Physalins B, F and G, seco-steroids purified from Physalis angulata L., inhibit lymphocyte function and allogeneic transplant rejection

Soares, Milena Botelho Pereira; Brustolim, Daniele; Santos, Luciane Amorim; Bellintani, Moema Cortizo; Paiva, F. P; Ribeiro, Yvone M; Tomassini, Therezinha Coelho Barbosa; Santos, Ricardo Ribeiro dos

Physalins B, F and G, seco-steroids purified from Physalis angulata L., inhibit lymphocyte function and allogeneic transplant rejection

Detalhes bibliográficos
Autor(a) principal:	Soares, Milena Botelho Pereira
Data de Publicação:	2006
Outros Autores:	Brustolim, Daniele, Santos, Luciane Amorim, Bellintani, Moema Cortizo, Paiva, F. P, Ribeiro, Yvone M, Tomassini, Therezinha Coelho Barbosa, Santos, Ricardo Ribeiro dos
Tipo de documento:	Artigo
Idioma:	eng
Título da fonte:	Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo:	https://www.arca.fiocruz.br/handle/icict/2800
Resumo:	Os autores gostariam de agradecer aos Drs. Augusto C. A. Mota e Washington L. C. Santos que gentilmente ajudaram com as análises estatísticas.

Metadados do item

id	CRUZ_323e4793ea5f8478c1c0f3dd852f8984
oai_identifier_str	oai:www.arca.fiocruz.br:icict/2800
network_acronym_str	CRUZ
network_name_str	Repositório Institucional da FIOCRUZ (ARCA)
repository_id_str	2135
spelling	Soares, Milena Botelho PereiraBrustolim, DanieleSantos, Luciane AmorimBellintani, Moema CortizoPaiva, F. PRibeiro, Yvone MTomassini, Therezinha Coelho BarbosaSantos, Ricardo Ribeiro dos2011-08-20T00:21:06Z2011-08-20T00:21:06Z2006SOARES, M. B. P. et al. Physalins B, F and G, seco-steroids purified from Physalis angulata L., inhibit lymphocyte function and allogeneic transplant rejection. International Immunopharmacology, v.6, n.3, p.408-414, 2006.1567-5769https://www.arca.fiocruz.br/handle/icict/280010.1016/j.intimp.2005.09.007Os autores gostariam de agradecer aos Drs. Augusto C. A. Mota e Washington L. C. Santos que gentilmente ajudaram com as análises estatísticas.Este trabalho foi financiado pelo CNPq, pelo Instituto do Milênio do Semiárido(IMSEAR-MCT) e pela FIOCRUZ (PDTIS).Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. Farmanguinhos. Rio de Janeiro, RJ, BrasilFundação Oswaldo Cruz. Farmanguinhos. Rio de Janeiro, RJ, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilPhysalis angulata is a solanaceae widely used in folk medicine in various tropical countries in the world. We have previously described that seco-steroids (physalins) purified from P. angulata are potent inhibitors of macrophage activation, blocking the production of pro-inflammatory cytokines and LPS-induced lethality. Herein we investigated the immunomodulatory activities of these substances in lymphocyte proliferation and cytokine production and in transplantation. The addition of physalins B, F or G to concanavalin A-activated splenocyte cultures induced a concentration-dependent inhibition of proliferation. Physalin B also inhibited IL-2 production by Con A-activated spleen cells. The addition of 2 Ag/ml physalin B to mixed lymphocyte reaction (MLR) caused a 100% inhibition of proliferation. More importantly, treatment of mice with physalin B, F or G prevented the rejection of allogeneic heterotopic heart transplant. Our results demonstrate the suppressive activity of physalins B, F and G in lymphocyte function and indicate the potential use of physalins as immunosuppressive agents for treatments of pathologies in which inhibition of immune responses is desired.engElsevierImunossupressãoLinfoproliferaçãoTransplantaçãoPhysalinImmunosuppressionLymphoproliferationTransplantationAnimaisProliferação de CélulasConcanavalina AFemininoRejeição de EnxertoTransplante de CoraçãoImunossupressoresInterleucina-2LinfócitosMasculinoCamundongosCamundongos Endogâmicos BALB CCamundongos Endogâmicos C3HCamundongos Endogâmicos C57BLCamundongos Endogâmicos CBAMifepristonaPhysalisSecoesteróidesBaçoPhysalins B, F and G, seco-steroids purified from Physalis angulata L., inhibit lymphocyte function and allogeneic transplant rejectioninfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINALSoares_Brustolim_Santos_etal.pdfSoares_Brustolim_Santos_etal.pdfapplication/pdf269374https://www.arca.fiocruz.br/bitstream/icict/2800/1/Soares_Brustolim_Santos_etal.pdf8adee9d9b1610cdac8a7c64218c075dcMD51LICENSElicense.txtlicense.txttext/plain; charset=utf-81648https://www.arca.fiocruz.br/bitstream/icict/2800/2/license.txte095249ac7cacefbfe39684dfe45e706MD52TEXTSoares_Brustolim_Santos_etal.pdf.txtSoares_Brustolim_Santos_etal.pdf.txtExtracted texttext/plain23514https://www.arca.fiocruz.br/bitstream/icict/2800/5/Soares_Brustolim_Santos_etal.pdf.txt6de4fb0c5de62baebdccb88c7eb3785dMD55THUMBNAILSoares_Brustolim_Santos_etal.pdf.jpgSoares_Brustolim_Santos_etal.pdf.jpgGenerated Thumbnailimage/jpeg2021https://www.arca.fiocruz.br/bitstream/icict/2800/4/Soares_Brustolim_Santos_etal.pdf.jpg13fa04a9e91fe6d1f05c5d2090a44c56MD54icict/28002023-03-15 14:33:00.741oai:www.arca.fiocruz.br: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Repositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-03-15T17:33Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv	Physalins B, F and G, seco-steroids purified from Physalis angulata L., inhibit lymphocyte function and allogeneic transplant rejection
title	Physalins B, F and G, seco-steroids purified from Physalis angulata L., inhibit lymphocyte function and allogeneic transplant rejection
spellingShingle	Physalins B, F and G, seco-steroids purified from Physalis angulata L., inhibit lymphocyte function and allogeneic transplant rejection Soares, Milena Botelho Pereira Imunossupressão Linfoproliferação Transplantação Physalin Immunosuppression Lymphoproliferation Transplantation Animais Proliferação de Células Concanavalina A Feminino Rejeição de Enxerto Transplante de Coração Imunossupressores Interleucina-2 Linfócitos Masculino Camundongos Camundongos Endogâmicos BALB C Camundongos Endogâmicos C3H Camundongos Endogâmicos C57BL Camundongos Endogâmicos CBA Mifepristona Physalis Secoesteróides Baço
title_short	Physalins B, F and G, seco-steroids purified from Physalis angulata L., inhibit lymphocyte function and allogeneic transplant rejection
title_full	Physalins B, F and G, seco-steroids purified from Physalis angulata L., inhibit lymphocyte function and allogeneic transplant rejection
title_fullStr	Physalins B, F and G, seco-steroids purified from Physalis angulata L., inhibit lymphocyte function and allogeneic transplant rejection
title_full_unstemmed	Physalins B, F and G, seco-steroids purified from Physalis angulata L., inhibit lymphocyte function and allogeneic transplant rejection
title_sort	Physalins B, F and G, seco-steroids purified from Physalis angulata L., inhibit lymphocyte function and allogeneic transplant rejection
author	Soares, Milena Botelho Pereira
author_facet	Soares, Milena Botelho Pereira Brustolim, Daniele Santos, Luciane Amorim Bellintani, Moema Cortizo Paiva, F. P Ribeiro, Yvone M Tomassini, Therezinha Coelho Barbosa Santos, Ricardo Ribeiro dos
author_role	author
author2	Brustolim, Daniele Santos, Luciane Amorim Bellintani, Moema Cortizo Paiva, F. P Ribeiro, Yvone M Tomassini, Therezinha Coelho Barbosa Santos, Ricardo Ribeiro dos
author2_role	author author author author author author author
dc.contributor.author.fl_str_mv	Soares, Milena Botelho Pereira Brustolim, Daniele Santos, Luciane Amorim Bellintani, Moema Cortizo Paiva, F. P Ribeiro, Yvone M Tomassini, Therezinha Coelho Barbosa Santos, Ricardo Ribeiro dos
dc.subject.other.pt_BR.fl_str_mv	Imunossupressão Linfoproliferação Transplantação
topic	Imunossupressão Linfoproliferação Transplantação Physalin Immunosuppression Lymphoproliferation Transplantation Animais Proliferação de Células Concanavalina A Feminino Rejeição de Enxerto Transplante de Coração Imunossupressores Interleucina-2 Linfócitos Masculino Camundongos Camundongos Endogâmicos BALB C Camundongos Endogâmicos C3H Camundongos Endogâmicos C57BL Camundongos Endogâmicos CBA Mifepristona Physalis Secoesteróides Baço
dc.subject.en.pt_BR.fl_str_mv	Physalin Immunosuppression Lymphoproliferation Transplantation
dc.subject.decs.pt_BR.fl_str_mv	Animais Proliferação de Células Concanavalina A Feminino Rejeição de Enxerto Transplante de Coração Imunossupressores Interleucina-2 Linfócitos Masculino Camundongos Camundongos Endogâmicos BALB C Camundongos Endogâmicos C3H Camundongos Endogâmicos C57BL Camundongos Endogâmicos CBA Mifepristona Physalis Secoesteróides Baço
description	Os autores gostariam de agradecer aos Drs. Augusto C. A. Mota e Washington L. C. Santos que gentilmente ajudaram com as análises estatísticas.
publishDate	2006
dc.date.issued.fl_str_mv	2006
dc.date.accessioned.fl_str_mv	2011-08-20T00:21:06Z
dc.date.available.fl_str_mv	2011-08-20T00:21:06Z
dc.type.status.fl_str_mv	info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv	info:eu-repo/semantics/article
format	article
status_str	publishedVersion
dc.identifier.citation.fl_str_mv	SOARES, M. B. P. et al. Physalins B, F and G, seco-steroids purified from Physalis angulata L., inhibit lymphocyte function and allogeneic transplant rejection. International Immunopharmacology, v.6, n.3, p.408-414, 2006.
dc.identifier.uri.fl_str_mv	https://www.arca.fiocruz.br/handle/icict/2800
dc.identifier.issn.none.fl_str_mv	1567-5769
dc.identifier.doi.none.fl_str_mv	10.1016/j.intimp.2005.09.007
identifier_str_mv	SOARES, M. B. P. et al. Physalins B, F and G, seco-steroids purified from Physalis angulata L., inhibit lymphocyte function and allogeneic transplant rejection. International Immunopharmacology, v.6, n.3, p.408-414, 2006. 1567-5769 10.1016/j.intimp.2005.09.007
url	https://www.arca.fiocruz.br/handle/icict/2800
dc.language.iso.fl_str_mv	eng
language	eng
dc.rights.driver.fl_str_mv	info:eu-repo/semantics/openAccess
eu_rights_str_mv	openAccess
dc.publisher.none.fl_str_mv	Elsevier
publisher.none.fl_str_mv	Elsevier
dc.source.none.fl_str_mv	reponame:Repositório Institucional da FIOCRUZ (ARCA) instname:Fundação Oswaldo Cruz (FIOCRUZ) instacron:FIOCRUZ
instname_str	Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str	FIOCRUZ
institution	FIOCRUZ
reponame_str	Repositório Institucional da FIOCRUZ (ARCA)
collection	Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv	https://www.arca.fiocruz.br/bitstream/icict/2800/1/Soares_Brustolim_Santos_etal.pdf https://www.arca.fiocruz.br/bitstream/icict/2800/2/license.txt https://www.arca.fiocruz.br/bitstream/icict/2800/5/Soares_Brustolim_Santos_etal.pdf.txt https://www.arca.fiocruz.br/bitstream/icict/2800/4/Soares_Brustolim_Santos_etal.pdf.jpg
bitstream.checksum.fl_str_mv	8adee9d9b1610cdac8a7c64218c075dc e095249ac7cacefbfe39684dfe45e706 6de4fb0c5de62baebdccb88c7eb3785d 13fa04a9e91fe6d1f05c5d2090a44c56
bitstream.checksumAlgorithm.fl_str_mv	MD5 MD5 MD5 MD5
repository.name.fl_str_mv	Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)
repository.mail.fl_str_mv	repositorio.arca@fiocruz.br
_version_	1794075772566110208

Physalins B, F and G, seco-steroids purified from Physalis angulata L., inhibit lymphocyte function and allogeneic transplant rejection

Registros relacionados