Balance of IL-10 and interferon-gamma plasma levels in human visceral leishmaniasis: implications in the pathogenesis.

Detalhes bibliográficos
Autor(a) principal: Caldas, Arlene de Jesus Mendes
Data de Publicação: 2005
Outros Autores: Favali, Cecilia Beatriz Fiuza, Aquino, Dorlene Maria Cardoso de, Vinhas, Vera Silvia de Freitas, Van Weyenbergh, Johan Jozef Rosa Maria, Brodskyn, Claudia Ida, Costa, Jackson Mauricio Lopes, Barral Netto, Manoel, Barral, Aldina Maria Prado
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/11018
Resumo: Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / Federal University of Maranhão. UFMA. Department of Nursing. São Luís, MA, Brasil
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spelling Caldas, Arlene de Jesus MendesFavali, Cecilia Beatriz FiuzaAquino, Dorlene Maria Cardoso deVinhas, Vera Silvia de FreitasVan Weyenbergh, Johan Jozef Rosa MariaBrodskyn, Claudia IdaCosta, Jackson Mauricio LopesBarral Netto, ManoelBarral, Aldina Maria Prado2015-06-30T17:07:14Z2015-06-30T17:07:14Z2005CALDAS, A. J. M. et al. Balance of IL-10 and interferon-gamma plasma levels in human visceral leishmaniasis: implications in the pathogenesis. BMC Infectious Diseases, v. 5, p. 113, 2005.1471-2334https://www.arca.fiocruz.br/handle/icict/1101810.1186/1471-2334-5-113engBioMed CentralBalance of IL-10 and interferon-gamma plasma levels in human visceral leishmaniasis: implications in the pathogenesis.info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / Federal University of Maranhão. UFMA. Department of Nursing. São Luís, MA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / Federal University of Maranhão. UFMA. Department of Nursing. São Luís, MA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / 4Institute of Investigation in Immunology. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / 4Institute of Investigation in Immunology. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, BrasilBACKGROUND: Leishmaniasis remains a serious public health problem in several parts of the developing world. Effective prophylactic measurements are hampered by imprecise comprehension of different aspects of the disease, including its immunoregulation. A better comprehension of immunoregulation in human VL may be useful both for designing and evaluating immunoprophylaxis. METHODS: To explore immunoregulatory mechanisms, 20 visceral leishmaniasis (VL) patients were evaluated during active disease and at different periods up to one year after treatment determining their plasma cytokine levels, clinical parameters (palpable spleen and liver) and antibody levels. RESULTS: Elevated plasma levels of IFN-gamma and of IL-12 p40 were observed during active disease, significantly decreasing after treatment whereas in vitro Leishmania antigen-stimulated IFN-gamma production by PBMC exhibited an inverse pattern being low during disease and increasing steadily thereafter. Absence of IFN-gamma activity is a hallmark of VL. The main candidate for blunting IFN-gamma activity is IL-10, a cytokine highly elevated in plasma with sharp decrease after treatment. Activity of IL-10 is inferred by high levels of anti-Leishmania specific IgG1 and IgG3. TGF-beta had elevated total, but not of active, levels lessening the likelihood of being the IFN-gamma counterpart. Spleen or liver size presented a steady decrease but return to normal values at only 120 days after treatment. Anti-Leishmania IgG (total and subclasses) levels and DTH or Leishmania-stimulated lymphocyte proliferation conversion to positive also present a slow decrease after treatment. IL-6 plasma levels were elevated in only a few patients. CONCLUSION: Taken together our results suggest that IFN-gamma and IL-10 are the molecules most likely involved in determining fate of disease. After treatment, there is a long delay before the immune profile returns to normal what precludes using plasma cytokine levels as criteria of cure as simpler clinical evaluations, as a palpable spleen or liver, can be used.Interferon gama/sangueInterleucina-10/sangueLeishmaniose Visceral/sangueLeishmaniose Visceral/fisiopatologiaAdolescenteAdultoAntiprotozoários/uso terapêuticoPré-EscolarCriançaFemininoHumanosLactenteInterferon gama/imunologiaInterleucina-10/imunologiaLeishmaniose Visceral/quimioterapiaFígado/patologiaMasculinoMeglumina/uso terapêuticoMeia-IdadeTamanho do ÓrgãoCompostos Organometálicos/uso terapêuticoBaço/patologiainfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82354https://www.arca.fiocruz.br/bitstream/icict/11018/1/license.txt8b4c200b4e10021c5683c6ccaba07169MD51ORIGINALCaldas A Balance of IL-10 and interferon.......pdfCaldas A Balance of IL-10 and interferon.......pdfapplication/pdf716910https://www.arca.fiocruz.br/bitstream/icict/11018/2/Caldas%20%20A%20%20%20Balance%20of%20IL-10%20and%20interferon.......pdf97412173b494bcb490cb197c3fb217c9MD52TEXTCaldas A Balance of IL-10 and interferon.......pdf.txtCaldas A Balance of IL-10 and interferon.......pdf.txtExtracted texttext/plain38491https://www.arca.fiocruz.br/bitstream/icict/11018/3/Caldas%20%20A%20%20%20Balance%20of%20IL-10%20and%20interferon.......pdf.txtcd0a635853e72faafa27655827a681d4MD53icict/110182023-03-15 14:32:58.04oai:www.arca.fiocruz.br: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Repositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-03-15T17:32:58Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv Balance of IL-10 and interferon-gamma plasma levels in human visceral leishmaniasis: implications in the pathogenesis.
title Balance of IL-10 and interferon-gamma plasma levels in human visceral leishmaniasis: implications in the pathogenesis.
spellingShingle Balance of IL-10 and interferon-gamma plasma levels in human visceral leishmaniasis: implications in the pathogenesis.
Caldas, Arlene de Jesus Mendes
Interferon gama/sangue
Interleucina-10/sangue
Leishmaniose Visceral/sangue
Leishmaniose Visceral/fisiopatologia
Adolescente
Adulto
Antiprotozoários/uso terapêutico
Pré-Escolar
Criança
Feminino
Humanos
Lactente
Interferon gama/imunologia
Interleucina-10/imunologia
Leishmaniose Visceral/quimioterapia
Fígado/patologia
Masculino
Meglumina/uso terapêutico
Meia-Idade
Tamanho do Órgão
Compostos Organometálicos/uso terapêutico
Baço/patologia
title_short Balance of IL-10 and interferon-gamma plasma levels in human visceral leishmaniasis: implications in the pathogenesis.
title_full Balance of IL-10 and interferon-gamma plasma levels in human visceral leishmaniasis: implications in the pathogenesis.
title_fullStr Balance of IL-10 and interferon-gamma plasma levels in human visceral leishmaniasis: implications in the pathogenesis.
title_full_unstemmed Balance of IL-10 and interferon-gamma plasma levels in human visceral leishmaniasis: implications in the pathogenesis.
title_sort Balance of IL-10 and interferon-gamma plasma levels in human visceral leishmaniasis: implications in the pathogenesis.
author Caldas, Arlene de Jesus Mendes
author_facet Caldas, Arlene de Jesus Mendes
Favali, Cecilia Beatriz Fiuza
Aquino, Dorlene Maria Cardoso de
Vinhas, Vera Silvia de Freitas
Van Weyenbergh, Johan Jozef Rosa Maria
Brodskyn, Claudia Ida
Costa, Jackson Mauricio Lopes
Barral Netto, Manoel
Barral, Aldina Maria Prado
author_role author
author2 Favali, Cecilia Beatriz Fiuza
Aquino, Dorlene Maria Cardoso de
Vinhas, Vera Silvia de Freitas
Van Weyenbergh, Johan Jozef Rosa Maria
Brodskyn, Claudia Ida
Costa, Jackson Mauricio Lopes
Barral Netto, Manoel
Barral, Aldina Maria Prado
author2_role author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Caldas, Arlene de Jesus Mendes
Favali, Cecilia Beatriz Fiuza
Aquino, Dorlene Maria Cardoso de
Vinhas, Vera Silvia de Freitas
Van Weyenbergh, Johan Jozef Rosa Maria
Brodskyn, Claudia Ida
Costa, Jackson Mauricio Lopes
Barral Netto, Manoel
Barral, Aldina Maria Prado
dc.subject.decs.pt_BR.fl_str_mv Interferon gama/sangue
Interleucina-10/sangue
Leishmaniose Visceral/sangue
Leishmaniose Visceral/fisiopatologia
Adolescente
Adulto
Antiprotozoários/uso terapêutico
Pré-Escolar
Criança
Feminino
Humanos
Lactente
Interferon gama/imunologia
Interleucina-10/imunologia
Leishmaniose Visceral/quimioterapia
Fígado/patologia
Masculino
Meglumina/uso terapêutico
Meia-Idade
Tamanho do Órgão
Compostos Organometálicos/uso terapêutico
Baço/patologia
topic Interferon gama/sangue
Interleucina-10/sangue
Leishmaniose Visceral/sangue
Leishmaniose Visceral/fisiopatologia
Adolescente
Adulto
Antiprotozoários/uso terapêutico
Pré-Escolar
Criança
Feminino
Humanos
Lactente
Interferon gama/imunologia
Interleucina-10/imunologia
Leishmaniose Visceral/quimioterapia
Fígado/patologia
Masculino
Meglumina/uso terapêutico
Meia-Idade
Tamanho do Órgão
Compostos Organometálicos/uso terapêutico
Baço/patologia
description Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / Federal University of Maranhão. UFMA. Department of Nursing. São Luís, MA, Brasil
publishDate 2005
dc.date.issued.fl_str_mv 2005
dc.date.accessioned.fl_str_mv 2015-06-30T17:07:14Z
dc.date.available.fl_str_mv 2015-06-30T17:07:14Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv CALDAS, A. J. M. et al. Balance of IL-10 and interferon-gamma plasma levels in human visceral leishmaniasis: implications in the pathogenesis. BMC Infectious Diseases, v. 5, p. 113, 2005.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/11018
dc.identifier.issn.none.fl_str_mv 1471-2334
dc.identifier.doi.none.fl_str_mv 10.1186/1471-2334-5-113
identifier_str_mv CALDAS, A. J. M. et al. Balance of IL-10 and interferon-gamma plasma levels in human visceral leishmaniasis: implications in the pathogenesis. BMC Infectious Diseases, v. 5, p. 113, 2005.
1471-2334
10.1186/1471-2334-5-113
url https://www.arca.fiocruz.br/handle/icict/11018
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv BioMed Central
publisher.none.fl_str_mv BioMed Central
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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