Congenital Zika virus syndrome in Brazil: a case series of the first 1501 livebirths with complete investigation
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| Publication Date: | 2016 |
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| Format: | Article |
| Language: | eng |
| Source: | Repositório Institucional da FIOCRUZ (ARCA) |
| Download full: | https://www.arca.fiocruz.br/handle/icict/41268 |
Summary: | Claudio M. P. Henriques e Eduardo H. Carmo - Autores vinculados à Fiocruz Brasília, mas não consta a informação no documento. |
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França, Giovanny Vinícius Araújo deSchuler-Faccini, LaviniaOliveira, Wanderson Kleber deHenriques, Cláudio Maierovitch PessanhaCarmo, Eduardo HagePedi, Vaneide DacianeNunes, Marília L.Castro, Marcia C.Serruya, Suzanne JacobSilveira, Mariângela F.Barros, Fernando C.Victora, Cesar G.2020-05-18T14:53:59Z2020-05-18T14:53:59Z2016FRANÇA, Giovanny V. A. et al. Congenital Zika virus syndrome in Brazil: a case series of the first 1501 livebirths with complete investigation. Lancet, [New York], v. 388, Aug. 2016.0140-6736https://www.arca.fiocruz.br/handle/icict/4126810.1016/S0140-6736(16)30902-3Claudio M. P. Henriques e Eduardo H. Carmo - Autores vinculados à Fiocruz Brasília, mas não consta a informação no documento.Ministério da Saúde e Organização Pan-Americana da Saúde.Ministério da Saúde. Secretaria de Vigilância em Saúde. Brasília, DF, Brasil.Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brasil.Ministério da Saúde. Secretaria de Vigilância em Saúde. Brasília, DF, Brasil.Ministério da Saúde. Secretaria de Vigilância em Saúde. Brasília, DF, Brasil / Fundação Oswaldo Cruz. Fiocruz Brasília. Brasília, DF, Brasil.Ministério da Saúde. Secretaria de Vigilância em Saúde. Brasília, DF, Brasil / Fundação Oswaldo Cruz. Fiocruz Brasília. Brasília, DF, Brasil.Ministério da Saúde. Secretaria de Vigilância em Saúde. Brasília, DF, Brasil.Ministério da Saúde. Secretaria de Vigilância em Saúde. Brasília, DF, Brasil.Harvard University. Harvard T H Chan School of Public Health. Boston, MA, USA.Universidade Federal de Pelotas. Programa de Pós-Graduação em Epidemiologia. Pelotas, RS, Brasil.Universidade Católica de Pelotas. Pelotas, RS, Brasil.Universidade Católica de Pelotas. Pelotas, RS, Brasil.Universidade Católica de Pelotas. Pelotas, RS, Brasil.Background In November, 2015, an epidemic of microcephaly was reported in Brazil, which was later attributed to congenital Zika virus infection. 7830 suspected cases had been reported to the Brazilian Ministry of Health by June 4, 2016, but little is known about their characteristics. We aimed to describe these newborn babies in terms of clinical fi ndings, anthropometry, and survival. Methods We reviewed all 1501 liveborn infants for whom investigation by medical teams at State level had been completed as of Feb 27, 2016, and classifi ed suspected cases into fi ve categories based on neuroimaging and laboratory results for Zika virus and other relevant infections. Defi nite cases had laboratory evidence of Zika virus infection; highly probable cases presented specifi c neuroimaging fi ndings, and negative laboratory results for other congenital infections; moderately probable cases had specifi c imaging fi ndings but other infections could not be ruled out; somewhat probable cases had imaging fi ndings, but these were not reported in detail by the local teams; all other newborn babies were classifi ed as discarded cases. Head circumference by gestational age was assessed with InterGrowth standards. First week mortality and history of rash were provided by the State medical teams. Findings Between Nov 19, 2015, and Feb 27, 2015, investigations were completed for 1501 suspected cases reported to the Brazilian Ministry of Health, of whom 899 were discarded. Of the remainder 602 cases, 76 were defi nite, 54 highly probable, 181 moderately probable, and 291 somewhat probable of congenital Zika virus syndrome. Clinical, anthropometric, and survival diff erences were small among the four groups. Compared with these four groups, the 899 discarded cases had larger head circumferences (mean Z scores –1•54 vs –3•13, diff erence 1•58 [95% CI 1•45–1•72]); lower fi rst-week mortality (14 per 1000 vs 51 per 1000; rate ratio 0•28 [95% CI 0•14–0•56]); and were less likely to have a history of rash during pregnancy (20•7% vs 61•4%, ratio 0•34 [95% CI 0•27–0•42]). Rashes in the third trimester of pregnancy were associated with brain abnormalities despite normal sized heads. One in fi ve defi nite or probable cases presented head circumferences in the normal range (above –2 SD below the median of the InterGrowth standard) and for one third of defi nite and probable cases there was no history of a rash during pregnancy. The peak of the epidemic occurred in late November, 2015. Interpretation Zika virus congenital syndrome is a new teratogenic disease. Because many defi nite or probable cases present normal head circumference values and their mothers do not report having a rash, screening criteria must be revised in order to detect all aff ected newborn babies.engElsevierBrazil / epidemiologyCephalometryConfounding Factors, EpidemiologicInfant MortalityMicrocephaly / epidemiologyMicrocephaly / pathologyMicrocephaly / virologyNeonatal Screening / methodsNeuroimagingPregnancyInfant, NewbornPregnancy Complications, Infectious / epidemiologyPregnancy Complications, Infectious / virologyZika Virus / isolation & purificationZika Virus Infection / congenitalZika Virus Infection / diagnosisZika Virus Infection / epidemiologyZika Virus Infection / pathologyZika virus infectionZika virusMicrocephalyInfant newbornEpidemiologyZika virusInfecção por Zika virusMicrocefaliaRecém-NascidoCongenital Zika virus syndrome in Brazil: a case series of the first 1501 livebirths with complete investigationinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINALve_Giovanny_França_etal.pdfve_Giovanny_França_etal.pdfArtigoapplication/pdf415699https://www.arca.fiocruz.br/bitstream/icict/41268/2/ve_Giovanny_Fran%c3%a7a_etal.pdf9b3eea4445e5ddb437eea3cbbcf37c2eMD52ve_Giovanny_França_etal_Supp.pdfve_Giovanny_França_etal_Supp.pdfMaterial de apoio application/pdf678354https://www.arca.fiocruz.br/bitstream/icict/41268/4/ve_Giovanny_Fran%c3%a7a_etal_Supp.pdff6e5baae72bb7d57be43771146f2715bMD54LICENSElicense.txtlicense.txttext/plain; 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| dc.title.pt_BR.fl_str_mv |
Congenital Zika virus syndrome in Brazil: a case series of the first 1501 livebirths with complete investigation |
| title |
Congenital Zika virus syndrome in Brazil: a case series of the first 1501 livebirths with complete investigation |
| spellingShingle |
Congenital Zika virus syndrome in Brazil: a case series of the first 1501 livebirths with complete investigation França, Giovanny Vinícius Araújo de Brazil / epidemiology Cephalometry Confounding Factors, Epidemiologic Infant Mortality Microcephaly / epidemiology Microcephaly / pathology Microcephaly / virology Neonatal Screening / methods Neuroimaging Pregnancy Infant, Newborn Pregnancy Complications, Infectious / epidemiology Pregnancy Complications, Infectious / virology Zika Virus / isolation & purification Zika Virus Infection / congenital Zika Virus Infection / diagnosis Zika Virus Infection / epidemiology Zika Virus Infection / pathology Zika virus infection Zika virus Microcephaly Infant newborn Epidemiology Zika virus Infecção por Zika virus Microcefalia Recém-Nascido |
| title_short |
Congenital Zika virus syndrome in Brazil: a case series of the first 1501 livebirths with complete investigation |
| title_full |
Congenital Zika virus syndrome in Brazil: a case series of the first 1501 livebirths with complete investigation |
| title_fullStr |
Congenital Zika virus syndrome in Brazil: a case series of the first 1501 livebirths with complete investigation |
| title_full_unstemmed |
Congenital Zika virus syndrome in Brazil: a case series of the first 1501 livebirths with complete investigation |
| title_sort |
Congenital Zika virus syndrome in Brazil: a case series of the first 1501 livebirths with complete investigation |
| author |
França, Giovanny Vinícius Araújo de |
| author_facet |
França, Giovanny Vinícius Araújo de Schuler-Faccini, Lavinia Oliveira, Wanderson Kleber de Henriques, Cláudio Maierovitch Pessanha Carmo, Eduardo Hage Pedi, Vaneide Daciane Nunes, Marília L. Castro, Marcia C. Serruya, Suzanne Jacob Silveira, Mariângela F. Barros, Fernando C. Victora, Cesar G. |
| author_role |
author |
| author2 |
Schuler-Faccini, Lavinia Oliveira, Wanderson Kleber de Henriques, Cláudio Maierovitch Pessanha Carmo, Eduardo Hage Pedi, Vaneide Daciane Nunes, Marília L. Castro, Marcia C. Serruya, Suzanne Jacob Silveira, Mariângela F. Barros, Fernando C. Victora, Cesar G. |
| author2_role |
author author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
França, Giovanny Vinícius Araújo de Schuler-Faccini, Lavinia Oliveira, Wanderson Kleber de Henriques, Cláudio Maierovitch Pessanha Carmo, Eduardo Hage Pedi, Vaneide Daciane Nunes, Marília L. Castro, Marcia C. Serruya, Suzanne Jacob Silveira, Mariângela F. Barros, Fernando C. Victora, Cesar G. |
| dc.subject.mesh.pt_BR.fl_str_mv |
Brazil / epidemiology Cephalometry Confounding Factors, Epidemiologic Infant Mortality Microcephaly / epidemiology Microcephaly / pathology Microcephaly / virology Neonatal Screening / methods Neuroimaging Pregnancy Infant, Newborn Pregnancy Complications, Infectious / epidemiology Pregnancy Complications, Infectious / virology Zika Virus / isolation & purification Zika Virus Infection / congenital Zika Virus Infection / diagnosis Zika Virus Infection / epidemiology Zika Virus Infection / pathology |
| topic |
Brazil / epidemiology Cephalometry Confounding Factors, Epidemiologic Infant Mortality Microcephaly / epidemiology Microcephaly / pathology Microcephaly / virology Neonatal Screening / methods Neuroimaging Pregnancy Infant, Newborn Pregnancy Complications, Infectious / epidemiology Pregnancy Complications, Infectious / virology Zika Virus / isolation & purification Zika Virus Infection / congenital Zika Virus Infection / diagnosis Zika Virus Infection / epidemiology Zika Virus Infection / pathology Zika virus infection Zika virus Microcephaly Infant newborn Epidemiology Zika virus Infecção por Zika virus Microcefalia Recém-Nascido |
| dc.subject.en.pt_BR.fl_str_mv |
Zika virus infection Zika virus Microcephaly Infant newborn Epidemiology |
| dc.subject.decs.pt_BR.fl_str_mv |
Zika virus Infecção por Zika virus Microcefalia Recém-Nascido |
| description |
Claudio M. P. Henriques e Eduardo H. Carmo - Autores vinculados à Fiocruz Brasília, mas não consta a informação no documento. |
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2016 |
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2016 |
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2020-05-18T14:53:59Z |
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2020-05-18T14:53:59Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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FRANÇA, Giovanny V. A. et al. Congenital Zika virus syndrome in Brazil: a case series of the first 1501 livebirths with complete investigation. Lancet, [New York], v. 388, Aug. 2016. |
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https://www.arca.fiocruz.br/handle/icict/41268 |
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0140-6736 |
| dc.identifier.doi.none.fl_str_mv |
10.1016/S0140-6736(16)30902-3 |
| identifier_str_mv |
FRANÇA, Giovanny V. A. et al. Congenital Zika virus syndrome in Brazil: a case series of the first 1501 livebirths with complete investigation. Lancet, [New York], v. 388, Aug. 2016. 0140-6736 10.1016/S0140-6736(16)30902-3 |
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Elsevier |
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Elsevier |
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