Molecular epidemiology of CTX-M producing Enterobacteriaceae isolated from bloodstream infections in Rio de Janeiro, Brazil: emergence of CTX-M-15
Autor(a) principal: | |
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Data de Publicação: | 2013 |
Outros Autores: | , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
Texto Completo: | https://www.arca.fiocruz.br/handle/icict/11870 |
Resumo: | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil. |
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Seki, Liliane MiyukiPereira, Polyana SilvaConceição, Magda de SouzaSouza, Maria JoséMarques, Elizabeth AndradeCarballido, Jupira MironCarvalho, Maria Elisabeth Serqueira deAssef, Ana Paula D’Alincourt CarvalhoAsensi, Marise Dutra2015-10-02T12:45:06Z2015-10-02T12:45:06Z2013SEKI, Liliane Miyuki; et al. Molecular epidemiology of CTX-M producing Enterobacteriaceae isolated from bloodstream infections in Rio de Janeiro, Brazil: emergence of CTX-M-15. The Brazilian Journal of Infectious Diseases, v.17, n.6, p.640-646, 2013.1413-8670https://www.arca.fiocruz.br/handle/icict/1187010.1016/j.bjid.2013.03.012engElsevierMolecular epidemiology of CTX-M producing Enterobacteriaceae isolated from bloodstream infections in Rio de Janeiro, Brazil: emergence of CTX-M-15info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil.Hospital Geral de Bonsucesso. Rio de Janeiro, RJ, Brasil.Hospital dos Servidores do Estado. Rio de Janeiro, RJ, Brasil.Universidade Estadual do Rio de Janeiro (UERJ). Hospital Universitário Pedro Ernesto. Rio de Janeiro, RJ, Brasil.Universidade Federal Fluminense. Hospital Universitário Antônio Pedro. Niterói, RJ, Brasil.Hospital Naval Marcílio Dias. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil.tObjective: The present study was designed to evaluate the molecular epidemiology of CTX-Mproducing Klebsiella pneumoniae, Enterobacter cloacae and Escherichia coli isolated from blood-stream infections at tertiary care hospitals in the State of Rio de Janeiro, Brazil.Material and methods: A total of 231 nonduplicate Enterobacteriaceae were isolated fromfive Brazilian hospitals between September 2007 and September 2008. The antimicrobialsusceptibility testing was performed by disk diffusion method according to the Clinical Lab-oratory Standard Institute. Isolates showing resistance to third-generation cephalosporinswere screened for ESBL activity by the double-disk synergy test. The presence of blaCTX-M,blaCTX-M-15and blaKPCgenes was determined by Polymerase Chain Reaction (PCR) amplifica-tion and DNA sequencing. The molecular typing of CTX-M producing isolates was performedby pulsed-field gel electrophoresis (PFGE).Results and discussion: Ninety-three isolates were screened as ESBL positive and 85 (91%)were found to carry CTX-M-type, as follows: K. pneumoniae 59 (49%), E. cloacae 15 (42%), andE. coli 11 (15%). Ten isolates resistant for carbapenems in K. pneumoniae were blaKPC-2genepositive. Among CTX-M type isolates, CTX-M-15 was predominant in more than 50% ofisolates for K. pneumoniae, E. coli, and E. cloacae. PFGE analysis of CTX-M producing isolatesshowed the predominance of CTX-M-15 in 10 of 24 pulsotypes in K. pneumoniae, 6 of 13 in E.cloacae and 3 of 6 in E. coli. CTX-M-15 was also predominant among KPC producing isolates. In conclusion, this study showed that CTX-M-15 was circulating in Rio de Janeiro state in 2007–2008. This data reinforce the need for continuing surveillance because this scenario may have changed over the years.EnterobacteriaceaeBloodstream infectionCTX-M-15PFGEKPCBrazilKlebsiella pneumoniaeEnterobacteriaceaeEscherichia coliinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txttext/plain1914https://www.arca.fiocruz.br/bitstream/icict/11870/1/license.txt7d48279ffeed55da8dfe2f8e81f3b81fMD51ORIGINALliliane_seki_etal_IOC_2013.pdfapplication/pdf1272377https://www.arca.fiocruz.br/bitstream/icict/11870/2/liliane_seki_etal_IOC_2013.pdfa496a5ad5e1af4e35dbe2ecbc47ee4feMD52TEXTliliane_seki_etal_IOC_2013.pdf.txtliliane_seki_etal_IOC_2013.pdf.txtExtracted texttext/plain27802https://www.arca.fiocruz.br/bitstream/icict/11870/3/liliane_seki_etal_IOC_2013.pdf.txt111856116a3c06680d96a3bac4a4bf7bMD53icict/118702022-06-24 13:10:53.963oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352022-06-24T16:10:53Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false |
dc.title.pt_BR.fl_str_mv |
Molecular epidemiology of CTX-M producing Enterobacteriaceae isolated from bloodstream infections in Rio de Janeiro, Brazil: emergence of CTX-M-15 |
title |
Molecular epidemiology of CTX-M producing Enterobacteriaceae isolated from bloodstream infections in Rio de Janeiro, Brazil: emergence of CTX-M-15 |
spellingShingle |
Molecular epidemiology of CTX-M producing Enterobacteriaceae isolated from bloodstream infections in Rio de Janeiro, Brazil: emergence of CTX-M-15 Seki, Liliane Miyuki Enterobacteriaceae Bloodstream infection CTX-M-15 PFGE KPC Brazil Klebsiella pneumoniae Enterobacteriaceae Escherichia coli |
title_short |
Molecular epidemiology of CTX-M producing Enterobacteriaceae isolated from bloodstream infections in Rio de Janeiro, Brazil: emergence of CTX-M-15 |
title_full |
Molecular epidemiology of CTX-M producing Enterobacteriaceae isolated from bloodstream infections in Rio de Janeiro, Brazil: emergence of CTX-M-15 |
title_fullStr |
Molecular epidemiology of CTX-M producing Enterobacteriaceae isolated from bloodstream infections in Rio de Janeiro, Brazil: emergence of CTX-M-15 |
title_full_unstemmed |
Molecular epidemiology of CTX-M producing Enterobacteriaceae isolated from bloodstream infections in Rio de Janeiro, Brazil: emergence of CTX-M-15 |
title_sort |
Molecular epidemiology of CTX-M producing Enterobacteriaceae isolated from bloodstream infections in Rio de Janeiro, Brazil: emergence of CTX-M-15 |
author |
Seki, Liliane Miyuki |
author_facet |
Seki, Liliane Miyuki Pereira, Polyana Silva Conceição, Magda de Souza Souza, Maria José Marques, Elizabeth Andrade Carballido, Jupira Miron Carvalho, Maria Elisabeth Serqueira de Assef, Ana Paula D’Alincourt Carvalho Asensi, Marise Dutra |
author_role |
author |
author2 |
Pereira, Polyana Silva Conceição, Magda de Souza Souza, Maria José Marques, Elizabeth Andrade Carballido, Jupira Miron Carvalho, Maria Elisabeth Serqueira de Assef, Ana Paula D’Alincourt Carvalho Asensi, Marise Dutra |
author2_role |
author author author author author author author author |
dc.contributor.author.fl_str_mv |
Seki, Liliane Miyuki Pereira, Polyana Silva Conceição, Magda de Souza Souza, Maria José Marques, Elizabeth Andrade Carballido, Jupira Miron Carvalho, Maria Elisabeth Serqueira de Assef, Ana Paula D’Alincourt Carvalho Asensi, Marise Dutra |
dc.subject.en.pt_BR.fl_str_mv |
Enterobacteriaceae Bloodstream infection CTX-M-15 PFGE KPC Brazil |
topic |
Enterobacteriaceae Bloodstream infection CTX-M-15 PFGE KPC Brazil Klebsiella pneumoniae Enterobacteriaceae Escherichia coli |
dc.subject.decs.pt_BR.fl_str_mv |
Klebsiella pneumoniae Enterobacteriaceae Escherichia coli |
description |
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil. |
publishDate |
2013 |
dc.date.issued.fl_str_mv |
2013 |
dc.date.accessioned.fl_str_mv |
2015-10-02T12:45:06Z |
dc.date.available.fl_str_mv |
2015-10-02T12:45:06Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
SEKI, Liliane Miyuki; et al. Molecular epidemiology of CTX-M producing Enterobacteriaceae isolated from bloodstream infections in Rio de Janeiro, Brazil: emergence of CTX-M-15. The Brazilian Journal of Infectious Diseases, v.17, n.6, p.640-646, 2013. |
dc.identifier.uri.fl_str_mv |
https://www.arca.fiocruz.br/handle/icict/11870 |
dc.identifier.issn.pt_BR.fl_str_mv |
1413-8670 |
dc.identifier.doi.pt_BR.fl_str_mv |
10.1016/j.bjid.2013.03.012 |
identifier_str_mv |
SEKI, Liliane Miyuki; et al. Molecular epidemiology of CTX-M producing Enterobacteriaceae isolated from bloodstream infections in Rio de Janeiro, Brazil: emergence of CTX-M-15. The Brazilian Journal of Infectious Diseases, v.17, n.6, p.640-646, 2013. 1413-8670 10.1016/j.bjid.2013.03.012 |
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https://www.arca.fiocruz.br/handle/icict/11870 |
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eng |
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eng |
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Elsevier |
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Elsevier |
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