacy. Curitiba, PR, Brazil.The seed oil of Annona salzmannii A. DC. was analyzed by GC-MS and 1H qNMR, revealing a mixture of unsaturated (80.5%) and saturated (18.7%) fatty acids. Linoleic (45.3%) and oleic (33.5%) acid were the major unsaturated fatty acids identified, while palmitic acid (14.3%) was the major saturated fatty acid. The larvicidal effects of A. salzmannii seed oil were evaluated against third-instar larvae of Aedes aegypti (Linn.). The oil exhibited moderate larvicidal activity, with a LC50 of 569.77 ppm (95% CI = 408.11 to 825.88 ppm). However, when the cytotoxic effects of the oil were evaluated, no expressive antiproliferative effects were observed in tumor cell lines B16-F10 (mouse melanoma), HepG2 (human hepatocellular carcinoma), K562 (human chronic myelocytic leukemia), HL-60 (human promyelocytic leukemia), and non-tumor cell line PBMC (peripheral blood mononuclear cells), with IC50 values > 50 μg·mL-1. This is the first study to evaluate the chemical composition, larvicidal and cytotoxic activity of A. salzmannii seed oil.engUniversidade de Sao Paulo. Faculdade de Ciências FarmaceuticasAnnonaceaeLarvicidasCitotóxicinasÓleo de semente.Annona salzmanniiAnnonaceaeLarvicidal activityCytotoxic activitySeed oilChemical composition, larvicidal and cytotoxic activity of Annona salzmannii (Annonaceae) seed oilinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83097https://www.arca.fiocruz.br/bitstream/icict/49786/1/license.txt36b51ef91c52b5338d9d29ba0cc807bcMD51ORIGINALRibeiro, L.C.J. Chemical composition....pdfRibeiro, L.C.J. Chemical composition....pdfapplication/pdf605614https://www.arca.fiocruz.br/bitstream/icict/49786/2/Ribeiro%2c%20L.C.J.%20Chemical%20composition....pdf15dedc7ce5a4b6a4e1d6ffb96a59dc8bMD52icict/497862023-03-15 14:34:30.714oai:www.arca.fiocruz.br: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Repositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-03-15T17:34:30Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false |
| dc.title.pt_BR.fl_str_mv |
Chemical composition, larvicidal and cytotoxic activity of Annona salzmannii (Annonaceae) seed oil |
| title |
Chemical composition, larvicidal and cytotoxic activity of Annona salzmannii (Annonaceae) seed oil |
| spellingShingle |
Chemical composition, larvicidal and cytotoxic activity of Annona salzmannii (Annonaceae) seed oil Ribeiro, Jane Cristina Lara Annonaceae Larvicidas Citotóxicinas Óleo de semente. Annona salzmannii Annonaceae Larvicidal activity Cytotoxic activity Seed oil |
| title_short |
Chemical composition, larvicidal and cytotoxic activity of Annona salzmannii (Annonaceae) seed oil |
| title_full |
Chemical composition, larvicidal and cytotoxic activity of Annona salzmannii (Annonaceae) seed oil |
| title_fullStr |
Chemical composition, larvicidal and cytotoxic activity of Annona salzmannii (Annonaceae) seed oil |
| title_full_unstemmed |
Chemical composition, larvicidal and cytotoxic activity of Annona salzmannii (Annonaceae) seed oil |
| title_sort |
Chemical composition, larvicidal and cytotoxic activity of Annona salzmannii (Annonaceae) seed oil |
| author |
Ribeiro, Jane Cristina Lara |
| author_facet |
Ribeiro, Jane Cristina Lara Bruginski, Estevan Zuccolotto, Tatiana Santos, Alan Diego da Conceição Bomfim, Larissa Mendes Rocha, Suellen Laila Andrade Barison, Andersson Sassaki, Guilherme Cavalcanti, Sócrates Cabral de Holanda Costa, Emmanoel Vilaça Soares, Milena Botelho Pereira Bezerra, Daniel Pereira Campos, Francinete Ramos |
| author_role |
author |
| author2 |
Bruginski, Estevan Zuccolotto, Tatiana Santos, Alan Diego da Conceição Bomfim, Larissa Mendes Rocha, Suellen Laila Andrade Barison, Andersson Sassaki, Guilherme Cavalcanti, Sócrates Cabral de Holanda Costa, Emmanoel Vilaça Soares, Milena Botelho Pereira Bezerra, Daniel Pereira Campos, Francinete Ramos |
| author2_role |
author author author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Ribeiro, Jane Cristina Lara Bruginski, Estevan Zuccolotto, Tatiana Santos, Alan Diego da Conceição Bomfim, Larissa Mendes Rocha, Suellen Laila Andrade Barison, Andersson Sassaki, Guilherme Cavalcanti, Sócrates Cabral de Holanda Costa, Emmanoel Vilaça Soares, Milena Botelho Pereira Bezerra, Daniel Pereira Campos, Francinete Ramos |
| dc.subject.other.pt_BR.fl_str_mv |
Annonaceae Larvicidas Citotóxicinas Óleo de semente. |
| topic |
Annonaceae Larvicidas Citotóxicinas Óleo de semente. Annona salzmannii Annonaceae Larvicidal activity Cytotoxic activity Seed oil |
| dc.subject.en.pt_BR.fl_str_mv |
Annona salzmannii Annonaceae Larvicidal activity Cytotoxic activity Seed oil |
| description |
Brazilian agencies CAPES, CNPq, FINEP, FAPITEC/SE, FAPESB, Fundação Araucária for their financial support and fellowships. |
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2021 |
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2021-11-11T19:18:20Z |
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2021-11-11T19:18:20Z |
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2021 |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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RIBEIRO, Jane Cristina Lara et al. Chemical composition, larvicidal and cytotoxic activity of Annona salzmannii (Annonaceae) seed oil. Brazilian journal of pharmaceutical sciences, 2021. |
| dc.identifier.uri.fl_str_mv |
https://www.arca.fiocruz.br/handle/icict/49786 |
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1984-8250 |
| dc.identifier.doi.none.fl_str_mv |
10.1590/s2175-97902020000418479 |
| identifier_str_mv |
RIBEIRO, Jane Cristina Lara et al. Chemical composition, larvicidal and cytotoxic activity of Annona salzmannii (Annonaceae) seed oil. Brazilian journal of pharmaceutical sciences, 2021. 1984-8250 10.1590/s2175-97902020000418479 |
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Universidade de Sao Paulo. Faculdade de Ciências Farmaceuticas |
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Universidade de Sao Paulo. Faculdade de Ciências Farmaceuticas |
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