Human genetic susceptibility of Leprosy recurrence
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2020 |
| Outros Autores: | , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/41139 |
Resumo: | UMDT Clinical Trial e Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) |
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Sartori, Priscila Verchai UaskaPenna, Gerson OliveiraBührer-Sékula, SamiraPontes, Maria Araci de AndradeGonçalves, Heitor de SáCruz, RossileneVirmond, Marcos da Cunha LopesBaptista, Ida Maria Foschiani DiasRosa, Patricia SammarcoPenna, Maria Lucia FernandesMedeiros Fava, ViniciusStefani, Mariane Martins de AraújoTávora Mira, Marcelo2020-05-06T19:10:17Z2020-05-06T19:10:17Z2020SARTORI, Priscila Verchai Uaska et al. Human genetic susceptibility of Leprosy recurrence. Scientific Reports, [Nova york], v. 10, n. 1284, p. 1-5, jun. 2020.2045-2322https://www.arca.fiocruz.br/handle/icict/4113910.1038/s41598-020-58079-3UMDT Clinical Trial e Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Pontifícia Universidade Católica do Paraná. Faculdade de Medicina. Programa de Pós-graduação em Ciências da Saúde. Curitiba, PR, Brasil.Universidade de Brasília. Faculdade de Medicina. Núcleo de Medicina Tropical. Brasília, DF, Brasil / Fundação Oswaldo Cruz. Fiocruz Brasília. Brasília, DF, Brasil.Universidade Federal do Goiás. Instituto de Patologia Tropical e Saúde Pública. Goiânia, GO, Brasil.Dona Libânia Dermatology Centre. Fortaleza, CE, Brasil.Fundação de Dermatologia Tropical e Venereologia Alfredo da Matta. Manaus, AM, Brasil.Instituto Lauro de Souza Lima. Bauru, SP, Brasil.Universidade Federal Fluminense. Departamento de Epidemiologia e Bioestatística. Niterói, RJ, Brasil.McGill University Health Centre. Infectious Diseases and Immunity in Global Health Program. Montreal, QC, Canada.Fundação Oswaldo Cruz. Fiocruz Brasília. Brasília, DF, Brasil.Pontifícia Universidade Católica do Paraná. Faculdade de Medicina. Programa de Pós-graduação em Ciências da Saúde. Curitiba, PR, Brasil.Host genetic susceptibility to leprosy has been intensively investigated over the last decades; however, there are no studies on the role of genetic variants in disease recurrence. A previous initiative identified three recurrent cases of leprosy for which none of the M. leprae strains, as obtained in the first and the second diagnosis, had any known genomic variants associated to resistance to Multidrug therapy; in addition, whole genome sequencing indicated that the same M. leprae was causing two out of the three recurrences. Thus, these individuals were suspected of being particularly susceptible to M. leprae infection, either as relapse or reinfection. To verify this hypothesis, 19 genetic markers distributed across 11 loci (14 genes) classically associated with leprosy were genotyped in the recurrent and in three matching non-recurrent leprosy cases. An enrichment of risk alleles was observed in the recurrent cases, suggesting the existence of a particularly high susceptibility genetic profile among leprosy patients predisposing to disease recurrence.engSpringer NatureLeprosyMycobacterium lepraeGenes, BacterialHuman GeneticsCommunicable DiseasesLeprosyHuman geneticMycobacterium lepraeHanseníaseMycobacterium lepraeGenes BacterianosGenética HumanaDoenças TransmissíveisHuman genetic susceptibility of Leprosy recurrenceinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; 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| dc.title.pt_BR.fl_str_mv |
Human genetic susceptibility of Leprosy recurrence |
| title |
Human genetic susceptibility of Leprosy recurrence |
| spellingShingle |
Human genetic susceptibility of Leprosy recurrence Sartori, Priscila Verchai Uaska Leprosy Mycobacterium leprae Genes, Bacterial Human Genetics Communicable Diseases Leprosy Human genetic Mycobacterium leprae Hanseníase Mycobacterium leprae Genes Bacterianos Genética Humana Doenças Transmissíveis |
| title_short |
Human genetic susceptibility of Leprosy recurrence |
| title_full |
Human genetic susceptibility of Leprosy recurrence |
| title_fullStr |
Human genetic susceptibility of Leprosy recurrence |
| title_full_unstemmed |
Human genetic susceptibility of Leprosy recurrence |
| title_sort |
Human genetic susceptibility of Leprosy recurrence |
| author |
Sartori, Priscila Verchai Uaska |
| author_facet |
Sartori, Priscila Verchai Uaska Penna, Gerson Oliveira Bührer-Sékula, Samira Pontes, Maria Araci de Andrade Gonçalves, Heitor de Sá Cruz, Rossilene Virmond, Marcos da Cunha Lopes Baptista, Ida Maria Foschiani Dias Rosa, Patricia Sammarco Penna, Maria Lucia Fernandes Medeiros Fava, Vinicius Stefani, Mariane Martins de Araújo Távora Mira, Marcelo |
| author_role |
author |
| author2 |
Penna, Gerson Oliveira Bührer-Sékula, Samira Pontes, Maria Araci de Andrade Gonçalves, Heitor de Sá Cruz, Rossilene Virmond, Marcos da Cunha Lopes Baptista, Ida Maria Foschiani Dias Rosa, Patricia Sammarco Penna, Maria Lucia Fernandes Medeiros Fava, Vinicius Stefani, Mariane Martins de Araújo Távora Mira, Marcelo |
| author2_role |
author author author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Sartori, Priscila Verchai Uaska Penna, Gerson Oliveira Bührer-Sékula, Samira Pontes, Maria Araci de Andrade Gonçalves, Heitor de Sá Cruz, Rossilene Virmond, Marcos da Cunha Lopes Baptista, Ida Maria Foschiani Dias Rosa, Patricia Sammarco Penna, Maria Lucia Fernandes Medeiros Fava, Vinicius Stefani, Mariane Martins de Araújo Távora Mira, Marcelo |
| dc.subject.mesh.pt_BR.fl_str_mv |
Leprosy Mycobacterium leprae Genes, Bacterial Human Genetics Communicable Diseases |
| topic |
Leprosy Mycobacterium leprae Genes, Bacterial Human Genetics Communicable Diseases Leprosy Human genetic Mycobacterium leprae Hanseníase Mycobacterium leprae Genes Bacterianos Genética Humana Doenças Transmissíveis |
| dc.subject.en.pt_BR.fl_str_mv |
Leprosy Human genetic Mycobacterium leprae |
| dc.subject.decs.pt_BR.fl_str_mv |
Hanseníase Mycobacterium leprae Genes Bacterianos Genética Humana Doenças Transmissíveis |
| description |
UMDT Clinical Trial e Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) |
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2020 |
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2020-05-06T19:10:17Z |
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2020-05-06T19:10:17Z |
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2020 |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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publishedVersion |
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SARTORI, Priscila Verchai Uaska et al. Human genetic susceptibility of Leprosy recurrence. Scientific Reports, [Nova york], v. 10, n. 1284, p. 1-5, jun. 2020. |
| dc.identifier.uri.fl_str_mv |
https://www.arca.fiocruz.br/handle/icict/41139 |
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2045-2322 |
| dc.identifier.eissn.none.fl_str_mv |
10.1038/s41598-020-58079-3 |
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SARTORI, Priscila Verchai Uaska et al. Human genetic susceptibility of Leprosy recurrence. Scientific Reports, [Nova york], v. 10, n. 1284, p. 1-5, jun. 2020. 2045-2322 10.1038/s41598-020-58079-3 |
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Springer Nature |
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Springer Nature |
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