Schistogram changes after administration of antischistosomal drugs in mice at the early phase of Schistosoma mansoni infection.

Detalhes bibliográficos
Autor(a) principal: Vimieiro, Andréa Cássia Simões
Data de Publicação: 2013
Outros Autores: Araújo, Neusa, Katz, Naftale, Kusel, John Robert, Coelho, Paulo Marcos Zech
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/29889
Resumo: Fundação Hospitalar do Estado de Minas Gerais. Hospital Alberto Cavalcanti. Belo Horizonte, MG, Brasil
id CRUZ_369c236f0311289b2a8a0e50bd6243c2
oai_identifier_str oai:www.arca.fiocruz.br:icict/29889
network_acronym_str CRUZ
network_name_str Repositório Institucional da FIOCRUZ (ARCA)
repository_id_str 2135
spelling Vimieiro, Andréa Cássia SimõesAraújo, NeusaKatz, NaftaleKusel, John RobertCoelho, Paulo Marcos Zech2018-11-06T13:14:36Z2018-11-06T13:14:36Z2013VIMIEIRO, Andréa Cássia Simões et al. Schistogram changes after administration of antischistosomal drugs in mice at the early phase of Schistosoma mansoni infection. Mem. Inst. Oswaldo Cruz, v. 108, n. 7, p. 881-886, 20130074-0276https://www.arca.fiocruz.br/handle/icict/2988910.1590/0074-0276130135engFundação Oswaldo CruzesquistogramaSchistosoma mansonioxaminiquinapraziquantelartesunatooogramaschistogramSchistosoma mansonioxamniquinepraziquantelartesunateoogramSchistogram changes after administration of antischistosomal drugs in mice at the early phase of Schistosoma mansoni infection.info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Hospitalar do Estado de Minas Gerais. Hospital Alberto Cavalcanti. Belo Horizonte, MG, BrasilFundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Laboratório de Esquistossomose. Belo Horizonte, MG, BrasilFundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Laboratório de Esquistossomose. Belo Horizonte, MG, Brasil/Academia Mineira de Medicina. Belo Horizonte, MG, BrasilUniversity of Glasgow. Scotland, UKFundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Laboratório de Esquistossomose. Belo Horizonte, MG, BrasilMice infected with Schistosoma mansoni were treated with oxamniquine, praziquantel, artesunate at the pre-patent phase, aiming at observing schistogram alterations. Half of the animals were perfused five days post-treatment for counting and classification of immature worms, based on pre-established morphological criteria (schistogram); the remaining animals were evaluated 42 or 100 days after infection and perfusion of the portal-system was performed for collection and counting of adult worms and oogram. It was observed that oxamniquine and artesunate treatment administered at the pre-postural phase causes significant reduction in the number of immature and adult worms. However, there was little reduction with praziquantel when used at the dose of 400 mg/kg for treatments administered 14, 15, 21 or 23 days post-infection. Artesunate was responsible for significant alterations in development of young worms, as well as for a higher number of worms presenting intestinal damages. Immature adult worms were detected in mice treated with artesunate or oxamniquine at the pre-patent phase of infection and recovered by perfusion 100 days after infection. Schistogram proved to be a very useful tool for experimental evaluation of the activity of antischistosomal drugs and a good model to identify the most sensitive stages to drugs.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83082https://www.arca.fiocruz.br/bitstream/icict/29889/1/license.txt9193a7c197bc67acd023525e72a03240MD51ORIGINALSchistogram changes after administration.pdfSchistogram changes after administration.pdfapplication/pdf5486444https://www.arca.fiocruz.br/bitstream/icict/29889/2/Schistogram%20changes%20after%20administration.pdf316262d82eb4adaddb84f108bc3b7a99MD52TEXTSchistogram changes after administration.pdf.txtSchistogram changes after administration.pdf.txtExtracted texttext/plain312https://www.arca.fiocruz.br/bitstream/icict/29889/3/Schistogram%20changes%20after%20administration.pdf.txt2fac13b5c582eb9f91a909fb27a996a8MD53icict/298892019-06-19 10:06:19.261oai:www.arca.fiocruz.br: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Repositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352019-06-19T13:06:19Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv Schistogram changes after administration of antischistosomal drugs in mice at the early phase of Schistosoma mansoni infection.
title Schistogram changes after administration of antischistosomal drugs in mice at the early phase of Schistosoma mansoni infection.
spellingShingle Schistogram changes after administration of antischistosomal drugs in mice at the early phase of Schistosoma mansoni infection.
Vimieiro, Andréa Cássia Simões
esquistograma
Schistosoma mansoni
oxaminiquina
praziquantel
artesunato
oograma
schistogram
Schistosoma mansoni
oxamniquine
praziquantel
artesunate
oogram
title_short Schistogram changes after administration of antischistosomal drugs in mice at the early phase of Schistosoma mansoni infection.
title_full Schistogram changes after administration of antischistosomal drugs in mice at the early phase of Schistosoma mansoni infection.
title_fullStr Schistogram changes after administration of antischistosomal drugs in mice at the early phase of Schistosoma mansoni infection.
title_full_unstemmed Schistogram changes after administration of antischistosomal drugs in mice at the early phase of Schistosoma mansoni infection.
title_sort Schistogram changes after administration of antischistosomal drugs in mice at the early phase of Schistosoma mansoni infection.
author Vimieiro, Andréa Cássia Simões
author_facet Vimieiro, Andréa Cássia Simões
Araújo, Neusa
Katz, Naftale
Kusel, John Robert
Coelho, Paulo Marcos Zech
author_role author
author2 Araújo, Neusa
Katz, Naftale
Kusel, John Robert
Coelho, Paulo Marcos Zech
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Vimieiro, Andréa Cássia Simões
Araújo, Neusa
Katz, Naftale
Kusel, John Robert
Coelho, Paulo Marcos Zech
dc.subject.other.pt_BR.fl_str_mv esquistograma
Schistosoma mansoni
oxaminiquina
praziquantel
artesunato
oograma
topic esquistograma
Schistosoma mansoni
oxaminiquina
praziquantel
artesunato
oograma
schistogram
Schistosoma mansoni
oxamniquine
praziquantel
artesunate
oogram
dc.subject.en.pt_BR.fl_str_mv schistogram
Schistosoma mansoni
oxamniquine
praziquantel
artesunate
oogram
description Fundação Hospitalar do Estado de Minas Gerais. Hospital Alberto Cavalcanti. Belo Horizonte, MG, Brasil
publishDate 2013
dc.date.issued.fl_str_mv 2013
dc.date.accessioned.fl_str_mv 2018-11-06T13:14:36Z
dc.date.available.fl_str_mv 2018-11-06T13:14:36Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv VIMIEIRO, Andréa Cássia Simões et al. Schistogram changes after administration of antischistosomal drugs in mice at the early phase of Schistosoma mansoni infection. Mem. Inst. Oswaldo Cruz, v. 108, n. 7, p. 881-886, 2013
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/29889
dc.identifier.issn.pt_BR.fl_str_mv 0074-0276
dc.identifier.doi.none.fl_str_mv 10.1590/0074-0276130135
identifier_str_mv VIMIEIRO, Andréa Cássia Simões et al. Schistogram changes after administration of antischistosomal drugs in mice at the early phase of Schistosoma mansoni infection. Mem. Inst. Oswaldo Cruz, v. 108, n. 7, p. 881-886, 2013
0074-0276
10.1590/0074-0276130135
url https://www.arca.fiocruz.br/handle/icict/29889
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Fundação Oswaldo Cruz
publisher.none.fl_str_mv Fundação Oswaldo Cruz
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/29889/1/license.txt
https://www.arca.fiocruz.br/bitstream/icict/29889/2/Schistogram%20changes%20after%20administration.pdf
https://www.arca.fiocruz.br/bitstream/icict/29889/3/Schistogram%20changes%20after%20administration.pdf.txt
bitstream.checksum.fl_str_mv 9193a7c197bc67acd023525e72a03240
316262d82eb4adaddb84f108bc3b7a99
2fac13b5c582eb9f91a909fb27a996a8
bitstream.checksumAlgorithm.fl_str_mv MD5
MD5
MD5
repository.name.fl_str_mv Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)
repository.mail.fl_str_mv repositorio.arca@fiocruz.br
_version_ 1798324810082680832

Registros relacionados