Morbidity and survival in advanced AIDS in Rio de Janeiro, Brazil

Detalhes bibliográficos
Autor(a) principal: Gadelha, Angela J.
Data de Publicação: 2002
Outros Autores: Accacio, Náurea, Costa, Regina L. B., Galhardo, Maria Clara, Cotrim, Maria Regina, Souza, Rogério V., Morgado, Mariza, Marzochi, Keyla, Lourenco, Maria Cristina, Rolla, Valeria C.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/31310
Resumo: Fundação Oswaldo Cruz. Escola Nacional de Saúde Pública. Rio de Janeiro, RJ, Brasil.
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spelling Gadelha, Angela J.Accacio, NáureaCosta, Regina L. B.Galhardo, Maria ClaraCotrim, Maria ReginaSouza, Rogério V.Morgado, MarizaMarzochi, KeylaLourenco, Maria CristinaRolla, Valeria C.2019-01-24T18:37:38Z2019-01-24T18:37:38Z2002GADELHA, Angela et al. Morbidity and survival in advanced AIDS in Rio de Janeiro, Brazil. Revista do Instituto de Medicina Tropical de São Paulo, v. 44, n. 4, p. 179-186, July/Ago. 2002.0036-4665https://www.arca.fiocruz.br/handle/icict/3131010.1590/S0036-46652002000400001engUniversidade de São PauloMorbidity and survival in advanced AIDS in Rio de Janeiro, Brazilinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Escola Nacional de Saúde Pública. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em DST/AIDS. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em DST/AIDS. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratorio de Imunologia em HIV/AIDS. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.Opportunistic diseases (OD) are the most common cause of death in AIDS patients. To access the incidence of OD and survival in advanced immunodeficiency, we included 79 patients with AIDS treated at Hospital Evandro Chagas (FIOCRUZ) from September 1997 to December 1999 with at least one CD4 count <or=100 cells/mm(3). The incidence of OD was analyzed by Poisson's regression, and survival by Kaplan Meier and Cox analysis, considering a retrospective (before CD4 <or=100 cells/mm(3)) and a prospective (after CD4 <or=100 cells/mm(3)) period, and controlling for demographic, clinical and laboratory characteristics. The confidence interval estipulated was 95%. Mean follow-up period was 733 days (CI = 683-782). During the study 9 (11.4%) patients died. Survival from AIDS diagnosis was a mean of 2589 days (CI = 2363-2816) and from the date of the CD4 count CD4 <or=100 cells/mm(3) was a mean of 1376 (CI = 1181-1572) days. Incidence of OD was 0.51 pp/y before CD4 <or= 100 cells/mm(3) and 0.29 pp/y after CD4 <or= 100 cells/mm(3). A lower number of ODs before CD4 < 100 cells/mm(3) was associated with lower incidence rates after CD4 <or= 100 cells/mm(3). AIDS diagnosis based on CD4+ counts <or= 200 cells/mm(3) was associated with lower incidence rates after CD4 <or= 100 cells/mm(3). Baseline CD4 counts above 50 cells/mm(3) (HR = 0.13) and restoration of baseline CD4+ counts above 100 cells/mm(3) (HR = 0.16) were associated with a lower risk of death. Controlling both variables, only restoration of baseline counts was statistically significant (HR = 0.22, p = 0.04). We found a very low incidence of OD and long survival after CD4 < 100 cells/mm(3). Survival was significantly associated with restoration of baseline CD4 counts above 100 cells/mm(3).AIDSMorbidityCD4 countsSurvivalinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83099https://www.arca.fiocruz.br/bitstream/icict/31310/1/license.txt586c046dcfeef936e32f0323bb9a47c0MD51ORIGINALMorbidity and survival_Regina_Cotrim_INI_Lapclin-AIDS_2002.pdfMorbidity and survival_Regina_Cotrim_INI_Lapclin-AIDS_2002.pdfapplication/pdf112473https://www.arca.fiocruz.br/bitstream/icict/31310/2/Morbidity%20and%20survival_Regina_Cotrim_INI_Lapclin-AIDS_2002.pdf937793045e3354537efb031e8b1f4c12MD52TEXTMorbidity and survival_Regina_Cotrim_INI_Lapclin-AIDS_2002.pdf.txtMorbidity and survival_Regina_Cotrim_INI_Lapclin-AIDS_2002.pdf.txtExtracted 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dc.title.pt_BR.fl_str_mv Morbidity and survival in advanced AIDS in Rio de Janeiro, Brazil
title Morbidity and survival in advanced AIDS in Rio de Janeiro, Brazil
spellingShingle Morbidity and survival in advanced AIDS in Rio de Janeiro, Brazil
Gadelha, Angela J.
AIDS
Morbidity
CD4 counts
Survival
title_short Morbidity and survival in advanced AIDS in Rio de Janeiro, Brazil
title_full Morbidity and survival in advanced AIDS in Rio de Janeiro, Brazil
title_fullStr Morbidity and survival in advanced AIDS in Rio de Janeiro, Brazil
title_full_unstemmed Morbidity and survival in advanced AIDS in Rio de Janeiro, Brazil
title_sort Morbidity and survival in advanced AIDS in Rio de Janeiro, Brazil
author Gadelha, Angela J.
author_facet Gadelha, Angela J.
Accacio, Náurea
Costa, Regina L. B.
Galhardo, Maria Clara
Cotrim, Maria Regina
Souza, Rogério V.
Morgado, Mariza
Marzochi, Keyla
Lourenco, Maria Cristina
Rolla, Valeria C.
author_role author
author2 Accacio, Náurea
Costa, Regina L. B.
Galhardo, Maria Clara
Cotrim, Maria Regina
Souza, Rogério V.
Morgado, Mariza
Marzochi, Keyla
Lourenco, Maria Cristina
Rolla, Valeria C.
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Gadelha, Angela J.
Accacio, Náurea
Costa, Regina L. B.
Galhardo, Maria Clara
Cotrim, Maria Regina
Souza, Rogério V.
Morgado, Mariza
Marzochi, Keyla
Lourenco, Maria Cristina
Rolla, Valeria C.
dc.subject.en.pt_BR.fl_str_mv AIDS
Morbidity
CD4 counts
Survival
topic AIDS
Morbidity
CD4 counts
Survival
description Fundação Oswaldo Cruz. Escola Nacional de Saúde Pública. Rio de Janeiro, RJ, Brasil.
publishDate 2002
dc.date.issued.fl_str_mv 2002
dc.date.accessioned.fl_str_mv 2019-01-24T18:37:38Z
dc.date.available.fl_str_mv 2019-01-24T18:37:38Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv GADELHA, Angela et al. Morbidity and survival in advanced AIDS in Rio de Janeiro, Brazil. Revista do Instituto de Medicina Tropical de São Paulo, v. 44, n. 4, p. 179-186, July/Ago. 2002.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/31310
dc.identifier.issn.pt_BR.fl_str_mv 0036-4665
dc.identifier.doi.none.fl_str_mv 10.1590/S0036-46652002000400001
identifier_str_mv GADELHA, Angela et al. Morbidity and survival in advanced AIDS in Rio de Janeiro, Brazil. Revista do Instituto de Medicina Tropical de São Paulo, v. 44, n. 4, p. 179-186, July/Ago. 2002.
0036-4665
10.1590/S0036-46652002000400001
url https://www.arca.fiocruz.br/handle/icict/31310
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Universidade de São Paulo
publisher.none.fl_str_mv Universidade de São Paulo
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/31310/1/license.txt
https://www.arca.fiocruz.br/bitstream/icict/31310/2/Morbidity%20and%20survival_Regina_Cotrim_INI_Lapclin-AIDS_2002.pdf
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