The genomic analysis of rubella virus detected from outbreak and sporadic cases in Rio de Janeiro state, Brazil

Detalhes bibliográficos
Autor(a) principal: Donadio, Flávia F.
Data de Publicação: 2003
Outros Autores: Siqueira, Marilda Agudo Mendonça Teixeira de, Vyse, Andrew, Jin, Lin, Oliveira, Solange A.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/51626
Resumo: Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Virologia. Rio de Janeiro, RJ, Brasil.
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spelling Donadio, Flávia F.Siqueira, Marilda Agudo Mendonça Teixeira deVyse, AndrewJin, LinOliveira, Solange A.2022-03-08T19:44:33Z2022-03-08T19:44:33Z2003DONADIO, Flávia F. et al. The genomic analysis of rubella virus detected from outbreak and sporadic cases in Rio de Janeiro state, Brazil. Journal of Clinical Virology, v. 27, p. 205-209, Nov. 2003.1873-5967https://www.arca.fiocruz.br/handle/icict/5162610.1016/S1386-6532(02)00270-6engElsevierVírus da RubéolaEpidemiologia molecularAnálise genômicaSurtoRio de JaneiroBrasilGenomic analysisMolecular epidemiologyOutbreakGenotypeRio de Janeiro stateBrazilRubella virusThe genomic analysis of rubella virus detected from outbreak and sporadic cases in Rio de Janeiro state, Brazilinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Virologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Virologia. Rio de Janeiro, RJ, Brasil.Enteric, Respiratory and Neurological Virus Laboratory, Central Public Health Laboratory. London NW9 5HT, UK.Enteric, Respiratory and Neurological Virus Laboratory, Central Public Health Laboratory. London NW9 5HT, UK.Universidade Federal Fluminense. Hospital Universitário Antonio Pedro. Departamento de Doenças Infecciosas. Niterói, RJ, Brasil.Background: The molecular epidemiology of rubella virus (RV) based on the analysis of the viral E1 gene sequences indicated the existence of two genotypes that differ from each other by 8 to 10% in their nucleotide sequences: genotype I is present in Europe, North America and Asia; and genotype II is present only in Asia. Objectives: The purpose of the study was to identify the RV genotypes circulating in Brazil. Study design: In this study, we analysed 86 clinical samples collected between 1996 and 1999 during a rubella outbreak and from sporadic cases of rubella in Rio de Janeiro State. For the molecular characterisation of RV strains we have used PCR/nested amplification and direct sequencing of a 513-nucleotide region of the E1 gene. Results: The E1 gene sequences of 14 RVs were obtained and were assigned to two lineages, both within genotype I. The percentage divergence of nucleotide sequence ranged from 3.4 to 5.1% between these two lineages. These results were in agreement with the pattern of variation observed among the sequences obtained from other lineages of RV. Conclusions: This work demonstrated that two new lineages of RV circulated simultaneously between the years 1996 and 1999 in the state of Rio de Janeiro. These results provided new approaches for monitoring the progress of vaccination efforts in Brazil.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/51626/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALFlaviaDonadio_MarilsdaSiqueira_etal_IOC_2003.pdfFlaviaDonadio_MarilsdaSiqueira_etal_IOC_2003.pdfapplication/pdf180250https://www.arca.fiocruz.br/bitstream/icict/51626/2/FlaviaDonadio_MarilsdaSiqueira_etal_IOC_2003.pdf88552349c13767c8016d18e9411e401eMD52icict/516262023-09-05 10:30:44.218oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-09-05T13:30:44Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv The genomic analysis of rubella virus detected from outbreak and sporadic cases in Rio de Janeiro state, Brazil
title The genomic analysis of rubella virus detected from outbreak and sporadic cases in Rio de Janeiro state, Brazil
spellingShingle The genomic analysis of rubella virus detected from outbreak and sporadic cases in Rio de Janeiro state, Brazil
Donadio, Flávia F.
Vírus da Rubéola
Epidemiologia molecular
Análise genômica
Surto
Rio de Janeiro
Brasil
Genomic analysis
Molecular epidemiology
Outbreak
Genotype
Rio de Janeiro state
Brazil
Rubella virus
title_short The genomic analysis of rubella virus detected from outbreak and sporadic cases in Rio de Janeiro state, Brazil
title_full The genomic analysis of rubella virus detected from outbreak and sporadic cases in Rio de Janeiro state, Brazil
title_fullStr The genomic analysis of rubella virus detected from outbreak and sporadic cases in Rio de Janeiro state, Brazil
title_full_unstemmed The genomic analysis of rubella virus detected from outbreak and sporadic cases in Rio de Janeiro state, Brazil
title_sort The genomic analysis of rubella virus detected from outbreak and sporadic cases in Rio de Janeiro state, Brazil
author Donadio, Flávia F.
author_facet Donadio, Flávia F.
Siqueira, Marilda Agudo Mendonça Teixeira de
Vyse, Andrew
Jin, Lin
Oliveira, Solange A.
author_role author
author2 Siqueira, Marilda Agudo Mendonça Teixeira de
Vyse, Andrew
Jin, Lin
Oliveira, Solange A.
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Donadio, Flávia F.
Siqueira, Marilda Agudo Mendonça Teixeira de
Vyse, Andrew
Jin, Lin
Oliveira, Solange A.
dc.subject.other.pt_BR.fl_str_mv Vírus da Rubéola
Epidemiologia molecular
Análise genômica
Surto
Rio de Janeiro
Brasil
topic Vírus da Rubéola
Epidemiologia molecular
Análise genômica
Surto
Rio de Janeiro
Brasil
Genomic analysis
Molecular epidemiology
Outbreak
Genotype
Rio de Janeiro state
Brazil
Rubella virus
dc.subject.en.pt_BR.fl_str_mv Genomic analysis
Molecular epidemiology
Outbreak
Genotype
Rio de Janeiro state
Brazil
Rubella virus
description Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Virologia. Rio de Janeiro, RJ, Brasil.
publishDate 2003
dc.date.issued.fl_str_mv 2003
dc.date.accessioned.fl_str_mv 2022-03-08T19:44:33Z
dc.date.available.fl_str_mv 2022-03-08T19:44:33Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv DONADIO, Flávia F. et al. The genomic analysis of rubella virus detected from outbreak and sporadic cases in Rio de Janeiro state, Brazil. Journal of Clinical Virology, v. 27, p. 205-209, Nov. 2003.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/51626
dc.identifier.issn.pt_BR.fl_str_mv 1873-5967
dc.identifier.doi.none.fl_str_mv 10.1016/S1386-6532(02)00270-6
identifier_str_mv DONADIO, Flávia F. et al. The genomic analysis of rubella virus detected from outbreak and sporadic cases in Rio de Janeiro state, Brazil. Journal of Clinical Virology, v. 27, p. 205-209, Nov. 2003.
1873-5967
10.1016/S1386-6532(02)00270-6
url https://www.arca.fiocruz.br/handle/icict/51626
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/51626/1/license.txt
https://www.arca.fiocruz.br/bitstream/icict/51626/2/FlaviaDonadio_MarilsdaSiqueira_etal_IOC_2003.pdf
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repository.name.fl_str_mv Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)
repository.mail.fl_str_mv repositorio.arca@fiocruz.br
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