Congenital cytomegalovirus and HIV perinatal transmission
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2018 |
| Outros Autores: | , , , , , , , , , , , , , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/33152 |
Resumo: | Valdilea Veloso e Beatriz Grinsztejn. Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Mariza G.Morgado. Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta a informação no documento. |
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Adachi, KristinaXu, JiahongAnk, BonnieWatts, D. HeatherCamarca, MargaretMofenson, Lynne M.Pilotto, Jose HenriqueJoao, EsauGray, GlendaTheron, GerhardSantos, BrenoFonseca, RosanaKreitchmann, RegisPinto, JorgeMussi-Pinhata, Marisa M.Machado, Daisy MariaCeriotto, MarianaMorgado, Mariza G.Bryson, Yvonne J.Veloso, Valdiléa G.Grinsztejn, BeatrizMirochnick, MarkMoye, JackNielsen-Saines, KarinMPH for the NICHD HPTN 040 Study Team2019-05-21T12:33:06Z2019-05-21T12:33:06Z2018ADACHI, Kristina et al. Congenital cytomegalovirus and HIV perinatal. Transmission. Pediatric Infectious Disease Journal, v. 37, n. 10, p. 1016-1021, 2018.0891-3668https://www.arca.fiocruz.br/handle/icict/3315210.1097/INF.00000000000019751532-0987Valdilea Veloso e Beatriz Grinsztejn. Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Mariza G.Morgado. Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta a informação no documento.2020-05-21David Geffen UCLA. School of Medicine. Los Angeles, CA, USA.Westat. Rockville, MD, USA.David Geffen UCLA. School of Medicine. Los Angeles, CA, USA.U.S. Department of State. Office of the Global AIDS Coordinator. Washington, DC, USA.Westat. Rockville, MD, USA.National Institutes of Health. Eunice Kennedy Shriver National Institute of Child Health and Human Development. Bethesda, MD, USA.Hospital Geral de Nova Iguaçu. Nova Iguaçu, RJ, Brasil.Hospital Federal dos Servidores do Estado. Rio de Janeiro, RJ, Brasil.University of Witwatersrand. SAMRC and Perinatal HIV Research Unit. Cape Town, South Africa.Stellenbosch Universit. Tygerberg Hospital. Cape Town, South Africa.Hospital Conceição. Porto Alegre, RS, Brasil.Hospital Femina. Porto Alegre, RS, Brasil.Irmandade da Santa Casa de Misericórdia de Porto Alegre. Porto Alegre, RS, Brasil.Federal University of Minas Gerais, Belo Horizonte, MG, BrazilUniversity of São Paulo. Ribeirão Preto Medical School. Ribeirão Preto, SP, Brazil.Universidade Federal de São Paulo. Escola Paulista de Medicina. São Paulo, SP, Brasil.Foundation for Maternal and Infant Health. Buenos Aires, Argentina.Fundação Oswaldo Cruz. Rio de Janeiro, RJ, Brasil.David Geffen UCLA. School of Medicine. Los Angeles, CA, USA.Fundação Oswaldo Cruz. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Rio de Janeiro, RJ, Brasil.Boston University. School of Medicine. Boston, MA, USA.National Institutes of Health. Eunice Kennedy Shriver National Institute of Child Health and Human Development. Bethesda, MD, USA.David Geffen UCLA. School of Medicine. Los Angeles, CA, USA.Background: Congenital cytomegalovirus (CMV) infection (cCMV) is an important cause of hearing loss and cognitive impairment. Prior studies suggest that HIV-exposed children are at higher risk of acquiring cCMV. We assessed the presence, magnitude and risk factors associated with cCMV among infants born to HIV-infected women, who were not receiving antiretrovirals uring pregnancy. Methods: cCMV and urinary CMV load were determined in a cohort of infants born to HIV-infected women not receiving antiretrovirals during pregnancy. Neonatal urines obtained at birth were tested for CMV DNA by qualitative and reflex quantitative real-time polymerase chain reaction. Results: Urine specimens were available for 992 (58.9%) of 1684 infants; 64 (6.5%) were CMV-positive. Mean CMV load (VL) was 470,276 copies/ml (range: < 200–2,000,000 copies/ml). Among 89 HIV-infected infants, 16 (18%) had cCMV versus 42 (4.9%) of 858 HIV-exposed, uninfected infants (P < 0.0001). cCMV was present in 23.2% of infants with in utero and 9.1% infants with intrapartum HIV infection (P < 0.0001). Rates of cCMV among HIV-infected infants were 4-fold greater (adjusted OR, 4.4; 95% CI: 2.3–8.2) and 6-fold greater among HIV in utero–infected infants (adjusted OR, 6; 95% CI: 3–12.1) compared with HIV-exposed, uninfected infants. cCMV was not associated with mode of delivery, gestational age, Apgar scores, 6-month infant mortality, maternal age, race/ethnicity, HIV viral load or CD4 count. Primary cCMV risk factors included infant HIV-infection, particularly in utero infection. Conclusion: High rates of cCMV with high urinary CMV VL were observed in HIV-exposed infants. In utero HIV infection appears to be a major risk factor for cCMV in infants whose mothers have not received combination antiretroviral therapy in pregnancy.engLippincott, Williams & WilkinsCongenital cytomegalovirus and HIV perinatal transmissioninfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleCongenital CMVHIV MTCTHIV perinatal transmissioninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83104https://www.arca.fiocruz.br/bitstream/icict/33152/1/license.txt79178e5f2a0eb066867a274556814938MD51ORIGINALve_Adachi_Kristina_etal_INI_2018.pdfve_Adachi_Kristina_etal_INI_2018.pdfapplication/pdf98823https://www.arca.fiocruz.br/bitstream/icict/33152/2/ve_Adachi_Kristina_etal_INI_2018.pdfae5affd5d7521b96a9ece11481d27e40MD52TEXTve_Adachi_Kristina_etal_INI_2018.pdf.txtve_Adachi_Kristina_etal_INI_2018.pdf.txtExtracted 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| dc.title.pt_BR.fl_str_mv |
Congenital cytomegalovirus and HIV perinatal transmission |
| title |
Congenital cytomegalovirus and HIV perinatal transmission |
| spellingShingle |
Congenital cytomegalovirus and HIV perinatal transmission Adachi, Kristina Congenital CMV HIV MTCT HIV perinatal transmission |
| title_short |
Congenital cytomegalovirus and HIV perinatal transmission |
| title_full |
Congenital cytomegalovirus and HIV perinatal transmission |
| title_fullStr |
Congenital cytomegalovirus and HIV perinatal transmission |
| title_full_unstemmed |
Congenital cytomegalovirus and HIV perinatal transmission |
| title_sort |
Congenital cytomegalovirus and HIV perinatal transmission |
| author |
Adachi, Kristina |
| author_facet |
Adachi, Kristina Xu, Jiahong Ank, Bonnie Watts, D. Heather Camarca, Margaret Mofenson, Lynne M. Pilotto, Jose Henrique Joao, Esau Gray, Glenda Theron, Gerhard Santos, Breno Fonseca, Rosana Kreitchmann, Regis Pinto, Jorge Mussi-Pinhata, Marisa M. Machado, Daisy Maria Ceriotto, Mariana Morgado, Mariza G. Bryson, Yvonne J. Veloso, Valdiléa G. Grinsztejn, Beatriz Mirochnick, Mark Moye, Jack Nielsen-Saines, Karin MPH for the NICHD HPTN 040 Study Team |
| author_role |
author |
| author2 |
Xu, Jiahong Ank, Bonnie Watts, D. Heather Camarca, Margaret Mofenson, Lynne M. Pilotto, Jose Henrique Joao, Esau Gray, Glenda Theron, Gerhard Santos, Breno Fonseca, Rosana Kreitchmann, Regis Pinto, Jorge Mussi-Pinhata, Marisa M. Machado, Daisy Maria Ceriotto, Mariana Morgado, Mariza G. Bryson, Yvonne J. Veloso, Valdiléa G. Grinsztejn, Beatriz Mirochnick, Mark Moye, Jack Nielsen-Saines, Karin MPH for the NICHD HPTN 040 Study Team |
| author2_role |
author author author author author author author author author author author author author author author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Adachi, Kristina Xu, Jiahong Ank, Bonnie Watts, D. Heather Camarca, Margaret Mofenson, Lynne M. Pilotto, Jose Henrique Joao, Esau Gray, Glenda Theron, Gerhard Santos, Breno Fonseca, Rosana Kreitchmann, Regis Pinto, Jorge Mussi-Pinhata, Marisa M. Machado, Daisy Maria Ceriotto, Mariana Morgado, Mariza G. Bryson, Yvonne J. Veloso, Valdiléa G. Grinsztejn, Beatriz Mirochnick, Mark Moye, Jack Nielsen-Saines, Karin MPH for the NICHD HPTN 040 Study Team |
| dc.subject.en.pt_BR.fl_str_mv |
Congenital CMV HIV MTCT HIV perinatal transmission |
| topic |
Congenital CMV HIV MTCT HIV perinatal transmission |
| description |
Valdilea Veloso e Beatriz Grinsztejn. Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Mariza G.Morgado. Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta a informação no documento. |
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2018 |
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2018 |
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2019-05-21T12:33:06Z |
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2019-05-21T12:33:06Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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ADACHI, Kristina et al. Congenital cytomegalovirus and HIV perinatal. Transmission. Pediatric Infectious Disease Journal, v. 37, n. 10, p. 1016-1021, 2018. |
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https://www.arca.fiocruz.br/handle/icict/33152 |
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0891-3668 |
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10.1097/INF.0000000000001975 |
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1532-0987 |
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ADACHI, Kristina et al. Congenital cytomegalovirus and HIV perinatal. Transmission. Pediatric Infectious Disease Journal, v. 37, n. 10, p. 1016-1021, 2018. 0891-3668 10.1097/INF.0000000000001975 1532-0987 |
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Lippincott, Williams & Wilkins |
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Lippincott, Williams & Wilkins |
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