Increase in virulence of Sporothrix brasiliensis over five years in a patient with chronic disseminated sporotrichosis

Detalhes bibliográficos
Autor(a) principal: Freitas, Dayvison F. S.
Data de Publicação: 2015
Outros Autores: Santos, Suelen S., Almeida-Paes, Rodrigo, Oliveira, Manoel M. E. de, Valle, Antonio C. F. do, Gutierrez-Galhardo, Maria Clara, Zancopé-Oliveira, Rosely M., Nosanchuk, Joshua D.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/31891
Resumo: Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil / Albert Einstein College of Medicine. New York, NY USA.
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spelling Freitas, Dayvison F. S.Santos, Suelen S.Almeida-Paes, RodrigoOliveira, Manoel M. E. deValle, Antonio C. F. doGutierrez-Galhardo, Maria ClaraZancopé-Oliveira, Rosely M.Nosanchuk, Joshua D.2019-02-27T13:24:16Z2019-02-27T13:24:16Z2015FREITAS, Dayvison F. S. et al. Increase in virulence of Sporothrix brasiliensis over five years in a patient with chronic disseminated sporotrichosis. Virulence, v. 6, n. 2, p. 112-120, Feb./Mar. 2015.2150-5594https://www.arca.fiocruz.br/handle/icict/3189110.1080/21505594.2015.10142742150-5608engTaylor & Francis OpenIncrease in virulence of Sporothrix brasiliensis over five years in a patient with chronic disseminated sporotrichosisinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil / Albert Einstein College of Medicine. New York, NY USA.Albert Einstein College of Medicine. New York, NY, USA / Universidade de São Paulo. Faculdade de Ciências Farmacêuticas. São Paulo, SP, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.Albert Einstein College of Medicine. New York, NY USA.The metropolitan region of Rio de Janeiro is hyperendemic for cat-associated sporotrichosis. This study aimed to assess the virulence of serial Sporothrix isolates from a 61-year-old male patient with chronic, destructive disseminated sporotrichosis. Five Sporothrix isolates were cultured from skin exudates and bone samples over a 5-year period, and all were molecularly identified as Sporothrix brasiliensis. The final isolate was significantly more virulent in Galleria mellonella larvae compared to earlier isolates. We conclude that S. brasiliensis has the capacity to increase in virulence in vivo. This finding is significant to clinicians caring for individuals with S. brasiliensis disease and it suggests that further studies are needed to identify the mechanisms underlying pathogenicity enhancement during chronic disease.BrazilChitin synthaseDisseminatedGalleria mellonellaReactive nitrogen intermediatesRio de JaneiroSporothrix brasiliensisSporotrichosisT3B PCRVirulenceinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; 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dc.title.pt_BR.fl_str_mv Increase in virulence of Sporothrix brasiliensis over five years in a patient with chronic disseminated sporotrichosis
title Increase in virulence of Sporothrix brasiliensis over five years in a patient with chronic disseminated sporotrichosis
spellingShingle Increase in virulence of Sporothrix brasiliensis over five years in a patient with chronic disseminated sporotrichosis
Freitas, Dayvison F. S.
Brazil
Chitin synthase
Disseminated
Galleria mellonella
Reactive nitrogen intermediates
Rio de Janeiro
Sporothrix brasiliensis
Sporotrichosis
T3B PCR
Virulence
title_short Increase in virulence of Sporothrix brasiliensis over five years in a patient with chronic disseminated sporotrichosis
title_full Increase in virulence of Sporothrix brasiliensis over five years in a patient with chronic disseminated sporotrichosis
title_fullStr Increase in virulence of Sporothrix brasiliensis over five years in a patient with chronic disseminated sporotrichosis
title_full_unstemmed Increase in virulence of Sporothrix brasiliensis over five years in a patient with chronic disseminated sporotrichosis
title_sort Increase in virulence of Sporothrix brasiliensis over five years in a patient with chronic disseminated sporotrichosis
author Freitas, Dayvison F. S.
author_facet Freitas, Dayvison F. S.
Santos, Suelen S.
Almeida-Paes, Rodrigo
Oliveira, Manoel M. E. de
Valle, Antonio C. F. do
Gutierrez-Galhardo, Maria Clara
Zancopé-Oliveira, Rosely M.
Nosanchuk, Joshua D.
author_role author
author2 Santos, Suelen S.
Almeida-Paes, Rodrigo
Oliveira, Manoel M. E. de
Valle, Antonio C. F. do
Gutierrez-Galhardo, Maria Clara
Zancopé-Oliveira, Rosely M.
Nosanchuk, Joshua D.
author2_role author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Freitas, Dayvison F. S.
Santos, Suelen S.
Almeida-Paes, Rodrigo
Oliveira, Manoel M. E. de
Valle, Antonio C. F. do
Gutierrez-Galhardo, Maria Clara
Zancopé-Oliveira, Rosely M.
Nosanchuk, Joshua D.
dc.subject.en.pt_BR.fl_str_mv Brazil
Chitin synthase
Disseminated
Galleria mellonella
Reactive nitrogen intermediates
Rio de Janeiro
Sporothrix brasiliensis
Sporotrichosis
T3B PCR
Virulence
topic Brazil
Chitin synthase
Disseminated
Galleria mellonella
Reactive nitrogen intermediates
Rio de Janeiro
Sporothrix brasiliensis
Sporotrichosis
T3B PCR
Virulence
description Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil / Albert Einstein College of Medicine. New York, NY USA.
publishDate 2015
dc.date.issued.fl_str_mv 2015
dc.date.accessioned.fl_str_mv 2019-02-27T13:24:16Z
dc.date.available.fl_str_mv 2019-02-27T13:24:16Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv FREITAS, Dayvison F. S. et al. Increase in virulence of Sporothrix brasiliensis over five years in a patient with chronic disseminated sporotrichosis. Virulence, v. 6, n. 2, p. 112-120, Feb./Mar. 2015.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/31891
dc.identifier.issn.pt_BR.fl_str_mv 2150-5594
dc.identifier.doi.none.fl_str_mv 10.1080/21505594.2015.1014274
dc.identifier.eissn.none.fl_str_mv 2150-5608
identifier_str_mv FREITAS, Dayvison F. S. et al. Increase in virulence of Sporothrix brasiliensis over five years in a patient with chronic disseminated sporotrichosis. Virulence, v. 6, n. 2, p. 112-120, Feb./Mar. 2015.
2150-5594
10.1080/21505594.2015.1014274
2150-5608
url https://www.arca.fiocruz.br/handle/icict/31891
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Taylor & Francis Open
publisher.none.fl_str_mv Taylor & Francis Open
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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