Identifying thresholds to classify moderate-to-heavy soil-transmitted helminth intensity infections for FECPAK(G2), McMaster, Mini-FLOTAC and qPCR

Levecke, Bruno; Cools, Piet; Albonico, Marco; Ame, Shaali; Angebault, Cécile; Ayana, Mio; Behnke, Jerzy M.; Bethony, Jeffrey Michael; Cringoli, Giuseppe; Dana, Daniel; Guillard, Bertrand; Hoa, Nguyen Thi Viet; Kang, Gagandeep; Kattula, Deepthi; Keiser, Jennifer; Kotze, Andrew C.; Matoso, Leonardo Ferreira; Maurelli, Maria P.; McCarthy, James S.; Mekonnen, Zeleke; Mirams, Greg; Montresor, Antonio; Oliveira, Rodrigo Corrêa de; Periago, Maria Victoria; Pinto, Simone Aparecida; Rinaldi, Laura; Sayasone, Somphou; Sumo, Laurentine; Tchuem-Tchuenté, Louis-Albert; Thach, Dang Thi Cam; Thomas, Eurion; Zeynudin, Ahmed; Verweij, Jaco J.; Vlaminck, Johnny; Vercruysse, Jozef

Identifying thresholds to classify moderate-to-heavy soil-transmitted helminth intensity infections for FECPAK(G2), McMaster, Mini-FLOTAC and qPCR

Detalhes bibliográficos
Autor(a) principal:	Levecke, Bruno
Data de Publicação:	2020
Outros Autores:	Cools, Piet, Albonico, Marco, Ame, Shaali, Angebault, Cécile, Ayana, Mio, Behnke, Jerzy M., Bethony, Jeffrey Michael, Cringoli, Giuseppe, Dana, Daniel, Guillard, Bertrand, Hoa, Nguyen Thi Viet, Kang, Gagandeep, Kattula, Deepthi, Keiser, Jennifer, Kotze, Andrew C., Matoso, Leonardo Ferreira, Maurelli, Maria P., McCarthy, James S., Mekonnen, Zeleke, Mirams, Greg, Montresor, Antonio, Oliveira, Rodrigo Corrêa de, Periago, Maria Victoria, Pinto, Simone Aparecida, Rinaldi, Laura, Sayasone, Somphou, Sumo, Laurentine, Tchuem-Tchuenté, Louis-Albert, Thach, Dang Thi Cam, Thomas, Eurion, Zeynudin, Ahmed, Verweij, Jaco J., Vlaminck, Johnny, Vercruysse, Jozef
Tipo de documento:	Artigo
Idioma:	eng
Título da fonte:	Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo:	https://www.arca.fiocruz.br/handle/icict/42568
Resumo:	Department of Virology. Parasitology and Immunology. Ghent University. Merelbeke, Belgium

Metadados do item

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network_name_str	Repositório Institucional da FIOCRUZ (ARCA)
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spelling	Levecke, BrunoCools, PietAlbonico, MarcoAme, ShaaliAngebault, CécileAyana, MioBehnke, Jerzy M.Bethony, Jeffrey MichaelCringoli, GiuseppeDana, DanielGuillard, BertrandHoa, Nguyen Thi VietKang, GagandeepKattula, DeepthiKeiser, JenniferKotze, Andrew C.Matoso, Leonardo FerreiraMaurelli, Maria P.McCarthy, James S.Mekonnen, ZelekeMirams, GregMontresor, AntonioOliveira, Rodrigo Corrêa dePeriago, Maria VictoriaPinto, Simone AparecidaRinaldi, LauraSayasone, SomphouSumo, LaurentineTchuem-Tchuenté, Louis-AlbertThach, Dang Thi CamThomas, EurionZeynudin, AhmedVerweij, Jaco J.Vlaminck, JohnnyVercruysse, Jozef2020-08-06T11:51:16Z2020-08-06T11:51:16Z2020LEVECKE, Bruno et al. Identifying thresholds to classify moderate-to-heavy soil-transmitted helminth intensity infections for FECPAKG2, McMaster, Mini-FLOTAC and qPCR. PLoS Negl Trop Dis, v. 14, n. 7, e0008296, 2020.1935-2727https://www.arca.fiocruz.br/handle/icict/4256810.1371/journal.pntd.0008296engPublic Library of ScienceIdentifying thresholds to classify moderate-to-heavy soil-transmitted helminth intensity infections for FECPAK(G2), McMaster, Mini-FLOTAC and qPCRinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleDepartment of Virology. Parasitology and Immunology. Ghent University. Merelbeke, BelgiumDepartment of Virology. Parasitology and Immunology. Ghent University. Merelbeke, BelgiumCenter for Tropical Diseases. Sacro Cuore Don Calabria Hospital. Negrar, Italy/Department of Life Sciences and Systems Biology. University of Turin. Turin, ItalyPublic Health Laboratory-Ivo de Carneri. Chake Chake, United Republic of TanzaniaClinical Laboratory. Institut Pasteur. Phnom Penh, CambodiaJimma University Institute of Health. Jimma University. Jimma, EthiopiaSchool of Life Sciences. University of Nottingham. Nottingham, United KingdomMicrobiology, Immunology, and Tropical Medicine. George Washington University Medical Center. Washington D.C., United States of AmericaDepartment of Veterinary Medicine and Animal Production. University of Naples Federico II. Naples, ItalyJimma University Institute of Health. Jimma University. Jimma, EthiopiaClinical Laboratory. Institut Pasteur. Phnom Penh, CambodiaDepartment of Parasitology. National Institute of Malariology, Parasitology and Entomology. Ha Noi, VietnamDepartment of Gastrointestinal Sciences. Christian Medical College. Vellore, IndiaDepartment of Gastrointestinal Sciences. Christian Medical College. Vellore, IndiaDepartment of Medical Parasitology and Infection Biology. Swiss Tropical and Public Health Institute. Basel, Switzerland/University of Basel. Basel, SwitzerlandDivision of Agriculture and Food. Commonwealth Scientific and Industrial Research Organization. St. Lucia, AustraliaFundação Oswaldo Cruz. Instituto René Rachou. Laboratório de Imunologia Molecular e Celular. Belo Horizonte, MG, BrasilDepartment of Veterinary Medicine and Animal Production. University of Naples Federico II. Naples, ItalyQIMR Berghofer Medical Research Institute. University of Queensland. Brisbane, AustraliaJimma University Institute of Health. Jimma University. Jimma, EthiopiaTechion Group Ltd. Dunedin, New ZealandDepartment of Control of Neglected Tropical Diseases. World Health Organization. Geneva, SwitzerlandFundação Oswaldo Cruz. Instituto René Rachou. Laboratório de Imunologia Molecular e Celular. Belo Horizonte, MG, BrasilFundação Oswaldo Cruz. Instituto René Rachou. Laboratório de Imunologia Molecular e Celular. Belo Horizonte, MG, BrasilFundação Oswaldo Cruz. Instituto René Rachou. Laboratório de Imunologia Molecular e Celular. Belo Horizonte, MG, BrasilDepartment of Veterinary Medicine and Animal Production, University of Naples Federico II, Naples, ItalyNational Institute of Public Health, Ministry of Health, Vientiane, Lao People’s Democratic RepublicCentre for Schistosomiasis and Parasitology, University of Yaoundé I, Yaoundé, CameroonCentre for Schistosomiasis and Parasitology, University of Yaoundé, Yaoundé, CameroonDepartment of Parasitology, National Institute of Malariology, Parasitology and Entomology, Ha Noi, VietnamTechion Group Ltd. Aberystwyth, United KingdomJimma University Institute of Health. Jimma University. Jimma, EthiopiaLaboratory for Medical Microbiology and Immunology. Elisabeth-Tweesteden Hospital. Tilburg, The NetherlandsDepartment of Virology, Parasitology and Immunology. Ghent University. Merelbeke, BelgiumDepartment of Virology, Parasitology and Immunology. Ghent University. Merelbeke, BelgiumWorld Health Organization (WHO) has defined moderate-to-heavy intensity (M&HI) infections with soil-transmitted helminths (Ascaris lumbricoides, Trichuris trichiura and the two hookworms, Ancylostoma duodenale and Necator americanus) based on specific values of eggs per gram of stool, as measured by the Kato-Katz method. There are a variety of novel microscopy and DNA-based methods but it remains unclear whether applying current WHO thresholds on to these methods allows for a reliable classification of M&HI infections. We evaluated both WHO and method-specific thresholds for classifying the M&HI infections for novel microscopic (FECPAKG2, McMaster and Mini-FLOTAC) and DNA-based (qPCR) diagnostic methods. For this, we determined method-specific thresholds that best classified M&HI infections (defined by Kato-Katz and WHO thresholds; reference method) in two multi-country drug efficacy studies. Subsequently, we verified whether applying these method-specific thresholds improved the agreement in classifying M&HI infections compared to the reference method. When we applied the WHO thresholds, the new microscopic methods mainly misclassified M&HI as low intensity, and to a lesser extent low intensity infection as M&HI. For FECPAKG2, applying the method-specific thresholds significantly improved the agreement for Ascaris (moderate → substantial), Trichuris and hookworms (fair → moderate). For Mini-FLOTAC, a significantly improved agreement was observed for hookworms only (fair → moderate). For the other STHs, the agreement was almost perfect and remained unchanged. For McMaster, the method-specific thresholds revealed a fair to a substantial agreement but did not significantly improve the agreement. For qPCR, the method-specific thresholds based on genome equivalents per ml of DNA moderately agreed with the reference method for hookworms and Trichuris infections. For Ascaris, there was a substantial agreement. We defined method-specific thresholds that improved the classification of M&HI infections. Validation studies are required before they can be recommended for general use in assessing M&HI infections in programmatic settings.Helminth infectionsHookwormsEggsAscarisTrichurisSoil-transmitted helminthiasesDiagnostic medicineGlobal healthinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83082https://www.arca.fiocruz.br/bitstream/icict/42568/1/license.txt9193a7c197bc67acd023525e72a03240MD51ORIGINALIdentifying thresholds to classify moderate.pdfIdentifying thresholds to classify moderate.pdfapplication/pdf2410816https://www.arca.fiocruz.br/bitstream/icict/42568/2/Identifying%20thresholds%20to%20classify%20moderate.pdf12c4982da5e5364e2d0182a2766878d3MD52TEXTIdentifying thresholds to classify moderate.pdf.txtIdentifying thresholds to classify moderate.pdf.txtExtracted 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dc.title.pt_BR.fl_str_mv	Identifying thresholds to classify moderate-to-heavy soil-transmitted helminth intensity infections for FECPAK(G2), McMaster, Mini-FLOTAC and qPCR
title	Identifying thresholds to classify moderate-to-heavy soil-transmitted helminth intensity infections for FECPAK(G2), McMaster, Mini-FLOTAC and qPCR
spellingShingle	Identifying thresholds to classify moderate-to-heavy soil-transmitted helminth intensity infections for FECPAK(G2), McMaster, Mini-FLOTAC and qPCR Levecke, Bruno Helminth infections Hookworms Eggs Ascaris Trichuris Soil-transmitted helminthiases Diagnostic medicine Global health
title_short	Identifying thresholds to classify moderate-to-heavy soil-transmitted helminth intensity infections for FECPAK(G2), McMaster, Mini-FLOTAC and qPCR
title_full	Identifying thresholds to classify moderate-to-heavy soil-transmitted helminth intensity infections for FECPAK(G2), McMaster, Mini-FLOTAC and qPCR
title_fullStr	Identifying thresholds to classify moderate-to-heavy soil-transmitted helminth intensity infections for FECPAK(G2), McMaster, Mini-FLOTAC and qPCR
title_full_unstemmed	Identifying thresholds to classify moderate-to-heavy soil-transmitted helminth intensity infections for FECPAK(G2), McMaster, Mini-FLOTAC and qPCR
title_sort	Identifying thresholds to classify moderate-to-heavy soil-transmitted helminth intensity infections for FECPAK(G2), McMaster, Mini-FLOTAC and qPCR
author	Levecke, Bruno
author_facet	Levecke, Bruno Cools, Piet Albonico, Marco Ame, Shaali Angebault, Cécile Ayana, Mio Behnke, Jerzy M. Bethony, Jeffrey Michael Cringoli, Giuseppe Dana, Daniel Guillard, Bertrand Hoa, Nguyen Thi Viet Kang, Gagandeep Kattula, Deepthi Keiser, Jennifer Kotze, Andrew C. Matoso, Leonardo Ferreira Maurelli, Maria P. McCarthy, James S. Mekonnen, Zeleke Mirams, Greg Montresor, Antonio Oliveira, Rodrigo Corrêa de Periago, Maria Victoria Pinto, Simone Aparecida Rinaldi, Laura Sayasone, Somphou Sumo, Laurentine Tchuem-Tchuenté, Louis-Albert Thach, Dang Thi Cam Thomas, Eurion Zeynudin, Ahmed Verweij, Jaco J. Vlaminck, Johnny Vercruysse, Jozef
author_role	author
author2	Cools, Piet Albonico, Marco Ame, Shaali Angebault, Cécile Ayana, Mio Behnke, Jerzy M. Bethony, Jeffrey Michael Cringoli, Giuseppe Dana, Daniel Guillard, Bertrand Hoa, Nguyen Thi Viet Kang, Gagandeep Kattula, Deepthi Keiser, Jennifer Kotze, Andrew C. Matoso, Leonardo Ferreira Maurelli, Maria P. McCarthy, James S. Mekonnen, Zeleke Mirams, Greg Montresor, Antonio Oliveira, Rodrigo Corrêa de Periago, Maria Victoria Pinto, Simone Aparecida Rinaldi, Laura Sayasone, Somphou Sumo, Laurentine Tchuem-Tchuenté, Louis-Albert Thach, Dang Thi Cam Thomas, Eurion Zeynudin, Ahmed Verweij, Jaco J. Vlaminck, Johnny Vercruysse, Jozef
author2_role	author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author
dc.contributor.author.fl_str_mv	Levecke, Bruno Cools, Piet Albonico, Marco Ame, Shaali Angebault, Cécile Ayana, Mio Behnke, Jerzy M. Bethony, Jeffrey Michael Cringoli, Giuseppe Dana, Daniel Guillard, Bertrand Hoa, Nguyen Thi Viet Kang, Gagandeep Kattula, Deepthi Keiser, Jennifer Kotze, Andrew C. Matoso, Leonardo Ferreira Maurelli, Maria P. McCarthy, James S. Mekonnen, Zeleke Mirams, Greg Montresor, Antonio Oliveira, Rodrigo Corrêa de Periago, Maria Victoria Pinto, Simone Aparecida Rinaldi, Laura Sayasone, Somphou Sumo, Laurentine Tchuem-Tchuenté, Louis-Albert Thach, Dang Thi Cam Thomas, Eurion Zeynudin, Ahmed Verweij, Jaco J. Vlaminck, Johnny Vercruysse, Jozef
dc.subject.en.pt_BR.fl_str_mv	Helminth infections Hookworms Eggs Ascaris Trichuris Soil-transmitted helminthiases Diagnostic medicine Global health
topic	Helminth infections Hookworms Eggs Ascaris Trichuris Soil-transmitted helminthiases Diagnostic medicine Global health
description	Department of Virology. Parasitology and Immunology. Ghent University. Merelbeke, Belgium
publishDate	2020
dc.date.accessioned.fl_str_mv	2020-08-06T11:51:16Z
dc.date.available.fl_str_mv	2020-08-06T11:51:16Z
dc.date.issued.fl_str_mv	2020
dc.type.status.fl_str_mv	info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv	info:eu-repo/semantics/article
format	article
status_str	publishedVersion
dc.identifier.citation.fl_str_mv	LEVECKE, Bruno et al. Identifying thresholds to classify moderate-to-heavy soil-transmitted helminth intensity infections for FECPAKG2, McMaster, Mini-FLOTAC and qPCR. PLoS Negl Trop Dis, v. 14, n. 7, e0008296, 2020.
dc.identifier.uri.fl_str_mv	https://www.arca.fiocruz.br/handle/icict/42568
dc.identifier.issn.pt_BR.fl_str_mv	1935-2727
dc.identifier.doi.none.fl_str_mv	10.1371/journal.pntd.0008296
identifier_str_mv	LEVECKE, Bruno et al. Identifying thresholds to classify moderate-to-heavy soil-transmitted helminth intensity infections for FECPAKG2, McMaster, Mini-FLOTAC and qPCR. PLoS Negl Trop Dis, v. 14, n. 7, e0008296, 2020. 1935-2727 10.1371/journal.pntd.0008296
url	https://www.arca.fiocruz.br/handle/icict/42568
dc.language.iso.fl_str_mv	eng
language	eng
dc.rights.driver.fl_str_mv	info:eu-repo/semantics/openAccess
eu_rights_str_mv	openAccess
dc.publisher.none.fl_str_mv	Public Library of Science
publisher.none.fl_str_mv	Public Library of Science
dc.source.none.fl_str_mv	reponame:Repositório Institucional da FIOCRUZ (ARCA) instname:Fundação Oswaldo Cruz (FIOCRUZ) instacron:FIOCRUZ
instname_str	Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str	FIOCRUZ
institution	FIOCRUZ
reponame_str	Repositório Institucional da FIOCRUZ (ARCA)
collection	Repositório Institucional da FIOCRUZ (ARCA)
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Identifying thresholds to classify moderate-to-heavy soil-transmitted helminth intensity infections for FECPAK(G2), McMaster, Mini-FLOTAC and qPCR

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