Outcomes in critically Ill patients with cancer-related complications
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2016 |
| Outros Autores: | , , , , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/32737 |
Resumo: | Universidade Federal do Rio de Janeiro. School of Medicin. Postgraduate Program in Internal Medicine. Rio de Janeiro, RJ, Brazil. |
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Torres, Viviane B. L.Vassalo, JulianaSilva, Ulysses V. A.Caruso, PedroTorelly, André P.Silva, EliezerTeles, José M. M.Knibel, MarcosRezende, EderlonNetto, José J. S.Piras, ClaudioAzevedo, Luciano C. P.Bozza, Fernando A.Spector, NelsonSalluh, Jorge I. F.Soares, Marcio2019-04-25T13:19:23Z2019-04-25T13:19:23Z2016TORRES, Viviane B. L. et al. Outcomes in critically ill patients with cancer-related complications. Plos One, p. 1-14, Oct. 20, 20161932-6203https://www.arca.fiocruz.br/handle/icict/3273710.1371/journal.pone.01645371932-6203engPublic Library of ScienceOutcomes in critically Ill patients with cancer-related complicationsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade Federal do Rio de Janeiro. School of Medicin. Postgraduate Program in Internal Medicine. Rio de Janeiro, RJ, Brazil.Universidade Federal do Rio de Janeiro. School of Medicin. Postgraduate Program in Internal Medicine. Rio de Janeiro, RJ, Brazil.Fundação Pio XII. Hospital do Câncer de Barretos. ICU. Barretos, SP, Brazil.A.C. Camargo Cancer Center. ICU. São Paulo, SP, Brazil.Irmandade da Santa Casa de Misericórdia de Porto Alegre. Rede Institucional de Pesquisa e Inovação em Medicina Intensiva. Porto Alegre, RS, Brasil.Hospital Israelita Albert Einstein. ICU. São Paulo, SP, Brazil.Hospital Português. ICU. Salvador, BA, Brazil.Hospital São Lucas. Rio de Janeiro, RJ, Brasil.Hospital do Servidor Público Estadual. ICU. São Paulo, SP, Brazil.Instituto Nacional de Câncer, Hospital do Câncer II. ICU. Rio de Janeiro, RJ, Brazil.Vitória Apart Hospital. ICU. Vitória, Brazil.Hospital Sírio-Libanês. Research and Education Institute. São Paulo, SP, Brazil.D’Or Institute for Research and Education. Rio de Janeiro, RJ, Brazil / Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. School of Medicin. Postgraduate Program in Internal Medicine. Rio de Janeiro, RJ, Brazil.Universidade Federal do Rio de Janeiro. School of Medicin. Postgraduate Program in Internal Medicine. Rio de Janeiro, RJ, Brazil / D’Or Institute for Research and Education. Rio de Janeiro, RJ, Brazil / Instituto Nacional de Câncer. Postgraduate Program. Rio de Janeiro, RJ, Brazil.Universidade Federal do Rio de Janeiro. School of Medicin. Postgraduate Program in Internal Medicine. Rio de Janeiro, RJ, Brazil / D’Or Institute for Research and Education. Rio de Janeiro, RJ, Brazil / Instituto Nacional de Câncer. Postgraduate Program. Rio de Janeiro, RJ, Brazil.Introduction: Cancer patients are at risk for severe complications related to the underlying malignancy or its treatment and, therefore, usually require admission to intensive care units (ICU). Here, we evaluated the clinical characteristics and outcomes in this subgroup of patients. Materials and Methods: Secondary analysis of two prospective cohorts of cancer patients admitted to ICUs. We used multivariable logistic regression to identify variables associated with hospital mortality. Results: Out of 2,028 patients, 456 (23%) had cancer-related complications. Compared to those without cancer-related complications, they more frequently had worse performance status (PS) (57% vs 36% with PS 2), active malignancy (95% vs 58%), need for vasopressors (45% vs 34%), mechanical ventilation (70% vs 51%) and dialysis (12% vs 8%) (P<0.001 for all analyses). ICU (47% vs. 27%) and hospital (63% vs. 38%) mortality rates were also higher in patients with cancer-related complications (P<0.001). Chemo/radiation therapyinduced toxicity (6%), venous thromboembolism (5%), respiratory failure (4%), gastrointestinal involvement (3%) and vena cava syndrome (VCS) (2%) were the most frequent cancer-related complications. In multivariable analysis, the presence of cancer-related complications per se was not associated with mortality [odds ratio (OR) = 1.25 (95% confidence interval, 0.94–1.66), P = 0.131]. However, among the individual cancer-related complications, VCS [OR = 3.79 (1.11–12.92), P = 0.033], gastrointestinal involvement [OR = 3.05 (1.57–5.91), P = <0.001] and respiratory failure [OR = 1.96(1.04–3.71), P = 0.038] were independently associated with in-hospital mortality. Conclusions: The prognostic impact of cancer-related complications was variable. Although some complications were associated with worse outcomes, the presence of an acute cancer-related complication per se should not guide decisions to admit a patient to ICU.Cancer patientsIntensive care unitsinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83104https://www.arca.fiocruz.br/bitstream/icict/32737/1/license.txt79178e5f2a0eb066867a274556814938MD51ORIGINALve_Torres_Viviane_etal_INI_2016.pdfve_Torres_Viviane_etal_INI_2016.pdfapplication/pdf1162676https://www.arca.fiocruz.br/bitstream/icict/32737/2/ve_Torres_Viviane_etal_INI_2016.pdfd29ed0330878e84f7c642a0d3dafa19cMD52TEXTve_Torres_Viviane_etal_INI_2016.pdf.txtve_Torres_Viviane_etal_INI_2016.pdf.txtExtracted texttext/plain50679https://www.arca.fiocruz.br/bitstream/icict/32737/3/ve_Torres_Viviane_etal_INI_2016.pdf.txtf85aeb6a2b96b43def613104e906c1ccMD53icict/327372019-04-26 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| dc.title.pt_BR.fl_str_mv |
Outcomes in critically Ill patients with cancer-related complications |
| title |
Outcomes in critically Ill patients with cancer-related complications |
| spellingShingle |
Outcomes in critically Ill patients with cancer-related complications Torres, Viviane B. L. Cancer patients Intensive care units |
| title_short |
Outcomes in critically Ill patients with cancer-related complications |
| title_full |
Outcomes in critically Ill patients with cancer-related complications |
| title_fullStr |
Outcomes in critically Ill patients with cancer-related complications |
| title_full_unstemmed |
Outcomes in critically Ill patients with cancer-related complications |
| title_sort |
Outcomes in critically Ill patients with cancer-related complications |
| author |
Torres, Viviane B. L. |
| author_facet |
Torres, Viviane B. L. Vassalo, Juliana Silva, Ulysses V. A. Caruso, Pedro Torelly, André P. Silva, Eliezer Teles, José M. M. Knibel, Marcos Rezende, Ederlon Netto, José J. S. Piras, Claudio Azevedo, Luciano C. P. Bozza, Fernando A. Spector, Nelson Salluh, Jorge I. F. Soares, Marcio |
| author_role |
author |
| author2 |
Vassalo, Juliana Silva, Ulysses V. A. Caruso, Pedro Torelly, André P. Silva, Eliezer Teles, José M. M. Knibel, Marcos Rezende, Ederlon Netto, José J. S. Piras, Claudio Azevedo, Luciano C. P. Bozza, Fernando A. Spector, Nelson Salluh, Jorge I. F. Soares, Marcio |
| author2_role |
author author author author author author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Torres, Viviane B. L. Vassalo, Juliana Silva, Ulysses V. A. Caruso, Pedro Torelly, André P. Silva, Eliezer Teles, José M. M. Knibel, Marcos Rezende, Ederlon Netto, José J. S. Piras, Claudio Azevedo, Luciano C. P. Bozza, Fernando A. Spector, Nelson Salluh, Jorge I. F. Soares, Marcio |
| dc.subject.en.pt_BR.fl_str_mv |
Cancer patients Intensive care units |
| topic |
Cancer patients Intensive care units |
| description |
Universidade Federal do Rio de Janeiro. School of Medicin. Postgraduate Program in Internal Medicine. Rio de Janeiro, RJ, Brazil. |
| publishDate |
2016 |
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2016 |
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2019-04-25T13:19:23Z |
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2019-04-25T13:19:23Z |
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TORRES, Viviane B. L. et al. Outcomes in critically ill patients with cancer-related complications. Plos One, p. 1-14, Oct. 20, 2016 |
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https://www.arca.fiocruz.br/handle/icict/32737 |
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1932-6203 |
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10.1371/journal.pone.0164537 |
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1932-6203 |
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TORRES, Viviane B. L. et al. Outcomes in critically ill patients with cancer-related complications. Plos One, p. 1-14, Oct. 20, 2016 1932-6203 10.1371/journal.pone.0164537 |
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