Reconstructed Lost Native American Populations from Eastern Brazil Are Shaped by Differential Jê/Tupi Ancestry

Detalhes bibliográficos
Autor(a) principal: Mas-Sandoval, Alex
Data de Publicação: 2019
Outros Autores: Arauna, Lara R., Gouveia, Mateus Henrique, Barreto, Mauricio Lima, Horta, Bernardo Lessa, Costa, Maria Fernanda Lima, Pereira, Alexandre da Costa, Salzano, Francisco M., Hünemeier, Tábita, Santos, Eduardo Tarazona, Bortolini, Maria Cátira, Comas, David
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/36280
Resumo: Spanish Ministerio de Economia y Competitividad - Programa CSIC de cooperaci on cient ıfica para el desarrollo (COOP20099), the Agencia Estatal de Investigaci on and Fondo Europeo de Desarollo Regional (FEDER) grant CGL2016-75389-P, the “Unidad de Excelencia Maria de Maeztu” MDM2014-0370, and Secretaria d’Universitats i Recerca del Departament d’Economia i Coneixement de la Generalitat de Catalunya (GRC 2017 SGR 00702). This study was financed in part by the Coordenac¸~ao de Aperfeic¸oamento de Pessoal de N ıvel Superior—Brasil (CAPES)—Finance Code 001. The EPÌGEN Brazil Initiative was funded by the Brazilian Ministry of Health (Department of Science and Technology from the Secretaria de Ci^encia, Tecnologia e Insumos Estrat egicos) through Financiadora de Estudos e Projetos.
id CRUZ_4006528c41278f856a219b20a2da3867
oai_identifier_str oai:www.arca.fiocruz.br:icict/36280
network_acronym_str CRUZ
network_name_str Repositório Institucional da FIOCRUZ (ARCA)
repository_id_str 2135
spelling Mas-Sandoval, AlexArauna, Lara R.Gouveia, Mateus HenriqueBarreto, Mauricio LimaHorta, Bernardo LessaCosta, Maria Fernanda LimaPereira, Alexandre da CostaSalzano, Francisco M.Hünemeier, TábitaSantos, Eduardo TarazonaBortolini, Maria CátiraComas, David2019-10-08T16:52:06Z2019-10-08T16:52:06Z2019MAS-SANDOVAL, Alex et al. Reconstructed Lost Native American Populations from Eastern Brazil Are Shaped by Differential Jê/Tupi Ancestry. Genome Biology and Evolution, v. 11, n. 9, p. 2593-2604, 2019.1759-6653https://www.arca.fiocruz.br/handle/icict/3628010.1093/gbe/evz161Spanish Ministerio de Economia y Competitividad - Programa CSIC de cooperaci on cient ıfica para el desarrollo (COOP20099), the Agencia Estatal de Investigaci on and Fondo Europeo de Desarollo Regional (FEDER) grant CGL2016-75389-P, the “Unidad de Excelencia Maria de Maeztu” MDM2014-0370, and Secretaria d’Universitats i Recerca del Departament d’Economia i Coneixement de la Generalitat de Catalunya (GRC 2017 SGR 00702). This study was financed in part by the Coordenac¸~ao de Aperfeic¸oamento de Pessoal de N ıvel Superior—Brasil (CAPES)—Finance Code 001. The EPÌGEN Brazil Initiative was funded by the Brazilian Ministry of Health (Department of Science and Technology from the Secretaria de Ci^encia, Tecnologia e Insumos Estrat egicos) through Financiadora de Estudos e Projetos.Universidade Federal do Rio Grande do Sul. Instituto de Biociências. Departamento de Genética. Porto Alegre, RS, Brazil / Universitat Pompeu Fabra. Institute of Evolutionary Biology. Departament de Ciències Experimentals i de la Salut. Barcelona, Spain.Universitat Pompeu Fabra. Institute of Evolutionary Biology. Departament de Ciències Experimentals i de la Salut. Barcelona, Spain.Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Biologia Geral. Belo Horizonte, MG, Brazil.Universidade Federal da Bahia. Instituto de Saúde Coletiva. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Centro de Integração de Dados e Conhecimentos para Saúde. Salvador, BA, Brasil.Programa de Universidade Federal de Pelotas. Pós-Graduação em Epidemiologia. Pelotas, RS, Brazil.Fundação Oswaldo Cruz. Instituto de Pesquisa Rene Rachou. Belo Horizonte, MG, Brasil.Universidade de São Paulo. Instituto do Coração. São Paulo, SP, Brasil.Universidade Federal do Rio Grande do Sul. Instituto de Biociências. Departamento de Genética. Porto Alegre, RS, BrazilUniversity of São Paulo. Department of Genetics and Evolutionary Biology, Biosciences Institute. São Paulo, SP, Brasil.Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Biologia Geral. Belo Horizonte, MG, Brazil.Universidade Federal do Rio Grande do Sul. Instituto de Biociências. Departamento de Genética. Porto Alegre, RS, Brazil / Universitat Pompeu Fabra. Institute of Evolutionary Biology. Departament de Ciències Experimentals i de la Salut. Barcelona, Spain.Universitat Pompeu Fabra. Institute of Evolutionary Biology. Departament de Ciències Experimentals i de la Salut. Barcelona, Spain.After the colonization of the Americas by Europeans and the consequent Trans-Atlantic Slave Trade, most Native American populations in eastern Brazil disappeared or went through an admixture process that configured a population composed of three main genetic components: the European, the sub-Saharan African, and the Native American. The study of the Native American genetic history is challenged by the lack of availability of genome-wide samples from Native American populations, the technical difficulties to develop ancient DNA studies, and the low proportions of the Native American component in the admixed Brazilian populations (on average 7%). We analyzed genome-wide data of 5,825 individuals from three locations of eastern Brazil: Salvador (North-East), Bambui (South-East), and Pelotas (South) and we reconstructed populations that emulate the Native American groups that were living in the 16th century around the sampling locations. This genetic reconstruction was performed after local ancestry analysis of the admixed Brazilian populations, through the rearrangement of the Native American haplotypes into reconstructed individuals with full Native American ancestry (51 reconstructed individuals in Salvador, 45 in Bambui, and 197 in Pelotas). We compared the reconstructed populations with nonadmixed Native American populations from other regions of Brazil through haplotype-based methods. Our results reveal a population structure shaped by the dichotomy of Tupi-/Jê-speaking ancestry related groups. We also show evidence of a decrease of the diversity of nonadmixed Native American groups after the European contact, in contrast with the reconstructed populations, suggesting a reservoir of the Native American genetic diversity within the admixed Brazilian population.engOxford University PressDiversidade do genoma humanoGrupos indígenas americanosBrasilHuman genome diversityNative American groupsBrazilReconstructed Lost Native American Populations from Eastern Brazil Are Shaped by Differential Jê/Tupi Ancestryinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/36280/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALMas-Sandovaletal, A. Reconstructed....pdfMas-Sandovaletal, A. Reconstructed....pdfapplication/pdf1118221https://www.arca.fiocruz.br/bitstream/icict/36280/2/Mas-Sandovaletal%2c%20A.%20Reconstructed....pdf09b3ef882afc6571089612877598602dMD52icict/362802023-03-15 14:34:22.354oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-03-15T17:34:22Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv Reconstructed Lost Native American Populations from Eastern Brazil Are Shaped by Differential Jê/Tupi Ancestry
title Reconstructed Lost Native American Populations from Eastern Brazil Are Shaped by Differential Jê/Tupi Ancestry
spellingShingle Reconstructed Lost Native American Populations from Eastern Brazil Are Shaped by Differential Jê/Tupi Ancestry
Mas-Sandoval, Alex
Diversidade do genoma humano
Grupos indígenas americanos
Brasil
Human genome diversity
Native American groups
Brazil
title_short Reconstructed Lost Native American Populations from Eastern Brazil Are Shaped by Differential Jê/Tupi Ancestry
title_full Reconstructed Lost Native American Populations from Eastern Brazil Are Shaped by Differential Jê/Tupi Ancestry
title_fullStr Reconstructed Lost Native American Populations from Eastern Brazil Are Shaped by Differential Jê/Tupi Ancestry
title_full_unstemmed Reconstructed Lost Native American Populations from Eastern Brazil Are Shaped by Differential Jê/Tupi Ancestry
title_sort Reconstructed Lost Native American Populations from Eastern Brazil Are Shaped by Differential Jê/Tupi Ancestry
author Mas-Sandoval, Alex
author_facet Mas-Sandoval, Alex
Arauna, Lara R.
Gouveia, Mateus Henrique
Barreto, Mauricio Lima
Horta, Bernardo Lessa
Costa, Maria Fernanda Lima
Pereira, Alexandre da Costa
Salzano, Francisco M.
Hünemeier, Tábita
Santos, Eduardo Tarazona
Bortolini, Maria Cátira
Comas, David
author_role author
author2 Arauna, Lara R.
Gouveia, Mateus Henrique
Barreto, Mauricio Lima
Horta, Bernardo Lessa
Costa, Maria Fernanda Lima
Pereira, Alexandre da Costa
Salzano, Francisco M.
Hünemeier, Tábita
Santos, Eduardo Tarazona
Bortolini, Maria Cátira
Comas, David
author2_role author
author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Mas-Sandoval, Alex
Arauna, Lara R.
Gouveia, Mateus Henrique
Barreto, Mauricio Lima
Horta, Bernardo Lessa
Costa, Maria Fernanda Lima
Pereira, Alexandre da Costa
Salzano, Francisco M.
Hünemeier, Tábita
Santos, Eduardo Tarazona
Bortolini, Maria Cátira
Comas, David
dc.subject.other.pt_BR.fl_str_mv Diversidade do genoma humano
Grupos indígenas americanos
Brasil
topic Diversidade do genoma humano
Grupos indígenas americanos
Brasil
Human genome diversity
Native American groups
Brazil
dc.subject.en.pt_BR.fl_str_mv Human genome diversity
Native American groups
Brazil
description Spanish Ministerio de Economia y Competitividad - Programa CSIC de cooperaci on cient ıfica para el desarrollo (COOP20099), the Agencia Estatal de Investigaci on and Fondo Europeo de Desarollo Regional (FEDER) grant CGL2016-75389-P, the “Unidad de Excelencia Maria de Maeztu” MDM2014-0370, and Secretaria d’Universitats i Recerca del Departament d’Economia i Coneixement de la Generalitat de Catalunya (GRC 2017 SGR 00702). This study was financed in part by the Coordenac¸~ao de Aperfeic¸oamento de Pessoal de N ıvel Superior—Brasil (CAPES)—Finance Code 001. The EPÌGEN Brazil Initiative was funded by the Brazilian Ministry of Health (Department of Science and Technology from the Secretaria de Ci^encia, Tecnologia e Insumos Estrat egicos) through Financiadora de Estudos e Projetos.
publishDate 2019
dc.date.accessioned.fl_str_mv 2019-10-08T16:52:06Z
dc.date.available.fl_str_mv 2019-10-08T16:52:06Z
dc.date.issued.fl_str_mv 2019
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv MAS-SANDOVAL, Alex et al. Reconstructed Lost Native American Populations from Eastern Brazil Are Shaped by Differential Jê/Tupi Ancestry. Genome Biology and Evolution, v. 11, n. 9, p. 2593-2604, 2019.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/36280
dc.identifier.issn.pt_BR.fl_str_mv 1759-6653
dc.identifier.doi.pt_BR.fl_str_mv 10.1093/gbe/evz161
identifier_str_mv MAS-SANDOVAL, Alex et al. Reconstructed Lost Native American Populations from Eastern Brazil Are Shaped by Differential Jê/Tupi Ancestry. Genome Biology and Evolution, v. 11, n. 9, p. 2593-2604, 2019.
1759-6653
10.1093/gbe/evz161
url https://www.arca.fiocruz.br/handle/icict/36280
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Oxford University Press
publisher.none.fl_str_mv Oxford University Press
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/36280/1/license.txt
https://www.arca.fiocruz.br/bitstream/icict/36280/2/Mas-Sandovaletal%2c%20A.%20Reconstructed....pdf
bitstream.checksum.fl_str_mv 5a560609d32a3863062d77ff32785d58
09b3ef882afc6571089612877598602d
bitstream.checksumAlgorithm.fl_str_mv MD5
MD5
repository.name.fl_str_mv Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)
repository.mail.fl_str_mv repositorio.arca@fiocruz.br
_version_ 1798325037310148608

Registros relacionados