Whole blood transfusion improves vascular integrity and increases survival in artemether‑treated experimental cerebral malaria

Bibliographic Details
Main Author: Gul, Saba
Publication Date: 2021
Other Authors: Gomes, Flavia L. Ribeiro, Moreira, Aline S., Sanches, Guilherme S., Conceição, Fabiana G., Ribeiro, CláudioTadeu Daniel, Ackerman, Hans C., Carvalho, Leonardo J. M.
Format: Article
Language: eng
Source: Repositório Institucional da FIOCRUZ (ARCA)
Download full: https://www.arca.fiocruz.br/handle/icict/49033
Summary: Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Malária. Rio de Janeiro, RJ, Brasil.
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spelling Gul, SabaGomes, Flavia L. RibeiroMoreira, Aline S.Sanches, Guilherme S.Conceição, Fabiana G.Ribeiro, CláudioTadeu DanielAckerman, Hans C.Carvalho, Leonardo J. M.2021-09-07T21:01:11Z2021-09-07T21:01:11Z2021GUL, Saba et al. Whole blood transfusion improves vascular integrity and increases survival in artemether‑treated experimental cerebral malaria. Scientifc Reports, v. 11, 12077, 13 p, 2021.2045-2322https://www.arca.fiocruz.br/handle/icict/4903310.1038/s41598-021-91499-3engNatureTransfusão de sangueIntegridade vascularArtmether tratadoAumento de SobrevivênciaExperimental Malária CerebralMalária CerebralWhole blood transfusionVascular integrityIncreases survivalArtemether‑treated experimentalCerebral MalariaWhole blood transfusion improves vascular integrity and increases survival in artemether‑treated experimental cerebral malariainfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Malária. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Malária. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Malária. Rio de Janeiro, RJ, Brasil / Laboratory of Malaria and Vector Research, NIAID, NIH, Rockville, MD, USA.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Malária. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Malária. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Malária. Rio de Janeiro, RJ, Brasil.Laboratory of Malaria and Vector Research, NIAID, NIH, Rockville, MD, USA.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Malária. Rio de Janeiro, RJ, Brasil.Changes in blood and blood vessels are a pathological hallmark of Plasmodium falciparum infection, and are particularly intense in its deadly complication, cerebral malaria (CM). Mechanical obstruction of cerebral blood vessels by sequestration of parasitized red blood cells (pRBCs) reduces cerebral blood fow and oxy gen consumption1–3 . Anemia and loss of RBC deformability impair the perfusion of various organs4 . Severe malaria also leads to alterations of biochemical characteristics of the plasma, with depletion of plasmatic factors related with vascular health such as l-arginine5 , haptoglobin6 and angiopoietin-1 (Ang-1), a critical regulator of endothelial integrity7 . Ang-1 maintains vascular quiescence by signaling through the Tie-2 receptor8 , whereas Ang-2, stored in Weibel-Palade bodies, can be rapidly released upon endothelial activation and displace Ang-1, sensitizing the endothelium to low concentrations of infammatory cytokines such as TNF8 . Indeed, Ang-2 levels are elevated in severe malaria9 and have been associated with CM retinopathy10, and blood-retinal breakdown associated with death or sequelae in pediatric CM11. Together with coagulation disorders like platelet activa tion and thrombocytopenia12,13, these changes disturb endothelial quiescence, leading to vascular dysfunction, impaired cerebral perfusion, acidosis14 and breakdown of the blood–brain barrier (BBB)15. Whole blood transfusion is a practice already adopted in the adjuvant treatment of patients with severe malarial anemia16. In areas of high malaria endemicity, the World Health Organization (WHO) recommends blood transfusion when the hemoglobin concentration is less than 4 g/dL, this threshold is increased to 6 g/dL in case anemia is accompanied by acidosis, impaired consciousness, shock, or parasitaemia greater than 20%17,18. Recently, Ackerman and colleagues have shown that whole blood transfusion was associated with improved sur vival in children with severe falciparum malaria, and patients with impaired consciousness and hyperlactatemia benefted from transfusion even at moderate levels of anemia.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/49033/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALClaudioTRibeiro_FalviaGomes_etal_IOC_2021.pdfClaudioTRibeiro_FalviaGomes_etal_IOC_2021.pdfapplication/pdf2315652https://www.arca.fiocruz.br/bitstream/icict/49033/2/ClaudioTRibeiro_FalviaGomes_etal_IOC_2021.pdf4bcec6d89579da37d1bb3e71b9ffb7e2MD52TEXTClaudioTRibeiro_FalviaGomes_etal_IOC_2021.pdf.txtClaudioTRibeiro_FalviaGomes_etal_IOC_2021.pdf.txtExtracted 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dc.title.pt_BR.fl_str_mv Whole blood transfusion improves vascular integrity and increases survival in artemether‑treated experimental cerebral malaria
title Whole blood transfusion improves vascular integrity and increases survival in artemether‑treated experimental cerebral malaria
spellingShingle Whole blood transfusion improves vascular integrity and increases survival in artemether‑treated experimental cerebral malaria
Gul, Saba
Transfusão de sangue
Integridade vascular
Artmether tratado
Aumento de Sobrevivência
Experimental Malária Cerebral
Malária Cerebral
Whole blood transfusion
Vascular integrity
Increases survival
Artemether‑treated experimental
Cerebral Malaria
title_short Whole blood transfusion improves vascular integrity and increases survival in artemether‑treated experimental cerebral malaria
title_full Whole blood transfusion improves vascular integrity and increases survival in artemether‑treated experimental cerebral malaria
title_fullStr Whole blood transfusion improves vascular integrity and increases survival in artemether‑treated experimental cerebral malaria
title_full_unstemmed Whole blood transfusion improves vascular integrity and increases survival in artemether‑treated experimental cerebral malaria
title_sort Whole blood transfusion improves vascular integrity and increases survival in artemether‑treated experimental cerebral malaria
author Gul, Saba
author_facet Gul, Saba
Gomes, Flavia L. Ribeiro
Moreira, Aline S.
Sanches, Guilherme S.
Conceição, Fabiana G.
Ribeiro, CláudioTadeu Daniel
Ackerman, Hans C.
Carvalho, Leonardo J. M.
author_role author
author2 Gomes, Flavia L. Ribeiro
Moreira, Aline S.
Sanches, Guilherme S.
Conceição, Fabiana G.
Ribeiro, CláudioTadeu Daniel
Ackerman, Hans C.
Carvalho, Leonardo J. M.
author2_role author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Gul, Saba
Gomes, Flavia L. Ribeiro
Moreira, Aline S.
Sanches, Guilherme S.
Conceição, Fabiana G.
Ribeiro, CláudioTadeu Daniel
Ackerman, Hans C.
Carvalho, Leonardo J. M.
dc.subject.other.pt_BR.fl_str_mv Transfusão de sangue
Integridade vascular
Artmether tratado
Aumento de Sobrevivência
Experimental Malária Cerebral
Malária Cerebral
topic Transfusão de sangue
Integridade vascular
Artmether tratado
Aumento de Sobrevivência
Experimental Malária Cerebral
Malária Cerebral
Whole blood transfusion
Vascular integrity
Increases survival
Artemether‑treated experimental
Cerebral Malaria
dc.subject.en.pt_BR.fl_str_mv Whole blood transfusion
Vascular integrity
Increases survival
Artemether‑treated experimental
Cerebral Malaria
description Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Malária. Rio de Janeiro, RJ, Brasil.
publishDate 2021
dc.date.accessioned.fl_str_mv 2021-09-07T21:01:11Z
dc.date.available.fl_str_mv 2021-09-07T21:01:11Z
dc.date.issued.fl_str_mv 2021
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv GUL, Saba et al. Whole blood transfusion improves vascular integrity and increases survival in artemether‑treated experimental cerebral malaria. Scientifc Reports, v. 11, 12077, 13 p, 2021.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/49033
dc.identifier.issn.pt_BR.fl_str_mv 2045-2322
dc.identifier.doi.none.fl_str_mv 10.1038/s41598-021-91499-3
identifier_str_mv GUL, Saba et al. Whole blood transfusion improves vascular integrity and increases survival in artemether‑treated experimental cerebral malaria. Scientifc Reports, v. 11, 12077, 13 p, 2021.
2045-2322
10.1038/s41598-021-91499-3
url https://www.arca.fiocruz.br/handle/icict/49033
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Nature
publisher.none.fl_str_mv Nature
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/49033/1/license.txt
https://www.arca.fiocruz.br/bitstream/icict/49033/2/ClaudioTRibeiro_FalviaGomes_etal_IOC_2021.pdf
https://www.arca.fiocruz.br/bitstream/icict/49033/3/ClaudioTRibeiro_FalviaGomes_etal_IOC_2021.pdf.txt
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repository.mail.fl_str_mv repositorio.arca@fiocruz.br
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