Role of interleukin-4 and prostaglandin E2 in Leishmania amazonensis infection of BALB/c mice.

Detalhes bibliográficos
Autor(a) principal: Guimarães, Elisalva Teixeira
Data de Publicação: 2006
Outros Autores: Santos, Luana A, Santos, Ricardo Ribeiro dos, Teixeira, Mauro Martins, dosSantos, Washington Luis Conrado, Soares, Milena Botelho Pereira
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/7661
Resumo: Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil
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spelling Guimarães, Elisalva TeixeiraSantos, Luana ASantos, Ricardo Ribeiro dosTeixeira, Mauro MartinsdosSantos, Washington Luis ConradoSoares, Milena Botelho Pereira2014-05-28T16:49:50Z2014-05-28T16:49:50Z2006GUIMARÃES, E. T. et al. Role of interleukin-4 and prostaglandin E2 in Leishmania amazonensis infection of BALB/c mice. Microbes and Infection, v. 8, n. 5, p. 1219-1226, 2006.1286-4579https://www.arca.fiocruz.br/handle/icict/766110.1016/j.micinf.2005.11.011engElsevierRole of interleukin-4 and prostaglandin E2 in Leishmania amazonensis infection of BALB/c mice.info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, BrasilUniversidade Federal de Minas Gerais. Departamento de Bioquímica e Imunologia. Instituto de Ciências Biológicas. Belo Horizonte, MG, BrasilFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, BrasilThe role of cytokines in Leishmania amazonensis experimental infection has not been as well studied as in Leishmania major infection model. Here we investigated the role of interleukin (IL)-4 and PGE(2) in L. amazonensis infection of susceptible BALB/c mice. IL-4 deficient (-/-) or wild-type (+/+) BALB/c mice were infected with different inocula of L. amazonensis. Two weeks after infection with 5x10(6) promastigotes/footpad, the production of interferon (IFN)-gamma upon L. amazonensis antigen stimulation was significantly higher in lymph node cell cultures of IL-4-/- mice than in IL-4+/+ mice. The levels of anti-leishmania IgG2a antibodies were also significantly higher in serum from IL-4-/- mice. In contrast, the levels of IgG1 antibodies were increased in IL-4+/+ mice and almost undetectable in IL-4-/- mice. Despite the increased Th1 response, lesions of IL-4-/- BALB/c mice progressed similarly to those of IL-4+/+ mice upon infection with the 5x10(6) inoculum. However, IL-4-/- mice developed smaller lesions upon infection with 10(5), 10(4) or 10(3) parasites than IL-4+/+ mice. The resistance of IL-4-/- correlated with higher Th1 response, compared to IL-4+/+ upon infection with 10(4)L. amazonensis. IL-4+/+ mice treated with indomethacin, an inhibitor of PGE(2) synthesis, during the first 3weeks of infection developed smaller lesions and lower parasitic load when compared to the control group. The lesions of indomethacin-treated groups contained mostly macrophages without vacuoles and small or absent necrotic areas. These results indicate that IL-4 and PGE(2) are susceptibility factors to L. amazonensis infection.Leishmania amazonensisBALB/c miceInterleukin-4Prostaglandin E2IndomethacinDinoprostona/metabolismoInterleucina-4/metabolismoLeishmania mexicanaLeishmaniose Cutânea/imunologiaAnimaisAnti-Inflamatórios não Esteroides/uso terapêuticoSuscetibilidade a DoençasFemininoHumanosIndometacina/uso terapêuticoInterferon gama/biossínteseLeishmania mexicana/imunologiaLeishmaniose Cutânea/quimioterapiaLeishmaniose Cutânea/fisiopatologiaCamundongosCamundongos Endogâmicos BALB Cinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINALGuimaraes ET Role of interleukin....pdfGuimaraes ET Role of interleukin....pdfapplication/pdf2518206https://www.arca.fiocruz.br/bitstream/icict/7661/1/Guimaraes%20ET%20Role%20of%20interleukin....pdf5aa9ae54662af73cda95cec5f944510aMD51LICENSElicense.txtlicense.txttext/plain; charset=utf-81914https://www.arca.fiocruz.br/bitstream/icict/7661/2/license.txt7d48279ffeed55da8dfe2f8e81f3b81fMD52TEXTGuimaraes ET Role of interleukin....pdf.txtGuimaraes ET Role of interleukin....pdf.txtExtracted texttext/plain37817https://www.arca.fiocruz.br/bitstream/icict/7661/5/Guimaraes%20ET%20Role%20of%20interleukin....pdf.txtc6a02e8526985365ad5d1ebc7cdfedfaMD55THUMBNAILGuimaraes ET Role of interleukin....pdf.jpgGuimaraes ET Role of interleukin....pdf.jpgGenerated Thumbnailimage/jpeg2267https://www.arca.fiocruz.br/bitstream/icict/7661/4/Guimaraes%20ET%20Role%20of%20interleukin....pdf.jpgd6d168ffb3ae885433ee7b090301f407MD54icict/76612023-03-15 14:33:15.231oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-03-15T17:33:15Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv Role of interleukin-4 and prostaglandin E2 in Leishmania amazonensis infection of BALB/c mice.
title Role of interleukin-4 and prostaglandin E2 in Leishmania amazonensis infection of BALB/c mice.
spellingShingle Role of interleukin-4 and prostaglandin E2 in Leishmania amazonensis infection of BALB/c mice.
Guimarães, Elisalva Teixeira
Leishmania amazonensis
BALB/c mice
Interleukin-4
Prostaglandin E2
Indomethacin
Dinoprostona/metabolismo
Interleucina-4/metabolismo
Leishmania mexicana
Leishmaniose Cutânea/imunologia
Animais
Anti-Inflamatórios não Esteroides/uso terapêutico
Suscetibilidade a Doenças
Feminino
Humanos
Indometacina/uso terapêutico
Interferon gama/biossíntese
Leishmania mexicana/imunologia
Leishmaniose Cutânea/quimioterapia
Leishmaniose Cutânea/fisiopatologia
Camundongos
Camundongos Endogâmicos BALB C
title_short Role of interleukin-4 and prostaglandin E2 in Leishmania amazonensis infection of BALB/c mice.
title_full Role of interleukin-4 and prostaglandin E2 in Leishmania amazonensis infection of BALB/c mice.
title_fullStr Role of interleukin-4 and prostaglandin E2 in Leishmania amazonensis infection of BALB/c mice.
title_full_unstemmed Role of interleukin-4 and prostaglandin E2 in Leishmania amazonensis infection of BALB/c mice.
title_sort Role of interleukin-4 and prostaglandin E2 in Leishmania amazonensis infection of BALB/c mice.
author Guimarães, Elisalva Teixeira
author_facet Guimarães, Elisalva Teixeira
Santos, Luana A
Santos, Ricardo Ribeiro dos
Teixeira, Mauro Martins
dosSantos, Washington Luis Conrado
Soares, Milena Botelho Pereira
author_role author
author2 Santos, Luana A
Santos, Ricardo Ribeiro dos
Teixeira, Mauro Martins
dosSantos, Washington Luis Conrado
Soares, Milena Botelho Pereira
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Guimarães, Elisalva Teixeira
Santos, Luana A
Santos, Ricardo Ribeiro dos
Teixeira, Mauro Martins
dosSantos, Washington Luis Conrado
Soares, Milena Botelho Pereira
dc.subject.en.pt_BR.fl_str_mv Leishmania amazonensis
BALB/c mice
Interleukin-4
Prostaglandin E2
Indomethacin
topic Leishmania amazonensis
BALB/c mice
Interleukin-4
Prostaglandin E2
Indomethacin
Dinoprostona/metabolismo
Interleucina-4/metabolismo
Leishmania mexicana
Leishmaniose Cutânea/imunologia
Animais
Anti-Inflamatórios não Esteroides/uso terapêutico
Suscetibilidade a Doenças
Feminino
Humanos
Indometacina/uso terapêutico
Interferon gama/biossíntese
Leishmania mexicana/imunologia
Leishmaniose Cutânea/quimioterapia
Leishmaniose Cutânea/fisiopatologia
Camundongos
Camundongos Endogâmicos BALB C
dc.subject.decs.pt_BR.fl_str_mv Dinoprostona/metabolismo
Interleucina-4/metabolismo
Leishmania mexicana
Leishmaniose Cutânea/imunologia
Animais
Anti-Inflamatórios não Esteroides/uso terapêutico
Suscetibilidade a Doenças
Feminino
Humanos
Indometacina/uso terapêutico
Interferon gama/biossíntese
Leishmania mexicana/imunologia
Leishmaniose Cutânea/quimioterapia
Leishmaniose Cutânea/fisiopatologia
Camundongos
Camundongos Endogâmicos BALB C
description Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil
publishDate 2006
dc.date.issued.fl_str_mv 2006
dc.date.accessioned.fl_str_mv 2014-05-28T16:49:50Z
dc.date.available.fl_str_mv 2014-05-28T16:49:50Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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dc.identifier.citation.fl_str_mv GUIMARÃES, E. T. et al. Role of interleukin-4 and prostaglandin E2 in Leishmania amazonensis infection of BALB/c mice. Microbes and Infection, v. 8, n. 5, p. 1219-1226, 2006.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/7661
dc.identifier.issn.none.fl_str_mv 1286-4579
dc.identifier.doi.none.fl_str_mv 10.1016/j.micinf.2005.11.011
identifier_str_mv GUIMARÃES, E. T. et al. Role of interleukin-4 and prostaglandin E2 in Leishmania amazonensis infection of BALB/c mice. Microbes and Infection, v. 8, n. 5, p. 1219-1226, 2006.
1286-4579
10.1016/j.micinf.2005.11.011
url https://www.arca.fiocruz.br/handle/icict/7661
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
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