Effects of standardized Brazilian green propolis extract (EPP-AF®) on inflammation in haemodialysis patients: a clinical trial
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2022 |
| Outros Autores: | , , , , , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/57315 |
Resumo: | Instituto D'Or de Pesquisa e Ensino (IDOR). Apis Flora Indl. Com. Ltda. Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES). Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq). |
| id |
CRUZ_2170f5137221177e6384dcb0f9e3b5dd |
|---|---|
| oai_identifier_str |
oai:www.arca.fiocruz.br:icict/57315 |
| network_acronym_str |
CRUZ |
| network_name_str |
Repositório Institucional da FIOCRUZ (ARCA) |
| repository_id_str |
2135 |
| spelling |
Silveira, Marcelo Augusto DuarteSantos, Hayna MaltaSilva, Jéssica RebouçasTeles, FlávioGalvão, Erica Batista Dos SantosSouza, Sergio Pinto deDutra, Fábio Ricardo DantasGomes, Marcel Miranda DantasTeixeira, Maurício BritoConceição, Luís Filipe Miranda Rebelo daNascimento, Carolina SaNonaka, Carolina Kymie VasquesCezar, Rodrigo SilvaBatista, Paulo Benigno PenaBerretta, Andresa AparecidaBorges, Valeria M.Passos, Rogerio da Hora2023-03-09T13:41:05Z2023-03-09T13:41:05Z2022SILVEIRA, Marcelo Augusto Duarte et al. Effects of standardized Brazilian green propolis extract (EPP-AF®) on inflammation in haemodialysis patients: a clinical trial. International Journal of Nephrology, v. 2022, p. 1-9, 2022.2090-2158https://www.arca.fiocruz.br/handle/icict/5731510.1155/2022/1035475Instituto D'Or de Pesquisa e Ensino (IDOR). Apis Flora Indl. Com. Ltda. Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES). Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq).Instituto de Pesquisa e Ensino D'Or. Hospital São Rafael. Serviço de Nefrologia. Salvador, BA, Brasil / Faculdade de Medicina da UNIME. Lauro de Freitas, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, Brasil.Universidade Federal de Alagoas. Faculdade de Medicina. Maceió, AL Brasil.Instituto de Pesquisa e Ensino D'Or. Hospital São Rafael. Serviço de Nefrologia. Salvador, BA, Brasil.Instituto de Pesquisa e Ensino D'Or. Hospital São Rafael. Serviço de Nefrologia. Salvador, BA, Brasil / Escola Bahiana de Medicina e Saúde Pública. Salvador, BA, Brasil.Instituto de Pesquisa e Ensino D'Or. Hospital São Rafael. Serviço de Nefrologia. Salvador, BA, Brasil.Instituto de Pesquisa e Ensino D'Or. Hospital São Rafael. Serviço de Nefrologia. Salvador, BA, Brasil.Instituto de Pesquisa e Ensino D'Or. Hospital São Rafael. Serviço de Nefrologia. Salvador, BA, Brasil /Escola Bahiana de Medicina e Saúde Pública. Salvador, BA, Brasil / Universidade do Estado da Bahia. Salvador, BA, Brasil.Instituto de Pesquisa e Ensino D'Or. Hospital São Rafael. Serviço de Nefrologia. Salvador, BA, Brasil.Instituto de Pesquisa e Ensino D'Or. Hospital São Rafael. Serviço de Nefrologia. Salvador, BA, Brasil.Instituto de Pesquisa e Ensino D'Or. Hospital São Rafael. Serviço de Nefrologia. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil.Instituto de Pesquisa e Ensino D'Or. Hospital São Rafael. Serviço de Nefrologia. Salvador, BA, Brasil.Instituto de Pesquisa e Ensino D'Or. Hospital São Rafael. Serviço de Nefrologia. Salvador, BA, Brasil / Faculdade de Medicina da UNIME. Lauro de Freitas, BA, Brasil.Departamento de Pesquisa. Desenvolvimento e Inovação, Apis Flora Indl. Com. Ltda. Ribeirão Preto, SP, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, Brasil.Instituto de Pesquisa e Ensino D'Or. Hospital São Rafael. Serviço de Nefrologia. Salvador, BA, Brasil.Background: Patients on haemodialysis (HD) present a significant inflammatory status, which has a pronounced negative impact on their outcomes. Propolis is a natural resin with anti-inflammatory and immunomodulatory properties. We assessed the safety and impact of a standardized Brazilian green propolis extract (EPP-AF®) on the inflammatory status in patients under conventional HD. Methods: Patients were assigned to receive 200 mg/day of EPP-AF® for 4 weeks followed by 4 weeks without the drug, and changes in plasma levels of interleukins (ILs), interferon gamma (IFN-γ), tumour necrosis factor-alpha (TNF-α), and high-sensitivityc-reactive protein (HsCRP) were measured. A heatmap was used to illustrate trends in data variation. Results: In total, 37 patients were included in the final analysis. Patients presented an exacerbated inflammatory state at baseline. During EPP-AF® use, there was a significant reduction in IFN-γ (p=0.005), IL-13 (p=0.04 2), IL-17 (p=0.039), IL-1ra (p=0.008), IL-8 (p=0.009), and TNF-α (p < 0.001) levels compared to baseline, and significant changes were found in Hs-CRP levels. The heatmap demonstrated a pattern of pronounced proinflammatory status at baseline, especially in patients with primary glomerulopathies, and a clear reduction in this pattern during the use of EPP-AF®. There was a tendency to maintain this reduction after suspension of EPP-AF®. No significant side effects were observed. Conclusion: Patients under haemodialysis presented a pronounced inflammatory status, and EPP-AF® was demonstrated to be safe and associated with a significant and maintained reduction in proinflammatory cytokines in this population. This trial is registered with Clinicaltrials.gov .engHindawiExtrato de própolis verdeInflamaçãoPacientes em hemodiáliseGreen propolis extractInflammationHaemodialysis patientsPrópoleInflamaçãoDiálise renalEffects of standardized Brazilian green propolis extract (EPP-AF®) on inflammation in haemodialysis patients: a clinical trialinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/57315/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALSilveira, M.A.D. Effects of standardized brazilian..2022.pdfSilveira, M.A.D. Effects of standardized brazilian..2022.pdfapplication/pdf955933https://www.arca.fiocruz.br/bitstream/icict/57315/2/Silveira%2c%20M.A.D.%20Effects%20of%20standardized%20brazilian..2022.pdf8818a5b15c6630b358a567b6d7178000MD52icict/573152023-03-15 14:32:47.646oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-03-15T17:32:47Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false |
| dc.title.en_US.fl_str_mv |
Effects of standardized Brazilian green propolis extract (EPP-AF®) on inflammation in haemodialysis patients: a clinical trial |
| title |
Effects of standardized Brazilian green propolis extract (EPP-AF®) on inflammation in haemodialysis patients: a clinical trial |
| spellingShingle |
Effects of standardized Brazilian green propolis extract (EPP-AF®) on inflammation in haemodialysis patients: a clinical trial Silveira, Marcelo Augusto Duarte Extrato de própolis verde Inflamação Pacientes em hemodiálise Green propolis extract Inflammation Haemodialysis patients Própole Inflamação Diálise renal |
| title_short |
Effects of standardized Brazilian green propolis extract (EPP-AF®) on inflammation in haemodialysis patients: a clinical trial |
| title_full |
Effects of standardized Brazilian green propolis extract (EPP-AF®) on inflammation in haemodialysis patients: a clinical trial |
| title_fullStr |
Effects of standardized Brazilian green propolis extract (EPP-AF®) on inflammation in haemodialysis patients: a clinical trial |
| title_full_unstemmed |
Effects of standardized Brazilian green propolis extract (EPP-AF®) on inflammation in haemodialysis patients: a clinical trial |
| title_sort |
Effects of standardized Brazilian green propolis extract (EPP-AF®) on inflammation in haemodialysis patients: a clinical trial |
| author |
Silveira, Marcelo Augusto Duarte |
| author_facet |
Silveira, Marcelo Augusto Duarte Santos, Hayna Malta Silva, Jéssica Rebouças Teles, Flávio Galvão, Erica Batista Dos Santos Souza, Sergio Pinto de Dutra, Fábio Ricardo Dantas Gomes, Marcel Miranda Dantas Teixeira, Maurício Brito Conceição, Luís Filipe Miranda Rebelo da Nascimento, Carolina Sa Nonaka, Carolina Kymie Vasques Cezar, Rodrigo Silva Batista, Paulo Benigno Pena Berretta, Andresa Aparecida Borges, Valeria M. Passos, Rogerio da Hora |
| author_role |
author |
| author2 |
Santos, Hayna Malta Silva, Jéssica Rebouças Teles, Flávio Galvão, Erica Batista Dos Santos Souza, Sergio Pinto de Dutra, Fábio Ricardo Dantas Gomes, Marcel Miranda Dantas Teixeira, Maurício Brito Conceição, Luís Filipe Miranda Rebelo da Nascimento, Carolina Sa Nonaka, Carolina Kymie Vasques Cezar, Rodrigo Silva Batista, Paulo Benigno Pena Berretta, Andresa Aparecida Borges, Valeria M. Passos, Rogerio da Hora |
| author2_role |
author author author author author author author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Silveira, Marcelo Augusto Duarte Santos, Hayna Malta Silva, Jéssica Rebouças Teles, Flávio Galvão, Erica Batista Dos Santos Souza, Sergio Pinto de Dutra, Fábio Ricardo Dantas Gomes, Marcel Miranda Dantas Teixeira, Maurício Brito Conceição, Luís Filipe Miranda Rebelo da Nascimento, Carolina Sa Nonaka, Carolina Kymie Vasques Cezar, Rodrigo Silva Batista, Paulo Benigno Pena Berretta, Andresa Aparecida Borges, Valeria M. Passos, Rogerio da Hora |
| dc.subject.other.en_US.fl_str_mv |
Extrato de própolis verde Inflamação Pacientes em hemodiálise |
| topic |
Extrato de própolis verde Inflamação Pacientes em hemodiálise Green propolis extract Inflammation Haemodialysis patients Própole Inflamação Diálise renal |
| dc.subject.en.en_US.fl_str_mv |
Green propolis extract Inflammation Haemodialysis patients |
| dc.subject.decs.en_US.fl_str_mv |
Própole Inflamação Diálise renal |
| description |
Instituto D'Or de Pesquisa e Ensino (IDOR). Apis Flora Indl. Com. Ltda. Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES). Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq). |
| publishDate |
2022 |
| dc.date.issued.fl_str_mv |
2022 |
| dc.date.accessioned.fl_str_mv |
2023-03-09T13:41:05Z |
| dc.date.available.fl_str_mv |
2023-03-09T13:41:05Z |
| dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
| dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.citation.fl_str_mv |
SILVEIRA, Marcelo Augusto Duarte et al. Effects of standardized Brazilian green propolis extract (EPP-AF®) on inflammation in haemodialysis patients: a clinical trial. International Journal of Nephrology, v. 2022, p. 1-9, 2022. |
| dc.identifier.uri.fl_str_mv |
https://www.arca.fiocruz.br/handle/icict/57315 |
| dc.identifier.issn.en_US.fl_str_mv |
2090-2158 |
| dc.identifier.doi.none.fl_str_mv |
10.1155/2022/1035475 |
| identifier_str_mv |
SILVEIRA, Marcelo Augusto Duarte et al. Effects of standardized Brazilian green propolis extract (EPP-AF®) on inflammation in haemodialysis patients: a clinical trial. International Journal of Nephrology, v. 2022, p. 1-9, 2022. 2090-2158 10.1155/2022/1035475 |
| url |
https://www.arca.fiocruz.br/handle/icict/57315 |
| dc.language.iso.fl_str_mv |
eng |
| language |
eng |
| dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
| eu_rights_str_mv |
openAccess |
| dc.publisher.none.fl_str_mv |
Hindawi |
| publisher.none.fl_str_mv |
Hindawi |
| dc.source.none.fl_str_mv |
reponame:Repositório Institucional da FIOCRUZ (ARCA) instname:Fundação Oswaldo Cruz (FIOCRUZ) instacron:FIOCRUZ |
| instname_str |
Fundação Oswaldo Cruz (FIOCRUZ) |
| instacron_str |
FIOCRUZ |
| institution |
FIOCRUZ |
| reponame_str |
Repositório Institucional da FIOCRUZ (ARCA) |
| collection |
Repositório Institucional da FIOCRUZ (ARCA) |
| bitstream.url.fl_str_mv |
https://www.arca.fiocruz.br/bitstream/icict/57315/1/license.txt https://www.arca.fiocruz.br/bitstream/icict/57315/2/Silveira%2c%20M.A.D.%20Effects%20of%20standardized%20brazilian..2022.pdf |
| bitstream.checksum.fl_str_mv |
5a560609d32a3863062d77ff32785d58 8818a5b15c6630b358a567b6d7178000 |
| bitstream.checksumAlgorithm.fl_str_mv |
MD5 MD5 |
| repository.name.fl_str_mv |
Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ) |
| repository.mail.fl_str_mv |
repositorio.arca@fiocruz.br |
| _version_ |
1798324680700985344 |