Genetic variants in the fat mass and obesity-associated (FTO) gene confer risk for extreme obesity and modulate adiposity in a Brazilian population
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2020 |
| Outros Autores: | , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/42447 |
Resumo: | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Gen[etica Humana. Rio de Janeiro, RJ, Brasil. |
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Fonseca, Ana Carolina Proença daMarchesini, BrunaZembrzuski, Verônica MarquesVoigt, Danielle DutraRamos, Vivianne GalanteCarneiro, João Regis IvarNogueira Neto, José FirminoCabello, Giselda Maria Kalil deCabello, Pedro Hernán2020-07-29T17:43:01Z2020-07-29T17:43:01Z2020FONSECA, Ana Carolina Proença da et al. Genetic variants in the fat mass and obesity-associated (FTO) gene confer risk for extreme obesity and modulate adiposity in a Brazilian population. Genetics and Molecular Biology, v. 43, n. 1, e20180264, 9p, 2020.1415-4757https://www.arca.fiocruz.br/handle/icict/4244710.1590/1678-4685-GMB-2018-02641678-4685engSociedade Brasileira de GenéticaObesidade extremaHaplotipoPolimorfismosBMIExtreme obesityFTOHaplotypePolymorphismsGenetic variants in the fat mass and obesity-associated (FTO) gene confer risk for extreme obesity and modulate adiposity in a Brazilian populationinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Gen[etica Humana. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Genética Humana. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Gen[etica Humana. Rio de Janeiro, RJ, Brasil.Universidade do Grande Rio. Laboratório de Genética Humana. Rio de Janeiro, RJ, Brasil.Universidade do Grande Rio. Laboratório de Genética Humana. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Hospital Universitário Clementino Fraga Filho. Rio de Janeiro, RJ, Brasil.Universidade do Estado do Rio de Janeiro. Departamento de Patologia. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Hospital Universitário Clementino Fraga Filho. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Gen[etica Humana. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Genética Humana. Rio de Janeiro, RJ, Brasil.Obesity is a major public health problem worldwide. It has a complex etiology, influenced by environmental and genetic factors. FTO has been recognized as an important genetic factor for obesity development. This study evaluated the contribution of FTO polymorphisms (rs9939609 and rs17817449) for extreme obesity in terms of the period of obesity onset, anthropometric, and biochemical parameters. The haplotype and the combined effects of FTO risk alleles on obesity susceptibility were evaluated. We investigated 169 normal-weight subjects (body mass index, BMI: 22.8 [21.0; 24.0] kg/m2) and 123 extremely obese individuals (BMI: 47.6 [44.1; 53.1] kg/m2). Genotyping was performed by real time PCR. Our results showed a strong association between FTO variants and extreme obesity. Carriers of the AT haplotype had an increased risk for extreme obesity. Gene scores suggested that the risk of developing extreme obesity was increased 1.37-fold per risk allele added. Both polymorphisms also influenced BMI and body weight. Additionally, rs17817449 influenced triglyceride levels. No effect of FTO variants on the period of obesity onset was found. In conclusion, the FTO polymorphisms showed a strong association with development of extreme phenotype of obesity and adiposity modulation in a Brazilian population.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/42447/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALBrunaMArchesini_GiseldaCabello_etal_IOC_2020.pdfBrunaMArchesini_GiseldaCabello_etal_IOC_2020.pdfapplication/pdf476895https://www.arca.fiocruz.br/bitstream/icict/42447/2/BrunaMArchesini_GiseldaCabello_etal_IOC_2020.pdf6c6b8374c9345bb1fb74cc6131bc78a8MD52TEXTBrunaMArchesini_GiseldaCabello_etal_IOC_2020.pdf.txtBrunaMArchesini_GiseldaCabello_etal_IOC_2020.pdf.txtExtracted 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| dc.title.pt_BR.fl_str_mv |
Genetic variants in the fat mass and obesity-associated (FTO) gene confer risk for extreme obesity and modulate adiposity in a Brazilian population |
| title |
Genetic variants in the fat mass and obesity-associated (FTO) gene confer risk for extreme obesity and modulate adiposity in a Brazilian population |
| spellingShingle |
Genetic variants in the fat mass and obesity-associated (FTO) gene confer risk for extreme obesity and modulate adiposity in a Brazilian population Fonseca, Ana Carolina Proença da Obesidade extrema Haplotipo Polimorfismos BMI Extreme obesity FTO Haplotype Polymorphisms |
| title_short |
Genetic variants in the fat mass and obesity-associated (FTO) gene confer risk for extreme obesity and modulate adiposity in a Brazilian population |
| title_full |
Genetic variants in the fat mass and obesity-associated (FTO) gene confer risk for extreme obesity and modulate adiposity in a Brazilian population |
| title_fullStr |
Genetic variants in the fat mass and obesity-associated (FTO) gene confer risk for extreme obesity and modulate adiposity in a Brazilian population |
| title_full_unstemmed |
Genetic variants in the fat mass and obesity-associated (FTO) gene confer risk for extreme obesity and modulate adiposity in a Brazilian population |
| title_sort |
Genetic variants in the fat mass and obesity-associated (FTO) gene confer risk for extreme obesity and modulate adiposity in a Brazilian population |
| author |
Fonseca, Ana Carolina Proença da |
| author_facet |
Fonseca, Ana Carolina Proença da Marchesini, Bruna Zembrzuski, Verônica Marques Voigt, Danielle Dutra Ramos, Vivianne Galante Carneiro, João Regis Ivar Nogueira Neto, José Firmino Cabello, Giselda Maria Kalil de Cabello, Pedro Hernán |
| author_role |
author |
| author2 |
Marchesini, Bruna Zembrzuski, Verônica Marques Voigt, Danielle Dutra Ramos, Vivianne Galante Carneiro, João Regis Ivar Nogueira Neto, José Firmino Cabello, Giselda Maria Kalil de Cabello, Pedro Hernán |
| author2_role |
author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Fonseca, Ana Carolina Proença da Marchesini, Bruna Zembrzuski, Verônica Marques Voigt, Danielle Dutra Ramos, Vivianne Galante Carneiro, João Regis Ivar Nogueira Neto, José Firmino Cabello, Giselda Maria Kalil de Cabello, Pedro Hernán |
| dc.subject.other.pt_BR.fl_str_mv |
Obesidade extrema Haplotipo Polimorfismos |
| topic |
Obesidade extrema Haplotipo Polimorfismos BMI Extreme obesity FTO Haplotype Polymorphisms |
| dc.subject.en.pt_BR.fl_str_mv |
BMI Extreme obesity FTO Haplotype Polymorphisms |
| description |
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Gen[etica Humana. Rio de Janeiro, RJ, Brasil. |
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2020 |
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2020-07-29T17:43:01Z |
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2020-07-29T17:43:01Z |
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2020 |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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FONSECA, Ana Carolina Proença da et al. Genetic variants in the fat mass and obesity-associated (FTO) gene confer risk for extreme obesity and modulate adiposity in a Brazilian population. Genetics and Molecular Biology, v. 43, n. 1, e20180264, 9p, 2020. |
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https://www.arca.fiocruz.br/handle/icict/42447 |
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1415-4757 |
| dc.identifier.doi.none.fl_str_mv |
10.1590/1678-4685-GMB-2018-0264 |
| dc.identifier.eissn.none.fl_str_mv |
1678-4685 |
| identifier_str_mv |
FONSECA, Ana Carolina Proença da et al. Genetic variants in the fat mass and obesity-associated (FTO) gene confer risk for extreme obesity and modulate adiposity in a Brazilian population. Genetics and Molecular Biology, v. 43, n. 1, e20180264, 9p, 2020. 1415-4757 10.1590/1678-4685-GMB-2018-0264 1678-4685 |
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Sociedade Brasileira de Genética |
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Sociedade Brasileira de Genética |
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