Physical exercise promotes astrocyte coverage of microvessels in a model of chronic cerebral hypoperfusion
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2020 |
| Outros Autores: | , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/42503 |
Resumo: | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Investigação Cardiovascular. Rio de Janeiro, RJ, Brasil. |
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Tristão, Marina LeardiniAndrade, GiuliaGarcia, CelinaReis, Patrícia A.Lourenço, MillenaMoreira, Emilio T. S.Lima, Flavia R. S.Faria Neto, Hugo Caire C.Tibiriça, EduardoEstato, Vanessa2020-08-01T20:59:31Z2020-08-01T20:59:31Z2020TRISTÃO, Marina Leardini et al. Physical exercise promotes astrocyte coverage of microvessels in a model of chronic cerebral hypoperfusion. Journal of Neuroinflammation, v. 17, n. 117, p. 1-14, 2020.1742-2094https://www.arca.fiocruz.br/handle/icict/4250310.1186/s12974-020-01771-yengBMCExercícioHipoperfusão cerebralNeuroinflamaçãoCélulas da gliaMicrocirculaçãoExerciseCerebral hypoperfusionNeuroinflammationGlial cellsMicrocirculationPhysical exercise promotes astrocyte coverage of microvessels in a model of chronic cerebral hypoperfusioninfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Investigação Cardiovascular. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Investigação Cardiovascular. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Instituto de Ciências Biomédicas. Laboratório de Biologia Celular Glial. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ, BrasilFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Investigação Cardiovascular. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Instituto de Ciências Biomédicas. Laboratório de Biologia Celular Glial. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Investigação Cardiovascular. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Investigação Cardiovascular. Rio de Janeiro, RJ, Brasil / Instituto Nacional de Cardiologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Investigação Cardiovascular. Rio de Janeiro, RJ, Brasil.Brain circulation disorders such as chronic cerebral hypoperfusion have been associated with a decline in cognitive function during the development of dementia. Astrocytes together with microglia participate in the immune response in the CNS and make them potential sentinels in the brain parenchyma. In addition, astrocytes coverage integrity has been related to brain homeostasis. Currently, physical exercise has been proposed as an effective intervention to promote brain function improvement. However, the neuroprotective effects of early physical exercise on the astrocyte communication with the microcirculation and the microglial activation in a chronic cerebral hypoperfusion model are still unclear. The aim of this study was to investigate the impact of early intervention with physical exercise on cognition, brain microcirculatory, and inflammatory parameters in an experimental model of chronic cerebral hypoperfusion induced by permanent bilateral occlusion of the common carotid arteries (2VO).info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/42503/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALGiuliaAndrade_VanessaEstato_etal_IOC_2020.pdfGiuliaAndrade_VanessaEstato_etal_IOC_2020.pdfapplication/pdf6988277https://www.arca.fiocruz.br/bitstream/icict/42503/2/GiuliaAndrade_VanessaEstato_etal_IOC_2020.pdfa501bf5227dd96db30f80210c8588d2eMD52TEXTGiuliaAndrade_VanessaEstato_etal_IOC_2020.pdf.txtGiuliaAndrade_VanessaEstato_etal_IOC_2020.pdf.txtExtracted 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| dc.title.pt_BR.fl_str_mv |
Physical exercise promotes astrocyte coverage of microvessels in a model of chronic cerebral hypoperfusion |
| title |
Physical exercise promotes astrocyte coverage of microvessels in a model of chronic cerebral hypoperfusion |
| spellingShingle |
Physical exercise promotes astrocyte coverage of microvessels in a model of chronic cerebral hypoperfusion Tristão, Marina Leardini Exercício Hipoperfusão cerebral Neuroinflamação Células da glia Microcirculação Exercise Cerebral hypoperfusion Neuroinflammation Glial cells Microcirculation |
| title_short |
Physical exercise promotes astrocyte coverage of microvessels in a model of chronic cerebral hypoperfusion |
| title_full |
Physical exercise promotes astrocyte coverage of microvessels in a model of chronic cerebral hypoperfusion |
| title_fullStr |
Physical exercise promotes astrocyte coverage of microvessels in a model of chronic cerebral hypoperfusion |
| title_full_unstemmed |
Physical exercise promotes astrocyte coverage of microvessels in a model of chronic cerebral hypoperfusion |
| title_sort |
Physical exercise promotes astrocyte coverage of microvessels in a model of chronic cerebral hypoperfusion |
| author |
Tristão, Marina Leardini |
| author_facet |
Tristão, Marina Leardini Andrade, Giulia Garcia, Celina Reis, Patrícia A. Lourenço, Millena Moreira, Emilio T. S. Lima, Flavia R. S. Faria Neto, Hugo Caire C. Tibiriça, Eduardo Estato, Vanessa |
| author_role |
author |
| author2 |
Andrade, Giulia Garcia, Celina Reis, Patrícia A. Lourenço, Millena Moreira, Emilio T. S. Lima, Flavia R. S. Faria Neto, Hugo Caire C. Tibiriça, Eduardo Estato, Vanessa |
| author2_role |
author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Tristão, Marina Leardini Andrade, Giulia Garcia, Celina Reis, Patrícia A. Lourenço, Millena Moreira, Emilio T. S. Lima, Flavia R. S. Faria Neto, Hugo Caire C. Tibiriça, Eduardo Estato, Vanessa |
| dc.subject.other.pt_BR.fl_str_mv |
Exercício Hipoperfusão cerebral Neuroinflamação Células da glia Microcirculação |
| topic |
Exercício Hipoperfusão cerebral Neuroinflamação Células da glia Microcirculação Exercise Cerebral hypoperfusion Neuroinflammation Glial cells Microcirculation |
| dc.subject.en.pt_BR.fl_str_mv |
Exercise Cerebral hypoperfusion Neuroinflammation Glial cells Microcirculation |
| description |
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Investigação Cardiovascular. Rio de Janeiro, RJ, Brasil. |
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2020 |
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2020-08-01T20:59:31Z |
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2020-08-01T20:59:31Z |
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2020 |
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info:eu-repo/semantics/article |
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TRISTÃO, Marina Leardini et al. Physical exercise promotes astrocyte coverage of microvessels in a model of chronic cerebral hypoperfusion. Journal of Neuroinflammation, v. 17, n. 117, p. 1-14, 2020. |
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https://www.arca.fiocruz.br/handle/icict/42503 |
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1742-2094 |
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10.1186/s12974-020-01771-y |
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TRISTÃO, Marina Leardini et al. Physical exercise promotes astrocyte coverage of microvessels in a model of chronic cerebral hypoperfusion. Journal of Neuroinflammation, v. 17, n. 117, p. 1-14, 2020. 1742-2094 10.1186/s12974-020-01771-y |
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