Population genetic analysis reveals a high genetic diversity in the Brazilian Cryptococcus gattii VGII Pppulation and shifts the global origin from the Amazon Rainforest to the semi-arid desert in the Northeast of Brazil

Souto, Ana C. P.; Bonfietti, Lucas X.; Ferreira-Paim, Kennio; Trilles, Luciana; Martins, Marilena; Ribeiro-Alves, Marcelo; Pham, Cau D.; Martins, Liline; Santos, Wallace; Chang, Marilene; Brito-Santos, Fabio; Santos, Dayane C. S.; Fortes, Silvana; Lockhart, Shawn R.; Wanke, Bodo; Melhem, Márcia S. C.; Lazéra, Márcia S.; Meyer, Wieland

Population genetic analysis reveals a high genetic diversity in the Brazilian Cryptococcus gattii VGII Pppulation and shifts the global origin from the Amazon Rainforest to the semi-arid desert in the Northeast of Brazil

Detalhes bibliográficos
Autor(a) principal:	Souto, Ana C. P.
Data de Publicação:	2016
Outros Autores:	Bonfietti, Lucas X., Ferreira-Paim, Kennio, Trilles, Luciana, Martins, Marilena, Ribeiro-Alves, Marcelo, Pham, Cau D., Martins, Liline, Santos, Wallace, Chang, Marilene, Brito-Santos, Fabio, Santos, Dayane C. S., Fortes, Silvana, Lockhart, Shawn R., Wanke, Bodo, Melhem, Márcia S. C., Lazéra, Márcia S., Meyer, Wieland
Tipo de documento:	Artigo
Idioma:	eng
Título da fonte:	Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo:	https://www.arca.fiocruz.br/handle/icict/29121
Resumo:	Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.

Metadados do item

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spelling	Souto, Ana C. P.Bonfietti, Lucas X.Ferreira-Paim, KennioTrilles, LucianaMartins, MarilenaRibeiro-Alves, MarceloPham, Cau D.Martins, LilineSantos, WallaceChang, MarileneBrito-Santos, FabioSantos, Dayane C. S.Fortes, SilvanaLockhart, Shawn R.Wanke, BodoMelhem, Márcia S. C.Lazéra, Márcia S.Meyer, Wieland2018-09-27T18:24:21Z2018-09-27T18:24:21Z2016SOUTO, Ana C. P. et al. Population genetic analysis reveals a high genetic diversity in the Brazilian Cryptococcus Gattii VGII population and shifts the global origin from the Amazon Rainforest to the semi-arid desert in the Northeast of Brazil. PLoS Neglected Tropical Diseases, v. 10, n. 8, p. 1-19, 2016.1935-2727https://www.arca.fiocruz.br/handle/icict/2912110.1371/journal.pntd.0004885engPopulation genetic analysis reveals a high genetic diversity in the Brazilian Cryptococcus gattii VGII Pppulation and shifts the global origin from the Amazon Rainforest to the semi-arid desert in the Northeast of Brazilinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.Institute Adolfo Lutz. São Paulo, SP, Brazil.Molecular Mycology Research Laboratory. Centre for Infectious Diseases and Microbiology, Marie Bashir Institute for Emerging Infectious Diseases and Biosecurity. Sydney Medical School-Westmead Hospital. The University of Sydney. The Westmead Institute for Medical Research. Sydney, Australia / Infectious Disease Department. Triângulo Mineiro Federal University. Uberaba, MG, Brazil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil / Molecular Mycology Research Laboratory. Centre for Infectious Diseases and Microbiology, Marie Bashir Institute for Emerging Infectious Diseases and Biosecurity, Sydney Medical School-Westmead Hospital, The University of Sydney, The Westmead Institute for Medical Research. Sydney, Australia.Institute Adolfo Lutz, São Paulo, SP, Brazil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em DST/AIDS. Rio de Janeiro, RJ, Brasil.Centers for Disease Control and Prevention, Atlanta, USA.University of Piauí State. Teresina, PI, Brazil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil / Molecular Mycology Research Laboratory. Centre for Infectious Diseases and Microbiology. Marie Bashir Institute for Emerging Infectious Diseases and Biosecurity. Sydney Medical School-Westmead Hospital. The University of Sydney. The Westmead Institute for Medical Research. Sydney, Australia / Federal University of Pará. Belém, PA, Brazil.Federal University of Mato Grosso do Sul. Campo Grande, MS, Brazil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.Institute Adolfo Lutz. São Paulo, SP, Brazil.Biodiversity Research Center. Federal University of Roraima. Boa Vista, RR, Brazil.Centers for Disease Control and Prevention. Atlanta, USA.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.Institute Adolfo Lutz. São Paulo, SP, Brazil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil / Molecular Mycology Research Laboratory. Centre for Infectious Diseases and Microbiology. Marie Bashir Institute for Emerging Infectious Diseases and Biosecurity. Sydney Medical School-Westmead Hospital. The University of Sydney. The Westmead Institute for Medical Research. Sydney, Australia.Cryptococcus neoformans and Cryptococcus gattii are responsible globally for almost one million cryptococcosis cases yearly, mostly in immunocompromised patients, such as those living with HIV. Infections due to C. gattii have mainly been described in tropical and subtropical regions, but its adaptation to temperate regions was crucial in the species evolution and highlighted the importance of this pathogenic yeast in the context of disease. Cryptococcus gattii molecular type VGII has come to the forefront in connection with an on-going emergence in the Pacific North West of North America. Taking into account that previous work pointed towards South America as an origin of this species, the present work aimed to assess the genetic diversity within the Brazilian C. gattii VGII population in order to gain new insights into its origin and global dispersal from the South American continent using the ISHAM consensus MLST typing scheme. Our results corroborate the finding that the Brazilian C. gattii VGII population is highly diverse. The diversity is likely due to recombination generated from sexual reproduction, as evidenced by the presence of both mating types in clinical and environmental samples. The data presented herein strongly supports the emergence of highly virulent strains from ancestors in the Northern regions of Brazil, Amazonia and the Northeast. Numerous genotypes represent a link between Brazil and other parts of the world reinforcing South America as the most likely origin of the C. gattii VGII subtypes and their subsequent global spread, including their dispersal into North America, where they caused a major emergence.Genetic diversityBrazilian Cryptococcus gattii VGIIPppulationAmazon RainforestNortheast of Brazilinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83099https://www.arca.fiocruz.br/bitstream/icict/29121/1/license.txt586c046dcfeef936e32f0323bb9a47c0MD51ORIGINALPopulation Genetic Analysis Reveals a High Genetic Diversity in the Brazilian Cryptococcus_Marcelo_Alves_etal_INI_Lapclin_2016.PDFPopulation Genetic Analysis Reveals a High Genetic Diversity in the Brazilian Cryptococcus_Marcelo_Alves_etal_INI_Lapclin_2016.PDFapplication/pdf2734374https://www.arca.fiocruz.br/bitstream/icict/29121/2/Population%20Genetic%20Analysis%20Reveals%20a%20High%20Genetic%20Diversity%20in%20the%20Brazilian%20Cryptococcus_Marcelo_Alves_etal_INI_Lapclin_2016.PDF22e034c2ef566de6a2fcb77aed96c5d3MD52TEXTPopulation Genetic Analysis Reveals a High Genetic Diversity in the Brazilian Cryptococcus_Marcelo_Alves_etal_INI_Lapclin_2016.PDF.txtPopulation Genetic Analysis Reveals a High Genetic Diversity in the Brazilian Cryptococcus_Marcelo_Alves_etal_INI_Lapclin_2016.PDF.txtExtracted texttext/plain60663https://www.arca.fiocruz.br/bitstream/icict/29121/3/Population%20Genetic%20Analysis%20Reveals%20a%20High%20Genetic%20Diversity%20in%20the%20Brazilian%20Cryptococcus_Marcelo_Alves_etal_INI_Lapclin_2016.PDF.txt553d5260e8ef6a02004a9e80674f16c1MD53icict/291212019-04-20 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dc.title.pt_BR.fl_str_mv	Population genetic analysis reveals a high genetic diversity in the Brazilian Cryptococcus gattii VGII Pppulation and shifts the global origin from the Amazon Rainforest to the semi-arid desert in the Northeast of Brazil
title	Population genetic analysis reveals a high genetic diversity in the Brazilian Cryptococcus gattii VGII Pppulation and shifts the global origin from the Amazon Rainforest to the semi-arid desert in the Northeast of Brazil
spellingShingle	Population genetic analysis reveals a high genetic diversity in the Brazilian Cryptococcus gattii VGII Pppulation and shifts the global origin from the Amazon Rainforest to the semi-arid desert in the Northeast of Brazil Souto, Ana C. P. Genetic diversity Brazilian Cryptococcus gattii VGII Pppulation Amazon Rainforest Northeast of Brazil
title_short	Population genetic analysis reveals a high genetic diversity in the Brazilian Cryptococcus gattii VGII Pppulation and shifts the global origin from the Amazon Rainforest to the semi-arid desert in the Northeast of Brazil
title_full	Population genetic analysis reveals a high genetic diversity in the Brazilian Cryptococcus gattii VGII Pppulation and shifts the global origin from the Amazon Rainforest to the semi-arid desert in the Northeast of Brazil
title_fullStr	Population genetic analysis reveals a high genetic diversity in the Brazilian Cryptococcus gattii VGII Pppulation and shifts the global origin from the Amazon Rainforest to the semi-arid desert in the Northeast of Brazil
title_full_unstemmed	Population genetic analysis reveals a high genetic diversity in the Brazilian Cryptococcus gattii VGII Pppulation and shifts the global origin from the Amazon Rainforest to the semi-arid desert in the Northeast of Brazil
title_sort	Population genetic analysis reveals a high genetic diversity in the Brazilian Cryptococcus gattii VGII Pppulation and shifts the global origin from the Amazon Rainforest to the semi-arid desert in the Northeast of Brazil
author	Souto, Ana C. P.
author_facet	Souto, Ana C. P. Bonfietti, Lucas X. Ferreira-Paim, Kennio Trilles, Luciana Martins, Marilena Ribeiro-Alves, Marcelo Pham, Cau D. Martins, Liline Santos, Wallace Chang, Marilene Brito-Santos, Fabio Santos, Dayane C. S. Fortes, Silvana Lockhart, Shawn R. Wanke, Bodo Melhem, Márcia S. C. Lazéra, Márcia S. Meyer, Wieland
author_role	author
author2	Bonfietti, Lucas X. Ferreira-Paim, Kennio Trilles, Luciana Martins, Marilena Ribeiro-Alves, Marcelo Pham, Cau D. Martins, Liline Santos, Wallace Chang, Marilene Brito-Santos, Fabio Santos, Dayane C. S. Fortes, Silvana Lockhart, Shawn R. Wanke, Bodo Melhem, Márcia S. C. Lazéra, Márcia S. Meyer, Wieland
author2_role	author author author author author author author author author author author author author author author author author
dc.contributor.author.fl_str_mv	Souto, Ana C. P. Bonfietti, Lucas X. Ferreira-Paim, Kennio Trilles, Luciana Martins, Marilena Ribeiro-Alves, Marcelo Pham, Cau D. Martins, Liline Santos, Wallace Chang, Marilene Brito-Santos, Fabio Santos, Dayane C. S. Fortes, Silvana Lockhart, Shawn R. Wanke, Bodo Melhem, Márcia S. C. Lazéra, Márcia S. Meyer, Wieland
dc.subject.en.pt_BR.fl_str_mv	Genetic diversity Brazilian Cryptococcus gattii VGII Pppulation Amazon Rainforest Northeast of Brazil
topic	Genetic diversity Brazilian Cryptococcus gattii VGII Pppulation Amazon Rainforest Northeast of Brazil
description	Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.
publishDate	2016
dc.date.issued.fl_str_mv	2016
dc.date.accessioned.fl_str_mv	2018-09-27T18:24:21Z
dc.date.available.fl_str_mv	2018-09-27T18:24:21Z
dc.type.status.fl_str_mv	info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv	info:eu-repo/semantics/article
format	article
status_str	publishedVersion
dc.identifier.citation.fl_str_mv	SOUTO, Ana C. P. et al. Population genetic analysis reveals a high genetic diversity in the Brazilian Cryptococcus Gattii VGII population and shifts the global origin from the Amazon Rainforest to the semi-arid desert in the Northeast of Brazil. PLoS Neglected Tropical Diseases, v. 10, n. 8, p. 1-19, 2016.
dc.identifier.uri.fl_str_mv	https://www.arca.fiocruz.br/handle/icict/29121
dc.identifier.issn.pt_BR.fl_str_mv	1935-2727
dc.identifier.doi.none.fl_str_mv	10.1371/journal.pntd.0004885
identifier_str_mv	SOUTO, Ana C. P. et al. Population genetic analysis reveals a high genetic diversity in the Brazilian Cryptococcus Gattii VGII population and shifts the global origin from the Amazon Rainforest to the semi-arid desert in the Northeast of Brazil. PLoS Neglected Tropical Diseases, v. 10, n. 8, p. 1-19, 2016. 1935-2727 10.1371/journal.pntd.0004885
url	https://www.arca.fiocruz.br/handle/icict/29121
dc.language.iso.fl_str_mv	eng
language	eng
dc.rights.driver.fl_str_mv	info:eu-repo/semantics/openAccess
eu_rights_str_mv	openAccess
dc.source.none.fl_str_mv	reponame:Repositório Institucional da FIOCRUZ (ARCA) instname:Fundação Oswaldo Cruz (FIOCRUZ) instacron:FIOCRUZ
instname_str	Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str	FIOCRUZ
institution	FIOCRUZ
reponame_str	Repositório Institucional da FIOCRUZ (ARCA)
collection	Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv	https://www.arca.fiocruz.br/bitstream/icict/29121/1/license.txt https://www.arca.fiocruz.br/bitstream/icict/29121/2/Population%20Genetic%20Analysis%20Reveals%20a%20High%20Genetic%20Diversity%20in%20the%20Brazilian%20Cryptococcus_Marcelo_Alves_etal_INI_Lapclin_2016.PDF https://www.arca.fiocruz.br/bitstream/icict/29121/3/Population%20Genetic%20Analysis%20Reveals%20a%20High%20Genetic%20Diversity%20in%20the%20Brazilian%20Cryptococcus_Marcelo_Alves_etal_INI_Lapclin_2016.PDF.txt
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Population genetic analysis reveals a high genetic diversity in the Brazilian Cryptococcus gattii VGII Pppulation and shifts the global origin from the Amazon Rainforest to the semi-arid desert in the Northeast of Brazil

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