A Pilot Study of Dietetic, Phenotypic, and Genotypic Features Influencing Hypertensive Disorders of Pregnancy in Women with Pregestational Diabetes Mellitus

Detalhes bibliográficos
Autor(a) principal: Santos, Karina dos
Data de Publicação: 2023
Outros Autores: Rosado, Eliane Lopes, Fonseca, Ana Carolina Proença da, Belfort, Gabriella Pinto, Silva, Letícia Barbosa Gabriel da, Ribeiro-Alves, Marcelo, Zembrzuski, Verônica Marques, Campos Jr., Mario, Zajdenverg, Lenita, Drehmer, Michele, Martínez, J. Alfredo, Saunders, Cláudia
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/60240
Resumo: Institutional Review Board Statement: The study was conducted in accordance with the Declaration of Helsinki and approved by the Ethics Committee of Maternidade Escola da UFRJ (CAAE–46913115.0.0000.5275; 15 July 2015). The study was registered in the Brazilian Registry of Clinical Trials (RBR-4tbgv6). Informed Consent Statement: Written informed consent was obtained from the patient(s) to publish this paper. Data Availability Statement: Please, contact the correspondent author to verify the availability of the research data. Acknowledgments: Thanks to Marcus Miranda, Karina Bilda de Castro Rezende, Rita Bornia, Joffre Amin, Jr., and Jorge Rezende Filho for their support during the study.
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spelling Santos, Karina dosRosado, Eliane LopesFonseca, Ana Carolina Proença daBelfort, Gabriella PintoSilva, Letícia Barbosa Gabriel daRibeiro-Alves, MarceloZembrzuski, Verônica MarquesCampos Jr., MarioZajdenverg, LenitaDrehmer, MicheleMartínez, J. AlfredoSaunders, Cláudia2023-08-26T16:06:45Z2023-08-26T16:06:45Z2023SANTOS, Karina dos et al. A Pilot Study of Dietetic, Phenotypic, and Genotypic Features Influencing Hypertensive Disorders of Pregnancy in Women with Pregestational Diabetes Mellitus. Life (Basel), v. 13, n. 5, p. 1-17, Apr. 2023.2075-1729https://www.arca.fiocruz.br/handle/icict/6024010.3390/life130511042075-1729Institutional Review Board Statement: The study was conducted in accordance with the Declaration of Helsinki and approved by the Ethics Committee of Maternidade Escola da UFRJ (CAAE–46913115.0.0000.5275; 15 July 2015). The study was registered in the Brazilian Registry of Clinical Trials (RBR-4tbgv6). Informed Consent Statement: Written informed consent was obtained from the patient(s) to publish this paper. Data Availability Statement: Please, contact the correspondent author to verify the availability of the research data. Acknowledgments: Thanks to Marcus Miranda, Karina Bilda de Castro Rezende, Rita Bornia, Joffre Amin, Jr., and Jorge Rezende Filho for their support during the study.This research received financial support from: National Council for Scientific and Technological Development (Conselho Nacional de Desenvolvimento Científico e Tecnológico–CNPq-Brazil), grant number: 409032/2016-6; Carlos Chagas Filho Foundation to Research in the State of Rio de Janeiro (Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro—FAPERJBrazil), grant numbers: E-26/202.972/2016-6 and E-26/201.193/2021; and Coordination for the Improvement of Higher Education Personnel (Coordenação de Aperfeiçoamento de Pessoal de Nível Superior–CAPES-Brazil), Finance Code 001.Universidade Federal do Rio de Janeiro. Instituto de Nutrição Josué de Castro. Programa de Pós-Graduação em Nutrição. Rio de Janeiro, RJ, Brazil / Universidade Federal do Estado do Rio de Janeiro. Escola de Nutrição. Rio de Janeiro, RJ, Brazil.Universidade Federal do Rio de Janeiro. Instituto de Nutrição Josué de Castro. Programa de Pós-Graduação em Nutrição. Rio de Janeiro, RJ, Brazil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Genética Humana. Rio de Janeiro, RJ, Brazil.Universidade Federal do Rio de Janeiro. Instituto de Nutrição Josué de Castro. Programa de Pós-Graduação em Nutrição. Rio de Janeiro, RJ, Brazil / Universidade Federal do Estado do Rio de Janeiro. Escola de Nutrição. Rio de Janeiro, RJ, Brazil.Universidade Federal do Rio de Janeiro. Instituto de Nutrição Josué de Castro. Programa de Pós-Graduação em Nutrição. Rio de Janeiro, RJ, Brazil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brazil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Genética Humana. Rio de Janeiro, RJ, Brazil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Genética Humana. Rio de Janeiro, RJ, Brazil.Universidade Federal do Rio de Janeiro. Faculdade de Medicina. Departamento de Clínica Médica. Rio de Janeiro, RJ, Brazil.Universidade Federal do Rio Grande do Sul. Faculdade de Medicina. Programa de Pós-Graduação em Epidemiologia. Programa de Pós-Graduação em Alimentação, Nutrição e Saúde. Porto Alegre, RS, Brazil.Precision Nutrition and Cardiometabolic Health Program. IMDEA Food Institute (Instituto Madrileño de Estudos Avanzados en Alimentación). Crta. de Canto Blanco, Madrid, Spain.Universidade Federal do Rio de Janeiro. Instituto de Nutrição Josué de Castro. Programa de Pós-Graduação em Nutrição. Rio de Janeiro, RJ, Brazil.Hypertensive disorders of pregnancy (HDP) are a leading cause of maternal and perinatal morbimortality. Dietetic, phenotypic, and genotypic factors influencing HDP were analyzed during a nutrigenetic trial in Rio de Janeiro, Brazil (2016-2020). Pregnant women with pregestational diabetes mellitus (n = 70) were randomly assigned to a traditional or DASH diet group. Systolic blood pressure (SBP) and diastolic blood pressure (DBP) were measured during prenatal visits and HDP were diagnosed using international criteria. Phenotypic data were obtained from medical records and personal interviews. Genotyping for FTO and ADRB2 polymorphisms used RT-PCR. Linear mixed-effect models and time-to-event analyses were performed. The variables with significant effect on the risk for progression to HDP were: black skin color (adjusted hazard ratio [aHR] 8.63, p = 0.01), preeclampsia in previous pregnancy (aHR 11.66, p < 0.01), SBP ≥ 114 mmHg in the third trimester (aHR 5.56, p 0.04), DBP ≥ 70 mmHg in the first trimester (aHR 70.15, p = 0.03), mean blood pressure > 100 mmHg (aHR 18.42, p = 0.03), and HbA1c ≥ 6.41% in the third trimester (aHR 4.76, p = 0.03). Dietetic and genotypic features had no significant effect on the outcome, although there was limited statistical power to test both.engMDPIA Pilot Study of Dietetic, Phenotypic, and Genotypic Features Influencing Hypertensive Disorders of Pregnancy in Women with Pregestational Diabetes Mellitusinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleDASH dietNutrigeneticsPreeclampsiaPregnancy in diabetesPregnancy-induced hypertensioninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; 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dc.title.en_US.fl_str_mv A Pilot Study of Dietetic, Phenotypic, and Genotypic Features Influencing Hypertensive Disorders of Pregnancy in Women with Pregestational Diabetes Mellitus
title A Pilot Study of Dietetic, Phenotypic, and Genotypic Features Influencing Hypertensive Disorders of Pregnancy in Women with Pregestational Diabetes Mellitus
spellingShingle A Pilot Study of Dietetic, Phenotypic, and Genotypic Features Influencing Hypertensive Disorders of Pregnancy in Women with Pregestational Diabetes Mellitus
Santos, Karina dos
DASH diet
Nutrigenetics
Preeclampsia
Pregnancy in diabetes
Pregnancy-induced hypertension
title_short A Pilot Study of Dietetic, Phenotypic, and Genotypic Features Influencing Hypertensive Disorders of Pregnancy in Women with Pregestational Diabetes Mellitus
title_full A Pilot Study of Dietetic, Phenotypic, and Genotypic Features Influencing Hypertensive Disorders of Pregnancy in Women with Pregestational Diabetes Mellitus
title_fullStr A Pilot Study of Dietetic, Phenotypic, and Genotypic Features Influencing Hypertensive Disorders of Pregnancy in Women with Pregestational Diabetes Mellitus
title_full_unstemmed A Pilot Study of Dietetic, Phenotypic, and Genotypic Features Influencing Hypertensive Disorders of Pregnancy in Women with Pregestational Diabetes Mellitus
title_sort A Pilot Study of Dietetic, Phenotypic, and Genotypic Features Influencing Hypertensive Disorders of Pregnancy in Women with Pregestational Diabetes Mellitus
author Santos, Karina dos
author_facet Santos, Karina dos
Rosado, Eliane Lopes
Fonseca, Ana Carolina Proença da
Belfort, Gabriella Pinto
Silva, Letícia Barbosa Gabriel da
Ribeiro-Alves, Marcelo
Zembrzuski, Verônica Marques
Campos Jr., Mario
Zajdenverg, Lenita
Drehmer, Michele
Martínez, J. Alfredo
Saunders, Cláudia
author_role author
author2 Rosado, Eliane Lopes
Fonseca, Ana Carolina Proença da
Belfort, Gabriella Pinto
Silva, Letícia Barbosa Gabriel da
Ribeiro-Alves, Marcelo
Zembrzuski, Verônica Marques
Campos Jr., Mario
Zajdenverg, Lenita
Drehmer, Michele
Martínez, J. Alfredo
Saunders, Cláudia
author2_role author
author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Santos, Karina dos
Rosado, Eliane Lopes
Fonseca, Ana Carolina Proença da
Belfort, Gabriella Pinto
Silva, Letícia Barbosa Gabriel da
Ribeiro-Alves, Marcelo
Zembrzuski, Verônica Marques
Campos Jr., Mario
Zajdenverg, Lenita
Drehmer, Michele
Martínez, J. Alfredo
Saunders, Cláudia
dc.subject.en.en_US.fl_str_mv DASH diet
Nutrigenetics
Preeclampsia
Pregnancy in diabetes
Pregnancy-induced hypertension
topic DASH diet
Nutrigenetics
Preeclampsia
Pregnancy in diabetes
Pregnancy-induced hypertension
description Institutional Review Board Statement: The study was conducted in accordance with the Declaration of Helsinki and approved by the Ethics Committee of Maternidade Escola da UFRJ (CAAE–46913115.0.0000.5275; 15 July 2015). The study was registered in the Brazilian Registry of Clinical Trials (RBR-4tbgv6). Informed Consent Statement: Written informed consent was obtained from the patient(s) to publish this paper. Data Availability Statement: Please, contact the correspondent author to verify the availability of the research data. Acknowledgments: Thanks to Marcus Miranda, Karina Bilda de Castro Rezende, Rita Bornia, Joffre Amin, Jr., and Jorge Rezende Filho for their support during the study.
publishDate 2023
dc.date.accessioned.fl_str_mv 2023-08-26T16:06:45Z
dc.date.available.fl_str_mv 2023-08-26T16:06:45Z
dc.date.issued.fl_str_mv 2023
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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status_str publishedVersion
dc.identifier.citation.fl_str_mv SANTOS, Karina dos et al. A Pilot Study of Dietetic, Phenotypic, and Genotypic Features Influencing Hypertensive Disorders of Pregnancy in Women with Pregestational Diabetes Mellitus. Life (Basel), v. 13, n. 5, p. 1-17, Apr. 2023.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/60240
dc.identifier.issn.en_US.fl_str_mv 2075-1729
dc.identifier.doi.none.fl_str_mv 10.3390/life13051104
dc.identifier.eissn.none.fl_str_mv 2075-1729
identifier_str_mv SANTOS, Karina dos et al. A Pilot Study of Dietetic, Phenotypic, and Genotypic Features Influencing Hypertensive Disorders of Pregnancy in Women with Pregestational Diabetes Mellitus. Life (Basel), v. 13, n. 5, p. 1-17, Apr. 2023.
2075-1729
10.3390/life13051104
url https://www.arca.fiocruz.br/handle/icict/60240
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
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instacron_str FIOCRUZ
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reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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