Beyond inflammation: Centrally mediated antinociceptive properties of Spirulina platensis LEB-18 biomass via the opioid system
Autor(a) principal: | |
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Data de Publicação: | 2020 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
Texto Completo: | https://www.arca.fiocruz.br/handle/icict/45752 |
Resumo: | Ministério da Ciência, Tecnologia e Inovação (MCTI); Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq); and Fundação de Amparo à Pesquisa do Estado da Bahia (FAPESB) [grant number 465594/2014-0]. This study was financed in part by the Coordenação de Aperfeiçoamento de Pessoal de Nível Superior, Brasil (CAPES), Finance Code 001. |
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Santos, Dourivaldo SilvaLauria, Pedro Santana SalesEvangelista, Afrânio FerreiraAzeredo, Francine JohanssonCosta, Jorge Alberto VieiraSoares, Milena Botelho PereiraDruzian, Janice IzabelVillarreal, Cristiane Flora2021-01-20T12:19:35Z2021-01-20T12:19:35Z2020SANTOS, Dourivaldo Silva et al. Beyond inflammation: Centrally mediated antinociceptive properties of Spirulina platensis LEB-18 biomass via the opioid system. Journal of Functional Foods, v. 72, 2020.1756-4646https://www.arca.fiocruz.br/handle/icict/4575210.1016/j.jff.2020.104083Ministério da Ciência, Tecnologia e Inovação (MCTI); Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq); and Fundação de Amparo à Pesquisa do Estado da Bahia (FAPESB) [grant number 465594/2014-0]. This study was financed in part by the Coordenação de Aperfeiçoamento de Pessoal de Nível Superior, Brasil (CAPES), Finance Code 001.Federal University of Bahia. Faculty of Pharmacy. Salvador, BA, Brazil.Federal University of Bahia. Faculty of Pharmacy. Salvador, BA, Brazil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Bahia, Brasil.Federal University of Bahia. Faculty of Pharmacy. Salvador, BA, Brazil.Federal University of Rio Grande. College of Chemistry and Food Engineering. Rio Grande, RS, Brazil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Bahia, Brasil.Federal University of Bahia. Faculty of Pharmacy. Salvador, BA, Brazil.Federal University of Bahia. Faculty of Pharmacy. Salvador, BA, Brazil.The management of pain is a world health issue. Available painkillers induce undesired side effects and are sometimes inefficient. Spirulina biomass has promoted anti-inflammatory activity in preclinical and clinical trials. This work characterizes the antinociceptive properties of Spirulina platensis LEB-18 biomass (SP-LEB18) and their mechanisms of action. In the CFA model in mice, SP-LEB18 reduced paw edema and mechanical allodynia, confirming its anti-inflammatory action and showing its antinociceptive activity. Cytokines levels were evaluated by ELISA; SP-LEB18 promoted an increase of IL-10 levels and a reduction of TNF-α and IL-1β levels. SP-LEB18 promoted centrally mediated antinociception, as indicated by the tail flick test. When the same set of experiments was conducted with IL-10 knockout mice, the antinociception was still detected in the tail flick test, but not in the CFA model. Pretreatment with naloxone abolished the effect of SP-LEB18, demonstrating a pure antinociceptive action of Spirulina biomass via the opioid system.engElsevierBioprospecçãoAnalgésicoAnti-inflamatórioIL-10OpioideSpirulinaBioprospectionAnalgesicAnti-inflammatoryIL-10OpioidBeyond inflammation: Centrally mediated antinociceptive properties of Spirulina platensis LEB-18 biomass via the opioid systeminfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83097https://www.arca.fiocruz.br/bitstream/icict/45752/1/license.txt36b51ef91c52b5338d9d29ba0cc807bcMD51ORIGINALSantos, Dourivaldo Silva Beyound....pdfSantos, Dourivaldo Silva 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dc.title.pt_BR.fl_str_mv |
Beyond inflammation: Centrally mediated antinociceptive properties of Spirulina platensis LEB-18 biomass via the opioid system |
title |
Beyond inflammation: Centrally mediated antinociceptive properties of Spirulina platensis LEB-18 biomass via the opioid system |
spellingShingle |
Beyond inflammation: Centrally mediated antinociceptive properties of Spirulina platensis LEB-18 biomass via the opioid system Santos, Dourivaldo Silva Bioprospecção Analgésico Anti-inflamatório IL-10 Opioide Spirulina Bioprospection Analgesic Anti-inflammatory IL-10 Opioid |
title_short |
Beyond inflammation: Centrally mediated antinociceptive properties of Spirulina platensis LEB-18 biomass via the opioid system |
title_full |
Beyond inflammation: Centrally mediated antinociceptive properties of Spirulina platensis LEB-18 biomass via the opioid system |
title_fullStr |
Beyond inflammation: Centrally mediated antinociceptive properties of Spirulina platensis LEB-18 biomass via the opioid system |
title_full_unstemmed |
Beyond inflammation: Centrally mediated antinociceptive properties of Spirulina platensis LEB-18 biomass via the opioid system |
title_sort |
Beyond inflammation: Centrally mediated antinociceptive properties of Spirulina platensis LEB-18 biomass via the opioid system |
author |
Santos, Dourivaldo Silva |
author_facet |
Santos, Dourivaldo Silva Lauria, Pedro Santana Sales Evangelista, Afrânio Ferreira Azeredo, Francine Johansson Costa, Jorge Alberto Vieira Soares, Milena Botelho Pereira Druzian, Janice Izabel Villarreal, Cristiane Flora |
author_role |
author |
author2 |
Lauria, Pedro Santana Sales Evangelista, Afrânio Ferreira Azeredo, Francine Johansson Costa, Jorge Alberto Vieira Soares, Milena Botelho Pereira Druzian, Janice Izabel Villarreal, Cristiane Flora |
author2_role |
author author author author author author author |
dc.contributor.author.fl_str_mv |
Santos, Dourivaldo Silva Lauria, Pedro Santana Sales Evangelista, Afrânio Ferreira Azeredo, Francine Johansson Costa, Jorge Alberto Vieira Soares, Milena Botelho Pereira Druzian, Janice Izabel Villarreal, Cristiane Flora |
dc.subject.other.pt_BR.fl_str_mv |
Bioprospecção Analgésico Anti-inflamatório IL-10 Opioide |
topic |
Bioprospecção Analgésico Anti-inflamatório IL-10 Opioide Spirulina Bioprospection Analgesic Anti-inflammatory IL-10 Opioid |
dc.subject.en.pt_BR.fl_str_mv |
Spirulina Bioprospection Analgesic Anti-inflammatory IL-10 Opioid |
description |
Ministério da Ciência, Tecnologia e Inovação (MCTI); Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq); and Fundação de Amparo à Pesquisa do Estado da Bahia (FAPESB) [grant number 465594/2014-0]. This study was financed in part by the Coordenação de Aperfeiçoamento de Pessoal de Nível Superior, Brasil (CAPES), Finance Code 001. |
publishDate |
2020 |
dc.date.issued.fl_str_mv |
2020 |
dc.date.accessioned.fl_str_mv |
2021-01-20T12:19:35Z |
dc.date.available.fl_str_mv |
2021-01-20T12:19:35Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
SANTOS, Dourivaldo Silva et al. Beyond inflammation: Centrally mediated antinociceptive properties of Spirulina platensis LEB-18 biomass via the opioid system. Journal of Functional Foods, v. 72, 2020. |
dc.identifier.uri.fl_str_mv |
https://www.arca.fiocruz.br/handle/icict/45752 |
dc.identifier.issn.pt_BR.fl_str_mv |
1756-4646 |
dc.identifier.doi.none.fl_str_mv |
10.1016/j.jff.2020.104083 |
identifier_str_mv |
SANTOS, Dourivaldo Silva et al. Beyond inflammation: Centrally mediated antinociceptive properties of Spirulina platensis LEB-18 biomass via the opioid system. Journal of Functional Foods, v. 72, 2020. 1756-4646 10.1016/j.jff.2020.104083 |
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https://www.arca.fiocruz.br/handle/icict/45752 |
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eng |
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eng |
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Elsevier |
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Elsevier |
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