Immunological tolerance to pig-serum partially inhibits the formation of septal fibrosis of the liver in Capillaria hepatica-infected rats.
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2005 |
| Outros Autores: | , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/3250 |
Resumo: | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, Bahia, Brasil. |
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Andrade, Rodrigo GuimarãesGotardo, Bruna MagalhãesAssis, Bárbara Cristina Alves deMengele Junior, José OrivaldoAndrade, Zilton de Araújo2011-10-04T20:58:54Z2011-10-04T20:58:54Z2005ANDRADE, R. G. et al. Immunological tolerance to pig-serum partially inhibits the formation of septal fibrosis of the liver in Capillaria hepatica-infected rats. Memórias do Instituto Oswaldo Cruz, v. 99, n. 7, p. 703-707, nov. 2004.0074-0276https://www.arca.fiocruz.br/handle/icict/3250engImmunological tolerance to pig-serum partially inhibits the formation of septal fibrosis of the liver in Capillaria hepatica-infected rats.info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, Bahia, Brasil.Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, Bahia, Brasil.Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, Bahia, Brasil.Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, Bahia, Brasil.Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, Bahia, Brasil.Systhematized septal fibrosis of the liver can be induced in rats either by repeated intraperitoneal injections of pig-serum or by Capillaria hepatica infection. The relationship between these two etiological factors, as far as hepatic fibrosis is concerned, is not known, and present investigation attempts to investigate it. C. hepatica-induced septal fibrosis of the liver was considerably inhibited in rats previously rendered tolerant to pig-serum. Pig-serum-tolerant rats developed antibodies against pig-serum when infected with C. hepatica, but this did not happen when the infection occurred in normal rats. On the other hand, anti-C. hepatica antibodies failed to recognize any epitope in pig-serum, by Western blot. However, no evidence of an immunological cross reactivity was found, at least at the humoral level. Alternatively, cell-mediated mechanisms may be involved, and further investigations are warranted.Pig-serum modelCapillaria hepaticaHepatic septal fibrosisAnticorpos Anti-HelmínticosAntígenos de HelmintosCapillariaInfecções por EnoplidaTolerância ImunológicaCirrose Hepática ExperimentalHepatopatias ParasitáriasWestern BlottingRatos WistarELISAinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINALAndrade RG Immunological tolerance to pig....pdfAndrade RG Immunological tolerance to pig....pdfapplication/pdf50128https://www.arca.fiocruz.br/bitstream/icict/3250/1/Andrade%20RG%20Immunological%20tolerance%20to%20pig....pdf29e7388fe2d1b1abbd8f08e9f73d17dbMD51LICENSElicense.txtlicense.txttext/plain; charset=utf-81648https://www.arca.fiocruz.br/bitstream/icict/3250/2/license.txte095249ac7cacefbfe39684dfe45e706MD52TEXTAndrade RG Immunological tolerance to pig....pdf.txtAndrade RG Immunological tolerance to pig....pdf.txtExtracted texttext/plain23669https://www.arca.fiocruz.br/bitstream/icict/3250/5/Andrade%20RG%20Immunological%20tolerance%20to%20pig....pdf.txtb033d4d8dcdaa315c844676073236da0MD55THUMBNAILAndrade RG Immunological tolerance to pig....pdf.jpgAndrade RG Immunological tolerance to pig....pdf.jpgGenerated Thumbnailimage/jpeg2434https://www.arca.fiocruz.br/bitstream/icict/3250/4/Andrade%20RG%20Immunological%20tolerance%20to%20pig....pdf.jpg2e688cd85333840377ffb46ce70b1da6MD54icict/32502023-03-15 14:33:26.935oai:www.arca.fiocruz.br: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Repositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-03-15T17:33:26Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false |
| dc.title.pt_BR.fl_str_mv |
Immunological tolerance to pig-serum partially inhibits the formation of septal fibrosis of the liver in Capillaria hepatica-infected rats. |
| title |
Immunological tolerance to pig-serum partially inhibits the formation of septal fibrosis of the liver in Capillaria hepatica-infected rats. |
| spellingShingle |
Immunological tolerance to pig-serum partially inhibits the formation of septal fibrosis of the liver in Capillaria hepatica-infected rats. Andrade, Rodrigo Guimarães Pig-serum model Capillaria hepatica Hepatic septal fibrosis Anticorpos Anti-Helmínticos Antígenos de Helmintos Capillaria Infecções por Enoplida Tolerância Imunológica Cirrose Hepática Experimental Hepatopatias Parasitárias Western Blotting Ratos Wistar ELISA |
| title_short |
Immunological tolerance to pig-serum partially inhibits the formation of septal fibrosis of the liver in Capillaria hepatica-infected rats. |
| title_full |
Immunological tolerance to pig-serum partially inhibits the formation of septal fibrosis of the liver in Capillaria hepatica-infected rats. |
| title_fullStr |
Immunological tolerance to pig-serum partially inhibits the formation of septal fibrosis of the liver in Capillaria hepatica-infected rats. |
| title_full_unstemmed |
Immunological tolerance to pig-serum partially inhibits the formation of septal fibrosis of the liver in Capillaria hepatica-infected rats. |
| title_sort |
Immunological tolerance to pig-serum partially inhibits the formation of septal fibrosis of the liver in Capillaria hepatica-infected rats. |
| author |
Andrade, Rodrigo Guimarães |
| author_facet |
Andrade, Rodrigo Guimarães Gotardo, Bruna Magalhães Assis, Bárbara Cristina Alves de Mengele Junior, José Orivaldo Andrade, Zilton de Araújo |
| author_role |
author |
| author2 |
Gotardo, Bruna Magalhães Assis, Bárbara Cristina Alves de Mengele Junior, José Orivaldo Andrade, Zilton de Araújo |
| author2_role |
author author author author |
| dc.contributor.author.fl_str_mv |
Andrade, Rodrigo Guimarães Gotardo, Bruna Magalhães Assis, Bárbara Cristina Alves de Mengele Junior, José Orivaldo Andrade, Zilton de Araújo |
| dc.subject.en.pt_BR.fl_str_mv |
Pig-serum model Capillaria hepatica Hepatic septal fibrosis |
| topic |
Pig-serum model Capillaria hepatica Hepatic septal fibrosis Anticorpos Anti-Helmínticos Antígenos de Helmintos Capillaria Infecções por Enoplida Tolerância Imunológica Cirrose Hepática Experimental Hepatopatias Parasitárias Western Blotting Ratos Wistar ELISA |
| dc.subject.decs.pt_BR.fl_str_mv |
Anticorpos Anti-Helmínticos Antígenos de Helmintos Capillaria Infecções por Enoplida Tolerância Imunológica Cirrose Hepática Experimental Hepatopatias Parasitárias Western Blotting Ratos Wistar ELISA |
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Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, Bahia, Brasil. |
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2005 |
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2005 |
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2011-10-04T20:58:54Z |
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2011-10-04T20:58:54Z |
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ANDRADE, R. G. et al. Immunological tolerance to pig-serum partially inhibits the formation of septal fibrosis of the liver in Capillaria hepatica-infected rats. Memórias do Instituto Oswaldo Cruz, v. 99, n. 7, p. 703-707, nov. 2004. |
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0074-0276 |
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ANDRADE, R. G. et al. Immunological tolerance to pig-serum partially inhibits the formation of septal fibrosis of the liver in Capillaria hepatica-infected rats. Memórias do Instituto Oswaldo Cruz, v. 99, n. 7, p. 703-707, nov. 2004. 0074-0276 |
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