Marine-Derived Penicillium purpurogenum Reduces Tumor Size and Ameliorates Inflammation in an Erlich Mice Model
Autor(a) principal: | |
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Data de Publicação: | 2020 |
Outros Autores: | , , , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
Texto Completo: | https://www.arca.fiocruz.br/handle/icict/45477 |
Resumo: | Universidade Federal do Maranhão. Programa de Pós-Graduação em Biotecnologia. Laboratório de Cultura Celular. São Luis, MA, Brasil. |
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Teles, Amanda MaraPontes, Leticia Prince PereiraGuimarães, Sulayne Janayna AraújoButarelli, Ana LuizaSilva, Gabriel XavierNascimento, Flavia Raquel Fernandes doBezerra, Guesa Felipa de BarrosMoragas-Teles, Carla JunqueiraCosta, Rui Miguel Gil daSilva, Marcos Antonio Custodio Neto daSouza, Fernando AlmeidaCalabrese, Kátia da SilvaSantos, Ana Paula Silva AzevedoNascimento, Maria do Desterro Soares Brandão2020-12-30T15:11:42Z2020-12-30T15:11:42Z2020TELES, Amanda Mara et al. Marine-Derived Penicillium purpurogenum Reduces Tumor Size and Ameliorates Inflammation in an Erlich Mice Model. Marine Drugs, v. 18, n. 11, 541, p. 1-19, Oct. 2020.1660-3397https://www.arca.fiocruz.br/handle/icict/4547710.3390/md18110541engMDPITumor de EhlichP. purpurogenumInflamaçãoAnticorpos AntitumoraisEhlich’s tumorP. purpurogenumAntitumorMeroterpenoidsInflammationMarine-Derived Penicillium purpurogenum Reduces Tumor Size and Ameliorates Inflammation in an Erlich Mice Modelinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade Federal do Maranhão. Programa de Pós-Graduação em Biotecnologia. Laboratório de Cultura Celular. São Luis, MA, Brasil.Universidade Federal do Maranhão. Centro de Ciências Biológicas e da Saúde. Laboratório de Imunologia do Câncer Aplicado. São Luis, MA, Brasil.Universidade Federal do Maranhão. Centro de Ciências Biológicas e da Saúde. Laboratório de Imunologia do Câncer Aplicado. São Luís, MA, Brasil.Universidade Federal do Maranhão. Centro de Ciências Biológicas e da Saúde. Laboratório de Imunologia do Câncer Aplicado. São Luís, MA, Brasil.Universidade Federal do Maranhão. Programa de Pós-Graduação em Biotecnologia. Laboratório de Cultura Celular. São Luís, MA, Brasil.Universidade Federal do Maranhão. Centro de Ciências Biológicas e da Saúde. Laboratório de Imunofisiologia. São Luís, MA, Brasil.Universidade Federal do Maranhão. Programa de Pós-Graduação em Saúde do Adulto. São Luis, MA, Brasil.Fundação Oswaldo Cruz. Instituto de Tecnologia em Fármacos. Instituto de Tecnologia Farmacêutica. Laboratório de Produtos Naturais para Saúde Pública. Rio de Janeiro, RJ, Brasil.Universidade Federal do Maranhão. Programa de Pós-Graduação em Saúde do Adulto. São Luis, MA, Brasil / University of Trás-os-Montes and Alto Douro. Centre for the Research and Technology of Agro-Environmental and Biological Sciences . Vila Real, Portugal.Universidade Estadual de Campinas. Pós-Graduação em Medicina Interna. Campinas, SP, Brasil.Universidade do Estado do Maranhão. Programa de Pós-Graduação em Ciência Animal. Laboratório de Anatomopatologia. São Luis, MA, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunomodulação e Protozoologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunomodulação e Protozoologia. Rio de Janeiro, RJ, Brasil.Universidade Federal do Maranhão. Centro de Ciências Biológicas e da Saúde. Laboratório de Imunologia do Câncer Aplicado. São Luis, MA, Brasil.Universidade Federal do Maranhão. Programa de Pós-Graduação em Saúde do Adulto. São Luís, MA, Brasil.Background: This study addresses the antitumoral properties of Penicillium purpurogenum isolated from a polluted lagoon in Northeastern Brazil. Methods: Ethyl Acetate Extracellular Extract (EAE) was used. The metabolites were studied using direct infusion mass spectrometry. The solid Ehrlich tumor model was used for antitumor activity. Female Swiss mice were divided into groups (n = 10/group) as follows: The negative control (CTL−), treated with a phosphate buffered solution; the positive control (CTL+), treated with cyclophosphamide (25 mg/kg); extract treatments at doses of 4, 20, and 100 mg/kg; animals without tumors or treatments (Sham); and animals without tumors treated with an intermediate dose (EAE20). All treatments were performed intraperitoneally, daily, for 15 days. Subsequently, the animals were euthanized, and the tumor, lymphoid organs, and serum were used for immunological, histological, and biochemical parameter evaluations. Results: The extract was rich in meroterpenoids. All doses significantly reduced tumor size, and the 20 and 100 mg/kg doses reduced tumor-associated inflammation and tumor necrosis. The extract also reduced the cellular infiltration of lymphoid organs and circulating TNF-α levels. The extract did not induce weight loss or renal and hepatic toxic changes. Conclusions: These results indicate that P. purpurogenum exhibits immunomodulatory and antitumor properties in vivo. Thus, fungal fermentation is a valid biotechnological approach to the production of antitumor agents.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/45477/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALKatiaCalabrese_Fernandosouza_etal_IOC_2020.pdfKatiaCalabrese_Fernandosouza_etal_IOC_2020.pdfapplication/pdf3821662https://www.arca.fiocruz.br/bitstream/icict/45477/2/KatiaCalabrese_Fernandosouza_etal_IOC_2020.pdfb49ddc7443ae5d7ba5012ba7d7a03a7dMD52TEXTKatiaCalabrese_Fernandosouza_etal_IOC_2020.pdf.txtKatiaCalabrese_Fernandosouza_etal_IOC_2020.pdf.txtExtracted texttext/plain75536https://www.arca.fiocruz.br/bitstream/icict/45477/3/KatiaCalabrese_Fernandosouza_etal_IOC_2020.pdf.txt6fd322a592dcf5b3020af4246ec43d6cMD53icict/454772022-06-24 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dc.title.pt_BR.fl_str_mv |
Marine-Derived Penicillium purpurogenum Reduces Tumor Size and Ameliorates Inflammation in an Erlich Mice Model |
title |
Marine-Derived Penicillium purpurogenum Reduces Tumor Size and Ameliorates Inflammation in an Erlich Mice Model |
spellingShingle |
Marine-Derived Penicillium purpurogenum Reduces Tumor Size and Ameliorates Inflammation in an Erlich Mice Model Teles, Amanda Mara Tumor de Ehlich P. purpurogenum Inflamação Anticorpos Antitumorais Ehlich’s tumor P. purpurogenum Antitumor Meroterpenoids Inflammation |
title_short |
Marine-Derived Penicillium purpurogenum Reduces Tumor Size and Ameliorates Inflammation in an Erlich Mice Model |
title_full |
Marine-Derived Penicillium purpurogenum Reduces Tumor Size and Ameliorates Inflammation in an Erlich Mice Model |
title_fullStr |
Marine-Derived Penicillium purpurogenum Reduces Tumor Size and Ameliorates Inflammation in an Erlich Mice Model |
title_full_unstemmed |
Marine-Derived Penicillium purpurogenum Reduces Tumor Size and Ameliorates Inflammation in an Erlich Mice Model |
title_sort |
Marine-Derived Penicillium purpurogenum Reduces Tumor Size and Ameliorates Inflammation in an Erlich Mice Model |
author |
Teles, Amanda Mara |
author_facet |
Teles, Amanda Mara Pontes, Leticia Prince Pereira Guimarães, Sulayne Janayna Araújo Butarelli, Ana Luiza Silva, Gabriel Xavier Nascimento, Flavia Raquel Fernandes do Bezerra, Guesa Felipa de Barros Moragas-Teles, Carla Junqueira Costa, Rui Miguel Gil da Silva, Marcos Antonio Custodio Neto da Souza, Fernando Almeida Calabrese, Kátia da Silva Santos, Ana Paula Silva Azevedo Nascimento, Maria do Desterro Soares Brandão |
author_role |
author |
author2 |
Pontes, Leticia Prince Pereira Guimarães, Sulayne Janayna Araújo Butarelli, Ana Luiza Silva, Gabriel Xavier Nascimento, Flavia Raquel Fernandes do Bezerra, Guesa Felipa de Barros Moragas-Teles, Carla Junqueira Costa, Rui Miguel Gil da Silva, Marcos Antonio Custodio Neto da Souza, Fernando Almeida Calabrese, Kátia da Silva Santos, Ana Paula Silva Azevedo Nascimento, Maria do Desterro Soares Brandão |
author2_role |
author author author author author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Teles, Amanda Mara Pontes, Leticia Prince Pereira Guimarães, Sulayne Janayna Araújo Butarelli, Ana Luiza Silva, Gabriel Xavier Nascimento, Flavia Raquel Fernandes do Bezerra, Guesa Felipa de Barros Moragas-Teles, Carla Junqueira Costa, Rui Miguel Gil da Silva, Marcos Antonio Custodio Neto da Souza, Fernando Almeida Calabrese, Kátia da Silva Santos, Ana Paula Silva Azevedo Nascimento, Maria do Desterro Soares Brandão |
dc.subject.other.pt_BR.fl_str_mv |
Tumor de Ehlich P. purpurogenum Inflamação Anticorpos Antitumorais |
topic |
Tumor de Ehlich P. purpurogenum Inflamação Anticorpos Antitumorais Ehlich’s tumor P. purpurogenum Antitumor Meroterpenoids Inflammation |
dc.subject.en.pt_BR.fl_str_mv |
Ehlich’s tumor P. purpurogenum Antitumor Meroterpenoids Inflammation |
description |
Universidade Federal do Maranhão. Programa de Pós-Graduação em Biotecnologia. Laboratório de Cultura Celular. São Luis, MA, Brasil. |
publishDate |
2020 |
dc.date.accessioned.fl_str_mv |
2020-12-30T15:11:42Z |
dc.date.available.fl_str_mv |
2020-12-30T15:11:42Z |
dc.date.issued.fl_str_mv |
2020 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
TELES, Amanda Mara et al. Marine-Derived Penicillium purpurogenum Reduces Tumor Size and Ameliorates Inflammation in an Erlich Mice Model. Marine Drugs, v. 18, n. 11, 541, p. 1-19, Oct. 2020. |
dc.identifier.uri.fl_str_mv |
https://www.arca.fiocruz.br/handle/icict/45477 |
dc.identifier.issn.pt_BR.fl_str_mv |
1660-3397 |
dc.identifier.doi.none.fl_str_mv |
10.3390/md18110541 |
identifier_str_mv |
TELES, Amanda Mara et al. Marine-Derived Penicillium purpurogenum Reduces Tumor Size and Ameliorates Inflammation in an Erlich Mice Model. Marine Drugs, v. 18, n. 11, 541, p. 1-19, Oct. 2020. 1660-3397 10.3390/md18110541 |
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https://www.arca.fiocruz.br/handle/icict/45477 |
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eng |
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eng |
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info:eu-repo/semantics/openAccess |
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openAccess |
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MDPI |
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MDPI |
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