Neuro-COVID-19 With or Without the Multisystem Inflammatory Syndrome (MIS-C): A Single-Center Study
Autor(a) principal: | |
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Data de Publicação: | 2023 |
Outros Autores: | , , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
Texto Completo: | https://www.arca.fiocruz.br/handle/icict/57888 |
Resumo: | Universidade Federal de Minas Gerais. Departamento de Pediatria. Belo Horizonte, MG Brazil/Estado de Minas Gerais. Fundação Hospitalar de Minas Gerais. Hospital Infantil João Paulo II. Belo Horizonte, MG, Brazil |
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Bentes, Aline AlmeidaSantos Junior, Walter Rebuite dosPessoa, Natalia LimaCosta, Thais AlkifelesOliveira, Gabriela Fernanda GarciaDiniz, Lilian Martins OliveiraTorres, Bruna RibeiroTeixeira, Daniela CaldasMendes, Renata BarandasAvelar, Ana Beatriz AlvimCampos, Marco AntônioKroon, Erna GeessienDrumond, Betania Paiva2023-04-19T13:15:58Z2023-04-19T13:15:58Z2023BENTES, Aline Almeida et al. Neuro-COVID-19 With or Without the Multisystem Inflammatory Syndrome (MIS-C): A Single-Center Study. Journal of Molecular Neuroscience, p. 1-9, 2023. doi: 10.1007/s12031-023-02109-y0895-8696https://www.arca.fiocruz.br/handle/icict/57888engBirkhäuser BostonCOVID-19criançasCOVID-19ChildrenNeuro-COVID-19COVID-19-associated multisystem inflammatory syndromeSARS-CoV-2MIS-CNeuro-COVID-19 With or Without the Multisystem Inflammatory Syndrome (MIS-C): A Single-Center Studyinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade Federal de Minas Gerais. Departamento de Pediatria. Belo Horizonte, MG Brazil/Estado de Minas Gerais. Fundação Hospitalar de Minas Gerais. Hospital Infantil João Paulo II. Belo Horizonte, MG, BrazilUniversidade Federal de Minas Gerais. Departamento de Pediatria. Belo Horizonte, MG Brazil/Estado de Minas Gerais. Fundação Hospitalar de Minas Gerais. Hospital Infantil João Paulo II. Belo Horizonte, MG, BrazilUniversidade Federal de Minas Gerais. Departamento de Microbiologia. Laboratório de Vírus. Belo Horizonte, MG, BrazilUniversidade Federal de Minas Gerais. Departamento de Microbiologia. Laboratório de Vírus. Belo Horizonte, MG, Brazil/ Fundação Oswaldo Cruz. Instituto René Rachou. Imunologia de Doenças Virais. Belo Horizonte, MG, BrazilUniversidade Federal de Minas Gerais. Departamento de Microbiologia. Laboratório de Vírus. Belo Horizonte, MG, BrazilUniversidade Federal de Minas Gerais. Departamento de Microbiologia. Laboratório de Vírus. Belo Horizonte, MG, BrazilUniversidade Federal de Minas Gerais. Departamento de Pediatria. Belo Horizonte, MG Brazil/Estado de Minas Gerais. Fundação Hospitalar de Minas Gerais. Hospital Infantil João Paulo II. Belo Horizonte, MG, BrazilEstado de Minas Gerais. Fundação Hospitalar de Minas Gerais. Hospital Infantil João Paulo II. Belo Horizonte, MG, BrazilEstado de Minas Gerais. Fundação Hospitalar de Minas Gerais. Hospital Infantil João Paulo II. Belo Horizonte, MG, BrazilEstado de Minas Gerais. Fundação Hospitalar de Minas Gerais. Hospital Infantil João Paulo II. Belo Horizonte, MG, BrazilEstado de Minas Gerais. Fundação Hospitalar de Minas Gerais. Hospital Infantil João Paulo II. Belo Horizonte, MG, BrazilFundação Oswaldo Cruz. Instituto René Rachou. Imunologia de Doenças Virais. Belo Horizonte, MG, BrazilUniversidade Federal de Minas Gerais. Departamento de Microbiologia. Laboratório de Vírus. Belo Horizonte, MG, BrazilUniversidade Federal de Minas Gerais. Departamento de Microbiologia. Laboratório de Vírus. Belo Horizonte, MG, BrazilThis study evaluates the range of neurological manifestation in children with COVID-19 (neuro-COVID-19) both with and without the multisystem inflammatory syndrome (MIS-C) and the persistence of symptoms after hospital discharge. The study was conducted as a prospective study of children and adolescents under 18 years of age who were admitted to a children’s hospital for infectious diseases from January 2021 to January 2022. The children had no previous neurological or psychiatric disorders. Out of the 3021 patients evaluated, 232 were confirmed to have COVID-19 and 21 of these patients (9%) showed neurological manifestations associated with the virus. Of these 21 patients, 14 developed MIS-C, and 7 had neurological manifestations unrelated to MIS-C. There was no statistical difference regarding the neurological manifestations during hospitalization and outcomes between patients with neuro-COVID-19 who had or did not have MIS-C, except for seizures that occurred more frequently in patients with neuro-COVID-19 without MIS-C (p-value = 0.0263). One patient died, and 5 patients still had neurological or psychiatric manifestations at discharge, which persisted for up to 7 months. The study highlights that SARS-CoV-2 infection can affect the central and peripheral nervous system, particularly in children and adolescents with MIS-C, and that it is crucial to be vigilant for long-term adverse outcomes, as the neurological and psychiatric effects of COVID-19 in children are emerging during an important stage of brain development.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/57888/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALNeuro-COVID-19 With or Without the Multisystem Inflammatory Syndrome (MIS-C)_ A Single-Center Study.pdfNeuro-COVID-19 With or Without the Multisystem Inflammatory Syndrome (MIS-C)_ A Single-Center Study.pdfapplication/pdf740887https://www.arca.fiocruz.br/bitstream/icict/57888/2/Neuro-COVID-19%20With%20or%20Without%20the%20Multisystem%20Inflammatory%20Syndrome%20%28MIS-C%29_%20A%20Single-Center%20Study.pdf39a918153801a4628c3088cf0bf9cd97MD52icict/578882023-04-19 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dc.title.en_US.fl_str_mv |
Neuro-COVID-19 With or Without the Multisystem Inflammatory Syndrome (MIS-C): A Single-Center Study |
title |
Neuro-COVID-19 With or Without the Multisystem Inflammatory Syndrome (MIS-C): A Single-Center Study |
spellingShingle |
Neuro-COVID-19 With or Without the Multisystem Inflammatory Syndrome (MIS-C): A Single-Center Study Bentes, Aline Almeida COVID-19 crianças COVID-19 Children Neuro-COVID-19 COVID-19-associated multisystem inflammatory syndrome SARS-CoV-2 MIS-C |
title_short |
Neuro-COVID-19 With or Without the Multisystem Inflammatory Syndrome (MIS-C): A Single-Center Study |
title_full |
Neuro-COVID-19 With or Without the Multisystem Inflammatory Syndrome (MIS-C): A Single-Center Study |
title_fullStr |
Neuro-COVID-19 With or Without the Multisystem Inflammatory Syndrome (MIS-C): A Single-Center Study |
title_full_unstemmed |
Neuro-COVID-19 With or Without the Multisystem Inflammatory Syndrome (MIS-C): A Single-Center Study |
title_sort |
Neuro-COVID-19 With or Without the Multisystem Inflammatory Syndrome (MIS-C): A Single-Center Study |
author |
Bentes, Aline Almeida |
author_facet |
Bentes, Aline Almeida Santos Junior, Walter Rebuite dos Pessoa, Natalia Lima Costa, Thais Alkifeles Oliveira, Gabriela Fernanda Garcia Diniz, Lilian Martins Oliveira Torres, Bruna Ribeiro Teixeira, Daniela Caldas Mendes, Renata Barandas Avelar, Ana Beatriz Alvim Campos, Marco Antônio Kroon, Erna Geessien Drumond, Betania Paiva |
author_role |
author |
author2 |
Santos Junior, Walter Rebuite dos Pessoa, Natalia Lima Costa, Thais Alkifeles Oliveira, Gabriela Fernanda Garcia Diniz, Lilian Martins Oliveira Torres, Bruna Ribeiro Teixeira, Daniela Caldas Mendes, Renata Barandas Avelar, Ana Beatriz Alvim Campos, Marco Antônio Kroon, Erna Geessien Drumond, Betania Paiva |
author2_role |
author author author author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Bentes, Aline Almeida Santos Junior, Walter Rebuite dos Pessoa, Natalia Lima Costa, Thais Alkifeles Oliveira, Gabriela Fernanda Garcia Diniz, Lilian Martins Oliveira Torres, Bruna Ribeiro Teixeira, Daniela Caldas Mendes, Renata Barandas Avelar, Ana Beatriz Alvim Campos, Marco Antônio Kroon, Erna Geessien Drumond, Betania Paiva |
dc.subject.other.en_US.fl_str_mv |
COVID-19 crianças |
topic |
COVID-19 crianças COVID-19 Children Neuro-COVID-19 COVID-19-associated multisystem inflammatory syndrome SARS-CoV-2 MIS-C |
dc.subject.en.en_US.fl_str_mv |
COVID-19 Children Neuro-COVID-19 COVID-19-associated multisystem inflammatory syndrome SARS-CoV-2 MIS-C |
description |
Universidade Federal de Minas Gerais. Departamento de Pediatria. Belo Horizonte, MG Brazil/Estado de Minas Gerais. Fundação Hospitalar de Minas Gerais. Hospital Infantil João Paulo II. Belo Horizonte, MG, Brazil |
publishDate |
2023 |
dc.date.accessioned.fl_str_mv |
2023-04-19T13:15:58Z |
dc.date.available.fl_str_mv |
2023-04-19T13:15:58Z |
dc.date.issued.fl_str_mv |
2023 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
BENTES, Aline Almeida et al. Neuro-COVID-19 With or Without the Multisystem Inflammatory Syndrome (MIS-C): A Single-Center Study. Journal of Molecular Neuroscience, p. 1-9, 2023. doi: 10.1007/s12031-023-02109-y |
dc.identifier.uri.fl_str_mv |
https://www.arca.fiocruz.br/handle/icict/57888 |
dc.identifier.issn.en_US.fl_str_mv |
0895-8696 |
identifier_str_mv |
BENTES, Aline Almeida et al. Neuro-COVID-19 With or Without the Multisystem Inflammatory Syndrome (MIS-C): A Single-Center Study. Journal of Molecular Neuroscience, p. 1-9, 2023. doi: 10.1007/s12031-023-02109-y 0895-8696 |
url |
https://www.arca.fiocruz.br/handle/icict/57888 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
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openAccess |
dc.publisher.none.fl_str_mv |
Birkhäuser Boston |
publisher.none.fl_str_mv |
Birkhäuser Boston |
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reponame:Repositório Institucional da FIOCRUZ (ARCA) instname:Fundação Oswaldo Cruz (FIOCRUZ) instacron:FIOCRUZ |
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Fundação Oswaldo Cruz (FIOCRUZ) |
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FIOCRUZ |
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FIOCRUZ |
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Repositório Institucional da FIOCRUZ (ARCA) |
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