Naturally acquired antibodies to merozoite surface protein (MSP)-119 and cumulative exposure to Plasmodium falciparum and Plasmodium vivax in remote populations of the Amazon Basin of Brazil

Detalhes bibliográficos
Autor(a) principal: Andrade, Simone Ladeia
Data de Publicação: 2007
Outros Autores: Ferreira, Marcelo Urbano, Scopel, Kézia Katiani Gorza, Braga, Érika Martins, Bastos, Melissa da Silva, Wunderlich, Gerhard, Coura, José Rodrigues
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/33974
Resumo: Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Doenças Parasitárias. Rio de Janeiro, RJ. Brasil.
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spelling Andrade, Simone LadeiaFerreira, Marcelo UrbanoScopel, Kézia Katiani GorzaBraga, Érika MartinsBastos, Melissa da SilvaWunderlich, GerhardCoura, José Rodrigues2019-07-11T12:25:40Z2019-07-11T12:25:40Z2007ANDRADE, Simone Ladeia et al. Naturally acquired antibodies to merozoite surface protein (MSP)-119 and cumulative exposure to Plasmodium falciparum and Plasmodium vivax in remote populations of the Amazon Basin of Brazil. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 102, n. 8, p. 943-951, Dec. 2007.0074-0276https://www.arca.fiocruz.br/handle/icict/3397410.1590/S0074-027620070008000091678-8060engFundação Oswaldo Cruz. Instituto Oswaldo CruzMaláriaAmazôniaTaxas de transmissãoProteína de superfície de merozoito-1MalariaAmazonMerozoite surface protein-1Transmission ratesNaturally acquired antibodies to merozoite surface protein (MSP)-119 and cumulative exposure to Plasmodium falciparum and Plasmodium vivax in remote populations of the Amazon Basin of Brazilinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Doenças Parasitárias. Rio de Janeiro, RJ. Brasil.Universidade de São Paulo. Instituto de Ciências Biomédicas. Departamento de Parasitologia. São Paulo, SP, Brasil.Universidade Federal de Minas Gerais. Instituto de Ciências Biomédicas. Departamento de Parasitologia. Belo Horizonte, MG, Brasil.Universidade Federal de Minas Gerais. Instituto de Ciências Biomédicas. Departamento de Parasitologia. Belo Horizonte, MG, Brasil.Universidade de São Paulo. Instituto de Ciências Biomédicas. Departamento de Parasitologia. São Paulo, SP, Brasil.Universidade de São Paulo. Instituto de Ciências Biomédicas. Departamento de Parasitologia. São Paulo, SP, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Doenças Parasitárias. Rio de Janeiro, RJ. Brasil.To infer recent patterns of malaria transmission, we measured naturally acquired IgG antibodies to the conserved 19-kDa C-terminal region of the merozoite surface protein (MSP)-1 of both Plasmodium vivax (PvMSP-119) and Plasmodium falciparum (PfMSP-119) in remote malaria-exposed populations of the Amazon Basin. Community-based cross-sectional surveys were carried out between 2002 and 2003 in subjects of all age groups living along the margins of the Unini and Ja˙ rivers, Northwestern Brazil. We found high prevalence rates of IgG antibodies to PvMSP-119 (64.0 - 69.6%) and PfMSP-119 (51.6 - 52.0%), with significant differences in the proportion of subjects with antibodies to PvMSP-119 according to age, place of residence and habitual involvement in high-risk activities, defining some groups of highly exposed people who might be preferential targets of malaria control measures. In contrast, no risk factor other than age was significantly associated with seropositivity to PfMSP-119. Only 14.1% and 19.3% of the subjects tested for antibodies to PvMSP-119 and PfMSP-119 in consecutive surveys (142 - 203 days apart) seroconverted or had a three fold or higher increase in the levels of antibodies to these antigens. We discuss the extent to which serological data correlated with the classical malariometric indices and morbidity indicators measured in the studied population at the time of the seroprevalence surveys and highlight some limitations of serological data for epidemiological inference.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/33974/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALJoseCoura_SimoneAndrade_etal_IOC_2007.pdfJoseCoura_SimoneAndrade_etal_IOC_2007.pdfapplication/pdf291518https://www.arca.fiocruz.br/bitstream/icict/33974/2/JoseCoura_SimoneAndrade_etal_IOC_2007.pdf22db9171ca88462f679881e2910b3963MD52TEXTJoseCoura_SimoneAndrade_etal_IOC_2007.pdf.txtJoseCoura_SimoneAndrade_etal_IOC_2007.pdf.txtExtracted 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dc.title.pt_BR.fl_str_mv Naturally acquired antibodies to merozoite surface protein (MSP)-119 and cumulative exposure to Plasmodium falciparum and Plasmodium vivax in remote populations of the Amazon Basin of Brazil
title Naturally acquired antibodies to merozoite surface protein (MSP)-119 and cumulative exposure to Plasmodium falciparum and Plasmodium vivax in remote populations of the Amazon Basin of Brazil
spellingShingle Naturally acquired antibodies to merozoite surface protein (MSP)-119 and cumulative exposure to Plasmodium falciparum and Plasmodium vivax in remote populations of the Amazon Basin of Brazil
Andrade, Simone Ladeia
Malária
Amazônia
Taxas de transmissão
Proteína de superfície de merozoito-1
Malaria
Amazon
Merozoite surface protein-1
Transmission rates
title_short Naturally acquired antibodies to merozoite surface protein (MSP)-119 and cumulative exposure to Plasmodium falciparum and Plasmodium vivax in remote populations of the Amazon Basin of Brazil
title_full Naturally acquired antibodies to merozoite surface protein (MSP)-119 and cumulative exposure to Plasmodium falciparum and Plasmodium vivax in remote populations of the Amazon Basin of Brazil
title_fullStr Naturally acquired antibodies to merozoite surface protein (MSP)-119 and cumulative exposure to Plasmodium falciparum and Plasmodium vivax in remote populations of the Amazon Basin of Brazil
title_full_unstemmed Naturally acquired antibodies to merozoite surface protein (MSP)-119 and cumulative exposure to Plasmodium falciparum and Plasmodium vivax in remote populations of the Amazon Basin of Brazil
title_sort Naturally acquired antibodies to merozoite surface protein (MSP)-119 and cumulative exposure to Plasmodium falciparum and Plasmodium vivax in remote populations of the Amazon Basin of Brazil
author Andrade, Simone Ladeia
author_facet Andrade, Simone Ladeia
Ferreira, Marcelo Urbano
Scopel, Kézia Katiani Gorza
Braga, Érika Martins
Bastos, Melissa da Silva
Wunderlich, Gerhard
Coura, José Rodrigues
author_role author
author2 Ferreira, Marcelo Urbano
Scopel, Kézia Katiani Gorza
Braga, Érika Martins
Bastos, Melissa da Silva
Wunderlich, Gerhard
Coura, José Rodrigues
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Andrade, Simone Ladeia
Ferreira, Marcelo Urbano
Scopel, Kézia Katiani Gorza
Braga, Érika Martins
Bastos, Melissa da Silva
Wunderlich, Gerhard
Coura, José Rodrigues
dc.subject.other.pt_BR.fl_str_mv Malária
Amazônia
Taxas de transmissão
Proteína de superfície de merozoito-1
topic Malária
Amazônia
Taxas de transmissão
Proteína de superfície de merozoito-1
Malaria
Amazon
Merozoite surface protein-1
Transmission rates
dc.subject.en.pt_BR.fl_str_mv Malaria
Amazon
Merozoite surface protein-1
Transmission rates
description Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Doenças Parasitárias. Rio de Janeiro, RJ. Brasil.
publishDate 2007
dc.date.issued.fl_str_mv 2007
dc.date.accessioned.fl_str_mv 2019-07-11T12:25:40Z
dc.date.available.fl_str_mv 2019-07-11T12:25:40Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv ANDRADE, Simone Ladeia et al. Naturally acquired antibodies to merozoite surface protein (MSP)-119 and cumulative exposure to Plasmodium falciparum and Plasmodium vivax in remote populations of the Amazon Basin of Brazil. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 102, n. 8, p. 943-951, Dec. 2007.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/33974
dc.identifier.issn.pt_BR.fl_str_mv 0074-0276
dc.identifier.doi.pt_BR.fl_str_mv 10.1590/S0074-02762007000800009
dc.identifier.eissn.none.fl_str_mv 1678-8060
identifier_str_mv ANDRADE, Simone Ladeia et al. Naturally acquired antibodies to merozoite surface protein (MSP)-119 and cumulative exposure to Plasmodium falciparum and Plasmodium vivax in remote populations of the Amazon Basin of Brazil. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 102, n. 8, p. 943-951, Dec. 2007.
0074-0276
10.1590/S0074-02762007000800009
1678-8060
url https://www.arca.fiocruz.br/handle/icict/33974
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Fundação Oswaldo Cruz. Instituto Oswaldo Cruz
publisher.none.fl_str_mv Fundação Oswaldo Cruz. Instituto Oswaldo Cruz
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
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reponame_str Repositório Institucional da FIOCRUZ (ARCA)
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