Risk factors for Toxocara spp. seroprevalence and its association withatopy and asthma phenotypes in school-age children in a small town and semi-rural areas of Northeast Brazil

Detalhes bibliográficos
Autor(a) principal: Silva, Márcia B
Data de Publicação: 2016
Outros Autores: Amor, Ana Lúcia Moreno, Santos, Leonardo N, Galvão, Alana Alcântara, Vera, Aida Vera Oviedo, Silva, Eduardo S, Barbosa, Cynara Gomes, Gonçalves, Marilda de Souza, Cooper, Philip J, Figueiredo, Camila A, Ribeiro, Rita de Cassia, Neves, Neuza Maria Alcântara
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/14134
Resumo: Universidade Federal da Bahia. Instituto de Ciências da Saúde. Salvador, BA, Brasil
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spelling Silva, Márcia BAmor, Ana Lúcia MorenoSantos, Leonardo NGalvão, Alana AlcântaraVera, Aida Vera OviedoSilva, Eduardo SBarbosa, Cynara GomesGonçalves, Marilda de SouzaCooper, Philip JFigueiredo, Camila ARibeiro, Rita de CassiaNeves, Neuza Maria Alcântara2016-05-09T18:04:15Z2016-05-09T18:04:15Z2016SILVA, M. B. et al. Risk factors for Toxocara spp. seroprevalence and its association withatopy and asthma phenotypes in school-age children in a small town and semi-rural areas of Northeast Brazil. Acta Tropica, v. 16, p. 30170, 2016.0001-706Xhttps://www.arca.fiocruz.br/handle/icict/14134dx.doi.org/10.1016/j.actatropica.2016.04.005engElsevierRisk factors for Toxocara spp. seroprevalence and its association withatopy and asthma phenotypes in school-age children in a small town and semi-rural areas of Northeast Brazilinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade Federal da Bahia. Instituto de Ciências da Saúde. Salvador, BA, BrasilUniversidade Federal do Recôncavo da Bahia. Centro de Ciências da Saúde. Santo Antônio de Jesus, BA, BrasilUniversidade Federal da Bahia. Instituto de Ciências da Saúde. Salvador, BA, BrasilUniversidade Federal da Bahia. Instituto de Ciências da Saúde. Salvador, BA, BrasilUniversidade Federal da Bahia. Escola de Nutrição. Salvador, BA, BrasilUniversidade Federal da Bahia. Instituto de Ciências da Saúde. Salvador, BA, BrasilUniversidade Federal da Bahia. Faculdade de Farmácia. Salvador, BA, BrasilUniversidade Federal da Bahia. Faculdade de Farmácia. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilPontificia Universidad Católica del Ecuador. Centro de Investigación en Enfermedades Infecciosas. Quito, Ecuador / St George’s University of London. Division of Clinical Sciences. London, UKgUniversidade Federal da Bahia. Instituto de Ciências da Saúde. Salvador, BA, BrasilSt George’s University of London. Division of Clinical Sciences. London, UKgUniversidade Federal da Bahia. Instituto de Ciências da Saúde. Salvador, BA, BrasiltToxocara canis, Toxocara cati, are roundworms that live in the intestines of dogs and cats, respectively,and are predominantly agents of human toxocariasis. Studies have suggested that Toxocara spp. sero-prevalence increases levels of total and aeroallergen-specific IgE (sIgE), asthma prevalence and asthmamorbidity. Nevertheless, other work reported a negative association between Toxocara spp. seropositivitywith skin hypersensititity and a positive association with sIgE. The objective of the present study was toevaluate risk factors for acquiring Toxocara spp. infection and to investigate possible significant associa-tion between its seroprevalence with atopy and asthma. Students from elementary schools, residents in asmall town and its surroundings of Northeast Brazil, underwent blood sampling to measure levels of anti-Toxocara spp. IgG, peripheral blood eosinophils, and specific IgE to aeroallergens. We used univariable andmultivariable logistic regression analyses to assess possible risk factors for Toxocara spp. seropositivityand its association with atopy, wheeze/asthma with asthma phenotypes, in a sample of 791 elementaryschool children aged 6–13 years. Toxocara spp. seroprevalence reached 63.6%; 49.9% had sIgE; 7.2% and3.3% had atopic wheeze/asthma and non-atopic wheeze/asthma respectively. Risk factors associated withToxocara spp. seropositivity were: contact with dogs (adj. OR 2.33; 95% CI = 1.70–3.19) and cats (adj. OR3.09; 95% CI = 2.10–4.55), and male sex (adj. OR 2.21; 95% CI = 1.62–3.02). The presence of anti-ToxocaraIgG was statistically associated with blood eosinophils >4% and >10% (adj. OR 1.84; 95% CI = 1.33-2.55 andadj. OR 2.07; 95% CI = 1.45–2.97, respectively), and atopy (adj. OR 2.00; 95% CI = 1.49–2.68), but it was notassociated with wheeze/asthma. Concluding, the results obtained in this study showing the association ofToxocara spp. seroprevalence with sIgE may suggest a possible immunological cross-reactivity betweenIgE epitopes from Toxocara spp. and aeroallergensToxocariasisRisk factorsSpecific IgEAtopyAsthmainfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/14134/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALSilva MB Risk factors....pdfSilva MB Risk factors....pdfapplication/pdf578286https://www.arca.fiocruz.br/bitstream/icict/14134/2/Silva%20MB%20Risk%20factors....pdf5d075061aaf183445e1e313b4aa6dc52MD52TEXTSilva MB Risk factors....pdf.txtSilva MB Risk factors....pdf.txtExtracted 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dc.title.pt_BR.fl_str_mv Risk factors for Toxocara spp. seroprevalence and its association withatopy and asthma phenotypes in school-age children in a small town and semi-rural areas of Northeast Brazil
title Risk factors for Toxocara spp. seroprevalence and its association withatopy and asthma phenotypes in school-age children in a small town and semi-rural areas of Northeast Brazil
spellingShingle Risk factors for Toxocara spp. seroprevalence and its association withatopy and asthma phenotypes in school-age children in a small town and semi-rural areas of Northeast Brazil
Silva, Márcia B
Toxocariasis
Risk factors
Specific IgE
Atopy
Asthma
title_short Risk factors for Toxocara spp. seroprevalence and its association withatopy and asthma phenotypes in school-age children in a small town and semi-rural areas of Northeast Brazil
title_full Risk factors for Toxocara spp. seroprevalence and its association withatopy and asthma phenotypes in school-age children in a small town and semi-rural areas of Northeast Brazil
title_fullStr Risk factors for Toxocara spp. seroprevalence and its association withatopy and asthma phenotypes in school-age children in a small town and semi-rural areas of Northeast Brazil
title_full_unstemmed Risk factors for Toxocara spp. seroprevalence and its association withatopy and asthma phenotypes in school-age children in a small town and semi-rural areas of Northeast Brazil
title_sort Risk factors for Toxocara spp. seroprevalence and its association withatopy and asthma phenotypes in school-age children in a small town and semi-rural areas of Northeast Brazil
author Silva, Márcia B
author_facet Silva, Márcia B
Amor, Ana Lúcia Moreno
Santos, Leonardo N
Galvão, Alana Alcântara
Vera, Aida Vera Oviedo
Silva, Eduardo S
Barbosa, Cynara Gomes
Gonçalves, Marilda de Souza
Cooper, Philip J
Figueiredo, Camila A
Ribeiro, Rita de Cassia
Neves, Neuza Maria Alcântara
author_role author
author2 Amor, Ana Lúcia Moreno
Santos, Leonardo N
Galvão, Alana Alcântara
Vera, Aida Vera Oviedo
Silva, Eduardo S
Barbosa, Cynara Gomes
Gonçalves, Marilda de Souza
Cooper, Philip J
Figueiredo, Camila A
Ribeiro, Rita de Cassia
Neves, Neuza Maria Alcântara
author2_role author
author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Silva, Márcia B
Amor, Ana Lúcia Moreno
Santos, Leonardo N
Galvão, Alana Alcântara
Vera, Aida Vera Oviedo
Silva, Eduardo S
Barbosa, Cynara Gomes
Gonçalves, Marilda de Souza
Cooper, Philip J
Figueiredo, Camila A
Ribeiro, Rita de Cassia
Neves, Neuza Maria Alcântara
dc.subject.en.pt_BR.fl_str_mv Toxocariasis
Risk factors
Specific IgE
Atopy
Asthma
topic Toxocariasis
Risk factors
Specific IgE
Atopy
Asthma
description Universidade Federal da Bahia. Instituto de Ciências da Saúde. Salvador, BA, Brasil
publishDate 2016
dc.date.accessioned.fl_str_mv 2016-05-09T18:04:15Z
dc.date.available.fl_str_mv 2016-05-09T18:04:15Z
dc.date.issued.fl_str_mv 2016
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv SILVA, M. B. et al. Risk factors for Toxocara spp. seroprevalence and its association withatopy and asthma phenotypes in school-age children in a small town and semi-rural areas of Northeast Brazil. Acta Tropica, v. 16, p. 30170, 2016.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/14134
dc.identifier.issn.none.fl_str_mv 0001-706X
dc.identifier.doi.none.fl_str_mv dx.doi.org/10.1016/j.actatropica.2016.04.005
identifier_str_mv SILVA, M. B. et al. Risk factors for Toxocara spp. seroprevalence and its association withatopy and asthma phenotypes in school-age children in a small town and semi-rural areas of Northeast Brazil. Acta Tropica, v. 16, p. 30170, 2016.
0001-706X
dx.doi.org/10.1016/j.actatropica.2016.04.005
url https://www.arca.fiocruz.br/handle/icict/14134
dc.language.iso.fl_str_mv eng
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dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
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