Does Virus–Bacteria Coinfection Increase the Clinical Severity of Acute Respiratory Infection?

Detalhes bibliográficos
Autor(a) principal: Damasio, Guilherme A. C.
Data de Publicação: 2015
Outros Autores: Pereira, Luciane Aparecida, Moreira, Suzana D. R., Santos, Claudia Nunes Duarte dos, Dalla-Costa, Líbera Maria, Raboni, Sonia Mara
Tipo de documento: Artigo
Idioma: por
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/15753
Resumo: Universidade Federal do Paraná. Programa de Pós-Graduação em Microbiologia, Parasitologia e Patologia. Curitiba, PR, Brasil.
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spelling Damasio, Guilherme A. C.Pereira, Luciane AparecidaMoreira, Suzana D. R.Santos, Claudia Nunes Duarte dosDalla-Costa, Líbera MariaRaboni, Sonia Mara2016-09-12T15:03:57Z2016-09-12T15:03:57Z2015DAMASIO, Guilherme A. C et al. Does Virus–Bacteria Coinfection Increase the Clinical Severity of Acute Respiratory Infection? Journal of Medical Virology, v. 87, n. 9, p. 1456-1461, 2015.0146-6615https://www.arca.fiocruz.br/handle/icict/1575310.1002/jmv.24210porDoes Virus–Bacteria Coinfection Increase the Clinical Severity of Acute Respiratory Infection?info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade Federal do Paraná. Programa de Pós-Graduação em Microbiologia, Parasitologia e Patologia. Curitiba, PR, Brasil.Universidade Federal do Paraná. Laboratório de Virologia. Curitiba, PR, Brasil.Universidade Federal do Paraná. Divisão de Epidemiologia Hospitalar. Curitiba, PR, Brasil.Fundação Oswaldo Cruz. Instituto Carlos Chagas. Curitiba, PR, Brasil.Universidade Federal do Paraná. Laboratório de Bacteriologia. Curitiba, PR, Brasil / Faculdades e Instituto de Pesquisa Pelé Pequeno Príncipe. Curitiba, PR, Brasil.Universidade Federal do Paraná. Programa de Pós-Graduação em Microbiologia, Parasitologia e Patologia. Curitiba, PR, Brasil / Universidade Federal do Paraná. Laboratório de Virologia. Curitiba, PR, Brasil.This retrospective cohort study investigated the presence of bacteria in respiratory secretions of patients hospitalized with acute respiratory infections and analyzed the impact of viral and bacterial coinfection on severity and the mortality rate. A total of 169 patients with acute respiratory infections were included, viruses and bacteria in respiratory samples were detected using molecular methods. Among all samples, 73.3% and 59.7% were positive for viruses and bacteria, respectively; 45% contained both virus and bacteria. Bacterial coinfection was more frequent in patients infected by community respiratory viruses than influenza A H1N1pdm (83.3% vs. 40.6%). The most frequently bacteria detected were Streptococcus pneumoniae and Haemophilus influenzae. Both species were co-detected in 54 patients and identified alone in 22 and 21 patients, respectively. Overall, there were no significant differences in the period of hospitalization, severity, or mortality rate between patients infected with respiratory viruses alone and those coinfected by viruses and bacteria. The detection of mixed respiratory pathogens is frequent in hospitalized patients with acute respiratory infections, but its impact on the clinical outcome does not appear substantial. However, it should be noted that most of the patients received broad-spectrum antibiotic therapy, which may have contributed to this favorable outcome.Acute respiratory infectionsRespiratory virusesInfluenza A H1N1pdmBacteriainfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83074https://www.arca.fiocruz.br/bitstream/icict/15753/1/license.txt0271fb68963c017aa933c7aff60379f4MD51ORIGINALVirus bacteria coinfeccao 2015.pdfVirus bacteria coinfeccao 2015.pdfapplication/pdf326110https://www.arca.fiocruz.br/bitstream/icict/15753/2/Virus%20bacteria%20coinfeccao%202015.pdf7fcc59af94fe94f4a5f7a3c8c97bda9eMD52TEXTVirus bacteria coinfeccao 2015.pdf.txtVirus bacteria coinfeccao 2015.pdf.txtExtracted 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dc.title.pt_BR.fl_str_mv Does Virus–Bacteria Coinfection Increase the Clinical Severity of Acute Respiratory Infection?
title Does Virus–Bacteria Coinfection Increase the Clinical Severity of Acute Respiratory Infection?
spellingShingle Does Virus–Bacteria Coinfection Increase the Clinical Severity of Acute Respiratory Infection?
Damasio, Guilherme A. C.
Acute respiratory infections
Respiratory viruses
Influenza A H1N1pdm
Bacteria
title_short Does Virus–Bacteria Coinfection Increase the Clinical Severity of Acute Respiratory Infection?
title_full Does Virus–Bacteria Coinfection Increase the Clinical Severity of Acute Respiratory Infection?
title_fullStr Does Virus–Bacteria Coinfection Increase the Clinical Severity of Acute Respiratory Infection?
title_full_unstemmed Does Virus–Bacteria Coinfection Increase the Clinical Severity of Acute Respiratory Infection?
title_sort Does Virus–Bacteria Coinfection Increase the Clinical Severity of Acute Respiratory Infection?
author Damasio, Guilherme A. C.
author_facet Damasio, Guilherme A. C.
Pereira, Luciane Aparecida
Moreira, Suzana D. R.
Santos, Claudia Nunes Duarte dos
Dalla-Costa, Líbera Maria
Raboni, Sonia Mara
author_role author
author2 Pereira, Luciane Aparecida
Moreira, Suzana D. R.
Santos, Claudia Nunes Duarte dos
Dalla-Costa, Líbera Maria
Raboni, Sonia Mara
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Damasio, Guilherme A. C.
Pereira, Luciane Aparecida
Moreira, Suzana D. R.
Santos, Claudia Nunes Duarte dos
Dalla-Costa, Líbera Maria
Raboni, Sonia Mara
dc.subject.en.pt_BR.fl_str_mv Acute respiratory infections
Respiratory viruses
Influenza A H1N1pdm
Bacteria
topic Acute respiratory infections
Respiratory viruses
Influenza A H1N1pdm
Bacteria
description Universidade Federal do Paraná. Programa de Pós-Graduação em Microbiologia, Parasitologia e Patologia. Curitiba, PR, Brasil.
publishDate 2015
dc.date.issued.fl_str_mv 2015
dc.date.accessioned.fl_str_mv 2016-09-12T15:03:57Z
dc.date.available.fl_str_mv 2016-09-12T15:03:57Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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status_str publishedVersion
dc.identifier.citation.fl_str_mv DAMASIO, Guilherme A. C et al. Does Virus–Bacteria Coinfection Increase the Clinical Severity of Acute Respiratory Infection? Journal of Medical Virology, v. 87, n. 9, p. 1456-1461, 2015.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/15753
dc.identifier.issn.pt_BR.fl_str_mv 0146-6615
dc.identifier.doi.pt_BR.fl_str_mv 10.1002/jmv.24210
identifier_str_mv DAMASIO, Guilherme A. C et al. Does Virus–Bacteria Coinfection Increase the Clinical Severity of Acute Respiratory Infection? Journal of Medical Virology, v. 87, n. 9, p. 1456-1461, 2015.
0146-6615
10.1002/jmv.24210
url https://www.arca.fiocruz.br/handle/icict/15753
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