A cardiac rehabilitation exercise program potentially inhibits progressive inflammation in patients with severe Chagas cardiomyopathy: A pilot single-arm clinical trial

Detalhes bibliográficos
Autor(a) principal: Rodrigues Junior, Luiz Fernando
Data de Publicação: 2020
Outros Autores: Mendes, Fernanda de Souza Nogueira Sardinha, Pinto, Vivian Liane Mattos, Silva, Paula Simplicio, Silva, Gilberto Marcelo Sperandio da, Pinheiro, Roberta Olmo, Sousa, Andréa Silvestre, Mediano, Mauro Felippe Felix
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/41896
Resumo: Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em Doença de Chagas. Rio de Janeiro, RJ, Brasil / Instituto Nacional de Cardiologia. Serviço de Fisioterapia. Divisão de Apoio ao Cuidado. Rio de Janeiro, RJ, Brasil.
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spelling Rodrigues Junior, Luiz FernandoMendes, Fernanda de Souza Nogueira SardinhaPinto, Vivian Liane MattosSilva, Paula SimplicioSilva, Gilberto Marcelo Sperandio daPinheiro, Roberta OlmoSousa, Andréa SilvestreMediano, Mauro Felippe Felix2020-06-25T21:18:29Z2020-06-25T21:18:29Z2020RODRIGUES JUNIOR, Luiz Fernando et al. A cardiac rehabilitation exercise program potentially inhibits progressive inflammation in patients with severe Chagas cardiomyopathy: A pilot single-arm clinical trial. Journal of research in medical sciences, v. 25, n. 18, p. 1-4, 2020.1735-1995https://www.arca.fiocruz.br/handle/icict/4189610.4103/jrms.JRMS_175_18engMedknow PublicationsA cardiac rehabilitation exercise program potentially inhibits progressive inflammation in patients with severe Chagas cardiomyopathy: A pilot single-arm clinical trialinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em Doença de Chagas. Rio de Janeiro, RJ, Brasil / Instituto Nacional de Cardiologia. Serviço de Fisioterapia. Divisão de Apoio ao Cuidado. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em Doença de Chagas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em Doença de Chagas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em Doença de Chagas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em Doença de Chagas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hanseníase. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em Doença de Chagas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em Doença de Chagas. Rio de Janeiro, RJ, Brasil.Background: Cardiac rehabilitation exerts anti-inflammatory effect on several cardiovascular diseases; however, these effects were not described for Chagas cardiomyopathy, which is associated with pro-inflammatory imbalance. Materials and methods: Ten patients with severe Chagas cardiomyopathy performed 8 months of exercise training in a cardiac rehabilitation program. Interleukin-1 beta (IL-1β), IL-8, IL-10, interferon gamma (IF-γ), tumor necrosis factor alpha (TNF-α), and monocyte chemoattractant protein-1 (MCP-1) serum levels were measured using enzyme-linked immunosorbent assay at baseline, 4, and 8 months. The influence of exercise on cytokine levels was evaluated using the one-way analysis of variance for repeated measurements, with Bonferroni posttest for multiple comparisons. Results: Levels of pro-inflammatory (TNF-α, IL-1β, IL-8, IF-γ, and (MCP-1) and anti-inflammatory (IL-10) cytokines did not vary significantly during the observation period. Conclusion: Exercise may benefit patients with severe Chagas cardiomyopathy by curbing the production of pro-inflammatory cytokines in this disease characterized by a continuous state of inflammation.Cardiac rehabilitationChagas cardiomyopathyCytokinesHeart failureinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83099https://www.arca.fiocruz.br/bitstream/icict/41896/1/license.txt586c046dcfeef936e32f0323bb9a47c0MD51ORIGINALA cardiac_Luiz_Junior_etal_INI_2020.pdfA cardiac_Luiz_Junior_etal_INI_2020.pdfapplication/pdf584526https://www.arca.fiocruz.br/bitstream/icict/41896/2/A%20cardiac_Luiz_Junior_etal_INI_2020.pdf8374c892fe773d49fd1efa018abe9adbMD52icict/418962020-06-25 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dc.title.pt_BR.fl_str_mv A cardiac rehabilitation exercise program potentially inhibits progressive inflammation in patients with severe Chagas cardiomyopathy: A pilot single-arm clinical trial
title A cardiac rehabilitation exercise program potentially inhibits progressive inflammation in patients with severe Chagas cardiomyopathy: A pilot single-arm clinical trial
spellingShingle A cardiac rehabilitation exercise program potentially inhibits progressive inflammation in patients with severe Chagas cardiomyopathy: A pilot single-arm clinical trial
Rodrigues Junior, Luiz Fernando
Cardiac rehabilitation
Chagas cardiomyopathy
Cytokines
Heart failure
title_short A cardiac rehabilitation exercise program potentially inhibits progressive inflammation in patients with severe Chagas cardiomyopathy: A pilot single-arm clinical trial
title_full A cardiac rehabilitation exercise program potentially inhibits progressive inflammation in patients with severe Chagas cardiomyopathy: A pilot single-arm clinical trial
title_fullStr A cardiac rehabilitation exercise program potentially inhibits progressive inflammation in patients with severe Chagas cardiomyopathy: A pilot single-arm clinical trial
title_full_unstemmed A cardiac rehabilitation exercise program potentially inhibits progressive inflammation in patients with severe Chagas cardiomyopathy: A pilot single-arm clinical trial
title_sort A cardiac rehabilitation exercise program potentially inhibits progressive inflammation in patients with severe Chagas cardiomyopathy: A pilot single-arm clinical trial
author Rodrigues Junior, Luiz Fernando
author_facet Rodrigues Junior, Luiz Fernando
Mendes, Fernanda de Souza Nogueira Sardinha
Pinto, Vivian Liane Mattos
Silva, Paula Simplicio
Silva, Gilberto Marcelo Sperandio da
Pinheiro, Roberta Olmo
Sousa, Andréa Silvestre
Mediano, Mauro Felippe Felix
author_role author
author2 Mendes, Fernanda de Souza Nogueira Sardinha
Pinto, Vivian Liane Mattos
Silva, Paula Simplicio
Silva, Gilberto Marcelo Sperandio da
Pinheiro, Roberta Olmo
Sousa, Andréa Silvestre
Mediano, Mauro Felippe Felix
author2_role author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Rodrigues Junior, Luiz Fernando
Mendes, Fernanda de Souza Nogueira Sardinha
Pinto, Vivian Liane Mattos
Silva, Paula Simplicio
Silva, Gilberto Marcelo Sperandio da
Pinheiro, Roberta Olmo
Sousa, Andréa Silvestre
Mediano, Mauro Felippe Felix
dc.subject.en.pt_BR.fl_str_mv Cardiac rehabilitation
Chagas cardiomyopathy
Cytokines
Heart failure
topic Cardiac rehabilitation
Chagas cardiomyopathy
Cytokines
Heart failure
description Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em Doença de Chagas. Rio de Janeiro, RJ, Brasil / Instituto Nacional de Cardiologia. Serviço de Fisioterapia. Divisão de Apoio ao Cuidado. Rio de Janeiro, RJ, Brasil.
publishDate 2020
dc.date.accessioned.fl_str_mv 2020-06-25T21:18:29Z
dc.date.available.fl_str_mv 2020-06-25T21:18:29Z
dc.date.issued.fl_str_mv 2020
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv RODRIGUES JUNIOR, Luiz Fernando et al. A cardiac rehabilitation exercise program potentially inhibits progressive inflammation in patients with severe Chagas cardiomyopathy: A pilot single-arm clinical trial. Journal of research in medical sciences, v. 25, n. 18, p. 1-4, 2020.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/41896
dc.identifier.issn.pt_BR.fl_str_mv 1735-1995
dc.identifier.doi.none.fl_str_mv 10.4103/jrms.JRMS_175_18
identifier_str_mv RODRIGUES JUNIOR, Luiz Fernando et al. A cardiac rehabilitation exercise program potentially inhibits progressive inflammation in patients with severe Chagas cardiomyopathy: A pilot single-arm clinical trial. Journal of research in medical sciences, v. 25, n. 18, p. 1-4, 2020.
1735-1995
10.4103/jrms.JRMS_175_18
url https://www.arca.fiocruz.br/handle/icict/41896
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Medknow Publications
publisher.none.fl_str_mv Medknow Publications
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/41896/1/license.txt
https://www.arca.fiocruz.br/bitstream/icict/41896/2/A%20cardiac_Luiz_Junior_etal_INI_2020.pdf
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repository.name.fl_str_mv Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)
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