Parasite Killing of Leishmania (V) braziliensis by Standardized Propolis Extracts
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2017 |
| Outros Autores: | , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/25620 |
Resumo: | Conselho Nacional de Desenvolvimento Científico e Tecnológico, CNPq (Process no. 309988/2014-4) |
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Silva, Jéssica RebouçasCeles, Fabiana SantanaLima, Jonilson BerlinkBarud, Hernane da SilvaOliveira, Camila Indiani deBerretta, Andresa A.Borges, Valéria de Matos2018-04-04T19:00:54Z2018-04-04T19:00:54Z2017SILVA, Jéssica Rebouças et al. Parasite Killing of Leishmania (V) braziliensis by Standardized Propolis Extracts. Evidence-Based Complementary and Alternative Medicine, p.1-14, 2017.1741-427Xhttps://www.arca.fiocruz.br/handle/icict/2562010.1155/2017/6067172Conselho Nacional de Desenvolvimento Científico e Tecnológico, CNPq (Process no. 309988/2014-4)Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil.Universidade Federal do Oeste da Bahia. Centro das Ciências Biológicas e da Saúde. Barreiras, BA, Brasil.Universidade Estadual Paulista. Instituto de Química. Araraquara, SP, Brasil / Universidade de Araraquara. Pós-Graduação em Biotecnologia. Araraquara, SP, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil.Laboratório de Pesquisa, Desenvolvimento e Inovação. Apis Flora Industrial e Comercial Ltda. Ribeirão Preto, SP, Brasil / Universidade de São Paulo. Faculdade de Ciências Farmacêuticas de Ribeirão Preto. Departamento de Ciências Farmacêuticas. Ribeirão Preto, SP, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Salvador, BA, Brasil.Treatments based on antimonials to cutaneous leishmaniasis (CL) entail a range of toxic side effects. Propolis, a natural compound widely used in traditional medical applications, exhibits a range of biological effects, including activity against infectious agents. The aim of this study was to test the potential leishmanicidal effects of different propolis extracts againstLeishmania (Viannia) braziliensispromastigotes and intracellular amastigotes in vitro. Stationary-phaseL. (V) braziliensispromastigotes were incubated with medium alone or treated with dry, alcoholic, or glycolic propolis extract (10, 50, or 100 μg/mL) for 96 h. Our data showed that all extracts exhibited a dose-dependent effect on the viability ofL. (V) braziliensispromastigotes, while controlling the parasite burden inside infected macrophages. Dry propolis extract significantly modified the inflammatory profile of murine macrophages by downmodulating TGF-βand IL-10 production, while upmodulating TNF-α. All three types of propolis extract were found to reduce nitric oxide and superoxide levels in activatedL.braziliensis-infected macrophages. Altogether, our results showed that propolis extracts exhibited a leishmanicidal effect against both stages ofL. (V) braziliensis. The low cell toxicity and efficient microbicidal effect of alcoholic or glycolic propolis extracts make them candidates to an additive treatment for cutaneous leishmaniasis.engHindawi Publishing CorporationLeishmania braziliensisPropolisleishmaniose cutâneaHumanosLeishmania braziliensisPropolisCutaneous leishmaniasisHumansParasite Killing of Leishmania (V) braziliensis by Standardized Propolis Extractsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/25620/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALSilva JB Parasite Killing of by Standardized....pdfSilva JB Parasite Killing of by 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| dc.title.pt_BR.fl_str_mv |
Parasite Killing of Leishmania (V) braziliensis by Standardized Propolis Extracts |
| title |
Parasite Killing of Leishmania (V) braziliensis by Standardized Propolis Extracts |
| spellingShingle |
Parasite Killing of Leishmania (V) braziliensis by Standardized Propolis Extracts Silva, Jéssica Rebouças Leishmania braziliensis Propolis leishmaniose cutânea Humanos Leishmania braziliensis Propolis Cutaneous leishmaniasis Humans |
| title_short |
Parasite Killing of Leishmania (V) braziliensis by Standardized Propolis Extracts |
| title_full |
Parasite Killing of Leishmania (V) braziliensis by Standardized Propolis Extracts |
| title_fullStr |
Parasite Killing of Leishmania (V) braziliensis by Standardized Propolis Extracts |
| title_full_unstemmed |
Parasite Killing of Leishmania (V) braziliensis by Standardized Propolis Extracts |
| title_sort |
Parasite Killing of Leishmania (V) braziliensis by Standardized Propolis Extracts |
| author |
Silva, Jéssica Rebouças |
| author_facet |
Silva, Jéssica Rebouças Celes, Fabiana Santana Lima, Jonilson Berlink Barud, Hernane da Silva Oliveira, Camila Indiani de Berretta, Andresa A. Borges, Valéria de Matos |
| author_role |
author |
| author2 |
Celes, Fabiana Santana Lima, Jonilson Berlink Barud, Hernane da Silva Oliveira, Camila Indiani de Berretta, Andresa A. Borges, Valéria de Matos |
| author2_role |
author author author author author author |
| dc.contributor.author.fl_str_mv |
Silva, Jéssica Rebouças Celes, Fabiana Santana Lima, Jonilson Berlink Barud, Hernane da Silva Oliveira, Camila Indiani de Berretta, Andresa A. Borges, Valéria de Matos |
| dc.subject.other.pt_BR.fl_str_mv |
Leishmania braziliensis Propolis leishmaniose cutânea Humanos |
| topic |
Leishmania braziliensis Propolis leishmaniose cutânea Humanos Leishmania braziliensis Propolis Cutaneous leishmaniasis Humans |
| dc.subject.en.pt_BR.fl_str_mv |
Leishmania braziliensis Propolis Cutaneous leishmaniasis Humans |
| description |
Conselho Nacional de Desenvolvimento Científico e Tecnológico, CNPq (Process no. 309988/2014-4) |
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2017 |
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2017 |
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2018-04-04T19:00:54Z |
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2018-04-04T19:00:54Z |
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info:eu-repo/semantics/article |
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SILVA, Jéssica Rebouças et al. Parasite Killing of Leishmania (V) braziliensis by Standardized Propolis Extracts. Evidence-Based Complementary and Alternative Medicine, p.1-14, 2017. |
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https://www.arca.fiocruz.br/handle/icict/25620 |
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1741-427X |
| dc.identifier.doi.none.fl_str_mv |
10.1155/2017/6067172 |
| identifier_str_mv |
SILVA, Jéssica Rebouças et al. Parasite Killing of Leishmania (V) braziliensis by Standardized Propolis Extracts. Evidence-Based Complementary and Alternative Medicine, p.1-14, 2017. 1741-427X 10.1155/2017/6067172 |
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Hindawi Publishing Corporation |
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Hindawi Publishing Corporation |
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