Serum cytokines associated with severity and complications of kala-azar

Detalhes bibliográficos
Autor(a) principal: Costa, Dorcas Lamounier
Data de Publicação: 2013
Outros Autores: Rocha, Regina L, Carvalho, Rayssa Maria de Araujo, Lima Neto, Adelino S, Harhay, Michael O, Costa, Carlos Henrique Nery, Barral Netto, Manoel, Barral, Aldina Maria Prado
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/7260
Resumo: Federal University of Piauí. Maternal and Childhood Department. Piauí, Brasil / Institute of Tropical Medicine ‘Natan Portella’. Laboratory of Leishmaniasis. Piauí, Brasil
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spelling Costa, Dorcas LamounierRocha, Regina LCarvalho, Rayssa Maria de AraujoLima Neto, Adelino SHarhay, Michael OCosta, Carlos Henrique NeryBarral Netto, ManoelBarral, Aldina Maria Prado2013-11-25T18:51:32Z2013-11-25T18:51:32Z2013COSTA, D. et al. Serum cytokines associated with severity and complications of kala-azar. Pathogens and Global Health, v.107, p.78-87, 2013.https://www.arca.fiocruz.br/handle/icict/726010.1179/2047773213Y.0000000078engW. S. Maney & Son LtdSerum cytokines associated with severity and complications of kala-azarinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFederal University of Piauí. Maternal and Childhood Department. Piauí, Brasil / Institute of Tropical Medicine ‘Natan Portella’. Laboratory of Leishmaniasis. Piauí, BrasilFederal University of Minas Gerais. Department of Pediatrics. Minas Gerais, BH, BrasilFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Laboratorio de Imunoparasitologia. Salvador, BA, BrasilInstitute of Tropical Medicine ‘Natan Portella’. Laboratory of Leishmaniasis. Piauí, Brasil. / Federal University of Minas Gerais. Department of Community Medicine. Minas Gerais, BH, BrasilFederal University of Minas Gerais. Department of Community Medicine. Minas Gerais, BH, BrasilInstitute of Tropical Medicine ‘Natan Portella’. Laboratory of Leishmaniasis. Piauí, Brasil. / Federal University of Minas Gerais. Department of Community Medicine. Minas Gerais, BH, BrasilFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Laboratório de Imunoregulação. Salvador, Bahia, BrasilFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Laboratório de Imunoparasitologia. Salvador, BA, BrasilObjectives: Recent clinical data suggest that severe kala-azar (or visceral leishmaniasis) is an exaggerated innate immune response mediated by inflammatory cytokines, leading to a systemic inflammatory syndrome similar to what is observed in malaria, sepsis and other diseases. We tested this hypothesis by measuring serum cytokines in individuals with kala-azar. Methods: We compared patients with severe kala-azar (i.e. hemorrhagic manifestations, n538) with patients without evidence of hemorrhage (n596). We conducted a detailed clinical and laboratory evaluation, measuring serum IL-1beta, IL-6, IL-8, IL-10, IL-12, interferon-gamma, and TNF-alpha, and markers of disseminated intravascular coagulation (DIC). Results: Infants had higher levels of inflammatory cytokines, while HIV-infected patients had lower concentrations of IL-10 and interferon-gamma. Higher levels of IL-6, interferon-gamma, and IL-8 were found among deceased patients. IL-8 and interferon-gamma were independently associated with bleeding. Several cytokines were associated with different signs of severe clinical and laboratory manifestations, including DIC. IL-6 was highly positively and independently associated with IL-1beta, IL-8, IL-10, and negatively associated with TNF-alpha. IL-1beta and TNF-alpha were also highly independently associated with disease severity. Conclusion: In its severe form, kala-azar, a neglected tropical disease, initiates a systemic inflammatory response that leads to DIC and other manifestations. Children may have higher risk of death due to the more intense cytokine release. The data supports the notion that IL-6 is the central cytokine that is associated with lethal disease, but interferon-gamma, IL1beta, IL-8, and TNF-alpha are also involved with disease severity. Inhibition of IL-6 is a potential target of adjuvant therapy for severe or pediatric forms of this disease.CytokinesKala-azarLeishmania infantumDisseminated intravascular coagulationSystemic inflammatory responseinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINALCosta D Serum cytokines....pdfCosta D Serum cytokines....pdfapplication/pdf467811https://www.arca.fiocruz.br/bitstream/icict/7260/1/Costa%20D%20Serum%20cytokines....pdf85431be177c9e68c0cfe228a632e4fbfMD51LICENSElicense.txtlicense.txttext/plain; charset=utf-81914https://www.arca.fiocruz.br/bitstream/icict/7260/2/license.txt7d48279ffeed55da8dfe2f8e81f3b81fMD52TEXTCosta D Serum cytokines....pdf.txtCosta D Serum cytokines....pdf.txtExtracted texttext/plain42665https://www.arca.fiocruz.br/bitstream/icict/7260/5/Costa%20D%20Serum%20cytokines....pdf.txt3c6429b16e42aea654614b16e627eb76MD55THUMBNAILCosta D Serum cytokines....pdf.jpgCosta D Serum cytokines....pdf.jpgGenerated Thumbnailimage/jpeg2318https://www.arca.fiocruz.br/bitstream/icict/7260/4/Costa%20D%20Serum%20cytokines....pdf.jpg98ad7e82ed9842bd25e698bdc8799f20MD54icict/72602023-03-15 14:33:57.16oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-03-15T17:33:57Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv Serum cytokines associated with severity and complications of kala-azar
title Serum cytokines associated with severity and complications of kala-azar
spellingShingle Serum cytokines associated with severity and complications of kala-azar
Costa, Dorcas Lamounier
Cytokines
Kala-azar
Leishmania infantum
Disseminated intravascular coagulation
Systemic inflammatory response
title_short Serum cytokines associated with severity and complications of kala-azar
title_full Serum cytokines associated with severity and complications of kala-azar
title_fullStr Serum cytokines associated with severity and complications of kala-azar
title_full_unstemmed Serum cytokines associated with severity and complications of kala-azar
title_sort Serum cytokines associated with severity and complications of kala-azar
author Costa, Dorcas Lamounier
author_facet Costa, Dorcas Lamounier
Rocha, Regina L
Carvalho, Rayssa Maria de Araujo
Lima Neto, Adelino S
Harhay, Michael O
Costa, Carlos Henrique Nery
Barral Netto, Manoel
Barral, Aldina Maria Prado
author_role author
author2 Rocha, Regina L
Carvalho, Rayssa Maria de Araujo
Lima Neto, Adelino S
Harhay, Michael O
Costa, Carlos Henrique Nery
Barral Netto, Manoel
Barral, Aldina Maria Prado
author2_role author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Costa, Dorcas Lamounier
Rocha, Regina L
Carvalho, Rayssa Maria de Araujo
Lima Neto, Adelino S
Harhay, Michael O
Costa, Carlos Henrique Nery
Barral Netto, Manoel
Barral, Aldina Maria Prado
dc.subject.en.pt_BR.fl_str_mv Cytokines
Kala-azar
Leishmania infantum
Disseminated intravascular coagulation
Systemic inflammatory response
topic Cytokines
Kala-azar
Leishmania infantum
Disseminated intravascular coagulation
Systemic inflammatory response
description Federal University of Piauí. Maternal and Childhood Department. Piauí, Brasil / Institute of Tropical Medicine ‘Natan Portella’. Laboratory of Leishmaniasis. Piauí, Brasil
publishDate 2013
dc.date.accessioned.fl_str_mv 2013-11-25T18:51:32Z
dc.date.available.fl_str_mv 2013-11-25T18:51:32Z
dc.date.issued.fl_str_mv 2013
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv COSTA, D. et al. Serum cytokines associated with severity and complications of kala-azar. Pathogens and Global Health, v.107, p.78-87, 2013.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/7260
dc.identifier.doi.none.fl_str_mv 10.1179/2047773213Y.0000000078
identifier_str_mv COSTA, D. et al. Serum cytokines associated with severity and complications of kala-azar. Pathogens and Global Health, v.107, p.78-87, 2013.
10.1179/2047773213Y.0000000078
url https://www.arca.fiocruz.br/handle/icict/7260
dc.language.iso.fl_str_mv eng
language eng
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dc.publisher.none.fl_str_mv W. S. Maney & Son Ltd
publisher.none.fl_str_mv W. S. Maney & Son Ltd
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