HIV Infection Is Not Associated With Aortic Stiffness. Traditional Cardiovascular Risk Factors Are the Main Determinants—Cross-sectional Results of INI-ELSA-BRASIL

Detalhes bibliográficos
Autor(a) principal: Moreira, Rodrigo C.
Data de Publicação: 2018
Outros Autores: Mill, José G., Grinsztejn, Beatriz, Veloso, Valdiléa G., Fonseca, Maria de Jesus, Griep, Rosane H., Bensenor, Isabela, Cardoso, Sandra W., Lotufo, Paulo, Chor, Dóra, Pacheco, Antonio G.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/27034
Resumo: 2018-12-31
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spelling Moreira, Rodrigo C.Mill, José G.Grinsztejn, BeatrizVeloso, Valdiléa G.Fonseca, Maria de JesusGriep, Rosane H.Bensenor, IsabelaCardoso, Sandra W.Lotufo, PauloChor, DóraPacheco, Antonio G.2018-06-21T12:34:44Z2018-06-21T12:34:44Z2018MOREIRA, Rodrigo C. et al. HIV Infection Is Not Associated With Aortic Stiffness. Traditional Cardiovascular Risk Factors Are the Main Determinants—Cross-sectional Results of INI-ELSA-BRASIL. Journal of Acquired Immune Deficiency Syndromes, v. 78, n. 1, p. 73-81, May 2018.1525-4135https://www.arca.fiocruz.br/handle/icict/2703410.1097/QAI.00000000000016461944-7884engLippincott, Williams & WilkinsHIV Infection Is Not Associated With Aortic Stiffness. Traditional Cardiovascular Risk Factors Are the Main Determinants—Cross-sectional Results of INI-ELSA-BRASILinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article2018-12-31Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas,. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Presidência. Programa de Computação Científica. Rio de Janeiro, RJ, Brasil.Universidade Federal do Espírito Santo. Departamento de Ciências Fisiológicas. Vitória, ES, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas,. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas,. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Escola Nacional de Saúde Pública Sergio Arouca. Departamento de Epidemiologia e Métodos Quantitativos em Saúde. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Educação em Ambiente e Saúde. Rio de Janeiro, RJ. Brasil.Universidade de São Paulo. Escola de Medicina. São Paulo, SP, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas,. Rio de Janeiro, RJ, Brasil.Universidade de São Paulo. Escola de Medicina. São Paulo, SP, Brasil.Fundação Oswaldo Cruz. Escola Nacional de Saúde Pública Sergio Arouca. Departamento de Epidemiologia e Métodos Quantitativos em Saúde. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Presidência. Programa de Computação Científica. Rio de Janeiro, RJ, Brasil.Introduction: Aortic stiffness measured by carotid-femoral pulse wave velocity (cf-PWV) is a marker of subclinical atherosclerosis. We propose to assess whether HIV infection is associated with arterial stiffness and their determinants in HIV-infected subjects. Methods: We compared data from an HIV cohort (644 patients, HIV+) in Rio de Janeiro with 2 groups: 105 HIV-negative (HIV-) individuals and 14,873 participants of the ELSA-Brasil study. We used multivariable linear regression to investigate factors associated with cf-PWV and whether HIV was independently associated with aortic stiffness and propensity score weighting to control for imbalances between groups. Results: From 15,860 participants, cf-PWV was obtained in 15,622 (98.5%). Median age was 51 (interquartile range 45-58), 44.41 (35.73, 54.72), and 43.60 (36.01, 50.79) years (P < 0.001), and median cf-PWV (m/s; interquartile range) was 9.0 (8.10, 10.20), 8.70 (7.90, 10.20), and 8.48 (7.66, 9.40) for ELSA-Brasil, HIV- and HIV+, respectively (P < 0.001). In the final weighted multivariable models, HIV group was not associated with cf-PWV when compared either with ELSA-Brasil [β = -0.05; 95% confidence interval (CI) = -0.23; P = 0.12; P = 0.52] or with the HIV- groups (β = 0.10; 95% CI = -0.10; 0, 31; P = 0.32). Traditional risk factors were associated with higher cf-PWV levels in the HIV+ group, particularly waist-to-hip ratio (β = 0.20; 95% CI = 0.10; 0.30; P < 0.001, result per one SD change). Conclusions: HIV infection was not associated with higher aortic stiffness according to our study. In HIV-infected subjects, the stiffness of large arteries is mainly associated with traditional risk factors and not to the HIV infection per se.People living with HIVCardiovascular risk factorsArterial stiffnessINI ELSA Brasilinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/27034/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALbeatriz_grinsztejn_etal_IOC_2017.pdfbeatriz_grinsztejn_etal_IOC_2017.pdfapplication/pdf146812https://www.arca.fiocruz.br/bitstream/icict/27034/2/beatriz_grinsztejn_etal_IOC_2017.pdf93e228e51d0773b18ae674aecbea33a4MD52TEXTbeatriz_grinsztejn_etal_IOC_2017.pdf.txtbeatriz_grinsztejn_etal_IOC_2017.pdf.txtExtracted 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dc.title.pt_BR.fl_str_mv HIV Infection Is Not Associated With Aortic Stiffness. Traditional Cardiovascular Risk Factors Are the Main Determinants—Cross-sectional Results of INI-ELSA-BRASIL
title HIV Infection Is Not Associated With Aortic Stiffness. Traditional Cardiovascular Risk Factors Are the Main Determinants—Cross-sectional Results of INI-ELSA-BRASIL
spellingShingle HIV Infection Is Not Associated With Aortic Stiffness. Traditional Cardiovascular Risk Factors Are the Main Determinants—Cross-sectional Results of INI-ELSA-BRASIL
Moreira, Rodrigo C.
People living with HIV
Cardiovascular risk factors
Arterial stiffness
INI ELSA Brasil
title_short HIV Infection Is Not Associated With Aortic Stiffness. Traditional Cardiovascular Risk Factors Are the Main Determinants—Cross-sectional Results of INI-ELSA-BRASIL
title_full HIV Infection Is Not Associated With Aortic Stiffness. Traditional Cardiovascular Risk Factors Are the Main Determinants—Cross-sectional Results of INI-ELSA-BRASIL
title_fullStr HIV Infection Is Not Associated With Aortic Stiffness. Traditional Cardiovascular Risk Factors Are the Main Determinants—Cross-sectional Results of INI-ELSA-BRASIL
title_full_unstemmed HIV Infection Is Not Associated With Aortic Stiffness. Traditional Cardiovascular Risk Factors Are the Main Determinants—Cross-sectional Results of INI-ELSA-BRASIL
title_sort HIV Infection Is Not Associated With Aortic Stiffness. Traditional Cardiovascular Risk Factors Are the Main Determinants—Cross-sectional Results of INI-ELSA-BRASIL
author Moreira, Rodrigo C.
author_facet Moreira, Rodrigo C.
Mill, José G.
Grinsztejn, Beatriz
Veloso, Valdiléa G.
Fonseca, Maria de Jesus
Griep, Rosane H.
Bensenor, Isabela
Cardoso, Sandra W.
Lotufo, Paulo
Chor, Dóra
Pacheco, Antonio G.
author_role author
author2 Mill, José G.
Grinsztejn, Beatriz
Veloso, Valdiléa G.
Fonseca, Maria de Jesus
Griep, Rosane H.
Bensenor, Isabela
Cardoso, Sandra W.
Lotufo, Paulo
Chor, Dóra
Pacheco, Antonio G.
author2_role author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Moreira, Rodrigo C.
Mill, José G.
Grinsztejn, Beatriz
Veloso, Valdiléa G.
Fonseca, Maria de Jesus
Griep, Rosane H.
Bensenor, Isabela
Cardoso, Sandra W.
Lotufo, Paulo
Chor, Dóra
Pacheco, Antonio G.
dc.subject.en.pt_BR.fl_str_mv People living with HIV
Cardiovascular risk factors
Arterial stiffness
topic People living with HIV
Cardiovascular risk factors
Arterial stiffness
INI ELSA Brasil
dc.subject.en.none.fl_str_mv INI ELSA Brasil
description 2018-12-31
publishDate 2018
dc.date.accessioned.fl_str_mv 2018-06-21T12:34:44Z
dc.date.available.fl_str_mv 2018-06-21T12:34:44Z
dc.date.issued.fl_str_mv 2018
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv MOREIRA, Rodrigo C. et al. HIV Infection Is Not Associated With Aortic Stiffness. Traditional Cardiovascular Risk Factors Are the Main Determinants—Cross-sectional Results of INI-ELSA-BRASIL. Journal of Acquired Immune Deficiency Syndromes, v. 78, n. 1, p. 73-81, May 2018.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/27034
dc.identifier.issn.pt_BR.fl_str_mv 1525-4135
dc.identifier.doi.none.fl_str_mv 10.1097/QAI.0000000000001646
dc.identifier.eissn.none.fl_str_mv 1944-7884
identifier_str_mv MOREIRA, Rodrigo C. et al. HIV Infection Is Not Associated With Aortic Stiffness. Traditional Cardiovascular Risk Factors Are the Main Determinants—Cross-sectional Results of INI-ELSA-BRASIL. Journal of Acquired Immune Deficiency Syndromes, v. 78, n. 1, p. 73-81, May 2018.
1525-4135
10.1097/QAI.0000000000001646
1944-7884
url https://www.arca.fiocruz.br/handle/icict/27034
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Lippincott, Williams & Wilkins
publisher.none.fl_str_mv Lippincott, Williams & Wilkins
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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