Spatiotemporal Dynamics of the HIV-1 Subtype G Epidemic in West and Central Africa

Detalhes bibliográficos
Autor(a) principal: Delatorre, Edson
Data de Publicação: 2014
Outros Autores: Mir, Daiana, Bello, Gonzalo
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/9971
Resumo: Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de AIDS & Imunologia Molecular. Rio de Janeiro, RJ, Brasil
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spelling Delatorre, EdsonMir, DaianaBello, Gonzalo2015-04-14T12:38:11Z2015-04-14T12:38:11Z2014DELATORRE, Edson et al. Spatiotemporal Dynamics of the HIV-1 Subtype G Epidemic in West and Central Africa. Plos One, v.9, n. 6, 2014.https://www.arca.fiocruz.br/handle/icict/9971DOI: 10.1371/journal.pone.0098908engPlos OneHIV-1Infecções por HIVAfricaHiv-1HIV InfectionsAfricaHIV-1Infecciones por VIHAfricaSpatiotemporal Dynamics of the HIV-1 Subtype G Epidemic in West and Central Africainfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de AIDS & Imunologia Molecular. Rio de Janeiro, RJ, BrasilFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de AIDS e Imunologia Molecular. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de AIDS & Imunologia Molecular. Rio de Janeiro, RJ, BrasilThe human immunodeficiency virus type 1 (HIV-1) subtype G is the second most prevalent HIV-1 clade in West Africa, accounting for nearly 30% of infections in the region. There is no information about the spatiotemporal dynamics of dissemination of this HIV-1 clade in Africa. To this end, we analyzed a total of 305 HIV-1 subtype G pol sequences isolated from 11 different countries from West and Central Africa over a period of 20 years (1992 to 2011). Evolutionary, phylogeographic and demographic parameters were jointly estimated from sequence data using a Bayesian coalescentbased method. Our analyses indicate that subtype G most probably emerged in Central Africa in 1968 (1956–1976). From Central Africa, the virus was disseminated to West and West Central Africa at multiple times from the middle 1970s onwards. Two subtype G strains probably introduced into Nigeria and Togo between the middle and the late 1970s were disseminated locally and to neighboring countries, leading to the origin of two major western African clades (GWA-I and GWAII). Subtype G clades circulating in western and central African regions displayed an initial phase of exponential growth followed by a decline in growth rate since the early/middle 1990s; but the mean epidemic growth rate of GWA-I (0.75 year21) and GWA-II (0.95 year21) clades was about two times higher than that estimated for central African lineages (0.47 year21). Notably, the overall evolutionary and demographic history of GWA-I and GWA-II clades was very similar to that estimated for the CRF06_cpx clade circulating in the same region. These results support the notion that the spatiotemporal dissemination dynamics of major HIV-1 clades circulating in western Africa have probably been shaped by the same ecological factors.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txttext/plain1914https://www.arca.fiocruz.br/bitstream/icict/9971/1/license.txt7d48279ffeed55da8dfe2f8e81f3b81fMD51ORIGINALedson_delatorreetal_IOC_2014.pdfapplication/pdf5775865https://www.arca.fiocruz.br/bitstream/icict/9971/2/edson_delatorreetal_IOC_2014.pdf81a8f9c99eb12bf916f4b5b4a9123b55MD52TEXTedson_delatorreetal_IOC_2014.pdf.txtedson_delatorreetal_IOC_2014.pdf.txtExtracted texttext/plain48085https://www.arca.fiocruz.br/bitstream/icict/9971/3/edson_delatorreetal_IOC_2014.pdf.txt402fd9fc744d42361efd2d54e6ac7acbMD53icict/99712022-06-24 13:02:56.166oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352022-06-24T16:02:56Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv Spatiotemporal Dynamics of the HIV-1 Subtype G Epidemic in West and Central Africa
title Spatiotemporal Dynamics of the HIV-1 Subtype G Epidemic in West and Central Africa
spellingShingle Spatiotemporal Dynamics of the HIV-1 Subtype G Epidemic in West and Central Africa
Delatorre, Edson
HIV-1
Infecções por HIV
Africa
Hiv-1
HIV Infections
Africa
HIV-1
Infecciones por VIH
Africa
title_short Spatiotemporal Dynamics of the HIV-1 Subtype G Epidemic in West and Central Africa
title_full Spatiotemporal Dynamics of the HIV-1 Subtype G Epidemic in West and Central Africa
title_fullStr Spatiotemporal Dynamics of the HIV-1 Subtype G Epidemic in West and Central Africa
title_full_unstemmed Spatiotemporal Dynamics of the HIV-1 Subtype G Epidemic in West and Central Africa
title_sort Spatiotemporal Dynamics of the HIV-1 Subtype G Epidemic in West and Central Africa
author Delatorre, Edson
author_facet Delatorre, Edson
Mir, Daiana
Bello, Gonzalo
author_role author
author2 Mir, Daiana
Bello, Gonzalo
author2_role author
author
dc.contributor.author.fl_str_mv Delatorre, Edson
Mir, Daiana
Bello, Gonzalo
dc.subject.other.pt_BR.fl_str_mv HIV-1
Infecções por HIV
Africa
topic HIV-1
Infecções por HIV
Africa
Hiv-1
HIV Infections
Africa
HIV-1
Infecciones por VIH
Africa
dc.subject.en.pt_BR.fl_str_mv Hiv-1
HIV Infections
Africa
dc.subject.es.pt_BR.fl_str_mv HIV-1
Infecciones por VIH
Africa
description Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de AIDS & Imunologia Molecular. Rio de Janeiro, RJ, Brasil
publishDate 2014
dc.date.issued.fl_str_mv 2014
dc.date.accessioned.fl_str_mv 2015-04-14T12:38:11Z
dc.date.available.fl_str_mv 2015-04-14T12:38:11Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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status_str publishedVersion
dc.identifier.citation.fl_str_mv DELATORRE, Edson et al. Spatiotemporal Dynamics of the HIV-1 Subtype G Epidemic in West and Central Africa. Plos One, v.9, n. 6, 2014.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/9971
dc.identifier.doi.pt_BR.fl_str_mv DOI: 10.1371/journal.pone.0098908
identifier_str_mv DELATORRE, Edson et al. Spatiotemporal Dynamics of the HIV-1 Subtype G Epidemic in West and Central Africa. Plos One, v.9, n. 6, 2014.
DOI: 10.1371/journal.pone.0098908
url https://www.arca.fiocruz.br/handle/icict/9971
dc.language.iso.fl_str_mv eng
language eng
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dc.publisher.none.fl_str_mv Plos One
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dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
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