Perspectives From Systems Biology to Improve Knowledge of Leishmania Drug Resistance

Detalhes bibliográficos
Autor(a) principal: Horácio, Elvira Cynthia Alves
Data de Publicação: 2021
Outros Autores: Hickson, Jéssica, Murta, Silvane Maria Fonseca, Ruiz, Jeronimo Conceição, Nahum, Laila Alves
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/51757
Resumo: René Rachou Institute. Oswaldo Cruz Foundation. Belo Horizonte, MG, Brazil/Department of Genetics, Ecology and Evolution. Institute of Biological Sciences. Federal University of Minas Gerais. Belo Horizonte, MG, Brazil.
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spelling Horácio, Elvira Cynthia AlvesHickson, JéssicaMurta, Silvane Maria FonsecaRuiz, Jeronimo ConceiçãoNahum, Laila Alves2022-03-21T11:48:59Z2022-03-21T11:48:59Z2021HORÁCIO, Elvira Cynthia Alves et al. Perspectives From Systems Biology to Improve Knowledge of Leishmania Drug Resistance. Front Cell Infect Microbiol., v. 11, 653670, 2021. doi: 10.3389/fcimb.2021.653670.2235-2988https://www.arca.fiocruz.br/handle/icict/5175710.3389/fcimb.2021.653670engFrontiers Media ASPerspectives From Systems Biology to Improve Knowledge of Leishmania Drug Resistanceinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleRené Rachou Institute. Oswaldo Cruz Foundation. Belo Horizonte, MG, Brazil/Department of Genetics, Ecology and Evolution. Institute of Biological Sciences. Federal University of Minas Gerais. Belo Horizonte, MG, Brazil.René Rachou Institute. Oswaldo Cruz Foundation. Belo Horizonte, MG, Brazil.René Rachou Institute. Oswaldo Cruz Foundation. Belo Horizonte, MG, Brazil.René Rachou Institute. Oswaldo Cruz Foundation. Belo Horizonte, MG, Brazil.René Rachou Institute. Oswaldo Cruz Foundation. Belo Horizonte, MG, Brazil/Department of Genetics, Ecology and Evolution. Institute of Biological Sciences. Federal University of Minas Gerais. Belo Horizonte, MG, Brazil/Promove College of Technology. Belo Horizonte, MG, Brazil.Neglected Tropical Diseases include a broad range of pathogens, hosts, and vectors, which represent evolving complex systems. Leishmaniasis, caused by different Leishmania species and transmitted to humans by sandflies, are among such diseases. Leishmania and other Trypanosomatidae display some peculiar features, which make them a complex system to study. Leishmaniasis chemotherapy is limited due to high toxicity of available drugs, long-term treatment protocols, and occurrence of drug resistant parasite strains. Systems biology studies the interactions and behavior of complex biological processes and may improve knowledge of Leishmania drug resistance. System-level studies to understand Leishmania biology have been challenging mainly because of its unusual molecular features. Networks integrating the biochemical and biological pathways involved in drug resistance have been reported in literature. Antioxidant defense enzymes have been identified as potential drug targets against leishmaniasis. These and other biomarkers might be studied from the perspective of systems biology and systems parasitology opening new frontiers for drug development and treatment of leishmaniasis and other diseases. Our main goals include: 1) Summarize current advances in Leishmania research focused on chemotherapy and drug resistance. 2) Share our viewpoint on the application of systems biology to Leishmania studies. 3) Provide insights and directions for future investigation.Leishmaniachemotherapydrug resistancemolecular networkssystems biologysystems parasitologyinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83082https://www.arca.fiocruz.br/bitstream/icict/51757/1/license.txt9193a7c197bc67acd023525e72a03240MD51ORIGINALPerspectives From Systems Biology to Improve Knowledge of Leishmania Drug Resistance - fcimb-11-653670.pdfPerspectives From Systems Biology to Improve Knowledge of Leishmania Drug Resistance - 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dc.title.pt_BR.fl_str_mv Perspectives From Systems Biology to Improve Knowledge of Leishmania Drug Resistance
title Perspectives From Systems Biology to Improve Knowledge of Leishmania Drug Resistance
spellingShingle Perspectives From Systems Biology to Improve Knowledge of Leishmania Drug Resistance
Horácio, Elvira Cynthia Alves
Leishmania
chemotherapy
drug resistance
molecular networks
systems biology
systems parasitology
title_short Perspectives From Systems Biology to Improve Knowledge of Leishmania Drug Resistance
title_full Perspectives From Systems Biology to Improve Knowledge of Leishmania Drug Resistance
title_fullStr Perspectives From Systems Biology to Improve Knowledge of Leishmania Drug Resistance
title_full_unstemmed Perspectives From Systems Biology to Improve Knowledge of Leishmania Drug Resistance
title_sort Perspectives From Systems Biology to Improve Knowledge of Leishmania Drug Resistance
author Horácio, Elvira Cynthia Alves
author_facet Horácio, Elvira Cynthia Alves
Hickson, Jéssica
Murta, Silvane Maria Fonseca
Ruiz, Jeronimo Conceição
Nahum, Laila Alves
author_role author
author2 Hickson, Jéssica
Murta, Silvane Maria Fonseca
Ruiz, Jeronimo Conceição
Nahum, Laila Alves
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Horácio, Elvira Cynthia Alves
Hickson, Jéssica
Murta, Silvane Maria Fonseca
Ruiz, Jeronimo Conceição
Nahum, Laila Alves
dc.subject.en.pt_BR.fl_str_mv Leishmania
chemotherapy
drug resistance
molecular networks
systems biology
systems parasitology
topic Leishmania
chemotherapy
drug resistance
molecular networks
systems biology
systems parasitology
description René Rachou Institute. Oswaldo Cruz Foundation. Belo Horizonte, MG, Brazil/Department of Genetics, Ecology and Evolution. Institute of Biological Sciences. Federal University of Minas Gerais. Belo Horizonte, MG, Brazil.
publishDate 2021
dc.date.issued.fl_str_mv 2021
dc.date.accessioned.fl_str_mv 2022-03-21T11:48:59Z
dc.date.available.fl_str_mv 2022-03-21T11:48:59Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv HORÁCIO, Elvira Cynthia Alves et al. Perspectives From Systems Biology to Improve Knowledge of Leishmania Drug Resistance. Front Cell Infect Microbiol., v. 11, 653670, 2021. doi: 10.3389/fcimb.2021.653670.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/51757
dc.identifier.issn.pt_BR.fl_str_mv 2235-2988
dc.identifier.doi.none.fl_str_mv 10.3389/fcimb.2021.653670
identifier_str_mv HORÁCIO, Elvira Cynthia Alves et al. Perspectives From Systems Biology to Improve Knowledge of Leishmania Drug Resistance. Front Cell Infect Microbiol., v. 11, 653670, 2021. doi: 10.3389/fcimb.2021.653670.
2235-2988
10.3389/fcimb.2021.653670
url https://www.arca.fiocruz.br/handle/icict/51757
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Frontiers Media AS
publisher.none.fl_str_mv Frontiers Media AS
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
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reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/51757/1/license.txt
https://www.arca.fiocruz.br/bitstream/icict/51757/2/Perspectives%20From%20Systems%20Biology%20to%20Improve%20Knowledge%20of%20Leishmania%20Drug%20Resistance%20-%20fcimb-11-653670.pdf
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repository.name.fl_str_mv Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)
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