Persistence of Zika Virus After Birth: Clinical, Virological, Neuroimaging, and Neuropathological Documentation in a 5-Month Infant With Congenital Zika Syndrome
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2018 |
| Outros Autores: | , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/30639 |
Resumo: | 2019-03-01 |
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Chimelli, LeilaPone, Sheila MouraAvvad-Portari, ElyzabethVasconcelos, Zilton Farias Meira deZin, Andrea A.Cunha, Daniela PradoThompson, Nathalia RaposoMoreira, Maria Elisabeth LopesWiley, Clayton A.Pone, Marcos Vinicius da Silva2018-12-17T17:35:13Z2018-12-17T17:35:13Z2018CHIMELLI, Leila et al. Persistence of Zika Virus After Birth: Clinical, Virological, Neuroimaging, and Neuropathological Documentation in a 5-Month Infant With Congenital Zika Syndrome. ournal of Neuropathology and Experimental Neurology. v. 77. n. 3. mar. 20180022-3069https://www.arca.fiocruz.br/handle/icict/3063910.1093/jnen/nlx116engOxford University PressArtrogriposeCalcificaçãoHidrocefaliaMicrocefaliaNeuropatologiaRT-qPCRZika VirusArthrogryposisCalcificationHydrocephalusMicrocephalNeuropathologyRT-qPCRZika VirusPersistence of Zika Virus After Birth: Clinical, Virological, Neuroimaging, and Neuropathological Documentation in a 5-Month Infant With Congenital Zika Syndromeinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article2019-03-01Instituto Estadual do Cérebro Paulo Niemeyer. Laboratório de Neuropatologia. Rio de Janeiro, RJ, Brasil / Universidade Federal do Rio de Janeiro. Rio de Janeiro.Fundação Oswaldo Cruz. Instituto Nacional de Saúde da Mulher, da Criança e do Adolescente Fernandes Figueira. Enfermaria de Doenças Infecciosas em Pediatria. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Saúde da Mulher, da Criança e do Adolescente Fernandes Figueira. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Saúde da Mulher, da Criança e do Adolescente Fernandes Figueira. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Saúde da Mulher, da Criança e do Adolescente Fernandes Figueira. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Saúde da Mulher da Criança e do Adolescente Fernandes Figueira. Rio de Janeiro, RJ, Brasil.Hospital Pró Criança Jutta Batista. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Saúde da Mulher da Criança e do Adolescente Fernandes Figueira. Rio de Janeiro, RJ, Brasil.UPMC Presbiterian Hospital. Division of Neuropathology. Pittsburgh, Pennsylvania, United States.Fundação Oswaldo Cruz. Instituto Nacional de Saúde da Mulher da Criança e do Adolescente Fernandes Figueira. Rio de Janeiro, RJ, Brasil.During the Zika epidemic in Brazil, a baby was born at term with microcephaly and arthrogryposis. The mother had Zika symptoms at 10 weeks of gestation. At 17 weeks, ultrasound showed cerebral malformation and ventriculomegaly. At 24 weeks, the amniotic fluid contained ZIKV RNA and at birth, placenta and maternal blood were also positive using RT-qPCR. At birth the baby urine contained ZIKV RNA, whereas CSF at birth and urine at 17 days did not. Seizures started at 6 days. EEG was abnormal and CT scan showed cerebral atrophy, calcifications, lissencephaly, ventriculomegaly, and cerebellar hypoplasia. Bacterial sepsis at 2 months was treated. A sudden increase in head circumference occurred at 4 months necessitating ventricle-peritoneal shunt placement. At 5 months, the infant died with sepsis due to bacterial meningitis. Neuropathological findings were as severe as some of those found in neonates who died soon after birth, including hydrocephalus, destructive lesions/calcification, gliosis, abnormal neuronal migration, dysmaturation of nerve cells, hypomyelination, loss of descending axons, and spinal motor neurons. ZIKV RNA was detected only in frozen brain tissue using RT-qPCR, but infected cells were not detected by in situ hybridization. Progressive gliosis and microgliosis in the midbrain may have contributed to aqueduct compression and subsequent hydrocephalus. The etiology of progressive disease after in utero infection is not clear and requires investigation.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83142https://www.arca.fiocruz.br/bitstream/icict/30639/1/license.txt37a74d92f1f1fd437ab11671160e0230MD51ORIGINALve_CHIMELLI_Leila_etal_2018.pdfve_CHIMELLI_Leila_etal_2018.pdfapplication/pdf733804https://www.arca.fiocruz.br/bitstream/icict/30639/2/ve_CHIMELLI_Leila_etal_2018.pdf97eccb3db933e23e3b5787a4130d8928MD52TEXTve_CHIMELLI_Leila_etal_2018.pdf.txtve_CHIMELLI_Leila_etal_2018.pdf.txtExtracted texttext/plain24470https://www.arca.fiocruz.br/bitstream/icict/30639/3/ve_CHIMELLI_Leila_etal_2018.pdf.txt49c232b3ce2a1eae775e3cd7b9baea21MD53icict/306392021-03-24 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Persistence of Zika Virus After Birth: Clinical, Virological, Neuroimaging, and Neuropathological Documentation in a 5-Month Infant With Congenital Zika Syndrome |
| title |
Persistence of Zika Virus After Birth: Clinical, Virological, Neuroimaging, and Neuropathological Documentation in a 5-Month Infant With Congenital Zika Syndrome |
| spellingShingle |
Persistence of Zika Virus After Birth: Clinical, Virological, Neuroimaging, and Neuropathological Documentation in a 5-Month Infant With Congenital Zika Syndrome Chimelli, Leila Artrogripose Calcificação Hidrocefalia Microcefalia Neuropatologia RT-qPCR Zika Virus Arthrogryposis Calcification Hydrocephalus Microcephal Neuropathology RT-qPCR Zika Virus |
| title_short |
Persistence of Zika Virus After Birth: Clinical, Virological, Neuroimaging, and Neuropathological Documentation in a 5-Month Infant With Congenital Zika Syndrome |
| title_full |
Persistence of Zika Virus After Birth: Clinical, Virological, Neuroimaging, and Neuropathological Documentation in a 5-Month Infant With Congenital Zika Syndrome |
| title_fullStr |
Persistence of Zika Virus After Birth: Clinical, Virological, Neuroimaging, and Neuropathological Documentation in a 5-Month Infant With Congenital Zika Syndrome |
| title_full_unstemmed |
Persistence of Zika Virus After Birth: Clinical, Virological, Neuroimaging, and Neuropathological Documentation in a 5-Month Infant With Congenital Zika Syndrome |
| title_sort |
Persistence of Zika Virus After Birth: Clinical, Virological, Neuroimaging, and Neuropathological Documentation in a 5-Month Infant With Congenital Zika Syndrome |
| author |
Chimelli, Leila |
| author_facet |
Chimelli, Leila Pone, Sheila Moura Avvad-Portari, Elyzabeth Vasconcelos, Zilton Farias Meira de Zin, Andrea A. Cunha, Daniela Prado Thompson, Nathalia Raposo Moreira, Maria Elisabeth Lopes Wiley, Clayton A. Pone, Marcos Vinicius da Silva |
| author_role |
author |
| author2 |
Pone, Sheila Moura Avvad-Portari, Elyzabeth Vasconcelos, Zilton Farias Meira de Zin, Andrea A. Cunha, Daniela Prado Thompson, Nathalia Raposo Moreira, Maria Elisabeth Lopes Wiley, Clayton A. Pone, Marcos Vinicius da Silva |
| author2_role |
author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Chimelli, Leila Pone, Sheila Moura Avvad-Portari, Elyzabeth Vasconcelos, Zilton Farias Meira de Zin, Andrea A. Cunha, Daniela Prado Thompson, Nathalia Raposo Moreira, Maria Elisabeth Lopes Wiley, Clayton A. Pone, Marcos Vinicius da Silva |
| dc.subject.other.pt_BR.fl_str_mv |
Artrogripose Calcificação Hidrocefalia Microcefalia Neuropatologia RT-qPCR Zika Virus |
| topic |
Artrogripose Calcificação Hidrocefalia Microcefalia Neuropatologia RT-qPCR Zika Virus Arthrogryposis Calcification Hydrocephalus Microcephal Neuropathology RT-qPCR Zika Virus |
| dc.subject.en.pt_BR.fl_str_mv |
Arthrogryposis Calcification Hydrocephalus Microcephal Neuropathology RT-qPCR Zika Virus |
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2019-03-01 |
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2018 |
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2018-12-17T17:35:13Z |
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2018-12-17T17:35:13Z |
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2018 |
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info:eu-repo/semantics/article |
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CHIMELLI, Leila et al. Persistence of Zika Virus After Birth: Clinical, Virological, Neuroimaging, and Neuropathological Documentation in a 5-Month Infant With Congenital Zika Syndrome. ournal of Neuropathology and Experimental Neurology. v. 77. n. 3. mar. 2018 |
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https://www.arca.fiocruz.br/handle/icict/30639 |
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0022-3069 |
| dc.identifier.doi.none.fl_str_mv |
10.1093/jnen/nlx116 |
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CHIMELLI, Leila et al. Persistence of Zika Virus After Birth: Clinical, Virological, Neuroimaging, and Neuropathological Documentation in a 5-Month Infant With Congenital Zika Syndrome. ournal of Neuropathology and Experimental Neurology. v. 77. n. 3. mar. 2018 0022-3069 10.1093/jnen/nlx116 |
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Oxford University Press |
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Oxford University Press |
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