Predictors of mortality in multidrug-resistant tuberculosis patients from Brazilian reference centers, 2005 to 2012

Detalhes bibliográficos
Autor(a) principal: Gayoso, Regina
Data de Publicação: 2018
Outros Autores: Dalcolmo, Margareth, Braga, José Ueleres, Barreira, Draurio
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/40628
Resumo: Fundação Oswaldo Cruz. Escola Nacional de Saúde Publica Sergio Arouca. Centro de Referência Hélio Fraga. Rio de Janeiro, RJ, Brasil.
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spelling Gayoso, ReginaDalcolmo, MargarethBraga, José UeleresBarreira, Draurio2020-04-03T17:52:26Z2020-04-03T17:52:26Z2018GAYOSO, Regina et al. Predictors of mortality in multidrug-resistant tuberculosis patients from Brazilian reference centers, 2005 to 2012. Brazilian Journal of Infectious Diseases, v. 22, n. 4, p. 305-310, 2018.1413-8670https://www.arca.fiocruz.br/handle/icict/4062810.1016/j.bjid.2018.07.0021678-4391engBrazilian Society of Infectious DiseasesPredictors of mortality in multidrug-resistant tuberculosis patients from Brazilian reference centers, 2005 to 2012info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Escola Nacional de Saúde Publica Sergio Arouca. Centro de Referência Hélio Fraga. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Escola Nacional de Saúde Publica Sergio Arouca. Centro de Referência Hélio Fraga. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Escola Nacional de Saúde Publica Sergio Arouca. Rio de Janeiro, RJ, Brasil.UNITAID. Vernier, Suíça.Objectives: To determine the main predictors of death in multidrug-resistant (MDRTB) patients from Brazil. Design: Retrospective cohort study, a survival analysis of patients treated between 2005 and 2012. Results: Of 3802 individuals included in study, 64.7% were men, mean age was 39 (1-93) years, and 70.3% had bilateral pulmonary disease. Prevalence of human immunodeficiency virus (HIV) was 8.3%. There were 479 (12.6%) deaths. Median survival time was 1452 days (4 years). Factors associated with increased risk of death were age greater than or equal to 60 years (hazard rate [HR] = 1.6, confidence interval [CI] = 1.15-2.2), HIV co-infection (HR = 1.46; CI = 1.05-1.96), XDR resistance pattern (HR = 1.74, CI = 1.05-2.9), beginning of treatment after failure (HR = 1.72, CI = 1.27-2.32), drug abuse (HR = 1.64, CI = 1.22-2.2), resistance to ethambutol (HR = 1.30, CI = 1.06-1.6) or streptomycin (HR = 1.24, CI = 1.01-1.51). Mainly protective factors were presence of only pulmonary disease (HR = 0.57, CI = 0.35-0.92), moxifloxacin use (HR = 0.44, CI = 0.25-0.80), and levofloxacin use (HR = 0.75; CI = 0.60-0.94). Conclusion: A more comprehensive approach is needed to manage MDRTB, addressing early diagnostic, improving adhesion, and comorbidities, mainly HIV infection and drug abuse. The latest generation quinolones have an important effect in improving survival in MDRTB.SurvivalTuberculosis multidrug-resistantTuberculosisDeathTuberculosisSurvivalinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/40628/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALPredictorsMortality.pdfPredictorsMortality.pdfapplication/pdf541540https://www.arca.fiocruz.br/bitstream/icict/40628/2/PredictorsMortality.pdf549ca116dde71f0eb094665a5245df53MD52TEXTPredictorsMortality.pdf.txtPredictorsMortality.pdf.txtExtracted texttext/plain26674https://www.arca.fiocruz.br/bitstream/icict/40628/3/PredictorsMortality.pdf.txt979512710d8464b999f4b0b6142904b1MD53icict/406282020-06-12 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dc.title.pt_BR.fl_str_mv Predictors of mortality in multidrug-resistant tuberculosis patients from Brazilian reference centers, 2005 to 2012
title Predictors of mortality in multidrug-resistant tuberculosis patients from Brazilian reference centers, 2005 to 2012
spellingShingle Predictors of mortality in multidrug-resistant tuberculosis patients from Brazilian reference centers, 2005 to 2012
Gayoso, Regina
Survival
Tuberculosis multidrug-resistant
Tuberculosis
Death
Tuberculosis
Survival
title_short Predictors of mortality in multidrug-resistant tuberculosis patients from Brazilian reference centers, 2005 to 2012
title_full Predictors of mortality in multidrug-resistant tuberculosis patients from Brazilian reference centers, 2005 to 2012
title_fullStr Predictors of mortality in multidrug-resistant tuberculosis patients from Brazilian reference centers, 2005 to 2012
title_full_unstemmed Predictors of mortality in multidrug-resistant tuberculosis patients from Brazilian reference centers, 2005 to 2012
title_sort Predictors of mortality in multidrug-resistant tuberculosis patients from Brazilian reference centers, 2005 to 2012
author Gayoso, Regina
author_facet Gayoso, Regina
Dalcolmo, Margareth
Braga, José Ueleres
Barreira, Draurio
author_role author
author2 Dalcolmo, Margareth
Braga, José Ueleres
Barreira, Draurio
author2_role author
author
author
dc.contributor.author.fl_str_mv Gayoso, Regina
Dalcolmo, Margareth
Braga, José Ueleres
Barreira, Draurio
dc.subject.en.pt_BR.fl_str_mv Survival
Tuberculosis multidrug-resistant
Tuberculosis
Death
topic Survival
Tuberculosis multidrug-resistant
Tuberculosis
Death
Tuberculosis
Survival
dc.subject.decs.pt_BR.fl_str_mv Tuberculosis
Survival
description Fundação Oswaldo Cruz. Escola Nacional de Saúde Publica Sergio Arouca. Centro de Referência Hélio Fraga. Rio de Janeiro, RJ, Brasil.
publishDate 2018
dc.date.issued.fl_str_mv 2018
dc.date.accessioned.fl_str_mv 2020-04-03T17:52:26Z
dc.date.available.fl_str_mv 2020-04-03T17:52:26Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv GAYOSO, Regina et al. Predictors of mortality in multidrug-resistant tuberculosis patients from Brazilian reference centers, 2005 to 2012. Brazilian Journal of Infectious Diseases, v. 22, n. 4, p. 305-310, 2018.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/40628
dc.identifier.issn.pt_BR.fl_str_mv 1413-8670
dc.identifier.doi.none.fl_str_mv 10.1016/j.bjid.2018.07.002
dc.identifier.eissn.none.fl_str_mv 1678-4391
identifier_str_mv GAYOSO, Regina et al. Predictors of mortality in multidrug-resistant tuberculosis patients from Brazilian reference centers, 2005 to 2012. Brazilian Journal of Infectious Diseases, v. 22, n. 4, p. 305-310, 2018.
1413-8670
10.1016/j.bjid.2018.07.002
1678-4391
url https://www.arca.fiocruz.br/handle/icict/40628
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Brazilian Society of Infectious Diseases
publisher.none.fl_str_mv Brazilian Society of Infectious Diseases
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
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collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/40628/1/license.txt
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