Acute kidney injury associated to COVID-19 leads to a strong unbalance of circulant immune mediators

Detalhes bibliográficos
Autor(a) principal: Medeiros, Thalia
Data de Publicação: 2022
Outros Autores: Guimarães, Gabriel Macedo Costa, Carvalho, Fabiana Rabe, Alves, Lilian Santos, Faustino, Renan, Azevedo, Ana Carolina Campi, Pascoal, Vanessa Peruhype Magalhães, Carvalho, Andréa Teixeira de, Gomes, Matheus de Souza, Amaral, Laurence Rodrigues do, Martins Filho, Olindo Assis, Lugon, Jocemir Ronaldo, Almeida, Jorge Reis, Silva, Andrea Alice
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/56769
Resumo: Multiuser Laboratory for Research Support in Nephrology and Medical Sciences. Hospital Universitario Antonio Pedro. Faculty of Medicine. Universidade Federal Fluminense. Niteroi, RJ, Brazil/ Department of Pathology. Faculty of Medicine. Universidade Federal Fluminense. Niterói, RJ, Brazil.
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spelling Medeiros, ThaliaGuimarães, Gabriel Macedo CostaCarvalho, Fabiana RabeAlves, Lilian SantosFaustino, RenanAzevedo, Ana Carolina CampiPascoal, Vanessa Peruhype MagalhãesCarvalho, Andréa Teixeira deGomes, Matheus de SouzaAmaral, Laurence Rodrigues doMartins Filho, Olindo AssisLugon, Jocemir RonaldoAlmeida, Jorge ReisSilva, Andrea Alice2023-01-30T17:44:00Z2023-01-30T17:44:00Z2022MEDEIROS, Thalia et al. Acute kidney injury associated to COVID-19 leads to a strong unbalance of circulant immune mediators. Cytokine, v. 157, 155974, 2022. doi: 10.1016/j.cyto.2022.155974.1043-4666https://www.arca.fiocruz.br/handle/icict/56769engElsevier Science Ltd.Acute kidney injury associated to COVID-19 leads to a strong unbalance of circulant immune mediatorsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleMultiuser Laboratory for Research Support in Nephrology and Medical Sciences. Hospital Universitario Antonio Pedro. Faculty of Medicine. Universidade Federal Fluminense. Niteroi, RJ, Brazil/ Department of Pathology. Faculty of Medicine. Universidade Federal Fluminense. Niterói, RJ, Brazil.Multiuser Laboratory for Research Support in Nephrology and Medical Sciences. Hospital Universitario Antonio Pedro. Faculty of Medicine. Universidade Federal Fluminense. Niteroi, RJ, BrazilMultiuser Laboratory for Research Support in Nephrology and Medical Sciences. Hospital Universitario Antonio Pedro. Faculty of Medicine. Universidade Federal Fluminense. Niteroi, RJ, BrazilMultiuser Laboratory for Research Support in Nephrology and Medical Sciences. Hospital Universitario Antonio Pedro. Faculty of Medicine. Universidade Federal Fluminense. Niteroi, RJ, BrazilMultiuser Laboratory for Research Support in Nephrology and Medical Sciences. Hospital Universitario Antonio Pedro. Faculty of Medicine. Universidade Federal Fluminense. Niteroi, RJ, BrazilFundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, Minas Gerais, Brazil.Fundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, Minas Gerais, Brazil.Fundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, Minas Gerais, Brazil.Laboratory of Bioinformatics and Molecular Analysis. Federal University of Uberlandia. Patos de Minas, MG, Brazil.Laboratory of Bioinformatics and Molecular Analysis. Federal University of Uberlandia. Patos de Minas, MG, Brazil.Fundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, Minas Gerais, Brazil.Multiuser Laboratory for Research Support in Nephrology and Medical Sciences. Hospital Universitario Antonio Pedro. Faculty of Medicine. Universidade Federal Fluminense. Niteroi, RJ, Brazil/Department of Clinical Medicine – Nephrology. Faculty of Medicine. Universidade Federal Fluminense. Niteroi, RJ, Brazil.Multiuser Laboratory for Research Support in Nephrology and Medical Sciences. Hospital Universitario Antonio Pedro. Faculty of Medicine. Universidade Federal Fluminense. Niteroi, RJ, BrazilMultiuser Laboratory for Research Support in Nephrology and Medical Sciences. Hospital Universitario Antonio Pedro. Faculty of Medicine. Universidade Federal Fluminense. Niteroi, RJ, Brazil/ Department of Pathology. Faculty of Medicine. Universidade Federal Fluminense. Niterói, RJ, Brazil.Background: Severe cases of coronavirus disease 2019 (COVID-19) have increased risk for acute kidney injury (AKI). The exacerbation of the immune response seems to contribute to AKI development, but the immunopathological process is not completely understood. Objectives: To analyze levels of circulant immune mediators in COVID-19 patients evolving with or without AKI. We have also investigated possible associations of these mediators with viral load and clinical outcomes. Methods: This is a longitudinal study performed with hospitalized patients with moderate to severe COVID-19. Serum levels of 27 immune mediators were measured by a multiplex immunoassay. Data were analyzed at two timepoints during the follow-up: within the first 13 days of the disease onset (early sample) and from the 14th day to death or hospital discharge (follow-up sample). Results: We studied 82 COVID-19 patients (59.5 ± 17.5 years, 54.9% male). Of these, 34 (41.5%) developed AKI. These patients presented higher SARS-CoV-2 viral load (P = 0.03), higher frequency of diabetes (P = 0.01) and death (P = 0.0004). Overall, AKI patients presented significantly higher and sustained levels (P < 0.05) of CCL-2, CCL-3, CCL-4, CXCL-8, CXCL-10, IFN-γ, IL-2, IL-6, TNF-α, IL-1Ra, IL-10 and VEGF. Importantly, higher levels of CCL-2, CXCL-10, IL-2, TNF-α, IL-10, FGFb, and VEGF were observed in AKI patients independently of death. ROC curves demonstrated that early alterations in CCL-2, CXCL-8, CXCL-10, IFN-γ, IL-6, IL-1Ra and IL-10 show a good predictive value regarding AKI development. Lastly, immune mediators were significantly associated with each other and with SARS-CoV-2 viral load in AKI patients. Conclusions: COVID-19 associated AKI is accompanied by substantial alterations in circulant levels of immune mediators, which could significantly contribute to the establishment of kidney injury.Acute kidney injuryCOVID-19CytokinesImmune mediatorsinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/56769/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALAcute kidney injury associated to COVID-19 leads to a strong unbalance of circulant immune mediators _ Elsevier Enhanced Reader.pdfAcute kidney injury associated to COVID-19 leads to a strong unbalance of circulant immune mediators _ Elsevier Enhanced Reader.pdfapplication/pdf4882662https://www.arca.fiocruz.br/bitstream/icict/56769/2/Acute%20kidney%20injury%20associated%20to%20COVID-19%20leads%20to%20a%20strong%20unbalance%20of%20circulant%20immune%20mediators%20_%20Elsevier%20Enhanced%20Reader.pdf4d80ce7e2fb626ad281352b2a87810fbMD52icict/567692023-01-30 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dc.title.en_US.fl_str_mv Acute kidney injury associated to COVID-19 leads to a strong unbalance of circulant immune mediators
title Acute kidney injury associated to COVID-19 leads to a strong unbalance of circulant immune mediators
spellingShingle Acute kidney injury associated to COVID-19 leads to a strong unbalance of circulant immune mediators
Medeiros, Thalia
Acute kidney injury
COVID-19
Cytokines
Immune mediators
title_short Acute kidney injury associated to COVID-19 leads to a strong unbalance of circulant immune mediators
title_full Acute kidney injury associated to COVID-19 leads to a strong unbalance of circulant immune mediators
title_fullStr Acute kidney injury associated to COVID-19 leads to a strong unbalance of circulant immune mediators
title_full_unstemmed Acute kidney injury associated to COVID-19 leads to a strong unbalance of circulant immune mediators
title_sort Acute kidney injury associated to COVID-19 leads to a strong unbalance of circulant immune mediators
author Medeiros, Thalia
author_facet Medeiros, Thalia
Guimarães, Gabriel Macedo Costa
Carvalho, Fabiana Rabe
Alves, Lilian Santos
Faustino, Renan
Azevedo, Ana Carolina Campi
Pascoal, Vanessa Peruhype Magalhães
Carvalho, Andréa Teixeira de
Gomes, Matheus de Souza
Amaral, Laurence Rodrigues do
Martins Filho, Olindo Assis
Lugon, Jocemir Ronaldo
Almeida, Jorge Reis
Silva, Andrea Alice
author_role author
author2 Guimarães, Gabriel Macedo Costa
Carvalho, Fabiana Rabe
Alves, Lilian Santos
Faustino, Renan
Azevedo, Ana Carolina Campi
Pascoal, Vanessa Peruhype Magalhães
Carvalho, Andréa Teixeira de
Gomes, Matheus de Souza
Amaral, Laurence Rodrigues do
Martins Filho, Olindo Assis
Lugon, Jocemir Ronaldo
Almeida, Jorge Reis
Silva, Andrea Alice
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Medeiros, Thalia
Guimarães, Gabriel Macedo Costa
Carvalho, Fabiana Rabe
Alves, Lilian Santos
Faustino, Renan
Azevedo, Ana Carolina Campi
Pascoal, Vanessa Peruhype Magalhães
Carvalho, Andréa Teixeira de
Gomes, Matheus de Souza
Amaral, Laurence Rodrigues do
Martins Filho, Olindo Assis
Lugon, Jocemir Ronaldo
Almeida, Jorge Reis
Silva, Andrea Alice
dc.subject.en.en_US.fl_str_mv Acute kidney injury
COVID-19
Cytokines
Immune mediators
topic Acute kidney injury
COVID-19
Cytokines
Immune mediators
description Multiuser Laboratory for Research Support in Nephrology and Medical Sciences. Hospital Universitario Antonio Pedro. Faculty of Medicine. Universidade Federal Fluminense. Niteroi, RJ, Brazil/ Department of Pathology. Faculty of Medicine. Universidade Federal Fluminense. Niterói, RJ, Brazil.
publishDate 2022
dc.date.issued.fl_str_mv 2022
dc.date.accessioned.fl_str_mv 2023-01-30T17:44:00Z
dc.date.available.fl_str_mv 2023-01-30T17:44:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv MEDEIROS, Thalia et al. Acute kidney injury associated to COVID-19 leads to a strong unbalance of circulant immune mediators. Cytokine, v. 157, 155974, 2022. doi: 10.1016/j.cyto.2022.155974.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/56769
dc.identifier.issn.en_US.fl_str_mv 1043-4666
identifier_str_mv MEDEIROS, Thalia et al. Acute kidney injury associated to COVID-19 leads to a strong unbalance of circulant immune mediators. Cytokine, v. 157, 155974, 2022. doi: 10.1016/j.cyto.2022.155974.
1043-4666
url https://www.arca.fiocruz.br/handle/icict/56769
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Elsevier Science Ltd.
publisher.none.fl_str_mv Elsevier Science Ltd.
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/56769/1/license.txt
https://www.arca.fiocruz.br/bitstream/icict/56769/2/Acute%20kidney%20injury%20associated%20to%20COVID-19%20leads%20to%20a%20strong%20unbalance%20of%20circulant%20immune%20mediators%20_%20Elsevier%20Enhanced%20Reader.pdf
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repository.name.fl_str_mv Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)
repository.mail.fl_str_mv repositorio.arca@fiocruz.br
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