Epoxy-a-lapachone (2,2-Dimethyl-3,4-dihydro-spiro[2Hnaphtho[ 2,3-b]pyran-10,20-oxirane]-5(10H)-one): a promising molecule to control infections caused by protozoan parasites
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2023 |
| Outros Autores: | , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/58871 |
Resumo: | Fundação Oswaldo Cruz, Instituto Oswaldo Cruz, Laboratório de Biologia Molecular e Doenças Endêmicas. Rio de Janeiro, RJ, Brasil. |
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Peixoto, Juliana FigueiredoOliveira, Adriane da SilvaOliveira, Luiz Filipe GonçalvesSilva, Franklin SouzaAlves, Carlos Roberto2023-06-01T18:16:26Z2023-06-01T18:16:26Z2023PEIXOTO, Juliana Figueiredo et al. Epoxy-a-lapachone (2,2-Dimethyl-3,4-dihydro-spiro[2Hnaphtho[ 2,3-b]pyran-10,20-oxirane]-5(10H)-one): a promising molecule to control infections caused by protozoan parasites. The Brazilian Journal of Infection Diseases, v. 27, n. 2,: 102743, p. 1 - 9, Jan. 2023.1413-8670https://www.arca.fiocruz.br/handle/icict/5887110.1016/j.bjid.2023.102743engElsevier España, S.L.U.NaftoquinonaTratamentoLeishimanioseDoença de ChagasMaláriaEpóxi-a-lapachonaNaphthoquinoneEpoxy-a-lapachoneTreatmentLeishmaniasisChagas diseaseMalariaEpoxy-a-lapachone (2,2-Dimethyl-3,4-dihydro-spiro[2Hnaphtho[ 2,3-b]pyran-10,20-oxirane]-5(10H)-one): a promising molecule to control infections caused by protozoan parasitesinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz, Instituto Oswaldo Cruz, Laboratório de Biologia Molecular e Doenças Endêmicas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz, Instituto Oswaldo Cruz, Laboratório de Biologia Molecular e Doenças Endêmicas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz, Instituto Oswaldo Cruz, Laboratório de Biologia Molecular e Doenças Endêmicas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Centro de Desenvolvimento Tecnológico em Saúde. Rio de Janeiro, RJ, Brasil / Universidade Iguaçu. Nova Iguaçu, RJ, Brasil.Fundação Oswaldo Cruz, Instituto Oswaldo Cruz, Laboratório de Biologia Molecular e Doenças Endêmicas. Rio de Janeiro, RJ, Brasil.Natural products and their derivatives have been sources of search and research for new drugs for the treatment of neglected diseases. Naphthoquinones, a special group of quinones, are products of natural metabolites with a wide spectrum of biological activities and represent a group of interesting molecules for new therapeutic propositions. Among these compounds, lapachol stands out as a molecule from the heartwood of Tabebuia sp. whose structural changes resulted in compounds considered promising, such as epoxy-a-lapachone (ELAP). The biological activity of ELAP has been demonstrated, so far, for parasitic protozoa such as Leishmania spp., Trypanosoma cruzi and Plasmodium spp., species causing diseases needing new drug development and adequate health policy. This work gathers in vitro and in vivo studies on these parasites, as well as the toxicity profile, and the probable mechanisms of action elucidated until then. The potential of ELAP-based technology alternatives for a further drug is discussed here.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINALJulianaPeixoto_CarlosAalves_etal_IOC_2023.pdfJulianaPeixoto_CarlosAalves_etal_IOC_2023.pdfapplication/pdf596054https://www.arca.fiocruz.br/bitstream/icict/58871/2/JulianaPeixoto_CarlosAalves_etal_IOC_2023.pdf162ed58fae124d227906ee0242d3373aMD52LICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/58871/1/license.txt5a560609d32a3863062d77ff32785d58MD51icict/588712023-09-04 11:03:15.279oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-09-04T14:03:15Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false |
| dc.title.en_US.fl_str_mv |
Epoxy-a-lapachone (2,2-Dimethyl-3,4-dihydro-spiro[2Hnaphtho[ 2,3-b]pyran-10,20-oxirane]-5(10H)-one): a promising molecule to control infections caused by protozoan parasites |
| title |
Epoxy-a-lapachone (2,2-Dimethyl-3,4-dihydro-spiro[2Hnaphtho[ 2,3-b]pyran-10,20-oxirane]-5(10H)-one): a promising molecule to control infections caused by protozoan parasites |
| spellingShingle |
Epoxy-a-lapachone (2,2-Dimethyl-3,4-dihydro-spiro[2Hnaphtho[ 2,3-b]pyran-10,20-oxirane]-5(10H)-one): a promising molecule to control infections caused by protozoan parasites Peixoto, Juliana Figueiredo Naftoquinona Tratamento Leishimaniose Doença de Chagas Malária Epóxi-a-lapachona Naphthoquinone Epoxy-a-lapachone Treatment Leishmaniasis Chagas disease Malaria |
| title_short |
Epoxy-a-lapachone (2,2-Dimethyl-3,4-dihydro-spiro[2Hnaphtho[ 2,3-b]pyran-10,20-oxirane]-5(10H)-one): a promising molecule to control infections caused by protozoan parasites |
| title_full |
Epoxy-a-lapachone (2,2-Dimethyl-3,4-dihydro-spiro[2Hnaphtho[ 2,3-b]pyran-10,20-oxirane]-5(10H)-one): a promising molecule to control infections caused by protozoan parasites |
| title_fullStr |
Epoxy-a-lapachone (2,2-Dimethyl-3,4-dihydro-spiro[2Hnaphtho[ 2,3-b]pyran-10,20-oxirane]-5(10H)-one): a promising molecule to control infections caused by protozoan parasites |
| title_full_unstemmed |
Epoxy-a-lapachone (2,2-Dimethyl-3,4-dihydro-spiro[2Hnaphtho[ 2,3-b]pyran-10,20-oxirane]-5(10H)-one): a promising molecule to control infections caused by protozoan parasites |
| title_sort |
Epoxy-a-lapachone (2,2-Dimethyl-3,4-dihydro-spiro[2Hnaphtho[ 2,3-b]pyran-10,20-oxirane]-5(10H)-one): a promising molecule to control infections caused by protozoan parasites |
| author |
Peixoto, Juliana Figueiredo |
| author_facet |
Peixoto, Juliana Figueiredo Oliveira, Adriane da Silva Oliveira, Luiz Filipe Gonçalves Silva, Franklin Souza Alves, Carlos Roberto |
| author_role |
author |
| author2 |
Oliveira, Adriane da Silva Oliveira, Luiz Filipe Gonçalves Silva, Franklin Souza Alves, Carlos Roberto |
| author2_role |
author author author author |
| dc.contributor.author.fl_str_mv |
Peixoto, Juliana Figueiredo Oliveira, Adriane da Silva Oliveira, Luiz Filipe Gonçalves Silva, Franklin Souza Alves, Carlos Roberto |
| dc.subject.other.en_US.fl_str_mv |
Naftoquinona Tratamento Leishimaniose Doença de Chagas Malária Epóxi-a-lapachona |
| topic |
Naftoquinona Tratamento Leishimaniose Doença de Chagas Malária Epóxi-a-lapachona Naphthoquinone Epoxy-a-lapachone Treatment Leishmaniasis Chagas disease Malaria |
| dc.subject.en.en_US.fl_str_mv |
Naphthoquinone Epoxy-a-lapachone Treatment Leishmaniasis Chagas disease Malaria |
| description |
Fundação Oswaldo Cruz, Instituto Oswaldo Cruz, Laboratório de Biologia Molecular e Doenças Endêmicas. Rio de Janeiro, RJ, Brasil. |
| publishDate |
2023 |
| dc.date.accessioned.fl_str_mv |
2023-06-01T18:16:26Z |
| dc.date.available.fl_str_mv |
2023-06-01T18:16:26Z |
| dc.date.issued.fl_str_mv |
2023 |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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| dc.identifier.citation.fl_str_mv |
PEIXOTO, Juliana Figueiredo et al. Epoxy-a-lapachone (2,2-Dimethyl-3,4-dihydro-spiro[2Hnaphtho[ 2,3-b]pyran-10,20-oxirane]-5(10H)-one): a promising molecule to control infections caused by protozoan parasites. The Brazilian Journal of Infection Diseases, v. 27, n. 2,: 102743, p. 1 - 9, Jan. 2023. |
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https://www.arca.fiocruz.br/handle/icict/58871 |
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1413-8670 |
| dc.identifier.doi.none.fl_str_mv |
10.1016/j.bjid.2023.102743 |
| identifier_str_mv |
PEIXOTO, Juliana Figueiredo et al. Epoxy-a-lapachone (2,2-Dimethyl-3,4-dihydro-spiro[2Hnaphtho[ 2,3-b]pyran-10,20-oxirane]-5(10H)-one): a promising molecule to control infections caused by protozoan parasites. The Brazilian Journal of Infection Diseases, v. 27, n. 2,: 102743, p. 1 - 9, Jan. 2023. 1413-8670 10.1016/j.bjid.2023.102743 |
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Elsevier España, S.L.U. |
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Elsevier España, S.L.U. |
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