Long-term administration of IgG2a anti-NK1.1 monoclonal antibody ameliorates lupus-like disease in NZB/W mice in spite of an early worsening induced by an IgG2a-dependent BAFF/BLyS production.

Detalhes bibliográficos
Autor(a) principal: Postól, Edilberto
Data de Publicação: 2008
Outros Autores: Meyer, André Villanova, Cardillo, Fabíola, Alencar, Raquel de, Pessina, Daniel Huber, Nihei, Jorge Sadao, Mariano, Mário, Mengele Junior, José Orivaldo
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/10918
Resumo: University of São Paulo. Heart Institute. Immunology Laboratory. São Paulo, SP, Brasil
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spelling Postól, EdilbertoMeyer, André VillanovaCardillo, FabíolaAlencar, Raquel dePessina, Daniel HuberNihei, Jorge SadaoMariano, MárioMengele Junior, José Orivaldo2015-06-18T17:21:29Z2015-06-18T17:21:29Z2008POSTÓL, E. et al. Long-term administration of IgG2a anti-NK1.1 monoclonal antibody ameliorates lupus-like disease in NZB/W mice in spite of an early worsening induced by an IgG2a-dependent BAFF/BLyS production. Immunology, v. 125, n. 2, p. 184-196, 2008.1365-2567https://www.arca.fiocruz.br/handle/icict/1091810.1111/j.1365-2567.2008.02835.xengWileyLong-term administration of IgG2a anti-NK1.1 monoclonal antibody ameliorates lupus-like disease in NZB/W mice in spite of an early worsening induced by an IgG2a-dependent BAFF/BLyS production.info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversity of São Paulo. Heart Institute. Immunology Laboratory. São Paulo, SP, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilUniversity of São Paulo. Heart Institute. Immunology Laboratory. São Paulo, SP, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilFederal University of São Paulo. Department of Microbiology, Immunology and Parasitology. São Paulo, SP, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilThe role of natural killer (NK) T cells in the development of lupus-like disease in mice is still controversial. We treated NZB/W mice with anti- NK1.1 monoclonal antibodies (mAbs) and our results revealed that administration of either an irrelevant immunoglobulin G2a (IgG2a) mAb or an IgG2a anti-NK1.1 mAb increased the production of anti-dsDNA antibodies in young NZB/W mice. However, the continuous administration of an anti-NK1.1 mAb protected aged NZB/W mice from glomerular injury, leading to prolonged survival and stabilization of the proteinuria. Conversely, the administration of the control IgG2a mAb led to an aggravation of the lupus-like disease. Augmented titres of anti-dsDNA in NZB/ W mice, upon IgG2a administration, correlated with the production of BAFF/BLyS by dendritic, B and T cells. Treatment with an anti-NK1.1 mAb reduced the levels of interleukin-16, produced by T cells, in spleen cell culture supernatants from aged NZB/W. Adoptive transfer of NK T cells from aged to young NZB/W accelerated the production of antidsDNA in recipient NZB/W mice, suggesting that NK T cells from aged NZB/W are endowed with a B-cell helper activity. In vitro studies, using purified NK T cells from aged NZB/W, showed that these cells provided helper B-cell activity for the production of anti-dsDNA. We concluded that NK T cells are involved in the progression of lupus-like disease in mature NZB/W mice and that immunoglobulin of the IgG2a isotype has an enhancing effect on antibody synthesis due to the induction of BAFF/ BLyS, and therefore have a deleterious effect in the NZB/W mouse physiology.BAFF/BLySFc receptorInterleukin-16Natural killer T cellsSystemic lupus erythematosusToll-like receptoAnticorpos Monoclonais/uso terapêuticoFator Ativador de Células B/biossínteseImunoglobulina G/uso terapêuticoNefrite Lúpica/prevenção & controleEnvelhecimento/imunologiaAnimaisAnticorpos Antinucleares/biossínteseAnticorpos Monoclonais/imunologiaAntígenos Ly/imunologiaCélulas CultivadasProgressão da DoençaFemininoImunoglobulina G/imunologiaInterleucina-16/biossínteseCélulas Matadoras Naturais/imunologiaLipopolissacarídeos/imunologiaFígado/imunologiaNefrite Lúpica/imunologiaCamundongosSubfamília B de Receptores Semelhantes a Lectina de CélulasÍndice de Gravidade de DoençaLinfócitos T Auxiliares-Indutores/imunologiainfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; 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dc.title.pt_BR.fl_str_mv Long-term administration of IgG2a anti-NK1.1 monoclonal antibody ameliorates lupus-like disease in NZB/W mice in spite of an early worsening induced by an IgG2a-dependent BAFF/BLyS production.
title Long-term administration of IgG2a anti-NK1.1 monoclonal antibody ameliorates lupus-like disease in NZB/W mice in spite of an early worsening induced by an IgG2a-dependent BAFF/BLyS production.
spellingShingle Long-term administration of IgG2a anti-NK1.1 monoclonal antibody ameliorates lupus-like disease in NZB/W mice in spite of an early worsening induced by an IgG2a-dependent BAFF/BLyS production.
Postól, Edilberto
BAFF/BLyS
Fc receptor
Interleukin-16
Natural killer T cells
Systemic lupus erythematosus
Toll-like recepto
Anticorpos Monoclonais/uso terapêutico
Fator Ativador de Células B/biossíntese
Imunoglobulina G/uso terapêutico
Nefrite Lúpica/prevenção & controle
Envelhecimento/imunologia
Animais
Anticorpos Antinucleares/biossíntese
Anticorpos Monoclonais/imunologia
Antígenos Ly/imunologia
Células Cultivadas
Progressão da Doença
Feminino
Imunoglobulina G/imunologia
Interleucina-16/biossíntese
Células Matadoras Naturais/imunologia
Lipopolissacarídeos/imunologia
Fígado/imunologia
Nefrite Lúpica/imunologia
Camundongos
Subfamília B de Receptores Semelhantes a Lectina de Células
Índice de Gravidade de Doença
Linfócitos T Auxiliares-Indutores/imunologia
title_short Long-term administration of IgG2a anti-NK1.1 monoclonal antibody ameliorates lupus-like disease in NZB/W mice in spite of an early worsening induced by an IgG2a-dependent BAFF/BLyS production.
title_full Long-term administration of IgG2a anti-NK1.1 monoclonal antibody ameliorates lupus-like disease in NZB/W mice in spite of an early worsening induced by an IgG2a-dependent BAFF/BLyS production.
title_fullStr Long-term administration of IgG2a anti-NK1.1 monoclonal antibody ameliorates lupus-like disease in NZB/W mice in spite of an early worsening induced by an IgG2a-dependent BAFF/BLyS production.
title_full_unstemmed Long-term administration of IgG2a anti-NK1.1 monoclonal antibody ameliorates lupus-like disease in NZB/W mice in spite of an early worsening induced by an IgG2a-dependent BAFF/BLyS production.
title_sort Long-term administration of IgG2a anti-NK1.1 monoclonal antibody ameliorates lupus-like disease in NZB/W mice in spite of an early worsening induced by an IgG2a-dependent BAFF/BLyS production.
author Postól, Edilberto
author_facet Postól, Edilberto
Meyer, André Villanova
Cardillo, Fabíola
Alencar, Raquel de
Pessina, Daniel Huber
Nihei, Jorge Sadao
Mariano, Mário
Mengele Junior, José Orivaldo
author_role author
author2 Meyer, André Villanova
Cardillo, Fabíola
Alencar, Raquel de
Pessina, Daniel Huber
Nihei, Jorge Sadao
Mariano, Mário
Mengele Junior, José Orivaldo
author2_role author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Postól, Edilberto
Meyer, André Villanova
Cardillo, Fabíola
Alencar, Raquel de
Pessina, Daniel Huber
Nihei, Jorge Sadao
Mariano, Mário
Mengele Junior, José Orivaldo
dc.subject.en.pt_BR.fl_str_mv BAFF/BLyS
Fc receptor
Interleukin-16
Natural killer T cells
Systemic lupus erythematosus
Toll-like recepto
topic BAFF/BLyS
Fc receptor
Interleukin-16
Natural killer T cells
Systemic lupus erythematosus
Toll-like recepto
Anticorpos Monoclonais/uso terapêutico
Fator Ativador de Células B/biossíntese
Imunoglobulina G/uso terapêutico
Nefrite Lúpica/prevenção & controle
Envelhecimento/imunologia
Animais
Anticorpos Antinucleares/biossíntese
Anticorpos Monoclonais/imunologia
Antígenos Ly/imunologia
Células Cultivadas
Progressão da Doença
Feminino
Imunoglobulina G/imunologia
Interleucina-16/biossíntese
Células Matadoras Naturais/imunologia
Lipopolissacarídeos/imunologia
Fígado/imunologia
Nefrite Lúpica/imunologia
Camundongos
Subfamília B de Receptores Semelhantes a Lectina de Células
Índice de Gravidade de Doença
Linfócitos T Auxiliares-Indutores/imunologia
dc.subject.decs.pt_BR.fl_str_mv Anticorpos Monoclonais/uso terapêutico
Fator Ativador de Células B/biossíntese
Imunoglobulina G/uso terapêutico
Nefrite Lúpica/prevenção & controle
Envelhecimento/imunologia
Animais
Anticorpos Antinucleares/biossíntese
Anticorpos Monoclonais/imunologia
Antígenos Ly/imunologia
Células Cultivadas
Progressão da Doença
Feminino
Imunoglobulina G/imunologia
Interleucina-16/biossíntese
Células Matadoras Naturais/imunologia
Lipopolissacarídeos/imunologia
Fígado/imunologia
Nefrite Lúpica/imunologia
Camundongos
Subfamília B de Receptores Semelhantes a Lectina de Células
Índice de Gravidade de Doença
Linfócitos T Auxiliares-Indutores/imunologia
description University of São Paulo. Heart Institute. Immunology Laboratory. São Paulo, SP, Brasil
publishDate 2008
dc.date.issued.fl_str_mv 2008
dc.date.accessioned.fl_str_mv 2015-06-18T17:21:29Z
dc.date.available.fl_str_mv 2015-06-18T17:21:29Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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status_str publishedVersion
dc.identifier.citation.fl_str_mv POSTÓL, E. et al. Long-term administration of IgG2a anti-NK1.1 monoclonal antibody ameliorates lupus-like disease in NZB/W mice in spite of an early worsening induced by an IgG2a-dependent BAFF/BLyS production. Immunology, v. 125, n. 2, p. 184-196, 2008.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/10918
dc.identifier.issn.none.fl_str_mv 1365-2567
dc.identifier.doi.none.fl_str_mv 10.1111/j.1365-2567.2008.02835.x
identifier_str_mv POSTÓL, E. et al. Long-term administration of IgG2a anti-NK1.1 monoclonal antibody ameliorates lupus-like disease in NZB/W mice in spite of an early worsening induced by an IgG2a-dependent BAFF/BLyS production. Immunology, v. 125, n. 2, p. 184-196, 2008.
1365-2567
10.1111/j.1365-2567.2008.02835.x
url https://www.arca.fiocruz.br/handle/icict/10918
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dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
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dc.publisher.none.fl_str_mv Wiley
publisher.none.fl_str_mv Wiley
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
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